109 completed, 52 recruiting, 42 unknown, 15 active not recruiting. 120 Not applicable, 18 Phase 2, 14 Phase 1, 8 Phase 3, 6 Phase 4.
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Prospective Study of an Explainable AI Tool to Support Biliopancreatic Limb Selection in One-Anastomosis Gastric Bypass One-anastomosis gastric bypass with observed biliopancreatic limb length - Obesity, Severe Obesity | Not yet recruiting | The Society of Bariatric and Metabolic Surgeons of Kazakhstan | 120 | 2027-01-15 | 2026-09-14 | |
| VITAL-IMPACT: Improving Cardiometabolic Health in Black Individuals Through Therapeutic Augmentation of Cyclic Guanosine Mono-Phosphate Signaling Pathway Vericiguat 10 MG, Placebo, Insulin Sensitivity Test - Cardiovascular Diseases, Insulin Sensitivity/Resistance | Phase 2 | Not yet recruiting | University of Alabama at Birmingham | 200 | 2026-12-01 | 2026-01-23 |
| Theoretically Informed Behavioral Intervention LEARN 2 Platform - HIV, CVD | Not applicable | Not yet recruiting | Yale University | 164 | 2026-10-01 | 2026-06-16 |
| Exhaled Breath Electronic Nose for Multi-Disease Risk Prescreening Electronic-Nose Breath Assessment - Lung Cancer, Pulmonary Nodule | Not yet recruiting | The First Affiliated Hospital of Guangzhou Medical University | 20000 | 2026-09-01 | 2026-09-04 | |
| Endoscopic Sleeve Gastroplasty Technique Comparison for Weight Loss Endoscopic Sleeve Gastroplasty - Belt and Suspenders, Endoscopic Sleeve Gastroplasty - Belt - Obesity, Obesity, Morbid | Not applicable | Not yet recruiting | Brigham and Women's Hospital | 10 | 2026-09-01 | 2025-12-02 |
| Clinical Safety Evaluation and Preliminary Efficacy Study of Subcutaneous Myografts Transplantation Autologous differentiated myocyte transplantation - Metabolic Disease, Amyotrophy | Early Phase 1 | Not yet recruiting | National Clinical Research Center for Orthopedics, Sports Medicine and Rehabilitation, China | 6 | 2026-07-01 | 2026-02-23 |
| Assess the Safety and Tolerability of SNS851 in Study Participants SNS851, Placebo - Metabolic Disease | Phase 1 | Recruiting | Oneness Biotech Co., Ltd. | 52 | 2026-04-01 | 2026-08-28 |
| HYPERtension Reduction Through WALKing Stairs Versus Brisk Walking Stair and brisk walking combined, Brisk walking, Standard care - Metabolic Disease, Cardiovascular Diseases | Not applicable | Recruiting | Karolinska Institutet | 450 | 2025-11-27 | 2025-12-08 |
| A Feasibility Trial of a Bhangra Folk Dance Intervention to Improve Metabolic Health in Older Indian Women in the UK Bhangra for Health 1, Bhangra Dance class - Metabolic Disease | Not applicable | Completed | University of Wolverhampton | 99 | 2025-09-05 | 2026-08-17 |
| Quality of Recovery and Patient Satisfaction After Metabolic Surgery at a Tertiary Hospital in Gauteng (QoRPS-MS) Obesity, Obesity (Disorder) | Enrolling by invitation | Sefako Makgatho Health Sciences University | 84 | 2025-09-04 | 2026-09-04 | |
| Cardiometabolic Disease Risk Factors in Cameroon Cardiometabolic disease - Cardiac Disease, Metabolic Disease | Enrolling by invitation | Johns Hopkins University | 200 | 2025-07-09 | 2025-11-26 | |
| Ketogenic Metabolic Therapy in Schizophrenia, Bipolar Disorder, Major Depressive Disorder: Deep Omic Profiling LCHF Ketogenic Diet, Diet-as-Usual (DAU) - Schizophrenia, Schizophrenia and Related Disorders | Not applicable | Not yet recruiting | Stanford University | 120 | 2025-07-01 | 2025-05-16 |
| Effect of Endoscopic Sleeve Gastroplasty in Patients With Obesity and MASH: A Randomized Controlled Trial ESG + lifestyle modification, Lifestyle modification - Obesity, Liver Diseases | Not applicable | Recruiting | Pichamol Jirapinyo, MD, MPH | 132 | 2025-06-24 | 2026-06-25 |
| A Study to Investigate Safety and Effectiveness of Porcine Pancreatic Cells (OPF-310) in Patients With Type 1 Diabetes Mellitus OPF-310 - Diabetes Mellitus, Type 1, Hypoglycemia | Phase 1 / Phase 2 | Recruiting | Otsuka Pharmaceutical Factory, Inc. | 13 | 2025-06-10 | 2026-08-21 |
| Metabolic Effects of Linoleic Acid-Rich Oil Compared to a Blend Oil in Adults With Insulin Resistance Linoleic Acid-Rich Oil, Blend Oil - Insulin Resistance, Metabolic Disease | Not applicable | Recruiting | Pontificia Universidad Catolica de Chile | 120 | 2025-05-13 | 2025-12-17 |
| OPTIMISation of Cardio-renal-metabolic-pulmonary Disease Guideline Adherence in High Risk Community Dwelling Individuals NICE guidance - Cardiovascular Diseases, Renal Disease | Not applicable | Active not recruiting | University of Leeds | 138 | 2025-05-07 | 2025-09-17 |
| Pilot Haskap Metabolite Timing Project Haskap - Microbial Colonization, Metabolic Disease | Not applicable | Active not recruiting | Montana State University | 10 | 2025-05-01 | 2025-08-19 |
| Improving Coronary Vascular Health in Women Health Education, Subspecialty clinic referral - HIV-1-infection, Coronary Microvascular Dysfunction | Phase 2 | Recruiting | Massachusetts General Hospital | 80 | 2025-04-17 | 2026-09-08 |
| Gut Microbiota-dependent Health Impacts of Haskap Berries Haskap berry smoothie, Placebo comparator - Metabolic Disease, Inflammation | Not applicable | Recruiting | Montana State University | 120 | 2025-02-26 | 2025-04-02 |
| HIBOC = Hepatic Imaging Biomarkers in Obese Children Elastography, Shear Wave Elastography | Enrolling by invitation | Sahlgrenska University Hospital | 300 | 2025-02-01 | 2026-05-18 |
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Metabolic Diseases (253) · Obesity (63) · Diabetes Mellitus (52) · Glucose Metabolism Disorders (36) · Cardiovascular Diseases (32) · Endocrine System Diseases (29) · Diabetes Mellitus, Type 2 (25) · Insulin Resistance (25) · Autoimmune Diseases (14) · Diabetes Mellitus, Type 1 (14) · Inflammation (13) · Overweight (13) · Metabolic Syndrome (12) · Motor Activity (12) · Immune System Diseases (11)
Nutritional and Metabolic Diseases (253) · Pathological Conditions, Signs and Symptoms (112) · Signs and Symptoms (87) · Nutrition Disorders (68) · Overnutrition (67) · Body Weight (66) · Overweight (56) · Glucose Metabolism Disorders (55) · Endocrine System Diseases (45) · Nervous System Diseases (37) · Pathologic Processes (36) · Hyperinsulinism (32) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (27) · Behavior (26) · Urogenital Diseases (26)
Exercise (14) · Blood Specimen Collection (4) · Eating (3) · Observation (3) · Standard of Care (3) · Control Groups (2) · Diet (2) · Diet, Carbohydrate-Restricted (2) · Dietary Supplements (2) · Electrocardiography (2) · Food (2) · Glucose (2) · Low-Level Light Therapy (2) · Magnetic Resonance Imaging (2) · Meals (2)
KK Women's and Children's Hospital (6) · University of Michigan (5) · Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) (4) · University of Aarhus (4) · CRISPR Therapeutics AG (3) · Colorado State University (3) · Eli Lilly and Company (3) · Escola Superior de Tecnologia da Saúde do Porto (3) · Massachusetts General Hospital (3) · Montana State University (3) · National Human Genome Research Institute (NHGRI) (3) · Royal College of Surgeons, Ireland (3) · Singapore Institute of Food and Biotechnology Innovation (3) · University Hospital, Basel, Switzerland (3) · University of Alabama at Birmingham (3)
United States (77) · Canada (19) · United Kingdom (19) · China (16) · Denmark (13) · Italy (10) · Singapore (9) · France (8) · Sweden (7) · Brazil (6) · Taiwan (6) · Australia (5) · Switzerland (5) · Ireland (4) · Netherlands (4)
Mary P Miles, PhD (3) · Anne-Sophie Brazeau, PhD (2) · Bohdan Luhovyy, PhD (2) · Jack A Yanovski, M.D. (2) · Jeffrey F Horowitz (2) · Jessica Barnes, PhD (2) · Manasi Jaiman, MD, MPH (2) · Marcia U Rezende, MD; PhD (2) · Pankaj Arora, MD, FAHA (2) · Sandeep Soni, MD (2) · Adaliene VM Ferreira, PhD (1) · Adma M Babetto, Student (1) · Alessandro Martorana, MD, PhD (1)
PMID 42023429, PMID 11531930, PMID 12105286, PMID 12126214, PMID 15112907, PMID 16155283, PMID 17535868, PMID 18093200, PMID 18725595, PMID 18816058, PMID 19553295, PMID 20104270, PMID 20395192, PMID 20595645, PMID 21684333, PMID 22074723, PMID 22157326, PMID 22382873, PMID 22760563, PMID 23297654, PMID 23548751, PMID 23966250, PMID 24318487, PMID 24493161, PMID 24717420, PMID 24733029, PMID 25058615, PMID 25100072, PMID 25224267, PMID 25240079, PMID 25361834, PMID 25589213, PMID 25595796, PMID 25765670, PMID 26050254, PMID 26169157, PMID 26188212, PMID 26210388, PMID 26514124, PMID 26641646, PMID 26714769, PMID 26864362, PMID 26929599, PMID 26965492, PMID 26979583, PMID 27269925, PMID 27355107, PMID 27459449, PMID 27482750, PMID 27542885
2018 (3), 2019 (2), 2015 (1), 2017 (1), 2023 (1), K01DK103720 (1), K01DK119545 (1), K23HL147799 (1), K99ES026648 (1), P20GM109036 (1), P50MD017344 (1), R01AG081304 (1), R01DK125653 (1), R01DK130864 (1), R01DK132557 (1)