69 completed, 19 unknown, 15 recruiting, 4 active not recruiting. 79 Not applicable, 8 Phase 1, 2 Early Phase 1, 2 Phase 2, 2 Phase 4.
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| VITAL-IMPACT: Improving Cardiometabolic Health in Black Individuals Through Therapeutic Augmentation of Cyclic Guanosine Mono-Phosphate Signaling Pathway Vericiguat 10 MG, Placebo, Insulin Sensitivity Test - Cardiovascular Diseases, Insulin Sensitivity/Resistance | Phase 2 | Not yet recruiting | University of Alabama at Birmingham | 200 | 2026-12-01 | 2026-01-23 |
| Tracing Of Real-time glu13Cose Metabolism in Human Immune Cells - Intensive Care Unit 13C6-Glucose - Glucose, Metabolism | Not applicable | Not yet recruiting | Vanderbilt University Medical Center | 25 | 2026-11-01 | 2026-09-09 |
| A Clinical Study to Evaluate the Absorption, Metabolism, and Excretion of Oral [14C]GS1-144 in Healthy Postmenopausal Female Participants [14C]GS1-144 - Healthy Postmenopausal Women, Absorption | Phase 1 | Active not recruiting | Changchun GeneScience Pharmaceutical Co., Ltd. | 6 | 2026-04-09 | 2026-05-07 |
| Tracing Of Real-time glu13Cose Metabolism in Human Immune Cells 13C6-Glucose - Glucose, Metabolism | Not applicable | Recruiting | Vanderbilt University Medical Center | 12 | 2025-10-01 | 2025-11-04 |
| VITAL: Vaccination, Immunity, Time-restricted Eating, Aging and Lifestyle TRE: Time-restricted eating - Vaccination, Immunosenescence | Not applicable | Recruiting | Charite University, Berlin, Germany | 24 | 2025-09-10 | 2025-09-18 |
| Caloric Balance Markers Study Metabolism | Recruiting | Institute for Systems Biology | 400 | 2025-08-27 | 2025-09-03 | |
| Studying Phenotypic Risks for Obesity and Underlying Traits in Young Infants Meal Test - Human Milk, Meal Test - Infant Formula - Infant Body Composition and Metabolism, Metabolism | Recruiting | Pennington Biomedical Research Center | 40 | 2025-07-28 | 2025-08-22 | |
| The Impact of Nicotinamide Mononucleotide Sustained-release Tablets on Immunosenescence and Metablism in Middle-aged and Elderly Individuals With Metabolic Disorders. NMN, Placebo - Immunosenescence, Metabolism | Not applicable | Recruiting | Qing Su | 126 | 2025-06-05 | 2025-07-08 |
| GLYLO Supplement Pilot Trial on Glycation and Aging in Postmenopausal Women GLYLO, Placebo - Postmenopause, Metabolism | Not applicable | Recruiting | Buck Institute for Research on Aging | 30 | 2025-04-01 | 2025-09-08 |
| Evaluation of Blood and Cardiac Protein O-GlcNAcylation Levels in Cardiac Surgery in Children Cardiac Surgery, Extracorporeal Circulation; Complications | Recruiting | Nantes University Hospital | 300 | 2025-02-13 | 2025-04-13 | |
| Effect of Caloric Content and Timing of Meal on Postprandial Substrate Oxidation and Pulse Wave Analysis Mixed Meal Feeding Challenge - Feeding, Metabolism | Not applicable | Completed | George Washington University | 20 | 2024-11-03 | 2026-02-25 |
| Ketone Esters and Metabolism During Recovery from Endurance Exercise Ketone ester, Placebo - Exercise, Metabolism | Not applicable | Active not recruiting | University of Bath | 18 | 2024-11-01 | 2025-02-26 |
| The Impact of Short-Chain Fatty Acids on Gut Hormone Release After Delivery in the Small and Large Intestine of Healthy Volunteers SCFA, microcristalline cellulose - Satiety Hormones, Short-chain Fatty Acids | Not applicable | Completed | KU Leuven | 28 | 2024-09-25 | 2026-02-23 |
| Identifying Wearable Biomarkers to Monitor Dietary Intake High Calorie Meal Intervention, Low Calorie Meal Intervention - Energy Intake, Metabolism | Not applicable | Recruiting | Imperial College London | 10 | 2024-08-19 | 2025-02-18 |
| The Effects of Gyngerlean Supplementation on Energy Expenditure Gyngerlean - No Disease or Condition is Being Studied, Metabolism | Not applicable | Completed | Nova Southeastern University | 10 | 2024-07-23 | 2025-02-03 |
| Treatment of Sleep Apnea to Improve Metabolic Health Sleep Apnea, Obstructive, Metabolism | Recruiting | Uppsala University | 600 | 2024-05-13 | 2025-02-27 | |
| RMR Monitoring Feasibility and Acceptability Breezing Portable Indirect Calorimeter - Metabolism, Obesity | Not applicable | Unknown | University of British Columbia | 20 | 2024-04-19 | 2024-06-24 |
| Duration of Physical Inactivity and Postprandial Lipid Metabolism 4 hours of physical inactivity, 8 hours of physical inactivity, 12 hours of physical inactivity - Metabolism | Not applicable | Completed | University of Texas at Austin | 8 | 2024-04-01 | 2025-03-03 |
| Open-label Study of the Absorption, Metabolism, and Excretion of [14C]-Simufilam Following a Single Oral Dose in Healthy Male Subjects Simufilam - Absorption, Metabolism | Phase 1 | Completed | Cassava Sciences, Inc. | 8 | 2024-02-07 | 2025-03-20 |
| Evaluation of the Response to Hypoxia at Rest and During Exercise in a Healthy Subject After a Cryostimulation Exposure Cryostimulation - Hypoxia, Cryostimulation | Not applicable | Unknown | Poitiers University Hospital | 35 | 2024-01-25 | 2024-01-26 |
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Motor Activity (13) · Obesity (11) · Insulin Resistance (7) · Inflammation (5) · Diabetes Mellitus (4) · Fasting (4) · Weight Loss (4) · Cardiovascular Diseases (3) · Communicable Diseases (3) · Feeding Behavior (3) · Heart Diseases (3) · Coitus (2) · Diabetes Mellitus, Type 2 (2) · Endotoxemia (2) · Intermittent Fasting (2)
Pathological Conditions, Signs and Symptoms (28) · Behavior (25) · Nutritional and Metabolic Diseases (21) · Signs and Symptoms (20) · Body Weight (15) · Pathologic Processes (14) · Nutrition Disorders (13) · Glucose Metabolism Disorders (12) · Metabolic Diseases (11) · Overnutrition (11) · Overweight (11) · Infections (8) · Endocrine System Diseases (7) · Hyperinsulinism (7) · Nervous System Diseases (7)
Exercise (4) · Blood Specimen Collection (3) · Diet Therapy (3) · Capsaicin (2) · Gastrointestinal Microbiome (2) · Metformin (2) · 4-amino-8-(2-fluoro-6-methoxy-phenyl)-N-propylcinnoline-3-carboxamide (1) · Airway Resistance (1) · Amino Acids (1) · Anti-Bacterial Agents (1) · Ascorbic Acid (1) · Bilirubin (1) · Bupropion (1) · Butyrates (1) · Caffeine (1)
University of Aarhus (5) · University of Alabama at Birmingham (5) · Uppsala University (4) · Pennington Biomedical Research Center (3) · Wageningen University (3) · AstraZeneca (2) · Children's Mercy Hospital Kansas City (2) · KU Leuven (2) · Texas Tech University (2) · University of Copenhagen (2) · University of Prince Edward Island (2) · University of Reading (2) · University of Texas at Austin (2) · Vanderbilt University Medical Center (2) · Zoe Global Limited (2)
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Grant M Tinsley, PhD (2) · Lydia Afman, PhD (2) · Niels Moeller, Professor (2) · Pankaj Arora, MD, FAHA (2) · Andre van As, MD, PhD (1) · Anna Katharina Simon, Prof. Dr. (1) · Anna N Szumilewicz, Assoc. Prof. (1) · Arny A Ferrando, Ph.D. (1) · Barbara L Shay, PhD (1) · Barbara L Winters, PhD, RD (1) · Bradley Bolling, PhD (1) · Bruce D Hammock, PhD (1) · Chaur-Jong Hu, M.D. (1) · Chien-Wen Hou, Ph.D. (1) · Christian Benedict, PhD (1)
PMID 10071296, PMID 15222781, PMID 18098310, PMID 18794647, PMID 19820031, PMID 19830461, PMID 20599771, PMID 20834183, PMID 20930645, PMID 21456632, PMID 21551954, PMID 21802345, PMID 22588710, PMID 22835730, PMID 23112822, PMID 24500151, PMID 25106775, PMID 25546413, PMID 25595796, PMID 27036109, PMID 27265181, PMID 27542885, PMID 27745970, PMID 28125513, PMID 28330649, PMID 28623320, PMID 28651681, PMID 28736944, PMID 29188396, PMID 29430278, PMID 29895309, PMID 30077342, PMID 30541093, PMID 31162140, PMID 31504709, PMID 31608930, PMID 32528151, PMID 32690175, PMID 32831109, PMID 32970234, PMID 33188417, PMID 33568158, PMID 33684506, PMID 33693737, PMID 33722860, PMID 33968949, PMID 34100082, PMID 34168292, PMID 34188389, PMID 34596901
2023 (1), K01DK119545 (1), P01DK058398 (1), P30AG028740 (1), P42ES004699 (1), R01DA017987 (1), R01DK119619 (1), R01HL163852 (1), TL1TR000066 (1), U01DA020830 (1), UL1TR000064 (1)