7 completed, 5 unknown, 2 terminated, 1 recruiting. 11 Phase 1, 7 Phase 2, 1 Early Phase 1, 1 Not applicable, 1 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 11 | Completed 5, Unknown 4, Recruiting 1, Terminated 1 |
| Phase 2 | 7 | Unknown 4, Completed 2, Recruiting 1 |
| Early Phase 1 | 1 | Completed 1 |
| Not applicable | 1 | Completed 1 |
| Phase 3 | 1 | Terminated 1 |
Follow Mesenchymal Stromal Cells: new trials by email Literature Review of Mesenchymal Stromal Cells trials Research Report on Mesenchymal Stromal Cells
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| LYell SYndrome MEsenchymal Stromal Cells Treatment Adipose derived stromal cells intravenously injected - Epidermal Necrolysis, Lyell Syndrome | Phase 1 / Phase 2 | Recruiting | Assistance Publique - Hôpitaux de Paris | 15 | 2024-04-15 | 2025-08-01 |
| Safety of Topical Mesenchymal Stromal Cell Secretome for Ocular Surface Disease MSC Secretome Eye Drops - Mesenchymal Stromal Cells, Cornea | Early Phase 1 | Completed | University of Illinois at Chicago | 9 | 2024-01-24 | 2026-10-07 |
| ASC - Autism Study Adipose tissue derived mesenchymal stromal/stem cells (Cell2Cure®) - Autism Spectrum Disorder, Gastrointestinal Dysfunction | Phase 1 | Completed | Cell to Cure ApS | 10 | 2023-06-09 | 2024-09-26 |
| Effect of Mesenchymal Stem Cells on Healing of Foot Ulcers in Diabetes Patients. Adipose tissue derived mesenchymal stromal/stem cells (Cell2Cure®) - Diabetic Foot Ulcer, Mesenchymal Stromal Cells | Phase 1 | Terminated | Cell to Cure ApS | 21 | 2022-12-15 | 2025-12-23 |
| Efficacy and Safety of Expanded UCMSCs On Patients With Moderate to Severe Psoriasis Umbilical cord mesenchymal stem cells - Mesenchymal Stromal Cells, Psoriasis | Phase 1 / Phase 2 | Unknown | Guangdong Provincial Hospital of Traditional Chinese Medicine | 5 | 2021-08-31 | 2021-02-09 |
| Comparison of PSORI-CM01 Formula vs Gu Ben Hua Yu Formula Combined With AD-MSCs in Psoriasis PSORI-CM01 formula, Gu Ben Hua Yu formula, adipose-derived multipotent mesenchymal stem cells - Traditional Chinese Medicine, Drug Effect | Phase 1 / Phase 2 | Unknown | Guangdong Provincial Hospital of Traditional Chinese Medicine | 16 | 2021-03-17 | 2023-08-24 |
| Safety of Locally Delivered Allogeneic Mesenchymal Stromal Cells Allogeneic MSC - Mesenchymal Stromal Cells, Cornea | Phase 1 | Completed | University of Illinois at Chicago | 8 | 2021-03-05 | 2024-12-16 |
| Mesenchymal Stem Cells for Radiation-induced Xerostomia Autologous adipose-derived mesenchymal stem/stromal cells, Placebo - Radiation Toxicity, Xerostomia Due to Radiotherapy | Phase 1 / Phase 2 | Unknown | Copenhagen University Hospital, Rigshospitalet | 30 | 2020-08-01 | 2020-10-22 |
| MSCs in COVID-19 ARDS Remestemcel-L, Placebo - Mesenchymal Stromal Cells, Remestemcel-L | Phase 3 | Terminated | Icahn School of Medicine at Mount Sinai | 223 | 2020-04-30 | 2022-04-25 |
| Efficacy and Safety of AD-MSCs Plus Calpocitriol Ointment and PSORI-CM01 Granule in Psoriasis Patients Calcipotriol ointment, PSORI-CM01 Granule, adipose-derived multipotent mesenchymal stem cells - Mesenchymal Stromal Cells, Psoriasis | Not applicable | Completed | Guangdong Provincial Hospital of Traditional Chinese Medicine | 8 | 2020-04-01 | 2023-08-24 |
| Efficacy and Safety of AD-MSCs Plus Calpocitriol Ointment in Patients With Moderate to Severe Psoriasis Calcipotriol ointment, adipose-derived multipotent mesenchymal stem cells - Mesenchymal Stromal Cells, Psoriasis | Phase 1 / Phase 2 | Completed | Guangdong Provincial Hospital of Traditional Chinese Medicine | 8 | 2019-07-23 | 2023-08-24 |
| Allogeneic MSC Treatment for Pulmonary Emphysema Allogeneic MSC, Placebo - Pulmonary Emphysema, Mesenchymal Stromal Cells | Phase 2 | Unknown | Leiden University Medical Center | 30 | 2019-06-25 | 2021-06-09 |
| Allogeneic Mesenchymal Stem Cells for Radiation-induced Hyposalivation and Xerostomia/Dry Mouth Allogeneic adipose derived stem/stromal cells - Xerostomia Due to Radiotherapy, Hyposalivation | Phase 1 | Unknown | Copenhagen University Hospital, Rigshospitalet | 10 | 2019-03-18 | 2021-01-29 |
| Safety and Efficacy of Expanded Allogeneic AD-MSCs in Patients With Moderate to Severe Psoriasis adipose-derived multipotent mesenchymal stem cells - Mesenchymal Stromal Cells, Psoriasis | Phase 1 / Phase 2 | Completed | Guangdong Provincial Hospital of Traditional Chinese Medicine | 7 | 2017-09-24 | 2023-08-25 |
| Phase 1 Clinical Trial of PNEUMOSTEM® Treatment in Premature Infants With Intraventricular Hemorrhage pneumostem - Mesenchymal Stromal Cells | Phase 1 | Completed | Samsung Medical Center | 9 | 2014-10-01 | 2017-04-19 |
Psoriasis (5) · Drug-Related Side Effects and Adverse Reactions (4) · Corneal Diseases (2) · Xerostomia (2) · Autism Spectrum Disorder (1) · Cytokine Release Syndrome (1) · Diabetic Foot (1) · Inflammation (1) · Inflammatory Bowel Diseases (1) · Long Term Adverse Effects (1) · Oropharyngeal Neoplasms (1) · Pulmonary Emphysema (1) · Radiation Injuries (1) · Respiratory Distress Syndrome (1) · Salivary Gland Diseases (1)
Skin Diseases (7) · Skin and Connective Tissue Diseases (7) · Chemically-Induced Disorders (5) · Skin Diseases, Papulosquamous (5) · Mouth Diseases (3) · Pathologic Processes (3) · Pathological Conditions, Signs and Symptoms (3) · Stomatognathic Diseases (3) · Eye Diseases (2) · Lung Diseases (2) · Respiratory Tract Diseases (2) · Cardiovascular Diseases (1) · Child Development Disorders, Pervasive (1) · Chronic Disease (1) · Dermatitis (1)
calcipotriene (1) · remestemcel-l (1)
Guangdong Provincial Hospital of Traditional Chinese Medicine (5) · Cell to Cure ApS (2) · Copenhagen University Hospital, Rigshospitalet (2) · University of Illinois at Chicago (2) · Assistance Publique - Hôpitaux de Paris (1) · Icahn School of Medicine at Mount Sinai (1) · Leiden University Medical Center (1) · Samsung Medical Center (1)
China (5) · Denmark (4) · United States (3) · France (1) · Netherlands (1) · South Korea (1)
Chuanjian Lu, PhD (3) · Ali R Djalilian, MD (2) · Charlotte E Joslin, OD, PhD (2) · Charlotte Lynggaard, MD (2) · Jens Kastrup (2) · Annetine C Gelijns, PhD (1) · Chuanjian Lu (1) · Elmer Y Tu, MD (1) · Michael Mack, MD (1) · Peter Smith, MD (1) · Saskia Oro, PhD (1) · Won Soon Park, M.D. Ph.D (1)
PMID 28476287, PMID 34988162, PMID 38536165
1UG3EY031809-01 (1), 2014 (1), 2018 (1)