26 completed, 4 unknown, 3 terminated, 2 active not recruiting. 20 Not applicable, 3 Phase 3, 2 Phase 2, 1 Phase 4.
Follow Macular Hole: new trials by email Literature Review of Macular Hole trials Research Report on Macular Hole
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Outcomes of Macular Hole Surgery With Inverted Flap With vs Without Post op Posturing With SF6 in Macular Hole More Than 400 Micrometres Macular Hole Surgery With Inverted Internal Limiting Membrane Flap and SF6 Gas Tamponade, Face-Down Postoperative Positioning, No Face-Down Postoperative Positioning - Macular Hole | Not applicable | Active not recruiting | Lahore General Hospital | 52 | 2026-05-01 | 2026-09-10 |
| Retinal Clinical Assessment With AI-derived Quantitative Information AI-derived retinal quantitative information-assisted reporting - no Obvious Abnormalities, Diabetic Retinopathy (DR) | Not yet recruiting | Beijing Tongren Hospital | 29 | 2026-04-15 | 2026-04-29 | |
| UNITY VCS Vitreoretinal Surgery UNITY Vitreoretinal Cataract System (VCS), CONSTELLATION Vision System, Vitreoretinal ophthalmic surgery - Epiretinal Membrane, Macular Hole | Not applicable | Withdrawn | Alcon Research | 2026-01-01 | 2025-12-12 | |
| Comparison Between Outcomes of Closure of Idiopathic Macular Hole Using Autologus Tenon Capsule Graft and Internal Limiting Membrane Flap Techniques (Pilot Study) vitrectomy under topical anesthesia [Proparacaine HCL (Alcaine®)] - Macular Hole Surgery, ILM Peeling | Not applicable | Recruiting | Ain Shams University | 20 | 2025-11-09 | 2026-06-08 |
| No Endotamponade for Macular Hole Repair: the NEMAR Study Conventional surgery, ILM flap with no gas tamponade - Macular Hole, Macular Hole Surgery | Not applicable | Recruiting | Chinese University of Hong Kong | 180 | 2025-09-16 | 2025-09-30 |
| Intraocular Gas Tamponade for Treatment of Large Idiopathic Macular Holes Pars plana vitrectomy - Idiopathic Macular Hole, Macular Hole | Not applicable | Enrolling by invitation | The Filatov Institute of Eye Diseases and Tissue Therapy | 100 | 2025-02-01 | 2025-04-17 |
| Head Position Monitoring After Pars Planar Vitrectomy gyroscope embedded eye-sheild - Retinal Detachment, Macular Hole | Active not recruiting | Seoul National University Hospital | 100 | 2024-11-28 | 2025-05-22 | |
| Minimal Vitrectomy and ILM Flap with Sodium Hyaluronate Gel for MH minimal posterior pole vitrectomy combined with a sodium hyaluronate gel-covered internal limiting membrane(ILM) flap with balanced saline filling and postoperative supine position, Conventional vitrectomy combined with inner limiting membrane flap flip coverage with sterile air filling and postoperative prone position - Macular Hole, Macular Hole Surgery | Not applicable | Enrolling by invitation | Jie Zhong | 52 | 2024-11-01 | 2024-11-12 |
| Efficacy and Safety of Myopic Macular Hole Closure Surgery Without Endotamponade Agent ILM flap with no endotamponade technique - Macular Hole, Myopia | Not applicable | Completed | Chinese University of Hong Kong | 20 | 2024-01-18 | 2026-10-21 |
| Performance Comparison of the 25 Gauge 20,000cpm HYPERVIT Dual Blade vs. 10,000cpm ULTRAVIT Vitrectomy Cutter 25 gauge 20,000 cpm Hypervit Dual Blade, 25 gauge 10,000 cpm Ultravit Vitrectomy Cutter - Vitrectomy, Epiretinal Membrane | Not applicable | Completed | The University of Hong Kong | 72 | 2021-07-01 | 2023-02-02 |
| Visual Acuity and Optical Coherence Tomography One Year After ILM-flap Transposition optical coherence tomography - Macular Hole | Completed | Vienna Institute for Research in Ocular Surgery | 41 | 2017-09-01 | 2025-02-13 | |
| Internal Limiting Membrane Peeling-reposition to Treat Idiopathic Macular Holes peeling-reposition, peeling, Brilliant Blue G - Macular Hole, Surgery | Not applicable | Completed | Xinhua Hospital, Shanghai Jiao Tong University School of Medicine | 30 | 2017-01-01 | 2021-05-13 |
| Fourier Transformed Infrared Spectroscopy in Macular Surgery FTIR spectroscopy - Epiretinal Membrane, Macular Hole | Not applicable | Completed | Vienna Institute for Research in Ocular Surgery | 50 | 2017-01-01 | 2020-09-29 |
| Optical Coherence Tomography - Rescan During Dissection of Macular Membranes Lumera Microscope with OCT RESCAN, Conventional Microscope - Macular Hole, Epiretinal Membrane | Not applicable | Unknown | Federal University of São Paulo | 30 | 2016-05-01 | 2016-04-22 |
| Applicability of the Acai Fruit (Euterpe Oleracea) Dye for Chromovitrectomy in Humans Acai dye 10% - Epiretinal Membrane, Macular Hole | Not applicable | Completed | Federal University of São Paulo | 24 | 2016-02-01 | 2017-06-07 |
| Analysis of Aqueous and Vitreous Humor Ranibizumab, No Ranibizumab - Proliferative Diabetic Retinopathy, Macular Degeneration | Phase 2 | Unknown | California Retina Consultants | 45 | 2015-07-01 | 2017-03-01 |
| Effects of Different Area of Internal Limiting Membrane Peeling (ILM) Peeling on Anatomical Outcomes in Macular Hole Surgery ILM peeling surgery - Macular Hole | Phase 4 | Completed | Peking University People's Hospital | 128 | 2015-06-01 | 2016-10-12 |
| Objective Evaluation of Postoperative Positioning in Macular Hole Surgery Positioning measuring device - Macular Hole | Not applicable | Terminated | Helse Stavanger HF | 205 | 2014-11-01 | 2018-06-06 |
| DISCOVER Study: Microscope-integrated Intraoperative OCT Study Retinal Diseases, Fuchs Endothelial Dystrophy | Completed | The Cleveland Clinic | 2911 | 2014-01-01 | 2026-08-03 | |
| Comparison of Postoperative Aqueous Flare After 20G Versus 23G Pars Plana Vitrectomy 20G Vitrectomy, 23G vitrectomy - Macular Hole, Macular Pucker | Not applicable | Unknown | University of Cologne | 100 | 2013-10-01 | 2015-06-01 |
Showing 20 of 41. Sign in to see all of them.
Retinal Perforations (41) · Epiretinal Membrane (16) · Retinal Detachment (5) · Diabetic Retinopathy (3) · Fuchs' Endothelial Dystrophy (2) · Macular Degeneration (2) · Retinal Vein Occlusion (2) · Vitreous Hemorrhage (2) · Central Serous Chorioretinopathy (1) · Geographic Atrophy (1) · Glaucoma, Neovascular (1) · Gliosis (1) · Macular Edema (1) · Myopia (1) · Myopia, Degenerative (1)
Eye Diseases (41) · Retinal Diseases (40) · Cardiovascular Diseases (3) · Diabetes Complications (3) · Diabetes Mellitus (3) · Diabetic Angiopathies (3) · Endocrine System Diseases (3) · Pathologic Processes (3) · Pathological Conditions, Signs and Symptoms (3) · Vascular Diseases (3) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (2) · Corneal Diseases (2) · Corneal Dystrophies, Hereditary (2) · Embolism and Thrombosis (2) · Eye Diseases, Hereditary (2)
Vitrectomy (3) · coomassie Brilliant Blue (2) · Indocyanine Green (1) · Lutein (1) · Ophthalmic Solutions (1) · Ranibizumab (1) · Spectroscopy, Fourier Transform Infrared (1) · Surgical Flaps (1) · Timolol (1) · Tomography, Optical Coherence (1) · Tooth Exfoliation (1) · Transplantation (1) · Zeaxanthins (1) · brilliant blue (1) · dorzolamide (1)
Federal University of São Paulo (3) · Helse Stavanger HF (3) · Assistance Publique - Hôpitaux de Paris (2) · Centre Hospitalier Universitaire Dijon (2) · Chinese University of Hong Kong (2) · Kyorin University (2) · The Cleveland Clinic (2) · University of Cologne (2) · Vienna Institute for Research in Ocular Surgery (2) · Ain Shams University (1) · Alcon Research (1) · Asociación para Evitar la Ceguera en México (1) · Beijing Tongren Hospital (1) · California Retina Consultants (1) · Jie Zhong (1)
United States (8) · France (4) · China (3) · Germany (3) · Hong Kong (3) · Japan (3) · Norway (3) · Austria (2) · Brazil (2) · Taiwan (2) · Egypt (1) · Mexico (1) · Pakistan (1) · Poland (1) · South Korea (1)
Vegard Forsaa, MD (3) · Justis P Ehlers, MD (2) · Simon KH Szeto, MBChB, FRCOphth (2) · Ahmad Fauzan (1) · Bernd Kirchhof, MD (1) · Catherine Creuzot-Gracher, MD, PhD (1) · Chung-May Yang, MD (1) · Florian Gekeler, MD (1) · Jason Hsu, MD (1) · Katharina E Schmid-Kubista, MD (1) · Makoto INoue, MD (1) · Mauricio Maia (1) · Michel Farah, MD, PhD (1)
PMID 19823863, PMID 20615492, PMID 21878847, PMID 23620091, PMID 24441951, PMID 24736052, PMID 24782469, PMID 25055146, PMID 25077834, PMID 25525173, PMID 26114817, PMID 30448886, PMID 31044728, PMID 36695790, PMID 39276867
K23EY022947 (1)