53 completed, 44 unknown, 28 recruiting, 14 terminated. 54 Phase 2, 31 Not applicable, 23 Phase 1, 16 Phase 3, 3 Early Phase 1.
Follow Metastasis: new trials by email Literature Review of Metastasis trials Research Report on Metastasis
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Phase 2 Study of Luvometinib Combined With Anlotinib in KRAS-mutated NSCLC luvometinib + anlotinib - Non-small Cell Lung Caner, KRAS-mutated | Phase 2 | Recruiting | Shanghai Fosun Pharmaceutical Industrial Development Co. Ltd. | 48 | 2026-06-15 | 2026-09-02 |
| Real-world Study of SKB264 Monotherapy or Combination Therapy in Recurrent or Metastatic HER2-negative Breast Cancer SKB264 Monotherapy or Combination Therapy - HER2-negative Breast Cancer, Recurrence | Recruiting | Cancer Institute and Hospital, Chinese Academy of Medical Sciences | 500 | 2026-05-28 | 2026-08-18 | |
| Surgery Plus Systemic Therapy for Liver Cancer With Extrahepatic Metastases Primary Tumor Resection, Protocol-Allowed First-Line Immune-Based Systemic Therapy - Hepatocellular Carcinoma (HCC), Metastasis | Not applicable | Not yet recruiting | Tongji Hospital | 280 | 2026-04-30 | 2026-04-17 |
| A Study of Gefitinib, Trametinib, Disulfiram, and Sunitinib in Addition to Standard Chemotherapy in People With Osteosarcoma Methotrexate, Doxorubicin, Cisplatin - Osteosarcoma, Metastasis | Phase 2 | Recruiting | Memorial Sloan Kettering Cancer Center | 45 | 2026-03-11 | 2026-03-17 |
| Resection of the Primary Tumor vs. Systemic Treatment Alone for Patients With Small Intestinal Neuroendocrine Tumors and Unresectable Metastases: a Europe-wide Study Histopathological review - Neuroendocrine (NE) Tumors, Metastasis | Recruiting | Insel Gruppe AG, University Hospital Bern | 3200 | 2026-03-09 | 2026-03-18 | |
| Feasibility Study of Personalized Ultra-fractionated Stereotactic Ablative Radiotherapy (PULSAR) for Cancers of the Central Lung Personalized Ultra-fractionated stereotactic ablative radiotherapy (PULSAR) - Cancer, Lung, Metastasis | Early Phase 1 | Recruiting | University of Texas Southwestern Medical Center | 30 | 2025-09-19 | 2026-06-29 |
| A Clinical Study of Ifinatamab Deruxtecan Based Treatment Combinations or as Monotherapy to Treat Metastatic Castrate Resistant Prostate Cancer (mCRPC) (MK-2400-01A/IDeate-Prostate02) Docetaxel, Ifinatamab Deruxtecan, Opevesostat - Castration-Resistant Prostatic Cancer, Metastasis | Phase 1 / Phase 2 | Recruiting | Merck Sharp & Dohme LLC | 360 | 2025-07-03 | 2026-10-09 |
| Comparison of Two-Position and Four-Position Cervical Injection Techniques for Sentinel Lymph Node Mapping in Endometrial Cancer Using Methylene Blue Sentinel Lymph Node Detection/Cervical Methylene Blue Injection - Endometrial Neoplasms, Endometrial Cancer Stage I | Not applicable | Recruiting | Dokuz Eylul University | 100 | 2025-05-01 | 2025-06-27 |
| Rapid Assessment of Sentinel Lymph Node Metastasis Status Using a Pan-CK-targeting NIR-II Fluorescent Probe in Breast Cancer NIR-II probe (i.e ICG-CK) incubation solution - Breast Cancer Metastatic, Sentinel Lymph Node | Recruiting | Yunnan Cancer Hospital | 60 | 2025-02-01 | 2025-09-04 | |
| Validation of a miRNA Panel to Optimize Treatment Response in Patients With Metastatic Pancreatic Cancer (mirPANC 2) Pancreatic Cancer, Metastasis | Recruiting | Benedito Mauro Rossi | 60 | 2025-01-21 | 2025-04-27 | |
| A Clinical Trial to Evaluate Effect of IAE0972 Combined with Chemotherapy for R/M HNSCC or NPC(Note: It is Currently Phase II.). IAE0972+ Methotrexate, IAE0972+Docetaxel, IAE0972+Gemcitabine - NPC, HNSCC | Phase 2 / Phase 3 | Not yet recruiting | SUNHO（China）BioPharmaceutical CO., Ltd. | 60 | 2025-01-01 | 2024-12-05 |
| A Multi-mode Thermophysical Immunotherapy Study for Breast Cancer Liver Metastases Multi-mode tumor treatment system, Radiofrequency ablation therapeutic apparatus - Breast Neoplasms, Liver Neoplasms | Not applicable | Recruiting | Ruijin Hospital | 10 | 2024-12-09 | 2025-03-14 |
| SUPERvised Three-month Exercise Program in MEN With Prostate cAncer Receiving Androgen-deprivaTioN thERapy Physiotherapy - Prostatic Neoplasms, Metastasis | Not applicable | Withdrawn | Canisius-Wilhelmina Hospital | 2024-11-01 | 2026-03-23 | |
| A Study of Oral 7HP349 (Alintegimod) in Combination With Ipilimumab Followed by Nivolumab Monotherapy Alintegimod, Ipilimumab, Nivolumab - Advanced Cancer, Advanced Solid Tumor | Phase 1 / Phase 2 | Recruiting | 7 Hills Pharma, LLC | 126 | 2024-08-23 | 2026-04-13 |
| EchoTip AcuCore Post-Market Clinical Study EchoTip AcuCore - Adenocarcinoma, Neuroendocrine Tumors | Completed | Cook Research Incorporated | 183 | 2024-08-05 | 2025-09-22 | |
| Histamine Dihydrochloride and Interleukin-2 in Primary Resectable Pancreatic Cancer Histamine Dihydrochloride (HDC), Interleukin-2 (IL-2) - Pancreatic Cancer, Surgery | Phase 2 | Not yet recruiting | Sahlgrenska University Hospital | 50 | 2024-04-01 | 2023-11-22 |
| Predicting Tumor Metastasis by Employing a Target Organ/Primary Lesion Fusion Radiomics Model Metastasis, Predictive Cancer Model | Recruiting | Fudan University | 166 | 2024-01-01 | 2024-02-09 | |
| Definitive Radiation for High-Risk Spine Metastases SBRT to the spine - Metastatic Cancer, Metastatic Lung Cancer | Phase 2 | Recruiting | Stony Brook University | 26 | 2023-12-14 | 2025-05-14 |
| Retrospective Cervical Cancer Oligo States (Recurrence, Metastasis) Multicentre Outcomes Study Concurrent Chemoradiation, Systemic Chemotherapy other locally directed therapies (like surgery, ablation, etc.) - Cancer, Cervical, Recurrence | Not yet recruiting | Erasmus Medical Center | 350 | 2023-11-30 | 2023-12-01 | |
| Effect of Azeliragon Combined With Stereotactic Radiation Therapy in Patients With Brain Metastases Azeliragon, Stereotactic radiosurgery, Corticosteroid - Cancer, Metastasis | Phase 1 / Phase 2 | Suspended | Baptist Health South Florida | 46 | 2023-11-17 | 2026-06-16 |
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Neoplasm Metastasis (150) · Neoplasms (23) · Breast Neoplasms (20) · Recurrence (19) · Colorectal Neoplasms (18) · Prostatic Neoplasms (10) · Carcinoma, Hepatocellular (8) · Death (5) · Liver Neoplasms (5) · Lung Neoplasms (5) · Neoplastic Cells, Circulating (5) · Pancreatic Neoplasms (5) · Brain Neoplasms (4) · Carcinoma, Non-Small-Cell Lung (4) · Colonic Neoplasms (4)
Neoplastic Processes (150) · Pathologic Processes (150) · Pathological Conditions, Signs and Symptoms (150) · Neoplasms (127) · Neoplasms by Site (99) · Digestive System Diseases (46) · Digestive System Neoplasms (44) · Gastrointestinal Diseases (33) · Neoplasms by Histologic Type (32) · Gastrointestinal Neoplasms (31) · Neoplasms, Glandular and Epithelial (25) · Intestinal Diseases (24) · Intestinal Neoplasms (23) · Skin Diseases (23) · Skin and Connective Tissue Diseases (23)
Fluorouracil (7) · Leucovorin (5) · Oxaliplatin (5) · Drug Therapy (4) · Gemcitabine (4) · Sorafenib (4) · Sunitinib (4) · apatinib (4) · Bevacizumab (3) · Capecitabine (3) · Cisplatin (3) · Liver Transplantation (3) · Mitomycin (3) · Positron Emission Tomography Computed Tomography (3) · Radiosurgery (3)
Chang Gung Memorial Hospital (5) · Amsterdam UMC, location VUmc (4) · Tianjin Medical University (4) · Bristol-Myers Squibb (3) · Centre Leon Berard (3) · Fudan University (3) · Maastricht University Medical Center (3) · Seoul National University Hospital (3) · Assistance Publique - Hôpitaux de Paris (2) · Centre Francois Baclesse (2) · First Affiliated Hospital of Fujian Medical University (2) · Gustave Roussy, Cancer Campus, Grand Paris (2) · Insel Gruppe AG, University Hospital Bern (2) · Ruijin Hospital (2) · Sun Yat-sen University (2)
United States (35) · China (30) · France (18) · Netherlands (13) · Spain (12) · South Korea (11) · Taiwan (9) · Canada (8) · Germany (8) · Australia (7) · Belgium (7) · United Kingdom (7) · Italy (6) · Argentina (4) · Brazil (4)
Jeong Min Lee, MD (3) · Chia-Hsun Hsieh, M.D, M.S (2) · K Mosterd, MD, PhD (2) · Kaixiong Tao, Professor (2) · Yun-fei Xia, MD (2) · Alex HL Wong, MMedSc (1) · Alison Tree, FRCR (1) · Amy Tiersten, MD (1) · Andreas Muth (1) · Andreas Raabe, MD (1) · Anne L Thomas, PhD FRCS (1) · Antonio Llombart, MD (1)
PMID 24844673, PMID 32306237, PMID 10091726, PMID 10493478, PMID 11813623, PMID 11981766, PMID 12049862, PMID 12091661, PMID 12540794, PMID 12599286, PMID 1384570, PMID 15541580, PMID 15894098, PMID 16006574, PMID 18650514, PMID 19095497, PMID 19755046, PMID 20596978, PMID 20670137, PMID 21122462, PMID 21605146, PMID 21814467, PMID 21903473, PMID 22287157, PMID 22366187, PMID 22473170, PMID 22831982, PMID 23490654, PMID 24362862, PMID 24566862, PMID 24950987, PMID 25513855, PMID 25555421, PMID 25651787, PMID 25680955, PMID 25688058, PMID 25872567, PMID 25979230, PMID 26884585, PMID 27519353, PMID 30018133, PMID 30241526, PMID 30991692, PMID 31074641, PMID 31132111, PMID 32926761, PMID 33179149, PMID 33183307, PMID 33416261, PMID 34068083
2017 (1), 2018 (1), 2019 (1), 2023 (1), R21CA267584 (1)