123 completed. 123 Phase 2, 28 Phase 3, 19 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 123 | Completed 123 |
| Phase 3 | 28 | Completed 28 |
| Phase 1 | 19 | Completed 19 |
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Polyamine Treatment in Elderly Patients With Coronary Artery Disease Spermidine, Placebo - Ischemic Heart Disease, Myocardial Infarction | Phase 2 | Completed | University of Aarhus | 187 | 2024-01-01 | 2026-07-01 |
| Study of INV-202 in Patients With Obesity and Metabolic Syndrome INV-202, Placebo - Obesity, Metabolic Syndrome | Phase 2 | Completed | Inversago Pharma Inc. | 243 | 2023-09-08 | 2025-06-05 |
| Vericiguat in Patients With Metabolic Syndrome and Coronary Vascular Dysfunction Vericiguat, Placebo - Metabolic Syndrome, Coronary Microvascular Dysfunction | Phase 2 | Completed | Johns Hopkins University | 45 | 2023-06-16 | 2026-01-27 |
| A Pilot Study of Metformin to Reduce Cerebrovascular Dysfunction in Participants With HIV and Metabolic Syndrome. Metformin Extended Release Oral Tablet - Metabolic Syndrome, HIV Seropositivity | Phase 2 | Completed | University of Stellenbosch | 30 | 2022-08-11 | 2025-10-06 |
| Home-based Intervention With Semaglutide Treatment Of Neuroleptica-Related Prediabetes Semaglutide, 1.34 mg/mL, Placebo - Schizophrenia, Prediabetic State | Phase 2 | Completed | Jan Frystyk | 154 | 2022-01-01 | 2024-07-08 |
| A Proof-of-Activity Study With Orticumab in Subjects With Psoriasis and Cardiometabolic Risk Factors Orticumab, Placebo - Psoriasis, Inflammation | Phase 2 | Completed | Abcentra | 77 | 2021-06-30 | 2026-05-11 |
| Effects of Gum Arabic on Metabolic Syndrome Parameters in Postmenopausal Women Gum Arabic - Metabolic Syndrome in Postmenopausal Females | Phase 2 | Completed | University of Khartoum | 100 | 2019-12-04 | 2026-02-18 |
| Effect of Fucoxanthin on the Metabolic Syndrome, Insulin Sensitivity and Insulin Secretion Fucoxanthin, Placebo - Metabolic Syndrome | Phase 2 | Completed | University of Guadalajara | 28 | 2019-09-30 | 2024-11-21 |
| Amla on Metabolic Syndrome, Insulin Sensitivity and Insulin Secretion Amla, Placebo - Metabolic Syndrome | Phase 2 / Phase 3 | Completed | University of Guadalajara | 28 | 2019-04-01 | 2022-11-08 |
| FMT and Fiber in Patients With Metabolic Syndrome Fecal Microbial Transplant, Fiber, Cellulose - Obesity, Metabolic Syndrome | Phase 2 | Completed | University of Alberta | 68 | 2018-07-01 | 2020-05-05 |
| Berberine as Adjuvant Treatment for Schizophrenia Patients Berberine, Placebos, Antipsychotic Agents - Schizophrenia, Schizophrenia Spectrum and Other Psychotic Disorders | Phase 2 / Phase 3 | Completed | The University of Hong Kong | 113 | 2018-04-25 | 2021-01-22 |
| Fecal Microbial Transplantation and Fiber Supplementation in Participants With Obesity and Metabolic Syndrome. FMT, Placebo FMT, Prebiotic Fiber - Obesity, Metabolic Syndrome | Phase 2 | Completed | University of Alberta | 68 | 2018-04-09 | 2022-01-05 |
| Statins in Chronic Hepatitis C Patients Receiving Sofosbuvir/Daclatasvir Combination Simvastatin 10mg, sofosbuvir plus daclatasvir - Chronic Hepatitis c, Metabolic Syndrome | Phase 2 / Phase 3 | Completed | Ain Shams University | 100 | 2017-12-01 | 2018-09-20 |
| Exercise Dose and Metformin for Vascular Health in Metabolic Syndrome Metformin, Placebo, Low Intensity Exercise - Metabolic Syndrome | Phase 2 / Phase 3 | Completed | Rutgers University | 91 | 2017-08-07 | 2025-09-22 |
| Evaluation of 3-V Bioscience-2640 to Reduce de Novo Lipogenesis in Subjects With Characteristics of Metabolic Syndrome 3-V Bioscience-2640 - Metabolic Syndrome | Phase 1 / Phase 2 | Completed | University of Missouri-Columbia | 12 | 2017-02-01 | 2025-05-04 |
| Green Coffee Extract and Metabolic Syndrome green coffee extract, placebo - Metabolic Syndrome | Phase 2 / Phase 3 | Completed | National Nutrition and Food Technology Institute | 43 | 2016-12-01 | 2017-08-28 |
| Study of Testosterone vs Placebo in Testicular Cancer Survivors Testosterone, Placebos - Metabolic Syndrome, Testicular Cancer | Phase 2 / Phase 3 | Completed | Mikkel Bandak | 69 | 2016-11-01 | 2020-03-06 |
| Conjugated Linoleic Acid / Leucine Versus Metformin on Visceral Fat in Metabolic Syndrome Conjugated linoleic acid/Leucine, Metformin, Placebo of ACL/Leucine - Metabolic Syndrome | Phase 2 | Completed | Centro Universitario de Ciencias de la Salud, Mexico | 104 | 2016-03-01 | 2018-02-05 |
| Resveratrol for the Treatment of Non Alcoholic Fatty Liver Disease and Insulin Resistance in Overweight Adolescents Resveratrol, Placebo - NAFLD, TYPE 2 DIABETES | Phase 2 / Phase 3 | Completed | University of Manitoba | 10 | 2015-08-01 | 2017-05-05 |
| Acute Effects of Spices on Pathways Associated With Glucose Homeostasis and Inflammation on PBMCs of Healthy Subjects Fat challenge breakfast, Fat challenge breakfast+spices, Carbohydrate challenge breakfast - Healthy | Phase 1 / Phase 2 | Completed | Lund University | 12 | 2015-06-01 | 2015-09-22 |
Showing 20 of 123. Sign in to see all of them.
Insulin Resistance (38) · Obesity (30) · Diabetes Mellitus, Type 2 (16) · Hypertension (16) · Diabetes Mellitus (15) · Inflammation (12) · Cardiovascular Diseases (10) · Glucose Intolerance (9) · Hyperlipidemias (8) · Overweight (8) · Dyslipidemias (7) · Atherosclerosis (5) · Hypercholesterolemia (5) · Non-alcoholic Fatty Liver Disease (5)
Glucose Metabolism Disorders (123) · Hyperinsulinism (123) · Metabolic Diseases (122) · Nutritional and Metabolic Diseases (122) · Insulin Resistance (85) · Pathological Conditions, Signs and Symptoms (53) · Signs and Symptoms (43) · Body Weight (41) · Nutrition Disorders (41) · Overnutrition (40) · Endocrine System Diseases (33) · Overweight (32) · Lipid Metabolism Disorders (22) · Vascular Diseases (21) · Cardiovascular Diseases (20)
Metformin (11) · Exercise (5) · Atorvastatin (4) · Pioglitazone (4) · Rosiglitazone (4) · salicylsalicylic acid (4) · Cellulose (3) · Linseed Oil (3) · recombinant methionyl human leptin (3) · (1-6)-alpha-glucomannan (2) · Allopurinol (2) · Cholecalciferol (2) · Corn Oil (2) · Diet (2) · Dietary Fiber (2)
University of Guadalajara (7) · Joslin Diabetes Center (4) · Chinese Academy of Sciences (3) · National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) (3) · National Nutrition and Food Technology Institute (3) · University of Pennsylvania (3) · Bambino Gesù Hospital and Research Institute (2) · Charite University, Berlin, Germany (2) · Emory University (2) · Florida State University (2) · Johns Hopkins University (2) · Johnson & Johnson Pharmaceutical Research & Development, L.L.C. (2) · Lund University (2) · National Heart, Lung, and Blood Institute (NHLBI) (2) · National Institute on Aging (NIA) (2)
United States (49) · Canada (10) · Mexico (9) · Germany (6) · Italy (6) · Netherlands (5) · China (4) · Denmark (4) · Finland (4) · Sweden (4) · Australia (3) · India (3) · Spain (3) · France (2) · Norway (2)
Allison B. Goldfine, MD (4) · Xu Lin, MD, PhD (3) · Bahram H. Arjmandi, PhD, RD (2) · Francesco Squadrito, MD (2) · Julio Licinio, MD (2) · Karen Madsen, PhD (2) · Kathleen Jablonski, PhD (2) · Myrlene Staten, MD (2) · Sarah A. Johnson, PhD, RDN (2) · Steven E. Shoelson, MD, PhD (2) · Valerio Nobili, MD (2) · Vivian Fonseca, MD (2)
PMID 19889232, PMID 20826632, PMID 21070531, PMID 25091629, PMID 10480510, PMID 10523015, PMID 10868854, PMID 10963727, PMID 11411567, PMID 11443202, PMID 11556815, PMID 12145010, PMID 12523673, PMID 12622244, PMID 15070752, PMID 15168555, PMID 15333514, PMID 15713712, PMID 15949871, PMID 16054141, PMID 16157765, PMID 16626303, PMID 16636217, PMID 16818482, PMID 1695875, PMID 17069794, PMID 17086191, PMID 17112576, PMID 17135615, PMID 17517446, PMID 17578889, PMID 17684509, PMID 17959861, PMID 17986612, PMID 18266981, PMID 18274222, PMID 18726828, PMID 18769731, PMID 18854428, PMID 19100718, PMID 19208914, PMID 19500003, PMID 19592624, PMID 19777141, PMID 19819963, PMID 19909549, PMID 19929989, PMID 20029377, PMID 20101893, PMID 20208057
U01DK074556 (2), 2005 (1), 2009 (1), F32DK068902 (1), I01CX000982 (1), K23HL103976 (1), KL2RR024151 (1), P50HL083762 (1), P50HL083813 (1), R01AG018198 (1), R01AG028746 (1), R01DK041973 (1), R01DK058785 (1), R01DK058851 (1), R01DK060692 (1)