10 completed, 4 unknown, 1 withdrawn. 4 Phase 2, 3 Phase 1, 3 Phase 3, 1 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 4 | Completed 3, Unknown 1 |
| Phase 1 | 3 | Completed 2, Unknown 1 |
| Phase 3 | 3 | Completed 1, Unknown 1, Withdrawn 1 |
| Phase 4 | 1 | Completed 1 |
Follow Multi-drug Resistant Tuberculosis: new trials by email Literature Review of Multi-drug Resistant Tuberculosis trials Research Report on Multi-drug Resistant Tuberculosis
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Economic Evaluation of New MDR TB Regimens Bedaquiline, Pretomanid, Moxifloxacin - Multi-drug Resistant Tuberculosis, Extensively Drug-Resistant Tuberculosis | Phase 2 / Phase 3 | Completed | Medecins Sans Frontieres, Netherlands | 73 | 2020-10-20 | 2024-04-22 |
| New Genomic Techniques and Management of Multidrug-resistant Tuberculosis Multi-Drug Resistant Tuberculosis | Unknown | Assistance Publique - Hôpitaux de Paris | 172 | 2020-08-29 | 2022-03-29 | |
| Pharmacometrics to Advance Novel Regimens for Drug-resistant Tuberculosis-PandrTB Tuberculosis Multi-drug Resistant Tuberculosis | Unknown | University of Cape Town | 625 | 2020-01-30 | 2022-11-04 | |
| Case Control Study of Vitamin D Status and Adult Multidrug-resistant Pulmonary Tuberculosis in Maharashtra, India Serum Vitamin D - Multi-drug Resistant Tuberculosis | Completed | Harvard School of Public Health (HSPH) | 352 | 2020-01-27 | 2021-02-25 | |
| Single-dose Study in Two Panels of Healthy Adult Participants to Assess Immediate-Release and Dispersible Formulations of Pretomanid Pretomanid - Multi-drug Resistant Tuberculosis | Phase 1 | Completed | Global Alliance for TB Drug Development | 48 | 2020-01-14 | 2024-07-24 |
| PRACTECAL-PKPD Sub Study Bedaquiline, Pretomanid, Moxifloxacin - Multi-drug Resistant Tuberculosis, Extensively Drug-Resistant Tuberculosis | Phase 2 / Phase 3 | Unknown | Medecins Sans Frontieres, Netherlands | 240 | 2019-08-06 | 2021-05-14 |
| The Effect of 18-month Regimen Containing 6 Anti-tuberculosis Drugs for Patients With MDR-TB 18-month regimen containing 6 anti-TB drugs - Multi-drug Resistant Tuberculosis | Phase 4 | Completed | Beijing Chest Hospital | 515 | 2019-03-08 | 2022-10-12 |
| Clinical Study on Adoptive Treatment of MDR-TB With Allogeneic γδT Cells The adoptive treatment of allogeneic γδT cells, Control, Conventional treatment - Multi-drug Resistant Tuberculosis | Phase 1 | Unknown | Zhinan Yin, Ph.D. | 45 | 2018-06-01 | 2018-07-02 |
| Post Marketing Registry to Assess Usage, Safety and Effectiveness of Deltyba Tablets in Korean Patients With MDR-TB Multi-drug Resistant Tuberculosis | Completed | Korea Otsuka Pharmaceutical Co., Ltd. | 149 | 2017-05-25 | 2021-09-17 | |
| PK of Levofloxacin in MDR-TB Patients Multi-drug Resistant Tuberculosis | Completed | University Medical Center Groningen | 20 | 2016-05-04 | 2018-01-25 | |
| Treatment of Tuberculosis Multidrug Resistance Treatment of Tuberculosis Multidrug Resistance Km+ Mfx+ Pto + H + Cfz +E+Z - Multi-drug Resistant Tuberculosis | Completed | Centre de Recherche Médicale de Lambaréné | 23 | 2015-09-11 | 2026-03-17 | |
| A Study to Evaluate the Efficacy and Safety of TMC207 in Patients With Pulmonary Infection With Multi-drug Resistant Mycobacterium Tuberculosis Arm A Double-blind Phase: TMC207, Arm B Double-blind Phase: Placebo, Treatment Failure During Double-blind Phase: TMC207 - Multi-drug Resistant Tuberculosis | Phase 3 | Withdrawn | Janssen Infectious Diseases BVBA | 2014-03-01 | 2015-12-02 | |
| Clinical Analysis of the Patients With Cavitary Pulmonary TB and Endobronchial TB in the PPM-UUH Cohort Observation of AFB smear/culture - Tuberculosis, Tuberculosis, Pulmonary | Completed | University of Ulsan | 500 | 2010-01-01 | 2019-06-25 | |
| TBTC Study 30: Safety and Tolerability of Low Dose Linezolid in MDR TB Linezolid, Placebo - Multi-drug Resistant Tuberculosis, Extensively Drug Resistant Tuberculosis | Phase 1 / Phase 2 | Completed | Centers for Disease Control and Prevention | 36 | 2009-04-01 | 2026-07-06 |
| Metronidazole for Pulmonary Tuberculosis (South Korea) Metronidazole, Blood Draw, CT Scan - Tuberculosis, Multi-Drug Resistant Tuberculosis | Phase 2 | Completed | National Institute of Allergy and Infectious Diseases (NIAID) | 35 | 2006-12-01 | 2013-07-10 |
Tuberculosis, Multidrug-Resistant (15) · Extensively Drug-Resistant Tuberculosis (5) · Tuberculosis (4) · Tuberculosis, Pulmonary (3) · Anemia (1) · Disease (1) · Latent Tuberculosis (1) · Optic Nerve Diseases (1) · Peripheral Nervous System Diseases (1) · Thrombocytopenia (1) · Vitamin D Deficiency (1)
Actinomycetales Infections (15) · Bacterial Infections (15) · Bacterial Infections and Mycoses (15) · Gram-Positive Bacterial Infections (15) · Infections (15) · Mycobacterium Infections (15) · Tuberculosis (11) · Lung Diseases (3) · Respiratory Tract Diseases (3) · Respiratory Tract Infections (3) · Avitaminosis (1) · Blood Platelet Disorders (1) · Cranial Nerve Diseases (1) · Cytopenia (1) · Deficiency Diseases (1)
Linezolid (3) · pretomanid (3) · Clofazimine (2) · Moxifloxacin (2) · bedaquiline (2) · Blood Specimen Collection (1) · Culture Techniques (1) · Diet (1) · Magnetic Resonance Spectroscopy (1) · Metronidazole (1) · Protons (1) · stearic acid (1)
Medecins Sans Frontieres, Netherlands (2) · Assistance Publique - Hôpitaux de Paris (1) · Beijing Chest Hospital (1) · Centers for Disease Control and Prevention (1) · Centre de Recherche Médicale de Lambaréné (1) · Global Alliance for TB Drug Development (1) · Harvard School of Public Health (HSPH) (1) · Janssen Infectious Diseases BVBA (1) · Korea Otsuka Pharmaceutical Co., Ltd. (1) · National Institute of Allergy and Infectious Diseases (NIAID) (1) · University Medical Center Groningen (1) · University of Cape Town (1) · University of Ulsan (1) · Zhinan Yin, Ph.D. (1)
South Africa (5) · South Korea (4) · China (3) · Belarus (2) · Peru (2) · Brazil (1) · Cambodia (1) · Estonia (1) · Ethiopia (1) · France (1) · Gabon (1) · Georgia (1) · India (1) · Kazakhstan (1) · Latvia (1)
Antonio Lombardi, MD (1) · Ayola A Adegnika, MD, PhD (1) · Bern Nyang'wa, MB BS, MPH (1) · Clifton E Barry, Ph.D. (1) · Guofang Deng, Master (1) · Helen McIlleron, PhD (1) · Jan-Willem Alffenaar (1) · Jussi Saukkonen, MD (1) · Kwang Won Seo, M.D., Ph.D. (1) · Nesri Padayachin, MBChB (1) · Sedona Sweeny (1) · Wafaie W Fawzi, MBBS, MPH, MS, DrPH (1) · Waffa El-Sadr, MD (1)
PMID 11326818, PMID 15971391, PMID 19383184, PMID 20442432, PMID 21828024, PMID 23131255, PMID 23611033, PMID 23826878, PMID 30782999, PMID 33184081, PMID 34489274, PMID 34975844, PMID 36180816, PMID 39618688, PMID 41917253, PMID 42270675, PMID 9614254