6 completed, 4 unknown, 2 active not recruiting. 12 Phase 3, 2 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 12 | Completed 6, Unknown 4, Active not recruiting 2 |
| Phase 2 | 2 | Active not recruiting 1, Unknown 1 |
Follow Necrotizing Enterocolitis: new trials by email Literature Review of Necrotizing Enterocolitis trials Research Report on Necrotizing Enterocolitis
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Effect of Pentoxifylline Versus Probiotic on Preterm Neonates With Necrotizing Enterocolitis Pentoxifylline, Probiotic Formula - Necrotizing Enterocolitis | Phase 3 | Completed | Tanta University | 75 | 2022-06-30 | 2024-05-20 |
| Treatment of Classic Mid-trimester PPROM by Means of Continuous Amnioinfusion Continuous amnioinfusion with Amnion Flush Solution through the intraamniotic catheter - Bronchopulmonary Dysplasia, Necrotizing Enterocolitis | Phase 3 | Unknown | Martin-Luther-Universität Halle-Wittenberg | 68 | 2021-01-01 | 2021-01-12 |
| IBP-9414 for the Prevention of Necrotizing Enterocolitis - The Connection Study IBP-9414, Placebo - Necrotizing Enterocolitis | Phase 3 | Active not recruiting | Infant Bacterial Therapeutics | 2158 | 2019-07-04 | 2024-04-12 |
| Human Milk Fortification in Extremely Preterm Infants H2MF, Bovine milk-based fortifier - Necrotizing Enterocolitis, Sepsis | Phase 2 / Phase 3 | Active not recruiting | Thomas Abrahamsson, MD, PhD | 229 | 2019-02-01 | 2024-07-23 |
| Bovine Lactoferrin and Neonatal Survival in Low Birth Weight Babies. bLF (Bovine lactoferrin), Glucon-D 99.4% (Placebo) - Neonatal Sepsis, Necrotizing Enterocolitis | Phase 3 | Unknown | Aga Khan University | 300 | 2018-05-01 | 2020-04-09 |
| Role of Probiotics for Prevention of NEC in Preterm VLBW Infants Probiotics, Breast milk - Necrotizing Enterocolitis | Phase 3 | Completed | Sylhet M.A.G.Osmani Medical College | 60 | 2012-07-01 | 2016-01-08 |
| Lactobacillus Reuteri for Prevention of Necrotizing Enterocolitis in Very Low-birth Weight Infants Lactobacillus reuteri, Placebo - Necrotizing Enterocolitis, Very Low Birth Weight Infants | Phase 3 | Completed | Zekai Tahir Burak Women's Health Research and Education Hospital | 400 | 2012-02-01 | 2013-05-13 |
| Probiotics in the Management of Necrotizing Enterocolitis in HIV-exposed Premature Infants Probiotic, Placebo - Necrotizing Enterocolitis | Phase 3 | Completed | University of Stellenbosch | 184 | 2011-07-01 | 2013-07-22 |
| Effect of Saccharomyces Boulardii on Necrotizing Enterocolitis in Very Low Birth Weight Infants Saccharomyces boulardii, Placebo - Necrotizing Enterocolitis, Very Low Birth Weight Infants | Phase 3 | Unknown | Zekai Tahir Burak Women's Health Research and Education Hospital | 220 | 2011-02-01 | 2011-08-08 |
| Effect of Vitamin A in the Treatment of Neonatal Sepsis and Necrotizing Enterocolitis Vitamin A - Sepsis, Necrotizing Enterocolitis | Phase 3 | Completed | Johns Hopkins University | 424 | 2006-12-01 | 2013-09-25 |
| Cysteine Supplementation in Critically Ill Neonates Parenteral cysteine-HCl supplementation, Placebo - added premasol - Sepsis, Bronchopulmonary Dysplasia | Phase 2 / Phase 3 | Unknown | University of California, Los Angeles | 108 | 2006-09-01 | 2010-02-26 |
| Effect of Oral Probiotic Supplementation on The Rate of Hospital Acquired Infection and Necrotizing Enterocolitis in Preterm Very Low Birth Weight Infants probiotics - Nosocomial Infection, Necrotizing Enterocolitis | Phase 3 | Completed | King Chulalongkorn Memorial Hospital | 160 | 2005-01-01 | 2011-04-22 |
Enterocolitis, Necrotizing (12) · Sepsis (3) · Bronchopulmonary Dysplasia (2) · Acquired Immunodeficiency Syndrome (1) · Cross Infection (1) · Intracranial Hemorrhages (1) · Meningitis (1) · Neonatal Sepsis (1) · Pneumonia (1) · Premature Birth (1) · Preterm Premature Rupture of the Membranes (1) · Retinopathy of Prematurity (1) · Systemic Inflammatory Response Syndrome (1)
Digestive System Diseases (12) · Enterocolitis (12) · Gastroenteritis (12) · Gastrointestinal Diseases (12) · Intestinal Diseases (12) · Infections (6) · Pathologic Processes (6) · Pathological Conditions, Signs and Symptoms (6) · Inflammation (4) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (3) · Infant, Newborn, Diseases (3) · Lung Diseases (3) · Respiratory Tract Diseases (3) · Systemic Inflammatory Response Syndrome (3) · Infant, Premature, Diseases (2)
Probiotics (3) · Milk, Human (1) · Pentoxifylline (1) · Vitamin A (1) · amino-acid, glucose, and electrolyte solution (1)
Zekai Tahir Burak Women's Health Research and Education Hospital (2) · Aga Khan University (1) · Infant Bacterial Therapeutics (1) · Johns Hopkins University (1) · King Chulalongkorn Memorial Hospital (1) · Martin-Luther-Universität Halle-Wittenberg (1) · Sylhet M.A.G.Osmani Medical College (1) · Tanta University (1) · Thomas Abrahamsson, MD, PhD (1) · University of California, Los Angeles (1) · University of Stellenbosch (1)
Turkey (Türkiye) (2) · United States (2) · Bangladesh (1) · Bulgaria (1) · Egypt (1) · France (1) · Germany (1) · Hungary (1) · Israel (1) · Pakistan (1) · Poland (1) · Romania (1) · Serbia (1) · South Africa (1) · Spain (1)
Almas Aamir, MSC (1) · Christian L Coles, PhD (1) · Evette van Niekerk, M Dietetics (1) · Gamze Demirel, MD (1) · Josef Neu, MD (1) · Mehmet Yekta Oncel, MD (1) · Michael J Dibley, MB BS, MPH (1) · Michael Tchirikov, MD, Ph.D. (1) · Prof. M. Monojjir Ali, FCPS (1) · Sahar Hegazy, MD (1) · Santi Punnahitananda, M.D. (1) · Shabina Ariff, MBBS,FCPS (1) · Stephen B Shew, M.D. (1) · Thomas R Abrahamsson, MD, PhD (1)
PMID 24309022, PMID 24919691, PMID 28710882, PMID 33006765, PMID 33058137, PMID 33704071, PMID 34815288, PMID 36143388, PMID 37493095, PMID 38545091, PMID 38556499, PMID 40348496
K01DK075478 (1), K08HD052885 (1)