13 recruiting. 13 Phase 2, 7 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 13 | Recruiting 13 |
| Phase 1 | 7 | Recruiting 7 |
Follow Obstructive Sleep Apnea: new trials by email Literature Review of Obstructive Sleep Apnea trials Research Report on Obstructive Sleep Apnea
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Combination Upper-Airway Electrical and Pharmacological Stimulation for Obstructive Sleep Apnea Combination device and drug: Unilateral hypoglossal nerve stimulation & atomoxetine-plus-oxybutynin (HGNS+AtoOxy), Unilateral hypoglossal nerve stimulation (HGNS), active comparator condition, Atomoxetine-plus-oxybutynin (80/5 mg) (AtoOxy), active comparator condition - Obstructive Sleep Apnea, Sleep-disordered Breathing | Phase 1 / Phase 2 | Recruiting | Brigham and Women's Hospital | 24 | 2026-09-01 | 2026-09-21 |
| DRonabinol Treatment of OSA Dronabinol - Obstructive Sleep Apnea | Phase 1 / Phase 2 | Recruiting | VA Office of Research and Development | 120 | 2025-08-25 | 2026-11-05 |
| The Cardiovascular Consequences of Sleep Apnea Plus COPD (Overlap Syndrome) bi-level positive pressure non invasive ventilation, Oxygen gas - Obstructive Sleep Apnea, Chronic Obstructive Pulmonary Disease | Phase 2 | Recruiting | University of California, San Diego | 240 | 2024-02-13 | 2026-06-03 |
| Endotypic Traits and Obstructive Sleep Apnea Surgery Acetazolamide 500 MG QHS, Eszopiclone 3 mg QHS - Obstructive Sleep Apnea | Phase 2 | Recruiting | University of California, Los Angeles | 150 | 2024-01-07 | 2026-07-01 |
| Phototherapy for Non-responders to Oral Appliance Therapy for Obstructive Sleep Apnea Phototherapy - Obstructive Sleep Apnea | Phase 2 | Recruiting | University of Alberta | 528 | 2024-01-05 | 2026-06-01 |
| Trazodone on OSA Endotypes Placebo oral tablet, Trazodone Hydrochloride - Obstructive Sleep Apnea | Phase 1 / Phase 2 | Recruiting | Brigham and Women's Hospital | 18 | 2024-01-01 | 2025-02-06 |
| Down Syndrome Obstructive Sleep Apnea Oxygen - Down Syndrome, Obstructive Sleep Apnea | Phase 2 | Recruiting | Brigham and Women's Hospital | 230 | 2023-10-24 | 2026-09-30 |
| Rescue Pharmacotherapy for OSA Placebo, Acetazolamide, Trazodone - Obstructive Sleep Apnea | Phase 1 / Phase 2 | Recruiting | Brigham and Women's Hospital | 70 | 2023-07-01 | 2026-07-15 |
| Patient-centered and Neurocognitive Outcomes With Acetazolamide for Sleep Apnea Acetazolamide, Placebo - Obstructive Sleep Apnea | Phase 2 | Recruiting | University of California, San Diego | 60 | 2023-05-16 | 2026-05-08 |
| Intermittent Hypoxia-initiated Plasticity in Humans: A Multi-pronged Therapeutic Approach to Treat Sleep Apnea and Overlapping Co-morbidities Mild Intermittent Hypoxia, Sham MIH - Obstructive Sleep Apnea | Phase 1 / Phase 2 | Recruiting | VA Office of Research and Development | 60 | 2023-01-01 | 2025-12-04 |
| Dexmedetomidine Versus Propofol Sedation for Drug-Induced Sleep Endoscopy in Pediatric Obstructive Sleep Apnea Propofol sedation, Dexmedetomidine sedation - Obstructive Sleep Apnea | Phase 2 | Recruiting | Erin Kirkham | 90 | 2022-10-05 | 2026-05-14 |
| Atomoxetine and DAW2022 on OSA Severity Placebo oral capsule, Atomoxetine Oral Capsule [Strattera] - Obstructive Sleep Apnea | Phase 1 / Phase 2 | Recruiting | Brigham and Women's Hospital | 18 | 2022-06-01 | 2026-07-10 |
| Pharmacological Activation of HMN for OSA Aim 2 Placebo oral capsule, LTM1201AZ, LTM1201AT - Obstructive Sleep Apnea | Phase 1 / Phase 2 | Recruiting | Brigham and Women's Hospital | 16 | 2019-03-01 | 2022-09-21 |
Sleep Apnea, Obstructive (13) · Sleep Apnea Syndromes (2) · Down Syndrome (1) · Pulmonary Disease, Chronic Obstructive (1)
Apnea (13) · Dyssomnias (13) · Nervous System Diseases (13) · Respiration Disorders (13) · Respiratory Tract Diseases (13) · Sleep Disorders, Intrinsic (13) · Sleep Wake Disorders (13) · Sleep Apnea Syndromes (11) · Abnormalities, Multiple (1) · Chromosome Disorders (1) · Chronic Disease (1) · Congenital Abnormalities (1) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (1) · Disease Attributes (1) · Genetic Diseases, Inborn (1)
Acetazolamide (3) · Atomoxetine Hydrochloride (2) · Eszopiclone (2) · Trazodone (2) · Dronabinol (1) · Noninvasive Ventilation (1) · Oxygen (1) · Phototherapy (1) · nitrox (1)
Brigham and Women's Hospital (6) · University of California, San Diego (2) · VA Office of Research and Development (2) · Erin Kirkham (1) · University of Alberta (1) · University of California, Los Angeles (1)
United States (12) · Canada (1)
Atul Malhotra, MD (1) · Bharati Prasad, MD (1) · Christopher N Schmickl, MD, PhD (1) · Erin Kirkham, MD MPH (1) · Jason H Mateika, PhD MS BS (1) · Raouf Amin (1) · Scott A Sands, PhD (1) · Susan Redline (1)
I01CX002632 (1), K23HL153897 (1), K23HL161336 (1), R01HL160993 (1)