25 completed, 10 recruiting, 10 terminated, 5 unknown. 57 Phase 2, 17 Phase 1, 3 Phase 3.
Follow Neurofibrosarcoma: new trials by email Literature Review of Neurofibrosarcoma trials Research Report on Neurofibrosarcoma
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Combination of Avutometinib and Defactinib for Treatment of Relapsed, Refractory, Metastatic, or Unresectable Malignant Peripheral Nerve Sheath Tumor avutometinib capsule + defactinib tablet - MPNST (Malignant Peripheral Nerve Sheath Tumor) | Phase 2 | Not yet recruiting | Girish Dhall, MD | 25 | 2027-01-01 | 2026-10-28 |
| Trial of Selumetinib and Bromodomain Inhibitor With Durvalumab for Sarcomas Selumetinib + ZEN-3694 ± Durvalumab - MPNST, NF1 | Phase 2 | Recruiting | University of Alabama at Birmingham | 41 | 2026-08-04 | 2026-08-24 |
| Safety and Efficacy of BMS-986504 in Unresectable Malignant Peripheral Nerve Sheath Tumor BMS-986504 - Malignant Peripheral Nerve Sheath Tumors, MPNST | Phase 1 / Phase 2 | Recruiting | Ankit Mangla, MD | 17 | 2026-08-01 | 2026-08-11 |
| Early Phase Study Evaluating MEK and MDM2 Inhibition in Patients With NF1 and MPNST APG-115, Selumetinib - Malignant Peripheral Nerve Sheath Tumor (MPNST), Neurofibromatosis 1 (NF1) | Phase 1 / Phase 2 | Recruiting | AeRang Kim | 45 | 2026-06-01 | 2026-07-27 |
| Using CICS-1 and SPM-011 and ［18F］FBPA Commissioned by CICS and Sumitomo Heavy Industries and STELLA PHARMA BNCT, ［18F］FBPA - Thoracic Solid Malignant Tumor | Phase 1 / Phase 2 | Enrolling by invitation | Stella Pharma Corporation | 30 | 2025-04-10 | 2025-11-19 |
| IO Combined With AI as First-line Treatment for Patients With Soft Tissue Sarcoma(TAIS) Tislelizumab+liposomal doxorubicin+ifosfamide - Soft Tissue Sarcomas, Angiosarcoma | Phase 2 | Recruiting | Fudan University | 45 | 2025-02-25 | 2026-01-08 |
| Agnostic Therapy in Rare Solid Tumors Nivolumab - Urachal Cancer, Parathyroid Carcinoma | Phase 2 | Active not recruiting | Instituto do Cancer do Estado de São Paulo | 28 | 2024-07-16 | 2026-10-13 |
| NRSTS2021, A Risk Adapted Study Evaluating Maintenance Pazopanib, Limited Margin, Dose-Escalated Radiation Therapy and Selinexor in Non-Rhabdomyosarcoma Soft Tissue Sarcoma (NRSTS) Surgical resection, Proton beam radiation therapy, Pazopanib - Adipocytic Neoplasm, Liposarcoma | Phase 1 / Phase 2 | Recruiting | St. Jude Children's Research Hospital | 139 | 2024-03-27 | 2026-08-03 |
| MASCT-I Combined With Doxorubicin and Ifosfamide for First-line Treatment of Advanced Soft Tissue Sarcoma MASCT-I, Doxorubicin, Ifosfamide - Leiomyosarcoma, Liposarcoma | Phase 2 | Recruiting | HRYZ Biotech Co. | 148 | 2024-02-21 | 2025-07-24 |
| SPEARHEAD-3 Pediatric Study Afamitresgene autoleucel - Synovial Sarcoma, Malignant Peripheral Nerve Sheath Tumor (MPNST) | Phase 1 / Phase 2 | Recruiting | USWM CT, LLC | 20 | 2023-09-01 | 2026-08-11 |
| A Study of Selinexor in People With Wilms Tumors and Other Solid Tumors Selinexor - Wilms Tumor, Rhabdoid Tumor | Phase 2 | Recruiting | Memorial Sloan Kettering Cancer Center | 45 | 2023-08-01 | 2026-10-23 |
| Safety and Tolerability of TNG462 in Patients With MTAP-deleted Solid Tumors TNG462, Pembrolizumab - Locally Advanced Solid Tumor | Phase 1 / Phase 2 | Recruiting | Tango Therapeutics, Inc. | 225 | 2023-05-26 | 2026-09-08 |
| Safety and Tolerability of TNG908 in Patients With MTAP-deleted Solid Tumors TNG908 - Locally Advanced Solid Tumor | Phase 1 / Phase 2 | Terminated | Tango Therapeutics, Inc. | 110 | 2022-03-23 | 2026-04-15 |
| A Clinical Trial to Evaluate the Safety and Efficacy of AL2846 Capsules in Chinese Patients With Type I Neurofibromatosis AL2846 capsules - Neurofibromatosis and Malignant Peripheral Nerve Sheath Tumors | Phase 1 / Phase 2 | Terminated | Chia Tai Tianqing Pharmaceutical Group Co., Ltd. | 22 | 2021-09-07 | 2024-03-21 |
| Tazemetostat in Malignant Peripheral Nerve Sheath Tumors Tazemetostat - Peripheral Nerve Sheath Tumor | Phase 2 | Active not recruiting | University of Florida | 10 | 2021-08-25 | 2026-06-04 |
| A Study of ASTX727 in People With Malignant Peripheral Nerve Sheath Tumors (MPNST) ASTX727 - Malignant Peripheral Nerve Sheath Tumors (MPNST) | Phase 2 | Recruiting | Memorial Sloan Kettering Cancer Center | 25 | 2021-04-29 | 2026-02-05 |
| Donor Stem Cell Transplant After Chemotherapy for the Treatment of Recurrent or Refractory High-Risk Solid Tumors in Pediatric and Adolescent-Young Adults Allogeneic Hematopoietic Stem Cell Transplantation, Cyclosporine, Etoposide - Desmoplastic Small Round Cell Tumor, Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor | Phase 2 | Terminated | M.D. Anderson Cancer Center | 1 | 2020-08-19 | 2025-06-29 |
| SARC031: MEK Inhibitor Selumetinib (AZD6244) in Combination With the mTOR Inhibitor Sirolimus for Patients With Malignant Peripheral Nerve Sheath Tumors Selumetinib, Sirolimus - Malignant Peripheral Nerve Sheath Tumors, Neurofibromatosis 1 | Phase 2 | Completed | Sarcoma Alliance for Research through Collaboration | 21 | 2019-10-02 | 2026-05-27 |
| APX005M and Doxorubicin in Advanced Sarcoma Doxorubicin, APX005M - Soft Tissue Sarcoma | Phase 2 | Completed | Alexander Z. Wei, MD | 27 | 2019-03-20 | 2026-06-10 |
| A Study of APG-115 in as a Monotherapy or Combination With Pembrolizumab in Patients With Metastatic Melanomas or Advanced Solid Tumors Phase 1b: APG-115+pembrolizumab - Unresectable or Metastatic Melanoma or Advanced Solid Tumors, Melanoma | Phase 1 / Phase 2 | Active not recruiting | Ascentage Pharma Group Inc. | 230 | 2018-08-29 | 2025-08-07 |
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Sarcoma (39) · Leiomyosarcoma (30) · Sarcoma, Synovial (28) · Histiocytoma, Malignant Fibrous (25) · Liposarcoma (24) · Fibrosarcoma (23) · Hemangiosarcoma (21) · Rhabdomyosarcoma (18) · Sarcoma, Alveolar Soft Part (16) · Malignant mesenchymal tumor (11) · Dermatofibrosarcoma (10) · Hemangiopericytoma, Malignant (10) · Chondrosarcoma, Extraskeletal Myxoid (9) · Desmoplastic Small Round Cell Tumor (8)
Neoplasms (57) · Neoplasms by Histologic Type (57) · Neoplasms, Connective Tissue (57) · Neoplasms, Fibrous Tissue (57) · Neoplasms, Nerve Tissue (57) · Nervous System Diseases (57) · Nervous System Neoplasms (57) · Neurofibroma (57) · Neuromuscular Diseases (57) · Peripheral Nervous System Diseases (57) · Neoplasms, Connective and Soft Tissue (56) · Peripheral Nervous System Neoplasms (56) · Nerve Sheath Neoplasms (53) · Fibrosarcoma (34) · Neoplasms, Muscle Tissue (34)
Doxorubicin (8) · pazopanib (5) · Ifosfamide (4) · AZD 6244 (3) · Imatinib Mesylate (3) · Sirolimus (3) · pembrolizumab (3) · Etoposide (2) · Nivolumab (2) · Radiation Dose Hypofractionation (2) · Radiotherapy (2) · Sorafenib (2) · Trabectedin (2) · brostallicin (2) · selinexor (2)
European Organisation for Research and Treatment of Cancer - EORTC (7) · National Cancer Institute (NCI) (7) · Memorial Sloan Kettering Cancer Center (5) · Sarcoma Alliance for Research through Collaboration (5) · Maria Sklodowska-Curie National Research Institute of Oncology (2) · Novartis Pharmaceuticals (2) · Tango Therapeutics, Inc. (2) · AeRang Kim (1) · Alexander Z. Wei, MD (1) · Ankit Mangla, MD (1) · Ascentage Pharma Group Inc. (1) · Chia Tai Tianqing Pharmaceutical Group Co., Ltd. (1) · Children's Oncology Group (1) · City of Hope Medical Center (1) · Fudan University (1)
United States (37) · Belgium (5) · France (5) · Germany (4) · Netherlands (4) · China (3) · Denmark (3) · Poland (3) · United Kingdom (3) · Canada (2) · Slovakia (2) · Spain (2) · Australia (1) · Austria (1) · Brazil (1)
AeRang Kim, MD, PhD (3) · Brigitte C. Widemann, MD (2) · Brigitte Widemann, MD (2) · William Tap, MD (2) · Aaron R Weiss (1) · Alexander Wei, MD (1) · Ankit Mangla, MD (1) · Axel Le Cesne, MD (1) · Brian A Van Tine, M.D., Ph.D. (1) · Camila MV Moniz, Doctor (1) · Christopher W Ryan (1) · David M Loeb, MD, PhD (1) · Elizabeth A. Eisenhauer, MD (1) · Fiorella Iglesias Cardenas, MD (1) · Girish Dhall, MD (1)
PMID 11705489, PMID 12528778, PMID 12957454, PMID 15010069, PMID 15177491, PMID 15592836, PMID 15659504, PMID 16528479, PMID 17095209, PMID 17336054, PMID 19088049, PMID 19451429, PMID 19451433, PMID 20471824, PMID 23382028, PMID 24215845, PMID 27502708, PMID 30410720, PMID 31401903, PMID 31969335, PMID 32089640, PMID 32702309, PMID 32827353, PMID 33362722, PMID 33882143, PMID 34321280, PMID 34380663, PMID 34515544, PMID 34716198, PMID 37523624, PMID 38243705, PMID 38358334, PMID 39067873, PMID 39343510, PMID 39417692, PMID 39583952, PMID 39756156, PMID 39856213, PMID 40402690, PMID 40588371, PMID 41672597, PMID 41892875, PMID 41995270, PMID 42194972, PMID 42499790
P30CA008748 (3), N01CM62206 (2), U10CA180821 (2), U10CA180886 (2), 2009 (1), N01CM62201 (1), P30CA012197 (1), P30CA033572 (1), U01CA069856 (1), U10CA031946 (1), U10CA032102 (1), U10CA081851 (1), U10CA098543 (1), U10CA180830 (1), U10CA180888 (1)