23 completed, 13 unknown, 6 recruiting, 5 terminated. 54 Phase 2, 12 Phase 1, 7 Phase 3.
Follow Metastasis: new trials by email Literature Review of Metastasis trials Research Report on Metastasis
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Phase 2 Study of Luvometinib Combined With Anlotinib in KRAS-mutated NSCLC luvometinib + anlotinib - Non-small Cell Lung Caner, KRAS-mutated | Phase 2 | Recruiting | Shanghai Fosun Pharmaceutical Industrial Development Co. Ltd. | 48 | 2026-06-15 | 2026-09-02 |
| A Study of Gefitinib, Trametinib, Disulfiram, and Sunitinib in Addition to Standard Chemotherapy in People With Osteosarcoma Methotrexate, Doxorubicin, Cisplatin - Osteosarcoma, Metastasis | Phase 2 | Recruiting | Memorial Sloan Kettering Cancer Center | 45 | 2026-03-11 | 2026-03-17 |
| A Clinical Study of Ifinatamab Deruxtecan Based Treatment Combinations or as Monotherapy to Treat Metastatic Castrate Resistant Prostate Cancer (mCRPC) (MK-2400-01A/IDeate-Prostate02) Docetaxel, Ifinatamab Deruxtecan, Opevesostat - Castration-Resistant Prostatic Cancer, Metastasis | Phase 1 / Phase 2 | Recruiting | Merck Sharp & Dohme LLC | 360 | 2025-07-03 | 2026-10-09 |
| A Clinical Trial to Evaluate Effect of IAE0972 Combined with Chemotherapy for R/M HNSCC or NPC(Note: It is Currently Phase II.). IAE0972+ Methotrexate, IAE0972+Docetaxel, IAE0972+Gemcitabine - NPC, HNSCC | Phase 2 / Phase 3 | Not yet recruiting | SUNHO（China）BioPharmaceutical CO., Ltd. | 60 | 2025-01-01 | 2024-12-05 |
| A Study of Oral 7HP349 (Alintegimod) in Combination With Ipilimumab Followed by Nivolumab Monotherapy Alintegimod, Ipilimumab, Nivolumab - Advanced Cancer, Advanced Solid Tumor | Phase 1 / Phase 2 | Recruiting | 7 Hills Pharma, LLC | 126 | 2024-08-23 | 2026-04-13 |
| Histamine Dihydrochloride and Interleukin-2 in Primary Resectable Pancreatic Cancer Histamine Dihydrochloride (HDC), Interleukin-2 (IL-2) - Pancreatic Cancer, Surgery | Phase 2 | Not yet recruiting | Sahlgrenska University Hospital | 50 | 2024-04-01 | 2023-11-22 |
| Definitive Radiation for High-Risk Spine Metastases SBRT to the spine - Metastatic Cancer, Metastatic Lung Cancer | Phase 2 | Recruiting | Stony Brook University | 26 | 2023-12-14 | 2025-05-14 |
| Effect of Azeliragon Combined With Stereotactic Radiation Therapy in Patients With Brain Metastases Azeliragon, Stereotactic radiosurgery, Corticosteroid - Cancer, Metastasis | Phase 1 / Phase 2 | Suspended | Baptist Health South Florida | 46 | 2023-11-17 | 2026-06-16 |
| Comparative Study of Mitomycin and Lobaplatin in Advanced Colorectal Cancer Patients With Radical Surgery Combined With Hyperthermic Intraperitoneal Chemotherapy Mitomycin, Lobaplatin - Colorectal Cancer, Chemotherapy Effect | Phase 2 | Unknown | Union Hospital, Tongji Medical College, Huazhong University of Science and Technology | 201 | 2022-09-01 | 2022-02-21 |
| Phase 2 Basket Trial of Nab-sirolimus in Patients With Malignant Solid Tumors With Pathogenic Alterations in TSC1/TSC2 Genes (PRECISION 1) nab-sirolimus - Tumor, Tumor, Solid | Phase 2 | Completed | Aadi Bioscience, Inc. | 128 | 2022-03-10 | 2026-10-28 |
| Personalized Ultra-fractionated Stereotactic Adaptive Radiotherapy for Metastatic Cervical Cancer Ultra-fractionated radiation therapy - Stage IV Cervical Cancer FIGO 2018, Adenosquamous Carcinoma of Cervix | Phase 2 | Completed | University of Texas Southwestern Medical Center | 12 | 2022-02-01 | 2026-09-17 |
| Cemiplimab for Secondary Angiosarcomas Cemiplimab - Secondary Angiosarcoma, Locally Advanced Sarcoma | Phase 2 | Completed | Radboud University Medical Center | 18 | 2022-01-01 | 2024-10-31 |
| Chemotherapy and Surgical Resection in Patients With Hepatic Oligometastatic Adenocarcinoma of the Pancreas nal-irinotecan (nal-iri) (Onyvide), oxaliplatin (ox), 5-fluouracil (5-FU), folinic acid (FA) - Pancreatic Cancer, Metastasis | Phase 2 | Unknown | University of Cologne | 150 | 2021-10-10 | 2024-01-12 |
| Abemaciclib in Combination With Bicalutamide for Androgen Receptor-positive, HER2-negative Metastatic Breast Cancer Abemaciclib, Bicalutamide - Breast Cancer, Metastasis | Phase 1 / Phase 2 | Recruiting | Icahn School of Medicine at Mount Sinai | 42 | 2021-09-20 | 2026-04-13 |
| Comparative Study of Lobaplatin and Paclitaxel in Advanced Gastric Cancer Patients With D2 Surgery Combined With Hyperthermic Intraperitoneal Chemotherapy Paclitaxel, Lobaplatin - Gastric Cancer, Chemotherapy Effect | Phase 2 | Unknown | Union Hospital, Tongji Medical College, Huazhong University of Science and Technology | 231 | 2021-09-18 | 2022-02-21 |
| An Open-label, Multicentre, Phase II/III RCT of PFLL Versus GP Combined With JS001 as the First-line Therapy for mNPC Triprilimab(JS001), Cisplatin, 5-Fluorouracil - Nasopharyngeal Carcinoma, Metastasis | Phase 2 / Phase 3 | Not yet recruiting | Sun Yat-sen University | 622 | 2021-07-01 | 2021-05-18 |
| Apatinib Monotherapy Versus Apatinib Combined With Camrelizumab for Third-line Treatment of Metastatic Gastric Cancer Apatinib Mesylate, Camrelizumab - Gastric Cancer, Metastasis | Phase 2 | Unknown | Fudan University | 102 | 2021-03-17 | 2021-10-27 |
| Encorafenib, Binimetinib and Palbociclib in BRAF-mutant Metastatic Melanoma CELEBRATE Binimetinib, Encorafenib, Palbociclib - Melanoma, Metastasis | Phase 1 / Phase 2 | Unknown | Peter MacCallum Cancer Centre, Australia | 78 | 2020-06-04 | 2024-01-05 |
| Pulsatile High-dose Sunitinib Versus TAS-102 in Patients With Metastatic Colorectal Carcinoma (mCRC) Sunitinib Malate, TAS 102 - Colorectal Cancer, Metastasis | Phase 2 / Phase 3 | Unknown | Amsterdam UMC, location VUmc | 60 | 2019-10-01 | 2020-11-13 |
| A Study Evaluating Safety and Therapeutic Activity of THOR-707 in Adult Subjects With Advanced or Metastatic Solid Tumors (THOR-707-101) THOR-707, Checkpoint inhibitor, anti-EGFR antibody - Metastasis | Phase 1 / Phase 2 | Terminated | Synthorx, Inc, a Sanofi company | 175 | 2019-06-20 | 2025-12-15 |
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Neoplasm Metastasis (54) · Breast Neoplasms (9) · Colorectal Neoplasms (9) · Neoplasms (7) · Recurrence (5) · Carcinoma, Hepatocellular (4) · Brain Neoplasms (3) · Pancreatic Neoplasms (3) · Adenocarcinoma (2) · Carcinoma, Non-Small-Cell Lung (2) · Carcinoma, Renal Cell (2) · Colonic Neoplasms (2) · Liver Neoplasms (2) · Lung Neoplasms (2) · Melanoma (2)
Neoplastic Processes (54) · Pathologic Processes (54) · Pathological Conditions, Signs and Symptoms (54) · Neoplasms (47) · Neoplasms by Site (41) · Digestive System Diseases (19) · Digestive System Neoplasms (19) · Neoplasms by Histologic Type (15) · Gastrointestinal Diseases (13) · Gastrointestinal Neoplasms (13) · Carcinoma (11) · Neoplasms, Glandular and Epithelial (11) · Skin Diseases (11) · Skin and Connective Tissue Diseases (11) · Colonic Diseases (10)
Fluorouracil (5) · Oxaliplatin (4) · apatinib (4) · Cisplatin (3) · Gemcitabine (3) · Leucovorin (3) · Mitomycin (3) · Sunitinib (3) · Bevacizumab (2) · Capecitabine (2) · Cetuximab (2) · Dasatinib (2) · Folfox protocol (2) · Sorafenib (2) · abiraterone (2)
Bristol-Myers Squibb (3) · Centre Francois Baclesse (2) · Union Hospital, Tongji Medical College, Huazhong University of Science and Technology (2) · 7 Hills Pharma, LLC (1) · AHS Cancer Control Alberta (1) · Aadi Bioscience, Inc. (1) · Aarhus University Hospital (1) · Abramson Cancer Center at Penn Medicine (1) · Amsterdam UMC, location VUmc (1) · Asan Medical Center (1) · Asha Nayak (1) · Ashwin Somasundaram (1) · Assistance Publique - Hôpitaux de Paris (1) · Baptist Health South Florida (1) · Barretos Cancer Hospital (1)
United States (19) · China (8) · France (7) · South Korea (7) · Spain (6) · Australia (4) · Canada (4) · Italy (4) · Netherlands (4) · Argentina (3) · Belgium (3) · Germany (3) · United Kingdom (3) · Brazil (2) · Chile (2)
Kaixiong Tao, Professor (2) · Amy Tiersten, MD (1) · Andreas Muth (1) · Anne L Thomas, PhD FRCS (1) · Antonio Llombart, MD (1) · Ashwin Somasundaram, MD (1) · Baocai Xing, MD (1) · Damir Vrbanec, PhD MD (1) · Damon Reed, MD (1) · Daniela Grecea, MD (1) · Dirk Waldschmidt (1)
PMID 32306237, PMID 10091726, PMID 10493478, PMID 11813623, PMID 22287157, PMID 22831982, PMID 24362862, PMID 24950987, PMID 25680955, PMID 25688058, PMID 25872567, PMID 25979230, PMID 26884585, PMID 27519353, PMID 31132111, PMID 33416261, PMID 35767182, PMID 38425504, PMID 40571483, PMID 40973474, PMID 8156509
2017 (1), 2019 (1), 2023 (1)