20 completed, 6 unknown, 5 active not recruiting, 2 recruiting. 15 Not applicable, 6 Phase 2, 3 Phase 1, 3 Phase 3, 3 Phase 4.
Follow Nonalcoholic Fatty Liver: new trials by email Literature Review of Nonalcoholic Fatty Liver trials Research Report on Nonalcoholic Fatty Liver
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Effect of Adding TENS to Mediterranean Diet on Appetite and Liver Enzymes in Nonalcoholic Fatty Liver Patients Transcutaneous electrical stimulation (TENS), Mediterranean Diet - Nonalcoholic Fatty Liver | Not applicable | Completed | Cairo University | 50 | 2025-09-30 | 2026-09-22 |
| A Phase 3 Study Evaluating the Safety and Efficacy of Denifanstat in Patients With MASH and F2/F3 Fibrosis Denifanstat, Placebo - MASH, NASH | Phase 3 | Withdrawn | Sagimet Biosciences Inc. | 2025-03-01 | 2025-05-15 | |
| A Phase 3 Study Evaluating the Safety and Efficacy of Denifanstat in Patients With MASLD and MASH denifanstat, Placebo - MASLD, MASH | Phase 3 | Withdrawn | Sagimet Biosciences Inc. | 2025-03-01 | 2025-05-15 | |
| Effect of a GnRH Analog on Hepatic Steatosis Goserelin Acetate 3.6 mg inj, implant - Metabolic Dysfunction-Associated Steatotic Liver Disease, Nonalcoholic Fatty Liver | Phase 4 | Active not recruiting | Aristotle University Of Thessaloniki | 62 | 2024-11-26 | 2026-07-23 |
| Harnessing Macrophage Lysosomal Lipid Metabolism in Obesity Dietary consultation weight loss intervention - Obesity, Nonalcoholic Fatty Liver | Not applicable | Recruiting | Bettina Mittendorfer | 60 | 2024-08-01 | 2026-08-06 |
| Accurate Point of Care Liver Disease Diagnostics Liverscope® exam, MR exam, FibroScan® exam (optional) - NAFLD, Nonalcoholic Fatty Liver | Active not recruiting | University of California, San Diego | 50 | 2023-08-03 | 2025-10-23 | |
| Cardio-Metabolic Risk Evaluation in Overweight and Obese Children History and Clinical evaluation, Biological evaluation of the metabolic syndrome and components, Ultrasound evaluation of subclinical atherosclerosis and visceral fat storage - Pediatric Obesity, Metabolic Syndrome | Unknown | Neoped - Centru de Pediatrie | 50 | 2023-07-10 | 2023-06-18 | |
| Conditionally Increased Output (CIO) Enhanced Ultrasound System GE ultrasound system with increased acoustic output settings - Nonalcoholic Fatty Liver, Nonalcoholic Steatohepatitis | Not applicable | Completed | Massachusetts General Hospital | 24 | 2023-06-30 | 2025-05-23 |
| Safety Study of OA-235i in Subjects With Nonalcoholic Steatohepatitis OA-235i (4 mg), OA-235i (8 mg), OA-235i (16 mg) - Nonalcoholic Steatohepatitis, Nonalcoholic Fatty Liver | Phase 1 | Completed | Oasis Pharmaceuticals, LLC | 24 | 2023-03-06 | 2025-06-25 |
| Effect of Anti-osteoporotic Medications on Nonalcoholic Fatty Liver Disease Denosumab, Alendronate Sodium - Nonalcoholic Fatty Liver, Osteoporosis, Postmenopausal | Phase 4 | Completed | Aristotle University Of Thessaloniki | 72 | 2022-12-23 | 2026-07-23 |
| Digital Therapy for Fatty Liver Disease Software Group - Steatohepatitis, Nonalcoholic, Nonalcoholic Fatty Liver | Not applicable | Active not recruiting | Xinhua Hospital, Shanghai Jiao Tong University School of Medicine | 141 | 2022-11-19 | 2026-08-12 |
| The Impact of Ibutamoren on Nonalcoholic Fatty Liver Disease LUM-201 - NAFLD, Nonalcoholic Fatty Liver | Phase 2 | Completed | Massachusetts General Hospital | 12 | 2022-08-10 | 2026-01-06 |
| Study on GS300 on NAFLD GS300, Placebo - Nonalcoholic Fatty Liver, Weight Loss | Not applicable | Unknown | Gelesis, Inc. | 250 | 2022-07-01 | 2022-01-24 |
| Metabolic Pathology of Pediatric NAFLD Oral sugar tolerance test, De novo lipogenesis test, Gluconeogenesis test - Nonalcoholic Fatty Liver, Nonalcoholic Steatohepatitis | Not applicable | Unknown | University of Oklahoma | 100 | 2022-05-25 | 2024-03-06 |
| Weight, Energy, Lipids, and the Liver (WELL) Study Soybean Oil Foods, Palm Oil Foods - Nonalcoholic Fatty Liver | Not applicable | Active not recruiting | Ohio State University | 74 | 2022-05-02 | 2026-04-21 |
| Nonalcoholic Fatty Liver Disease - Intermittent Calorie Restriction (FLICR) Study Intermittent calorie restriction, Standard of care - Nonalcoholic Fatty Liver, Nonalcoholic Steatohepatitis | Not applicable | Completed | Ewha Womans University Mokdong Hospital | 72 | 2022-03-07 | 2024-02-20 |
| Non-invasive Biomarkers of Metabolic Liver Disease (NIMBLE) Study 1.2 Nonalcoholic Fatty Liver | Completed | Mayo Clinic | 17 | 2021-11-15 | 2022-11-29 | |
| Efficacy and Safety of Guanabenz for Nonalcoholic Fatty Liver Disease Experimental: 4 mg/day of WY-8678 (guanabenz acetate), Experimental: 8 mg/day of WY-8678 (guanabenz acetate) - Nonalcoholic Fatty Liver, Nonalcoholic Steatohepatitis | Phase 2 | Unknown | Yokohama City University | 29 | 2021-10-29 | 2022-09-27 |
| Noninvasive Biomarkers of Metabolic Liver Disease 1.1 Ultrasound based shear wave speed and fat quantification methods, Blood collection, Physical measurements - Nonalcoholic Steatohepatitis, Nonalcoholic Fatty Liver | Not applicable | Completed | Massachusetts General Hospital | 40 | 2021-03-18 | 2023-07-11 |
| Prevalence of NAFLD and Advanced Fibrosis in Patients With Type 1 Diabetes Transient Elastography - Nonalcoholic Fatty Liver, Nonalcoholic Steatohepatitis | Active not recruiting | Joslin Diabetes Center | 533 | 2021-01-14 | 2026-05-29 |
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Non-alcoholic Fatty Liver Disease (37) · Diabetes Mellitus, Type 2 (4) · Fatty Liver (4) · Liver Cirrhosis (4) · Obesity (4) · Liver Diseases (2) · Metabolic Syndrome (2) · Atherosclerosis (1) · Diabetes Mellitus (1) · Diabetes Mellitus, Type 1 (1) · Endometriosis (1) · Fibrosis (1) · Hepatitis (1) · Insulin Resistance (1) · Motor Activity (1)
Digestive System Diseases (37) · Liver Diseases (35) · Fatty Liver (33) · Nutritional and Metabolic Diseases (11) · Pathological Conditions, Signs and Symptoms (11) · Metabolic Diseases (9) · Glucose Metabolism Disorders (8) · Body Weight (6) · Endocrine System Diseases (6) · Signs and Symptoms (6) · Diabetes Mellitus (5) · Nutrition Disorders (5) · Overnutrition (5) · Overweight (5) · Pathologic Processes (5)
2-chloro-3-(1-hydroxy-5,6,7,8-tetrahydronaphthalen-2-yl)-6-oxo-5-phenyl-7H-thieno)(2,3-b)pyridin-4-olate potassium (2) · Blood Specimen Collection (2) · TVB-2640 (2) · Alendronate (1) · Aspirin (1) · Blood Donation (1) · Body Weights and Measures (1) · Cholestyramine Resin (1) · Curcumin (1) · Denosumab (1) · Diagnostic Imaging (1) · Diet, Mediterranean (1) · Dipeptidyl-Peptidase IV Inhibitors (1) · Drug Implants (1) · Goserelin (1)
Massachusetts General Hospital (4) · Aristotle University Of Thessaloniki (2) · Poxel SA (2) · Sagimet Biosciences Inc. (2) · University of California, San Diego (2) · Yokohama City University (2) · Bettina Mittendorfer (1) · Cairo University (1) · Duke University (1) · Ewha Womans University Mokdong Hospital (1) · Gelesis, Inc. (1) · Great China Fatty Liver Consortium Limited (1) · Hippocration General Hospital (1) · Joslin Diabetes Center (1) · Korea University Guro Hospital (1)
United States (21) · Greece (3) · Japan (2) · South Korea (2) · China (1) · Egypt (1) · Germany (1) · Iran (1) · Romania (1) · Spain (1)
Claude B Sirlin, MD (2) · Dimitrios G Goulis, MD, PhD (2) · Stergios A Polyzos, MD, PhD (2) · Angelos Daniilidis, MD, PhD (1) · Anthony E Samir, MD, MPH (1) · Antonis Goulas, MD, PhD (1) · Arun Sanyal, MD, PhD (1) · Athan Kuliopulos, MD, PhD (1) · Athanasios A Anastasilakis, MD, PhD (1) · Athanasios D Anastasilakis, MD, PhD (1) · Athina I Gkiomisi, MD, PhD (1) · Bettina Mittendorfer (1) · Chrysi Nalmpantidou, MD (1) · Dimitrios A Anastasilakis, MD, PhDc (1) · Donald A McClain, MD, PhD (1)
PMID 29805116, PMID 31690932, PMID 32629123, PMID 32907904, PMID 33486083, PMID 34560015, PMID 35028615, PMID 35820743, PMID 36871772, PMID 37533096, PMID 37815451, PMID 38502074, PMID 38762719, PMID 38914313, PMID 39181426, PMID 39254458, PMID 39401124, PMID 39739194, PMID 40255245, PMID 40404984, PMID 41811730, PMID 42677730
R01DK110186 (1), R01DK119913 (1), R01DK129656 (1), R01DK131188 (1), R43DK135225 (1), R43EB034626 (1), R44DK101240 (1)