139 completed, 80 recruiting, 52 unknown, 17 active not recruiting. 336 Not applicable.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 336 | Completed 139, Recruiting 80, Unknown 52, Active not recruiting 17, Not yet recruiting 13, Withdrawn 13, Terminated 12, Enrolling by invitation 8, Suspended 2 |
Follow Motor Neuron Disease: new trials by email Literature Review of Motor Neuron Disease trials Research Report on Motor Neuron Disease
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Interfacing With NeuroTechnology to Expand Neural Throughput (INTENT) INTENT Neural Interface System - Tetraplegia/Tetraparesis, Amyotrophic Lateral Sclerosis (ALS) | Not applicable | Recruiting | Johns Hopkins University | 5 | 2027-01-01 | 2026-10-09 |
| Dorsal Root Ganglion Stimulation After Lower Motor Neuron Damage Abbot Dorsal Root Ganglion Neurostimulator - Spinal Cord Injuries, Lower Motor Neuron Disease | Not applicable | Not yet recruiting | Peter J. Grahn, Ph.D. | 1 | 2026-12-01 | 2026-09-15 |
| Brain-Computer Interface Communication Device for People With ALS Cognixion ONE AR-BCI configuration, Cognixion ONE screen-based BCI configuration, Existing eye-gaze speech generating device - Amyotrophic Lateral Sclerosis | Not applicable | Recruiting | Cognixion | 30 | 2026-11-15 | 2026-10-16 |
| Effects of Different Stiffness Settings During Robotic Isokinetic Training in Children With SMA Portable Isokinetic Knee Training Robot With an Individually Optimized Compliant Setting, Portable Isokinetic Knee Training Robot With a Rigid Setting - Spinal Muscular Atrophy (SMA) | Not applicable | Recruiting | Peking University Third Hospital | 13 | 2026-10-22 | 2026-10-23 |
| Evaluation of the Feasibility and Efficacy of a Chronic Brain-computer Interface for Speech Rehabilitation in Patients With Locked-in-syndrome (LIS) Chronic speech BCI - Locked in Syndrome, ALS (Amyotrophic Lateral Sclerosis) | Not applicable | Not yet recruiting | University Hospital, Grenoble | 3 | 2026-10-10 | 2026-07-13 |
| iBCI Optimization for Veterans With Paralysis Mobile neural decoding platform (mobile iBCI) - Spinal Cord Injury, Amyotrophic Lateral Sclerosis | Not applicable | Not yet recruiting | VA Office of Research and Development | 2 | 2026-10-02 | 2026-07-27 |
| An OLIP Study (Open Label Individual Patient) of Nusinersen in a Participant With Spinal Muscular Atrophy Who Previously Participated in an Investigational Study With Nusinersen Nusinersen Injectable Product - SMA - Spinal Muscular Atrophy | Not applicable | Not yet recruiting | London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's | 1 | 2026-09-17 | 2026-09-24 |
| PhiCube for Bilateral Upper Limb Neuromotor and Cognitive Rehabilitation in Adults PhiCube, Conventional rehabilitation - Stroke, Parkinson Disease | Not applicable | Not yet recruiting | Istituto di Sistemi e Tecnologie Industriali Intelligenti per il Manifatturiero Avanzato | 80 | 2026-09-01 | 2026-10-08 |
| Self-Efficacy Enhancement Among Online Support Group of Primary Caregivers of Children With Neuro Muscular Dystrophy Multicomponent Intervention - Duchenne Muscular Dystrophy (DMD), Spinal Muscular Atrophy (SMA) | Not applicable | Active not recruiting | Aga Khan University | 34 | 2026-08-15 | 2026-10-09 |
| Do Video Recordings of Multidisciplinary Clinics Improve Quality of Life for People With ALS and Their Caregivers? Video recording, Notes Instruction - Amyotrophic Lateral Sclerosis (ALS) | Not applicable | Recruiting | Trustees of Dartmouth College | 800 | 2026-08-12 | 2026-10-08 |
| SMAdult - Monitoring of Movement on Spinal Muscular Atrophy wearable sensors - Spinal Amyotrophy | Not applicable | Recruiting | Centre Hospitalier Universitaire de Liege | 60 | 2026-07-17 | 2026-10-26 |
| Evaluation of the Impact of Virtual Park on Training Motivation in Adult Patients Dual-task training with Virtual Reality, Cycling training - Post-stroke, Parkinson Disease | Not applicable | Not yet recruiting | Marta Mondellini | 70 | 2026-06-01 | 2026-05-29 |
| Transcutaneous Superior Laryngeal Nerve Stimulation to Upregulate Swallowing Frequency and Urge to Swallow in Patients Living With ALS Transcutaneous Superior Laryngeal Nerve Stimulation to Upregulate Swallowing Frequency and Urge to Swallow - Amyotrophic Lateral Sclerosis (ALS), Dysphagia | Not applicable | Not yet recruiting | Nova Southeastern University | 5 | 2026-06-01 | 2026-05-26 |
| Auto-calibrating System for Upper Limb Disability Assessment, Neurological and Occupational Rehabilitation Auto-calibrating System for Upper Limb disability Assessment, neurological and occupational Rehabilitation, conventional therapy - Stroke, Amyotrophic Lateral Sclerosis | Not applicable | Not yet recruiting | University of Pavia | 30 | 2026-06-01 | 2026-06-09 |
| VRehab-SMA Phase 1.2 VRehab SMA device - Spinal Muscular Atrophy (SMA) | Not applicable | Active not recruiting | University of Oxford | 12 | 2026-05-27 | 2026-09-15 |
| Functional Outcomes and Control Using Synchron BCI - Australia Stentrode - Neurologic Disorder, Neurologic Diseases | Not applicable | Recruiting | Synchron, Inc. | 10 | 2026-05-22 | 2026-06-09 |
| Plasmapheresis in Amyotrophic Lateral Sclerosis With Autoantibody Against NRIP 2 (PALADIN2) plasmapheresis - Amyotrophic Lateral Sclerosis (ALS), Autoantibody | Not applicable | Recruiting | National Taiwan University Hospital | 20 | 2026-05-19 | 2026-07-24 |
| Resiliency Intervention for Patients With ALS and Their Care-Partners Resilient Together ALS - Amyotrophic Lateral Sclerosis (ALS), Emotional Distress | Not applicable | Not yet recruiting | Massachusetts General Hospital | 20 | 2026-05-13 | 2025-11-17 |
| INdependence Through Endovascular Neuroprosthetic Technology (INTENT): an Early Feasibility Study Stentrode - Neurological Disorder, ALS (Amyotrophic Lateral Sclerosis) | Not applicable | Recruiting | Synchron, Inc. | 10 | 2026-05-07 | 2026-10-21 |
| Tongue-strengthening Exercises in People With ALS. Isometric Lingual Strength Exercises - ALS (Amyotrophic Lateral Sclerosis), ALS - Amyotrophic Lateral Sclerosis | Not applicable | Recruiting | Nova Southeastern University | 20 | 2026-05-01 | 2026-08-12 |
Showing 20 of 336. Sign in to see all of them.
Amyotrophic Lateral Sclerosis (231) · Muscular Atrophy, Spinal (76) · Spinal Cord Injuries (36) · Neuromuscular Diseases (28) · Quadriplegia (20) · Muscular Dystrophies (17) · Spinal Muscular Atrophies of Childhood (17) · Parkinson Disease (16) · Stroke (16) · Brain Stem Infarctions (14) · Nervous System Diseases (13) · Paralysis (13) · Cerebral Palsy (11) · Locked-In Syndrome (10)
Neurodegenerative Diseases (328) · Nervous System Diseases (323) · Central Nervous System Diseases (315) · Spinal Cord Diseases (312) · Neuromuscular Diseases (308) · Nutritional and Metabolic Diseases (235) · Metabolic Diseases (234) · Proteostasis Deficiencies (231) · TDP-43 Proteinopathies (230) · Pathological Conditions, Signs and Symptoms (70) · Signs and Symptoms (62) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (53) · Brain Diseases (52) · Genetic Diseases, Inborn (51)
Blood Specimen Collection (13) · Surveys and Questionnaires (5) · Brain-Computer Interfaces (4) · Exercise (4) · Lidocaine (4) · Spinal Puncture (4) · Transcranial Magnetic Stimulation (4) · Magnetic Resonance Imaging (3) · Noninvasive Ventilation (3) · Range of Motion, Articular (3) · Standard of Care (3) · Calorimetry, Indirect (2) · Chest Wall Oscillation (2) · Continuous Positive Airway Pressure (2) · Genetic Testing (2)
Assistance Publique - Hôpitaux de Paris (17) · Assistance Publique Hopitaux De Marseille (7) · University of Michigan (7) · Johns Hopkins University (6) · MarsiBionics (6) · Neuralink Corp (6) · Nova Southeastern University (5) · Centre Hospitalier Universitaire de Liege (4) · Institut de Myologie, France (4) · National Taiwan University Hospital (4) · University Hospital, Toulouse (4) · University Hospital, Tours (4) · University of Ulm (4) · Bronx VA Medical Center (3) · Centre Hospitalier Universitaire de Nice (3)
United States (97) · France (67) · Italy (19) · United Kingdom (16) · China (15) · Germany (15) · Spain (14) · Canada (11) · Denmark (9) · Belgium (8) · Turkey (Türkiye) (8) · Taiwan (5) · Norway (4) · Switzerland (4) · Australia (3)
Alberto Benussi, MD (3) · Bradley Foerster, M.D. (3) · Jane Huggins, PhD (3) · Nieto Luis, Master (3) · Anne Olmstead, Ph.D. (2) · Barbara Borroni, MD (2) · Christian Lunetta, MD (2) · Ellen Langer, PhD (2) · Ferdinand Knieling, MD (2) · Jakub M Antczak, MD (2) · Jimin Lee, Ph.D. (2) · Laurent Servais, MD, PhD (2) · Marco Capogrosso (2)
PMID 16434671, PMID 41366786, PMID 10826123, PMID 11508406, PMID 13997180, PMID 15790844, PMID 15823706, PMID 15831718, PMID 16096237, PMID 16741123, PMID 17018025, PMID 17029646, PMID 17136445, PMID 17385269, PMID 17699621, PMID 19921501, PMID 20074461, PMID 20566854, PMID 20660719, PMID 20977930, PMID 21271789, PMID 21436513, PMID 21596768, PMID 22023158, PMID 22077695, PMID 22183182, PMID 22327252, PMID 22596161, PMID 23143995, PMID 23286757, PMID 23323867, PMID 23456136, PMID 23562111, PMID 23590556, PMID 23838067, PMID 23870000, PMID 24251381, PMID 24675128, PMID 24684860, PMID 24764156, PMID 24890442, PMID 25029916, PMID 25211238, PMID 25313375, PMID 25322741, PMID 25346245, PMID 25359355, PMID 25385765, PMID 25689247, PMID 25746907
2025 (2), R01DC021714 (2), 1DP2DC021055 (1), 2023 (1), F31DC019281 (1), I01RX003803 (1), I01RX004258 (1), R01DC009899 (1), R01DC014034 (1), R01NR010733 (1), R01NS045087 (1), R03HD097709 (1), R03HD111884 (1), R15DC016383 (1), R21EB035378 (1)