27 completed, 25 recruiting, 14 active not recruiting, 10 unknown. 35 Phase 2, 27 Not applicable, 14 Phase 3, 12 Phase 1, 2 Early Phase 1.
Follow Protons: new trials by email Literature Review of Protons trials Research Report on Protons
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Re-evaluating the Duration in Children of TB Treatment Rifampicin, Isoniazid, Pyrazinamide - Tuberculosis | Phase 2 | Not yet recruiting | University of Wisconsin, Madison | 230 | 2027-02-01 | 2026-11-02 |
| Optimal Treatment Duration for Radiographically Apparent, Bacteriologically Unconfirmed TB, Identified Through Active Case Finding (RADIO-TB Trial) Isoniazid (H), Rifampicin (R), Pyrazinamide (Z) - Tuberculosis (TB) | Phase 3 | Recruiting | University College, London | 784 | 2026-10-12 | 2026-10-26 |
| Clinical Trial of the 24-valent Pneumococcal Polysaccharide Conjugate Vaccine (CRM197/Tetanus Toxoid) 24-valent pneumococcal polysaccharide conjugate vaccine (CRM197/tetanus toxoid) (referred to as PCV24) (dose M), PCV24 vaccine (dose H), PCV24 vaccine (dose M) - Streptococcus Pneumoniae Infection | Phase 1 / Phase 2 | Recruiting | CanSino Biologics Inc. | 854 | 2026-05-24 | 2026-08-05 |
| This Study Investigates β-hydroxy-β-methylbutyrate (HMB) and 2-hydroxybenzylamine (2-HOBA), When Administered Either Individually or in Combination Contributes to an Increased Quality of Health, Specifically Improving Muscular Strength and Cognitive Functioning in Adults Over the Age of 65. β-Hydroxy-β-methylbutyrate, 2-hydroxybenzylamine, β-Hydroxy-β-methylbutyrate and 2-hydroxybenzylamine - Muscle, Cognitive Functioning | Not applicable | Recruiting | McGill University Health Centre/Research Institute of the McGill University Health Centre | 120 | 2026-03-06 | 2026-05-14 |
| ATORvastatin in Pulmonary TUBerculosis: a POPulation PharmacoKinetics -PharmacoDynamics Sub-study (ATORTUB popPK-PD) Atorvastatin 20 mg, Atorvastatin 40 mg, Atorvastatin 60 mg - Pulmonary Tuberculosis (TB) | Phase 2 | Recruiting | Obafemi Awolowo University Teaching Hospital | 80 | 2026-01-03 | 2026-01-23 |
| Short-Course Regimen With Bedaquiline, Moxifloxacin and Pyrazinamide for Early Bactericidal Activity in Drug-Susceptible Tuberculosis Bedaquiline (B), Moxifloxacin, Pyrazinamide (PZA) - Tuberculosis, Pulmonary, Drug-Susceptible Pulmonary Tuberculosis | Phase 2 | Not yet recruiting | Shanghai Pulmonary Hospital, Shanghai, China | 45 | 2025-08-20 | 2025-08-19 |
| Ultra-Short Regimen for Elderly DS-TB Bedaquiline (B), Sitafloxacin (S), Linezolid (L) - Pulmonary Tuberculosis | Phase 3 | Not yet recruiting | Shenzhen Third People's Hospital | 300 | 2025-07-25 | 2025-07-22 |
| Comparison of the Outcome of Treatment With Silymarin or N-Aceylcysteine in Patients Taking Anti-Tuberculous Drugs for Tuberculosis at a Tertiary Care Hospital , Karachi Silymarin 420 mg, N Acetyl Cysteine, Rifampicin (RMP) Ethambutol (E) Isoniazid (H) Pyrazinamid (Z) - Drug Induced Liver Injury, Tuberculosis (TB) | Phase 1 | Not yet recruiting | Liaquat National Hospital & Medical College | 410 | 2025-07-01 | 2025-07-10 |
| A PAN-USR TB Multi-Center Trial Bedaquiline (B), Sitafloxacin (S), Linezolid (L) - Pulmonary Tuberculosis | Phase 3 | Recruiting | Shenzhen Third People's Hospital | 610 | 2025-06-18 | 2025-12-01 |
| Shortened Regimen for Drug-susceptible TB in Children Isoniazid, Rifampin, Pyrazinamide - Tuberculosis, Tuberculosis, Pulmonary | Phase 3 | Recruiting | Johns Hopkins University | 860 | 2025-01-15 | 2026-07-24 |
| Proton Beam Radiation Therapy After Treatment for Resected N2 Non-Small Cell Lung Cancer Biospecimen Collection, Proton Beam Radiation Therapy, Radiology, Treatment Planning - Resectable Lung Non-Small Cell Carcinoma | Phase 2 | Recruiting | Emory University | 10 | 2024-12-13 | 2026-09-16 |
| Pyrotinib Plus Trastuzumab and Chemotherapy for HER2-Positive Early Breast Cancer Pyrotinib Maleate, Trastuzumab (H, 8mg/kg, pegylated liposomal doxorubicin hydrochloride - HER2-positive Breast Cancer | Phase 2 | Recruiting | Hebei Medical University Fourth Hospital | 182 | 2024-04-30 | 2026-06-09 |
| Long-term Cognitive and Functional Impact of Proton-therapy or Modern Fractionated Radiotherapy in Cavernous Sinus Meningioma: An Open-label Randomized 1:1 Phase III Study Proton-therapy, Photon radiotherapy - Cavernous Sinus Meningioma, Proton-therapy | Not applicable | Recruiting | Centre Francois Baclesse | 160 | 2024-02-26 | 2025-09-29 |
| Platform Assessing Regimens and Durations In a Global Multisite Consortium for TB Ganfeborole, BTZ-043, Bedaquiline (B) - Pulmonary Tuberculosis | Phase 2 | Recruiting | University College, London | 2500 | 2024-01-09 | 2026-10-15 |
| ATORvastatin in Pulmonary TUBerculosis Atorvastatin 20mg, Atorvastatin 40mg, Atorvastatin 60mg - Pulmonary Tuberculosis, Tuberculosis | Phase 2 | Recruiting | Obafemi Awolowo University Teaching Hospital | 440 | 2024-01-03 | 2025-09-25 |
| Phase 2 Trial Assessing TBAJ876 or Bedaquiline, With Pretomanid and Linezolid in Adults With Drug-sensitive Pulmonary Tuberculosis sorfequiline, Pretomanid, Linezolid - Pulmonary TB, Pulmonary Tuberculosis | Phase 2 | Active not recruiting | Global Alliance for TB Drug Development | 309 | 2023-10-31 | 2026-06-24 |
| A Dose Escalation Study of Proton and Carbon Ion Irradiation for HER2 Positive and Triple Negative Breast Cancer proton plus carbon ion radiotherapy - Triple Negative Breast Cancer, HER2-positive Breast Cancer | Phase 1 | Unknown | Shanghai Proton and Heavy Ion Center | 24 | 2023-01-10 | 2023-01-20 |
| Drug Exposure and Safety of a Shorter Tuberculosis Treatment Based on High-Dose Rifampicin and Pyrazinamide rifampicin, pyrazinamide, HRZE - Tuberculosis, Pulmonary | Phase 2 | Suspended | University Hospital, Linkoeping | 40 | 2022-11-30 | 2026-08-17 |
| Heterogeneously Hypofractionated Radiotherapy for Locally Advanced NSCLC Photon, Proton - Non-small Cell Lung Cancer Stage III, Radiotherapy Side Effect | Phase 2 | Not yet recruiting | Odense University Hospital | 182 | 2022-10-01 | 2022-09-21 |
| Enhanced Systemic Combined With Local Treatment for Primary and Metastatic Lesions in Oligo-metastatic Prostate Cancer Leuprolide acetate, Goserelin acetate, Triptorelin acetate - Prostate Cancer | Phase 2 | Unknown | Fudan University | 160 | 2022-04-01 | 2022-03-16 |
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Tuberculosis, Pulmonary (10) · Prostatic Neoplasms (9) · Tuberculosis (9) · Breast Neoplasms (7) · Carcinoma, Non-Small-Cell Lung (6) · Neoplasms (4) · Pancreatic Neoplasms (4) · Nasopharyngeal Carcinoma (3) · Brain Neoplasms (2) · Carcinoma, Adenoid Cystic (2) · Carcinoma, Hepatocellular (2) · Chordoma (2) · Glioblastoma (2) · Glioma (2) · Liver Neoplasms (2)
Loma Linda University (7) · M.D. Anderson Cancer Center (7) · Massachusetts General Hospital (7) · Mayo Clinic (5) · Shanghai Proton and Heavy Ion Center (5) · Emory University (4) · NRG Oncology (4) · Abramson Cancer Center at Penn Medicine (2) · EBG MedAustron GmbH (2) · Heidelberg University (2) · Indiana University (2) · Obafemi Awolowo University Teaching Hospital (2) · Shenzhen Third People's Hospital (2) · Technische Universität Dresden (2) · University College, London (2)
United States (43) · China (13) · Germany (6) · South Africa (4) · Canada (3) · India (3) · Uganda (3) · Austria (2) · France (2) · Mozambique (2) · Nigeria (2) · Taiwan (2) · Tanzania (2) · Zimbabwe (2) · Gabon (1)
Jerry D Slater, MD (3) · Annie W Chan, MD (2) · Bolanle A Omotoso, MD (2) · David A. Bush, MD (2) · Gary Yang, MD (2) · Jerry D. Slater, MD (2) · Olanisun O Adewole, MD (2) · Steven J Frank (2) · Zhongxing Liao (2) · Alexander Lin, MD (1) · Ana Djordjevic-Dikic, MD, PhD (1) · Andrea Russo, MD (1) · Anthony Garcia-Prats, MD, MSc, PhD (1) · Ariba Sultan (1) · Ayola A Adegnika, MD, PhD (1)
PMID 36808186, PMID 11326818, PMID 15508084, PMID 15971391, PMID 17476139, PMID 19383184, PMID 19470152, PMID 20442432, PMID 21054824, PMID 21264826, PMID 21729673, PMID 21828024, PMID 23433590, PMID 23611033, PMID 23826878, PMID 24663014, PMID 25084608, PMID 26038418, PMID 26104205, PMID 26400476, PMID 27084653, PMID 30788166, PMID 31619413, PMID 31773043, PMID 31996395, PMID 32615102, PMID 33051340, PMID 33096027, PMID 34749885, PMID 34841093, PMID 35116390, PMID 35273049, PMID 35315690, PMID 35550036, PMID 35606739, PMID 36053506, PMID 36092320, PMID 36546625, PMID 37567554, PMID 37980911, PMID 38739047, PMID 38768617, PMID 39571596, PMID 39651910, PMID 39736544, PMID 41005671, PMID 41290309, PMID 41391462, PMID 41616265, PMID 42156227
U10CA180868 (5), P30CA138292 (3), P01CA021239 (2), U19CA021239 (2), 2019 (1), P50CA127001 (1), R03CA188162 (1), R56DE025248 (1), U01AI192041 (1), U10CA021661 (1), U10CA180820 (1), U10CA180822 (1)