39 completed, 10 terminated, 7 unknown, 6 recruiting. 18 Not applicable, 17 Phase 2, 12 Phase 3, 8 Phase 1, 4 Phase 4.
Follow Pulmonary Emphysema: new trials by email Literature Review of Pulmonary Emphysema trials Research Report on Pulmonary Emphysema
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Clinical Utility of LIBS Multi-Element Imaging and the IFF Algorithm in Chronic Lung Diseases Interstitial Lung Diseases (ILD), Pulmonary Emphysema | Recruiting | University Hospital, Grenoble | 70 | 2026-10-01 | 2026-09-11 | |
| A Non-inferiority Pharmacokinetic and Safety/Tolerability Study of Two Different Doses of Weekly SC Alpha1-PI 15% Compared With Corresponding Standard IV Alpha1-PI in Participants With Alpha1-Antitrypsin Deficiency (AATD) Alpha-1 15%, Liquid Alpha1-PI - Alpha 1 Antitrypsin Deficiency | Phase 3 | Recruiting | Grifols Therapeutics LLC | 40 | 2026-05-05 | 2026-10-26 |
| Lung Diffusing Capacities Normality Thresholds in Pulmonary Fibrosis and Emphysema Interstitial Pulmonary Fibrosis, Emphysema | Completed | IRCCS Azienda Ospedaliera Universitaria San Martino - IST Istituto Nazionale per la Ricerca sul Cancro, Genoa, Italy | 120 | 2025-05-13 | 2025-07-29 | |
| Volumetric HRCT in Stable COPD Patients. Volumetric HRCT chest, Spirometry and Body Plethysmography - Chronic Obstructive Pulmonary Disease, Pulmonary Emphysema | Completed | Mansoura University | 75 | 2025-04-20 | 2026-09-09 | |
| Unilateral vs. Bilateral Lung Volume Reduction Surgery Unilateral LVRS, Bilateral LVRS - Emphysema, Pulmonary | Not applicable | Recruiting | Copenhagen University Hospital, Rigshospitalet | 146 | 2025-03-21 | 2026-07-28 |
| The REDUCE EU Study - Endobronchial Thermal Liquid Ablation (ETLA) for the Treatment of Emphysema Endobronchial Therman Liquid Ablation (ETLA) - Emphysema or COPD, Emphysema | Not applicable | Recruiting | Morair Medtech, LLC | 30 | 2025-01-10 | 2025-01-28 |
| Clinical-ultrasonographic Assessment of Pulmonary Emphysema Relationship between lung ultrasound and computed tomographic scan - Emphysema, Pulmonary Emphysema | Not applicable | Recruiting | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | 1628 | 2024-09-04 | 2026-05-22 |
| An Evaluation of the AeriSeal System for CONVERTing Collateral Ventilation Status in Patients With Severe Emphysema AeriSeal System - Emphysema, Pulmonary, Emphysema or COPD | Not applicable | Recruiting | Pulmonx Corporation | 200 | 2024-02-22 | 2026-09-17 |
| A Study to Evaluate Safety, Tolerability and Pharmacokinetics of Two Different Doses of Alpha1-Proteinase Inhibitor Subcutaneous (Human) 15% in Participants With Alpha1-Antitrypsin Deficiency Alpha-1 15%, Liquid Alpha1-Proteinase Inhibitor (Human) - Alpha1-Antitrypsin Deficiency | Phase 1 / Phase 2 | Completed | Grifols Therapeutics LLC | 17 | 2021-12-16 | 2026-10-08 |
| Video Assisted Thoracic Surgery (VATS) Fissure Completion Prior to Zephyr® Endobronchial Valve Insertion Video-assisted thoracoscopic surgery (VATS) fissure completion, Zephyr Valve insertion - Pulmonary Emphysema | Not applicable | Completed | Pulmonx Corporation | 9 | 2020-06-04 | 2025-04-29 |
| Post-Market Clinical Evaluation of the Zephyr Valve 5.5-LP EBV The Pulmonx Zephyr Endobronchial Valve (EBV) 5.5- LP - Pulmonary Emphysema | Completed | Pulmonx Corporation | 2 | 2020-02-05 | 2023-11-15 | |
| Description of Bullous Emphysema Using Lung Ultrasound and Comparison to the Characteristics of Pneumothorax Lung ultrasound, Chest radiography, Pulmonary function tests - Pulmonary Emphysema | Completed | University Hospital, Rouen | 35 | 2019-06-26 | 2022-11-08 | |
| Allogeneic MSC Treatment for Pulmonary Emphysema Allogeneic MSC, Placebo - Pulmonary Emphysema, Mesenchymal Stromal Cells | Phase 2 | Unknown | Leiden University Medical Center | 30 | 2019-06-25 | 2021-06-09 |
| Clinical Study to Evaluate the Exercise Capacity in Patients With Severe Emphysema Treated With Coils 10 coils in upper lobes, 15 coils in upper and lower lobes, cycloergometry - Pulmonary Emphysema | Not applicable | Unknown | Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz | 35 | 2016-11-01 | 2019-03-01 |
| Long Term Safety of Alpha1-Proteinase Inhibitor in Subjects With Alpha1 Antitrypsin Deficiency Alpha-1 MP - Pulmonary Emphysema in Alpha-1 Antitrypsin Deficiency | Phase 3 | Enrolling by invitation | Grifols Therapeutics LLC | 290 | 2016-07-01 | 2026-06-23 |
| Longitudinal Follow up to Assess Biomarkers Predictive of Emphysema Progression in Patients With COPD (Chronic Obstructive Pulmonary Disease) Pulmonary Disease, Chronic Obstructive, Pulmonary Emphysema | Completed | Boehringer Ingelheim | 463 | 2016-04-13 | 2024-08-16 | |
| A Prospective Multicenter Clinical Study to Evaluate the Safety and Effectiveness of the OL-BF-001 for Severe Emphysema OL-BF-001 - Emphysema | Not applicable | Terminated | Olympus Corporation | 38 | 2015-08-01 | 2019-08-28 |
| Evaluation of Novel Lung Function Parameters in Patients With Chronic Obstructive Pulmonary Disease (COPD) impulse oscillometry, multiple breath washout test, body plethysmography - COPD, Obstructive Ventilation Disorder | Unknown | Universitätsmedizin Mannheim | 150 | 2015-07-01 | 2020-03-24 | |
| ICS/LABA Adherence and COPD Exacerbation Non-Interventional Study - Pulmonary Disease, Chronic Obstructive | Completed | AstraZeneca | 10000 | 2015-05-01 | 2016-10-11 | |
| Diagnostic Value of Ultralow-dose Computed Tomography for the Detection of Pulmonary Nodules and Lung Parenchym Alterations Compared to Standard-dose CT Ultralow-Dose-CT - Multiple Pulmonary Nodules, Pulmonary Emphysema | Not applicable | Unknown | Cantonal Hospital of St. Gallen | 500 | 2015-01-01 | 2016-01-27 |
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Pulmonary Disease, Chronic Obstructive (42) · Emphysema (28) · Lung Diseases (18) · Respiratory Tract Diseases (13) · Bronchitis, Chronic (9) · Lung Diseases, Obstructive (8) · Pathologic Processes (7) · alpha 1-Antitrypsin Deficiency (7) · Respiratory Aspiration (4) · Disease Progression (2) · Genetic Diseases, Inborn (2) · Inflammation (2) · Subcutaneous Emphysema (2) · Airway Obstruction (1)
Chronic Disease (64) · Disease Attributes (64) · Pathological Conditions, Signs and Symptoms (64) · Pathologic Processes (57) · Lung Diseases, Obstructive (56) · Respiratory Tract Diseases (51) · Lung Diseases (46) · Pulmonary Disease, Chronic Obstructive (22) · Bronchial Diseases (9) · Bronchitis (9) · Infections (9) · Respiratory Tract Infections (9) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (7) · Digestive System Diseases (6) · Liver Diseases (6)
Pneumonectomy (4) · Mp alpha1 receptor (3) · 15-keto-17-phenyl-18,19,20-trinorprostaglandin F2 alpha-1-isopropyl ester (2) · Bronchoscopy (2) · Hydrogels (2) · Plethysmography, Whole Body (2) · Practice Management, Medical (2) · alpha 1-Antitrypsin (2) · Blood Specimen Collection (1) · Diagnostic Imaging (1) · Dietary Supplements (1) · Doxycycline (1) · Exercise (1) · Formoterol Fumarate (1) · Injections (1)
Aeris Therapeutics (13) · Grifols Therapeutics LLC (6) · Heidelberg University (3) · Pulmonx Corporation (3) · Royal Brompton & Harefield NHS Foundation Trust (3) · Mansoura University (2) · Olympus Corporation of the Americas (2) · University Hospital, Rouen (2) · Asan Medical Center (1) · AstraZeneca (1) · Boehringer Ingelheim (1) · Cantonal Hospital of St. Gallen (1) · Copenhagen University Hospital, Rigshospitalet (1) · Federal Research Clinical Center of Federal Medical & Biological Agency, Russia (1) · Federal University of São Paulo (1)
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Charlie Strange, MD (2) · Gerard Criner, MD (2) · Janine McDermott, MS CCRP (2) · Kim Hanna, MSc (2) · Mark Gotfried, MD (2) · William DC Man, MRCP PhD (2) · Ahmad Saad El-Morsi, Prof (1) · Aldemir Bilaqui, MD (1) · Alexander V Averyanov, MD, PhD (1) · Arschang Valipour, MD, FCCP (1) · Celso Carvalho, professor (1) · Christoph Corvinus, MD (1) · Christopher B Cooper, M.D. (1) · Christopher James, PA (1)
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