7 completed, 4 unknown, 3 terminated, 2 not yet recruiting. 16 Phase 3, 7 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 16 | Completed 7, Unknown 4, Terminated 3, Not yet recruiting 2 |
| Phase 2 | 7 | Completed 4, Not yet recruiting 2, Unknown 1 |
Follow Metastasis: new trials by email Literature Review of Metastasis trials Research Report on Metastasis
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Clinical Trial to Evaluate Effect of IAE0972 Combined with Chemotherapy for R/M HNSCC or NPC(Note: It is Currently Phase II.). IAE0972+ Methotrexate, IAE0972+Docetaxel, IAE0972+Gemcitabine - NPC, HNSCC | Phase 2 / Phase 3 | Not yet recruiting | SUNHO（China）BioPharmaceutical CO., Ltd. | 60 | 2025-01-01 | 2024-12-05 |
| An Open-label, Multicentre, Phase II/III RCT of PFLL Versus GP Combined With JS001 as the First-line Therapy for mNPC Triprilimab(JS001), Cisplatin, 5-Fluorouracil - Nasopharyngeal Carcinoma, Metastasis | Phase 2 / Phase 3 | Not yet recruiting | Sun Yat-sen University | 622 | 2021-07-01 | 2021-05-18 |
| TWICE-IRI: Optimization of Second-line Therapy With Aflibercept, Irinotecan (Day 1 or Day 1,3), 5-Fluorouracile and Folinic Acid in Patients With Metastatic Colorectal Cancer. A Randomized Phase III Study. Aflibercept-FOLFIRI, Aflibercept-mFOLFIRI3 - Cancer Colorectal, Metastasis | Phase 3 | Unknown | Hôpital Franco-Britannique-Fondation Cognacq-Jay | 202 | 2020-09-02 | 2023-10-23 |
| Ferumoxtran-10-enhanced MRI in Prostate Cancer Patients Ferrotran® (Ferumoxtran-10) - Prostate Cancer, Metastasis | Phase 3 | Terminated | Saving Patients' Lives Medical B.V. | 172 | 2020-05-27 | 2026-04-28 |
| Pulsatile High-dose Sunitinib Versus TAS-102 in Patients With Metastatic Colorectal Carcinoma (mCRC) Sunitinib Malate, TAS 102 - Colorectal Cancer, Metastasis | Phase 2 / Phase 3 | Unknown | Amsterdam UMC, location VUmc | 60 | 2019-10-01 | 2020-11-13 |
| Kypho-IORT vs. EBRT in Spinal Metastases Kypho-IORT, EBRT - Metastasis | Phase 3 | Terminated | Universitätsmedizin Mannheim | 6 | 2017-11-12 | 2022-07-22 |
| Optimal Sequencing of Treatment Options for Poor Risk mCRPC Previously Treated With Docetaxel Cabazitaxel, Abiraterone, Enzalutamide - Prostate Cancer Metastatic, Metastasis | Phase 2 / Phase 3 | Completed | The Netherlands Cancer Institute | 100 | 2017-05-07 | 2022-04-15 |
| A Study of Etirinotecan Pegol (NKTR-102) Versus Treatment of Physician's Choice (TPC) in Patients With Metastatic Breast Cancer Who Have Stable Brain Metastases and Have Been Previously Treated With an Anthracycline, a Taxane, and Capecitabine NKTR-102, Eribulin, Ixabepilone - Metastasis, Breast Cancer | Phase 3 | Completed | Nektar Therapeutics | 178 | 2016-11-01 | 2023-04-14 |
| Apatinib for Advanced Osteosarcoma After Failure of Standard Multimodal Therapy apatinib - Osteosarcoma, Metastasis | Phase 2 / Phase 3 | Completed | GUO WEI | 37 | 2016-03-01 | 2018-04-23 |
| Perioperative Chemotherapy Plus Cetuximab Versus Chemotherapy Alone for High Risk Resectable Colorectal Liver Metastasis Cetuximab plus FOLFIRI/FOLFOX, FOLFIRI/FOLFOX/CapeOX - Colorectal Cancer Stage IV, Metastasis | Phase 2 / Phase 3 | Completed | Peking University Cancer Hospital & Institute | 135 | 2016-01-01 | 2021-02-01 |
| A Multi-center Randomized Controlled Trial of Intraportal Chemotherapy Combined With Adjuvant Chemotherapy (mFOLFOX6) for Stage II and III Colon Cancer FUDR +oxaliplatin, oxaliplatin+Leucovorin+5-FU - Colorectal Cancer, Metastasis | Phase 3 | Unknown | Xu jianmin | 700 | 2015-02-01 | 2015-03-31 |
| Perioperative FOLFIRI VS Adjuvant FOLFIRI in Resectable Advanced CRC Failed to Oxaliplatin Irinotecan, 5-fluorouracil, Local radiotherapy - Colorectal Neoplasms, Effects of Chemotherapy | Phase 3 | Unknown | Sixth Affiliated Hospital, Sun Yat-sen University | 360 | 2011-01-01 | 2019-06-05 |
| TraStuzumAb-Radiotherapy : Impact on the Cerebral Prevention cerebral prophylactic radiation, Trastuzumab, Other chemotherapy in association with Trastuzumab - Breast Cancer, Metastasis | Phase 3 | Terminated | Centre Oscar Lambret | 13 | 2008-01-01 | 2026-09-17 |
| First-Line Treatment of Advanced Bladder Cancer Randomized vs. Gemcitabine ± Vinflunine in Patients Ineligible to Receive Cisplatin-Based Therapy Vinflunine, Gemcitabine, Placebo - Bladder Cancer, Transitional Cell Carcinoma | Phase 2 / Phase 3 | Completed | Bristol-Myers Squibb | 34 | 2007-01-01 | 2015-12-07 |
| Trial Comparing Two Strategies of Chemotherapy for Metastatic Colorectal Cancer 5-fluorouracil, leucovorin, irinotecan - Colorectal Cancer, Metastasis | Phase 3 | Completed | Gustave Roussy, Cancer Campus, Grand Paris | 570 | 2002-02-01 | 2015-08-13 |
| A Trial Comparing the Efficacy and Tolerability of Faslodex With Nolvadex in Postmenopausal Women With Advanced Breast Cancer Fulvestrant, Tamoxifen - Breast Cancer, Metastasis | Phase 3 | Completed | AstraZeneca | 51 | 1998-11-01 | 2012-06-06 |
Neoplasm Metastasis (16) · Colorectal Neoplasms (5) · Breast Neoplasms (3) · Carcinoma (1) · Carcinoma, Transitional Cell (1) · Colonic Neoplasms (1) · Nasopharyngeal Carcinoma (1) · Neoplasm Recurrence, Local (1) · Osteosarcoma (1) · Prostatic Neoplasms (1) · Recurrence (1) · Squamous Cell Carcinoma of Head and Neck (1) · Urinary Bladder Neoplasms (1)
Neoplasms (16) · Neoplastic Processes (16) · Pathologic Processes (16) · Pathological Conditions, Signs and Symptoms (16) · Neoplasms by Site (13) · Colonic Diseases (6) · Digestive System Diseases (6) · Digestive System Neoplasms (6) · Gastrointestinal Diseases (6) · Gastrointestinal Neoplasms (6) · Intestinal Diseases (6) · Intestinal Neoplasms (6) · Neoplasms by Histologic Type (5) · Rectal Diseases (5) · Neoplasms, Glandular and Epithelial (4)
Fluorouracil (3) · Gemcitabine (3) · Irinotecan (2) · Leucovorin (2) · 130-nm albumin-bound paclitaxel (1) · Association (1) · Cetuximab (1) · Cisplatin (1) · Docetaxel (1) · Floxuridine (1) · Folfox protocol (1) · Fulvestrant (1) · Oxaliplatin (1) · Paclitaxel (1) · Sunitinib (1)
Amsterdam UMC, location VUmc (1) · AstraZeneca (1) · Bristol-Myers Squibb (1) · Centre Oscar Lambret (1) · GUO WEI (1) · Gustave Roussy, Cancer Campus, Grand Paris (1) · Hôpital Franco-Britannique-Fondation Cognacq-Jay (1) · Nektar Therapeutics (1) · Peking University Cancer Hospital & Institute (1) · SUNHO（China）BioPharmaceutical CO., Ltd. (1) · Saving Patients' Lives Medical B.V. (1) · Sixth Affiliated Hospital, Sun Yat-sen University (1) · Sun Yat-sen University (1) · The Netherlands Cancer Institute (1) · Universitätsmedizin Mannheim (1)
France (6) · China (5) · Belgium (4) · Netherlands (4) · Australia (3) · Canada (3) · Germany (3) · Italy (3) · Spain (3) · United Kingdom (3) · United States (3) · Israel (2) · Poland (2) · Portugal (2) · Russia (2)
Baocai Xing, MD (1) · Frank Giordano, MD (1) · Henk Verheul, Prof. M.D. (1) · Hong Jiang, MD (1) · Jean-Pierre F Pignon, MD, PhD (1) · Michel Ducreux, Pr (1) · Ping Lan, MD (1) · Wei Guo, M.D. Ph.D. (1) · Yun-fei Xia, MD (1)
PMID 10493478, PMID 21903473, PMID 23490654, PMID 31074641, PMID 33183307, PMID 35552364, PMID 40973474