15 completed, 4 active not recruiting, 3 recruiting, 2 unknown. 8 Phase 2, 5 Phase 1, 3 Not applicable, 1 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 8 | Completed 3, Active not recruiting 2, Recruiting 2, Withdrawn 1 |
| Phase 1 | 5 | Active not recruiting 3, Completed 2 |
| Not applicable | 3 | Completed 3 |
| Phase 3 | 1 | Recruiting 1 |
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Trial to Test the Use of Dapansutrile, an Anti-inflammatory Medication, in People With Parkinson's Disease dapansutrile, placebo - Parkinson Disease | Phase 2 | Recruiting | Cambridge University Hospitals NHS Foundation Trust | 36 | 2026-02-02 | 2026-06-16 |
| Edmond J. Safra Accelerating Clinical Trials in Parkinson's Disease: A Multiarm Multi-stage Platform Trial Placebo, Telmisartan, Terazosin (Hytrin) - Parkinsons Disease (PD) | Phase 3 | Recruiting | University College, London | 1200 | 2025-09-12 | 2025-10-03 |
| Repurposing Metformin As a Leukemia-preventive Drug in CCUS and LR-MDS Metformin - Preleukemia, Myelodysplastic Neoplasm | Phase 2 | Recruiting | Kirsten Grønbæk | 40 | 2021-12-13 | 2024-11-22 |
| 13C-Glucose Tracing of Tumour and T Cells in the Ascites of Ovarian Cancer Patients. [U-13C]Glucose - Ovarian Cancer, Ascites | Unknown | British Columbia Cancer Agency | 10 | 2021-10-20 | 2024-08-09 | |
| Pancreatic Cancer Biomarker Study Pancreatic Adenocarcinoma | Unknown | Van Andel Research Institute | 300 | 2021-01-01 | 2024-04-23 | |
| A Longitudinal Study of Inflammatory Pathways in Depression Major Depressive Disorder, Suicide, Attempted | Completed | Van Andel Research Institute | 130 | 2019-10-01 | 2025-04-06 | |
| Guadecitabine and Durvalumab in Treating Patients With Advanced Liver, Pancreatic, Bile Duct, or Gallbladder Cancer Durvalumab, Guadecitabine - Extrahepatic Bile Duct Adenocarcinoma, Biliary Type, Gallbladder Adenocarcinoma, Biliary Type | Phase 1 | Active not recruiting | University of Southern California | 55 | 2018-02-07 | 2026-06-01 |
| Atezolizumab + Guadecitabine in Patients With Checkpoint Inhibitor Refractory or Resistant Urothelial Carcinoma Atezolizumab, Guadecitabine - Urothelial Carcinoma | Phase 2 | Active not recruiting | Fox Chase Cancer Center | 21 | 2017-11-27 | 2021-11-04 |
| Ascorbic Acid Levels in MDS, AML, and CMML Patients Peripheral blood collection - Myelodysplastic Syndromes, Acute Myeloid Leukemia | Completed | Van Andel Research Institute | 50 | 2017-11-01 | 2019-10-03 | |
| Pembrolizumab (Immunotherapy Drug) in Combination With Guadecitabine and Mocetinostat (Epigenetic Drugs) for Patients With Advanced Lung Cancer. Pembrolizumab, Guadecitabine, Mocetinostat - Lung Cancer | Phase 1 | Active not recruiting | Memorial Sloan Kettering Cancer Center | 28 | 2017-08-04 | 2026-08-05 |
| The Microbiome in Parkinson's Disease Microbiome specimens in stool - Parkinson Disease | Completed | Corewell Health West | 23 | 2017-04-17 | 2024-04-08 | |
| Biomarkers as Predictors of Suicidal Risk in Adolescents Clinical assessments and blood samples; follow-up for 12 mos, Clinical assessments and blood samples; no 12mo follow-up - Suicide, Attempted, Suicidal Ideation | Completed | The Cleveland Clinic | 80 | 2016-12-01 | 2021-07-16 | |
| Guadecitabine and Atezolizumab in Treating Patients With Advanced Myelodysplastic Syndrome or Chronic Myelomonocytic Leukemia That Is Refractory or Relapsed Atezolizumab, Guadecitabine - Chronic Myelomonocytic Leukemia, Myelodysplastic Syndrome | Phase 1 / Phase 2 | Active not recruiting | University of Southern California | 33 | 2016-11-02 | 2026-07-07 |
| Epigenetics, Vitamin C and Abnormal Hematopoiesis - Pilot Study Vitamin C, Placebo - Myelodysplastic Syndrome, Acute Myeloid Leukemia | Not applicable | Completed | Copenhagen University Hospital, Rigshospitalet | 20 | 2016-08-08 | 2018-09-24 |
| Decitabine and Talazoparib in Untreated AML and R/R AML Decitabine, talazoparib - Acute Myeloid Leukemia | Phase 1 / Phase 2 | Completed | University of Maryland, Baltimore | 25 | 2016-08-01 | 2023-03-29 |
| Targeting the Mechanisms Underlying Cutaneous Neurofibroma Formation in NF1: A Clinical Translational Approach. Skin Biopsy - Cutaneous Neurofibromas, Neurofibromatosis Type 1 | Completed | Corewell Health West | 71 | 2016-05-01 | 2025-07-24 | |
| Extracorporeal Membrane Oxygenation (ECMO): Blood Cells Blood specimen collection - Extracorporeal Membrane Oxygenation | Terminated | Corewell Health West | 371 | 2015-01-20 | 2024-06-05 | |
| Biological Triggers of Depression in Pregnancy Depression and Suicide, Mood Disorders | Completed | Michigan State University | 209 | 2014-10-23 | 2018-06-28 | |
| Phase I/II Study of SGI-110 With Irinotecan Versus Regorafenib or TAS-102 in Metastatic Colorectal Cancer SGI-110 Dose Escalation, Regorafenib, TAS-102 - Previously Treated Metastatic Colorectal Cancer | Phase 1 / Phase 2 | Completed | Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins | 118 | 2013-10-23 | 2020-10-06 |
| Analysis of Growth Factors in Patients Undergoing Lucentis or Avastin Injections for Diabetic Macular Edema and Exudative Macular Degeneration Avastin, Lucentis - Exudative Macular Degeneration, Diabetic Macular Edema | Not applicable | Completed | Vitreo-Retinal Associates, Michigan | 16 | 2011-11-01 | 2014-12-17 |
Showing 20 of 26. Sign in to see all of them.
Inflammation (4) · Leukemia, Myeloid, Acute (3) · Myelodysplastic Syndromes (3) · Pancreatic Neoplasms (3) · Parkinson Disease (3) · Suicide (3) · Depression (2) · Leukemia, Myelomonocytic, Chronic (2) · Neuroinflammatory Diseases (2) · Suicidal Ideation (2) · Suicide, Attempted (2) · Anemia, Refractory, with Excess of Blasts (1) · Ascites (1) · Carcinoma, Hepatocellular (1) · Carcinoma, Transitional Cell (1)
guadecitabine (5) · Blood Specimen Collection (2) · atezolizumab (2) · Ascorbic Acid (1) · Bevacizumab (1) · Decitabine (1) · Defecation (1) · Etoposide (1) · Gemcitabine (1) · Irinotecan (1) · Metformin (1) · Mitomycin (1) · Ranibizumab (1) · Telmisartan (1) · Terazosin (1)
United States (20) · Canada (2) · Denmark (2) · United Kingdom (2) · Netherlands (1) · Spain (1)
Anthony El-Khoueiry, MD (1) · Arthur S Alberts, PhD (1) · Ashok Sriram, MD, MS (1) · Brian Haab, PhD (1) · Caroline Williams-Gray, BMBCh MA(Cantab) FRCP PhD (1) · Casey O'Connell (1) · Daniel Auclair (1) · Eric Achtyes, M.D. (1) · Giselle Sholler, MD (1) · Jianfeng Xu, Dr.P.H. (1) · Joseph Mann, M.D. (1) · Kathryn Arbour, MD (1) · Lena Brundin, MD, PhD (1)
PMID 28445481, PMID 28937974, PMID 31623675, PMID 32471990, PMID 33731366, PMID 35078975, PMID 35256844, PMID 38312102, PMID 40996854, PMID 41364805, PMID 42274746
P30CA014089 (2), 1RC2CA148463-01 (1), R01MH104622 (1), R01MH118211 (1)