12 completed, 7 unknown, 5 recruiting, 1 active not recruiting. 28 Not applicable.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 28 | Completed 12, Unknown 7, Recruiting 5, Active not recruiting 1, Enrolling by invitation 1, Not yet recruiting 1, Withdrawn 1 |
Follow MDD: new trials by email Literature Review of MDD trials Research Report on MDD
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| tDCS: Sleep to Mood in Depression (S2M-D) transcranial direct current stimulation (tDCS) - Major Depressive Disorder, MDD | Not applicable | Recruiting | NYU Langone Health | 35 | 2026-06-04 | 2026-06-08 |
| Functional Electrical Stimulation for MDD Functional Electrical Stimulation (FES) - MDD | Not applicable | Not yet recruiting | Unity Health Toronto | 60 | 2026-05-25 | 2026-06-08 |
| Feasibility of Home-Based Intermittent 60Hz Light Therapy for Major Depressive Disorder (MDD) 60Hz Intermittent Light Therapy, Sham Light Therapy - Depression, MDD | Not applicable | Recruiting | NYU Langone Health | 40 | 2025-08-18 | 2026-06-29 |
| NUTRIMOOD-Inflammation and Depressive Comorbidity in Obesity: Modulation by Omega-3 Polyunsaturated Fatty Acids Status Eicosapentaenoic acid (omega-3 fatty acid), Placebo - Obese Adults, MDD | Not applicable | Recruiting | National Science and Technology Council, Taiwan | 50 | 2025-03-01 | 2026-02-27 |
| At-Home tDCS as Maintenance Therapy tDCS - MDD, Severe Depression | Not applicable | Recruiting | Technical University of Munich | 30 | 2024-10-01 | 2025-12-08 |
| Theta Burst Stimulation for Refractory Depression in Autism Spectrum Disorder Transcranial Magnetic Stimulation, Transcranial Magnetic Stimulation Sham - ASD, Autism Spectrum Disorder | Not applicable | Completed | Children's Hospital Medical Center, Cincinnati | 20 | 2024-09-16 | 2026-10-23 |
| pBFS Guided rTMS Over Different Targets for Treatment-Resistant Depression active rTMS stimulating - Major Depressive Disorder, Treatment Resistant Depression | Not applicable | Unknown | Changping Laboratory | 75 | 2024-02-20 | 2024-02-13 |
| Resonant Frequency rTMS: A Novel Approach to Target Circuit Modulation in Major Depressive Disorder Transcranial Magnetic Stimulation - MDD, Depression | Not applicable | Enrolling by invitation | University of California, Los Angeles | 84 | 2024-02-12 | 2026-09-24 |
| Take-home Functional Electrical Stimulation for MDD Functional Electrical Stimulation (FES), Sham FES - MDD | Not applicable | Active not recruiting | Unity Health Toronto | 20 | 2023-12-04 | 2026-06-03 |
| rTMS Therapy for Treatment-Resistant Depression With Different Targets Guided by pBFS active rTMS - MDD, Major Depressive Disorder | Not applicable | Unknown | Changping Laboratory | 100 | 2023-11-06 | 2024-02-06 |
| pBFS-Guided rTMS Therapy Over Different Targets for Treatment-Resistant Depression active rTMS stimulating - Major Depressive Disorder, Treatment Resistant Depression | Not applicable | Unknown | Changping Laboratory | 80 | 2023-08-29 | 2024-02-07 |
| pBFS Guided VS "5-cm Rule" rTMS Over DLPFC for MDD pBFS rTMS, 5-cm rTMS - Major Depression, MDD | Not applicable | Unknown | Changping Laboratory | 150 | 2023-08-20 | 2024-02-06 |
| pBFS Guided rTMS Therapy Over Different Targets for Treatment-Resistant Depression active rTMS - MDD, Major Depressive Disorder | Not applicable | Unknown | Changping Laboratory | 50 | 2023-08-04 | 2024-02-06 |
| Extended Reality Behavioral Activation: An Intervention for Major Depressive Disorder Extended Reality-Enhanced Behavioral Activation, Traditional Behavioral Activation - Major Depressive Disorder, MDD | Not applicable | Completed | Stanford University | 26 | 2022-12-19 | 2025-09-22 |
| Neural-Derived Plasma Exosomal MicroRNAs As Promising Novel Biomarkers for Suicidality and Treatment Outcome in Adolescents Genetic testing - Major Depressive Disorder, Suicidal Ideas | Not applicable | Recruiting | University of Alabama at Birmingham | 240 | 2022-10-01 | 2026-07-13 |
| Individualized Neuromodulation for Anhedonic Depression Individualized Accelerated Intermittent Theta Burst Stimulation (Ind-aiTBS), Standard Accelerated Intermittent Theta Burst Stimulation (Std-aiTBS), Sham Accelerated Intermittent Theta Burst Stimulation (Sham) - MDD, Anhedonia | Not applicable | Completed | University of California, San Diego | 60 | 2022-08-01 | 2026-02-13 |
| Neurofeedback to Treat Depression Active Closed Loop Real Time fMRI Neurofeedback, Sham Closed Loop Real Time fMRI Neurofeedback - MDD | Not applicable | Completed | University of Pennsylvania | 71 | 2022-05-25 | 2025-09-08 |
| The MOOD Study - External Combined Occipital and Trigeminal Nerve Stimulation (eCOT-NS) for the Treatment of Major Depressive Disorder (MDD) Relivion®DP- Active, Relivion®DP- Sham - MDD | Not applicable | Completed | Neurolief Ltd. | 124 | 2021-08-31 | 2025-08-12 |
| Mechanism of Action of tACS for the Treatment of MDD tACS, Sham tACS - Major Depressive Disorder, MDD | Not applicable | Completed | University of North Carolina, Chapel Hill | 20 | 2021-06-09 | 2024-09-19 |
| Virtual Reality Behavioral Activation: An Intervention for Major Depressive Disorder Virtual Reality Behavioral Activation, Behavioral Activation in real-life - Major Depressive Disorder, MDD | Not applicable | Completed | Stanford University | 20 | 2020-05-18 | 2021-06-02 |
Showing 20 of 28. Sign in to see all of them.
Depressive Disorder, Major (15) · Depression (8) · Depressive Disorder, Treatment-Resistant (4) · Anhedonia (1) · Autism Spectrum Disorder (1) · Autistic Disorder (1) · Suicide (1) · Suicide, Attempted (1)
Depressive Disorder (15) · Mental Disorders (15) · Mood Disorders (15) · Behavior (8) · Behavioral Symptoms (8) · Child Development Disorders, Pervasive (1) · Nervous System Diseases (1) · Neurobehavioral Manifestations (1) · Neurodevelopmental Disorders (1) · Neurologic Manifestations (1) · Pathological Conditions, Signs and Symptoms (1) · Self-Injurious Behavior (1) · Signs and Symptoms (1)
Transcranial Magnetic Stimulation (4) · Transcranial Direct Current Stimulation (2) · Biological Evolution (1) · Cholecalciferol (1) · Eicosapentaenoic Acid (1) · Fatty Acids, Omega-3 (1) · Genetic Testing (1) · Relaxation Therapy (1) · Selective Serotonin Reuptake Inhibitors (1) · Zinc Sulfate (1)
Changping Laboratory (5) · Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh (2) · NYU Langone Health (2) · Stanford University (2) · Unity Health Toronto (2) · University of California, San Francisco (2) · University of North Carolina, Chapel Hill (2) · Central South University (1) · Children's Hospital Medical Center, Cincinnati (1) · Jasper A. Smits (1) · National Science and Technology Council, Taiwan (1) · Neurolief Ltd. (1) · Technical University of Munich (1) · University of Alabama at Birmingham (1) · University of California, Los Angeles (1)
United States (16) · China (5) · Bangladesh (2) · Canada (1) · Germany (1) · Israel (1) · Taiwan (1)
Hesheng Liu, Ph.D. (4) · Patricia Arean, Ph.D. (2) · Brooke Hollister, Ph.D. (1) · David Rubinow, MD (1) · Flavio Frohlich, PhD (1) · Giuseppina Pilloni (1) · Giuseppina Pilloni, PhD (1) · Hesheng Liu (1) · Joe Gibbs (1) · Kim Bullock, M.D. (1) · Kim Bullock, MD (1) · Linda Carpenter, MD (1) · Margot D Paul, Psy.D. (1) · Margot Paul, MS (1) · Muaid Ithman, MD (1)
PMID 30093372, PMID 30123324, PMID 33031046, PMID 35404830, PMID 38437873, PMID 40319334, PMID 42721198
R01MH101547 (1), R01MH130539 (1), R01MH135293 (1), R61MH128492 (1)