14 completed, 7 unknown, 4 recruiting, 2 not yet recruiting. 17 Not applicable, 5 Phase 2, 2 Phase 1, 2 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 17 | Completed 7, Unknown 4, Not yet recruiting 2, Recruiting 2, Terminated 2 |
| Phase 2 | 5 | Completed 4, Recruiting 1 |
| Phase 1 | 2 | Completed 2 |
| Phase 3 | 2 | Recruiting 1, Unknown 1 |
Follow Nitric Oxide: new trials by email Literature Review of Nitric Oxide trials Research Report on Nitric Oxide
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Modified Inhaled Nitric Oxide in Ventilated Patients With Acute Respiratory Failure Modified iNO - Acute Respiratory Failure (ARF), Nitric Oxide | Not applicable | Not yet recruiting | Southeast University, China | 424 | 2026-11-01 | 2026-10-27 |
| Inhaled Nitric Oxide in Severe Obesity Nitric oxide - Obesity, Respiratory Insufficiency | Not applicable | Not yet recruiting | Massachusetts General Hospital | 60 | 2026-10-01 | 2026-05-20 |
| Evaluation of Adding Nitrate Into Foods for Regulating Nitric Oxide Bioavailability in Healthy Individuals Inorganic potassium nitrate-fortified biscuits supplementation, Inorganic potassium nitrate-fortified cereal bar supplementation, Inorganic potassium nitrate-fortified porridge supplementation - Healthy Volunteers, Nitric Oxide | Not applicable | Recruiting | Queen Mary University of London | 30 | 2025-10-15 | 2026-06-04 |
| Nitric Oxide for Reduced Intensive Support in Cardiac Surgery With Cardiopulmonary Bypass Nitric Oxide Gas, Standard Care Arm - Nitric Oxide, Cardiac Surgery | Phase 3 | Recruiting | Xijing Hospital | 3650 | 2025-05-19 | 2026-05-29 |
| Dose-Response Impact of Glucosyl-Hesperidin (CitraPeak) on Exercise Performance, Blood Flow, Stress, Cognition, and Other Perceptual Indicators 400 mg CITRAPEAK® (glucosyl-hesperidin) supplementation, Placebo, 200 mg CITRAPEAK® (glucosyl-hesperidin) supplementation - Exercise Performance, Exercise Recovery | Not applicable | Recruiting | Lindenwood University | 60 | 2025-04-15 | 2025-12-12 |
| Response to Exercise and Nitric Oxide in PAD Supervised Treadmill Exercise, Attention Control, Nitrate-Rich Beetroot Juice + supervised exercise therapy - Peripheral Artery Disease, Exercise | Phase 2 | Recruiting | Northwestern University | 200 | 2025-01-23 | 2026-07-27 |
| Nitrate Mouth Rinse and the Oral Microbiome Beet Root, Water - Nitric Oxide, Oral Microbiome | Not applicable | Completed | Dalhousie University | 21 | 2024-08-14 | 2025-09-02 |
| Mechanism of Nitric Oxide on Ventilator-induced Diaphragm Dysfunction with Extracorporeal Membrane Lung Assistance Nitric Oxide - Tracheal Intubation, Extracorporeal Membrane Oxygenation | Unknown | Zhongnan Hospital | 80 | 2024-01-16 | 2024-10-28 | |
| Inhaled NO in Surgical Patients With Recent COVID-19 Infection Nitric Oxide Gas - Nitric Oxide, COVID-19 | Phase 2 | Completed | Xijing Hospital | 660 | 2023-02-17 | 2024-05-10 |
| Potential for Inhaled Nitric Oxide and Ventilation-Perfusion Mismatch by Electrical Impedance Tomography in the ARDS Patients With Lung Recruitment Lung recruitment combined inhaled Nitric oxide, Lung recruitment - Nitric Oxide, Acute Respiratory Distress Syndrome | Not applicable | Unknown | Far Eastern Memorial Hospital | 100 | 2022-04-29 | 2023-01-31 |
| Impact of Beetroot Juice Ingestion on Female Rugby Performance Beetroot juice - Nitric Oxide, Placebo | Not applicable | Completed | Universidad Francisco de Vitoria | 13 | 2022-01-20 | 2022-04-21 |
| Effects of Nitrate-rich Beetroot Juice in Pregnant Women With High Blood Pressure Beetroot Juice - Preeclampsia, Hypertension | Not applicable | Unknown | Karolinska Institutet | 80 | 2022-01-01 | 2022-02-15 |
| Inhaled NO for the Treatment of Viral Pneumonia in Adults LungFit™ - Viral Pneumonia, Nitric Oxide | Not applicable | Completed | Beyond Air Inc. | 40 | 2020-11-25 | 2022-12-16 |
| Nutritional Supplementation and Insulin Sensitivity L-arginine + Nitrate / Nitrite, Placebo - Nitric Oxide, Insulin Sensitivity | Not applicable | Terminated | Maastricht University Medical Center | 1 | 2020-09-01 | 2021-06-11 |
| Inhaled NO for the Treatment of COVID-19 Caused by SARS-CoV-2 (US Trial) Nitric Oxide delivered via LungFit™ system - Corona Virus Infection, COVID-19 | Not applicable | Terminated | Beyond Air Inc. | 4 | 2020-06-13 | 2022-12-16 |
| Clinical Characteristics and Treatment of Chest Tightness Variant Asthma Inhaled corticosteriod/long-acting beta-agonist plus Montelukast, Inhaled corticosteriod/long-acting beta-agonist only - Asthma, Chest Syndrome | Not applicable | Unknown | Second Affiliated Hospital, Zhejiang University, School of Medicine | 300 | 2020-06-01 | 2020-05-12 |
| Nitric Oxide in Venoarterial Extracorporeal Membrane Oxygenation (VA ECMO) Inhaled nitric oxide - Extracorporeal Membrane Oxygenation, Nitric Oxide | Unknown | Filio Billia | 10 | 2019-08-08 | 2020-11-04 | |
| Nutritional Supplements and Nitric Oxide Bioactivity L-Arginine, Nitrate / Nitrite, Placebo - Nitric Oxide, Vascular Function | Not applicable | Completed | Maastricht University Medical Center | 20 | 2018-12-01 | 2020-02-20 |
| Evidence of Spreading Vasodilation in Human Gingiva nitroglycerin - Nitric Oxide, Vasodilation | Not applicable | Completed | Semmelweis University | 40 | 2018-07-25 | 2018-09-11 |
| Influence of Dietary Nitrate on Skin Inflammation Nitrate-rich Beetroot Juice, Nitrate-deplete Beetroot Juice - Cardiovascular Diseases, Inflammation | Phase 1 | Completed | Queen Mary University of London | 24 | 2017-02-02 | 2022-09-27 |
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Aneurysm (3) · COVID-19 (3) · Asthma (2) · Depressive Disorder, Major (2) · Eosinophilia (2) · Motor Activity (2) · Pneumonia, Viral (2) · Respiration Disorders (2) · Severe Acute Respiratory Syndrome (2) · Virus Diseases (2) · Acute Pain (1) · Bronchiolitis (1) · Cardiovascular Diseases (1) · Coronary Artery Disease (1) · Coronavirus Infections (1)
Pathological Conditions, Signs and Symptoms (10) · Respiratory Tract Diseases (10) · Lung Diseases (9) · Cardiovascular Diseases (8) · Vascular Diseases (8) · Respiratory Tract Infections (6) · Infections (5) · Signs and Symptoms (5) · Nutritional and Metabolic Diseases (4) · Pathologic Processes (4) · Bronchial Diseases (3) · Coronaviridae Infections (3) · Immune System Diseases (3) · Lung Diseases, Obstructive (3) · Metabolic Diseases (3)
Arginine (3) · Endothelium-Dependent Relaxing Factors (2) · Nitrates (2) · Nitric Oxide (2) · Nitrites (2) · Cardiopulmonary Bypass (1) · Dietary Supplements (1) · Fractional Exhaled Nitric Oxide Testing (1) · Guidelines as Topic (1) · Hemodynamic Monitoring (1) · Inosine (1) · Nitroglycerin (1) · Organization and Administration (1) · Sodium Nitrite (1) · Water (1)
Maastricht University Medical Center (3) · Beyond Air Inc. (2) · Massachusetts General Hospital (2) · Queen Mary University of London (2) · Second Affiliated Hospital, Zhejiang University, School of Medicine (2) · Xijing Hospital (2) · Beijing Tongren Hospital (1) · Dalhousie University (1) · Far Eastern Memorial Hospital (1) · Filio Billia (1) · Karolinska Institutet (1) · King's College London (1) · Lindenwood University (1) · Medical College of Wisconsin (1) · NYU Langone Health (1)
United States (9) · China (7) · Netherlands (3) · United Kingdom (3) · Canada (2) · Hungary (1) · Israel (1) · Russia (1) · Spain (1) · Sweden (1) · Taiwan (1)
Peter J Joris, PhD (2) · Amrita Ahluwalia, BSc PhD (1) · Asher Tal (1) · Ashik Tal, MD (1) · Chad M Kerksick, PhD (1) · Chong Lei, M.D., & phd (1) · Chong Lei, MD&phD (1) · Filio Billia, MD PhD (1) · Hou T Chang, Doctor (1) · Huahao Shen (1) · Leigha Rock, PhD (1) · Maria L Quintos-Alagheband, MD (1) · Mattias Carlstrom, PharmD, PhD (1) · Mei Y Chang, Master (1) · Michael E Widlansky (1)
PMID 10545552, PMID 10675427, PMID 16865510, PMID 2040056, PMID 23631417, PMID 24572255, PMID 25099540, PMID 25162920, PMID 26186889, PMID 29663984, PMID 30070030, PMID 30377712, PMID 31701693, PMID 3495737, PMID 38485487, PMID 40209616, PMID 42035974, PMID 42336097, PMID 8457043