6 recruiting, 2 not yet recruiting. 4 Not applicable, 1 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 4 | Recruiting 3, Not yet recruiting 1 |
| Phase 2 | 1 | Recruiting 1 |
Follow Major Depressive Episode (MDE): new trials by email Literature Review of Major Depressive Episode (MDE) trials Research Report on Major Depressive Episode (MDE)
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Evaluating the Therapeutic Potential of Focal Electrically Administered Seizure Therapy (FEAST) in the Treatment of Depression: A Multicenter Randomized Clinical Trial Stimulation by the Sigma ECT/FEAST device, Stimulation by Sigmastim ECT 200J device administered in right unilateral (RUL), Stimulation by Sigmastim ECT 200J device administered in bilateral (BT) - Major Depressive Episode (MDE), Unipolar Disorder | Not applicable | Not yet recruiting | Centre Hospitalier St Anne | 108 | 2026-11-02 | 2026-10-05 |
| Biomarker Discovery for Suicide Precision Circuit Therapeutics Suicidal Thoughts and Behaviors, Major Depressive Episode (MDE) | Not yet recruiting | Massachusetts General Hospital | 60 | 2026-07-01 | 2026-07-23 | |
| A Study to Evaluate TNX-102 SL Monotherapy Versus Placebo in Participants With Major Depressive Disorder (MDD) TNX-102 SL, Placebo sublingual tablet - Major Depressive Episode (MDE), Major Depressive Disorder (MDD) | Phase 2 | Recruiting | Tonix Pharmaceuticals, Inc. | 360 | 2026-06-25 | 2026-10-30 |
| Validation of a Composite Medical Device Using a Blood Biomarker-based Algorithm and MDQ for the Diagnosis of Bipolar Disorder Venous blood sample for measuring blood biomarkers related to bipolar disorder, Standardized psychiatric assessment tools - Bipolar Disorder (BD), Major Depressive Episode (MDE) | Not applicable | Recruiting | University Hospital, Montpellier | 623 | 2025-09-30 | 2025-10-07 |
| The Immunobiological Mechanisms of Depression in Perimenopause Perimenopause, Major Depressive Episode (MDE) | Recruiting | Van Andel Research Institute | 120 | 2025-03-13 | 2026-11-02 | |
| LHC-CIDI-5 in Hong Kong CIDI-5, LHC-CIDI-5 - Major Depressive Episode (MDE), Major Depressive Disorder (MDD) | Recruiting | The University of Hong Kong | 2500 | 2025-01-18 | 2026-03-10 | |
| Belief Update: The Effects of Depression and Antidepressants in Older People Response to questionnaire - Major Depressive Episode (MDE), Beliefs | Not applicable | Recruiting | Hospital Center Guillaume Régnier | 62 | 2025-01-14 | 2026-07-02 |
| Feasibility and Efficacy of rTMS in Depression in Patients With Autism Spectrum Disorder (ASD) rTMS, rTMS treatment with intermittent Theta Burst (ITBS) - Autism Spectrum Disorder, Depression | Not applicable | Recruiting | Hospital Center Guillaume Régnier | 25 | 2024-12-19 | 2025-12-02 |
Depression (4) · Depressive Disorder, Major (3) · Bipolar Disorder (2) · Suicidal Ideation (2) · Alcoholism (1) · Autism Spectrum Disorder (1) · Behavior (1) · Disease (1) · Disruptive, Impulse Control, and Conduct Disorders (1) · Generalized Anxiety Disorder (1) · Inflammation (1) · Mania (1) · Mental Disorders (1) · Obsessive-Compulsive Disorder (1) · Panic Disorder (1)
Behavioral Symptoms (6) · Behavior (5) · Depressive Disorder (3) · Mental Disorders (3) · Mood Disorders (3) · Pathological Conditions, Signs and Symptoms (3) · Bipolar and Related Disorders (2) · Pathologic Processes (2) · Suicide (2) · Alcohol-Related Disorders (1) · Anxiety Disorders (1) · Chemically-Induced Disorders (1) · Child Development Disorders, Pervasive (1) · Nervous System Diseases (1) · Neurobehavioral Manifestations (1)
cyclobenzaprine (1)
Hospital Center Guillaume Régnier (2) · Centre Hospitalier St Anne (1) · Massachusetts General Hospital (1) · The University of Hong Kong (1) · Tonix Pharmaceuticals, Inc. (1) · University Hospital, Montpellier (1) · Van Andel Research Institute (1)
France (4) · United States (2) · Hong Kong (1) · Monaco (1)
Eric Achytes, MD, MS (1) · Lauren M. Osborne, MD (1) · Lena Cecilia Brundin, MD, PhD (1) · Michael Y. Ni, MD (1) · Nagy Youssef, MD, PhD (1)
R01MH139201 (1)