18 completed, 3 recruiting, 2 terminated, 1 unknown. 14 Not applicable, 5 Phase 2, 3 Phase 1, 3 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 14 | Completed 12, Recruiting 2 |
| Phase 2 | 5 | Completed 2, Terminated 2, Unknown 1 |
| Phase 1 | 3 | Recruiting 1, Terminated 1, Unknown 1 |
| Phase 3 | 3 | Completed 3 |
Follow Zeaxanthins: new trials by email Literature Review of Zeaxanthins trials Research Report on Zeaxanthins
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Effect of Lutein, Zeaxanthin, and Meso-Zeaxanthin Supplementation on Skin Carotenoid Concentration: A Six-Month, Placebo-Controlled Crossover Study Lutein, Zeaxanthin, and Meso-Zeaxanthin Supplementation - Macular Degenerative Disease | Not applicable | Recruiting | Insight Eyecare Specialties, Inc. dba Vision Source Eyecare, | 60 | 2025-06-01 | 2026-09-01 |
| Lutein, Zeaxathin, and Fish Oil Supplementation Active Comparator (Lutein, zeaxanthin, and fish oil supplement (LZF), Placebo Comparator - Cognitive Performance, Age-Related Macular Degeneration | Not applicable | Recruiting | Texas A&M University | 80 | 2024-02-07 | 2025-09-30 |
| Determine Safety & Recommended Phase 2 Dosing of Zeaxanthin Alone or in Combination w/Pembrolizumab in Patients With Metastatic Cancer Zeaxanthin, Zeaxanthin Plus Pembrolizumab - Cancer Metastatic, Metastatic Solid Tumor | Phase 1 | Recruiting | Valley Health System | 72 | 2022-04-17 | 2026-06-05 |
| Clinical and Radiographic Assessment of PRF Versus Lutein Placement Lutein / Zeaxanthin, Platelet rich fibrin - Osteogenesis | Not applicable | Completed | Mansoura University | 30 | 2021-10-01 | 2024-04-10 |
| Effect of Micronutrient Supplementation on the Intestinal Microbiota in Patients With Age-related Macular Degeneration - The Gut-Retina-axis Study a micronutrient mix containing lutein (10 mg), zeaxanthin (2 mg), saffron (20 mg), vitamin C (80 mg), vitamin E (12 mg) and zinc (10mg), anti-VEGF treatment - Age-Related Macular Degeneration | Not applicable | Completed | Azienda Ospedaliero-Universitaria Careggi | 45 | 2021-03-01 | 2024-07-31 |
| Lutein & Zeaxanthin in Pregnancy - Carotenoid Supplementation During Pregnancy: Ocular and Systemic Effects Carotenoid Group, Control Group - Nutrient Deficiency, Pregnancy Related | Phase 2 | Completed | Paul S. Bernstein | 47 | 2019-09-26 | 2023-07-11 |
| Macular Pigment and Visual Performance in Glaucoma Patients Lutein, zeaxanthin and mesozeaxanthin, Placebo - Glaucoma | Phase 1 / Phase 2 | Terminated | Felipe Medeiros, MD | 8 | 2019-08-21 | 2023-01-03 |
| European Nutrition in Glaucoma Management Trial 10 mg Lutein, 2 mg zeaxanthin, 10 mg meso-zeaxanthin, Placebo - Glaucoma, Open-Angle | Not applicable | Completed | Centre for Eye Research Ireland | 64 | 2017-10-01 | 2021-08-06 |
| The Effects of Lutein and Zeaxanthin Supplementation on Vision in Patients With Albinism Lutein plus Zeaxanthin, Placebo - Ocular Albinism (OA), Oculocutaneous Albinism (OCA) | Not applicable | Completed | Johns Hopkins University | 10 | 2014-11-01 | 2018-12-28 |
| Association of Lutein, Zeaxanthin and Brilliant Blue in Chromovitrectomy Dye of Lutein, Zeaxanthin and Brilliant Blue - Epiretinal Membrane, Macular Hole | Phase 3 | Completed | Federal University of São Paulo | 18 | 2012-10-01 | 2016-03-16 |
| Efficacy of Lutein, Zeaxanthine and Trypan Blue to Stain the Anterior Lens Capsule dye of lutein, zeaxanthin, trypan blue - Cataract | Phase 3 | Completed | Federal University of São Paulo | 25 | 2012-06-01 | 2016-03-16 |
| The Effects of a Zeaxanthin Intervention on Visuomotor Function zeaxanthin, combinatory supplement - Behavior and Behavior Mechanisms | Not applicable | Completed | University of Georgia | 102 | 2012-02-01 | 2015-05-27 |
| The Role of Macular Pigment Carotenoids in the Pathogenesis and Treatment of Macular Telangiectasia Type 2 (MacTel) zeaxanthin - Idiopathic Juxtafoveal Telangiectasia | Completed | Paul S. Bernstein | 8 | 2011-11-01 | 2017-06-23 | |
| Macular Pigment Density Evolution in Unilateral Wet AMD Versus Non AMD Patients With or Without Lutein and Zeaxanthine Supplementation Nutrof Total, food supplement without Lutein and Zeaxanthin - Exudative Age-related Macular Degeneration | Not applicable | Completed | Affordance | 200 | 2011-09-01 | 2015-06-24 |
| Efficacy of Ubiquinone and Combined Antioxidant Therapy in Non-proliferative Diabetic Retinopathy Ubiquinone, Combined antioxidant therapy, Placebo - Non-proliferative Diabetic Retinopathy, Diabetes Mellitus Type 2 | Phase 2 | Completed | University of Guadalajara | 61 | 2011-02-01 | 2014-02-13 |
| Effects of Lutein and Zeaxanthin Supplementation on Early Age-related Macular Degeneration placebo, low lutein, high lutein - Age-related Macular Degeneration | Not applicable | Completed | Peking University | 168 | 2010-06-01 | 2014-08-29 |
| Effects of Lutein and Zeaxanthin Supplementation on Age-related Macular Degeneration lutein, Lutein, placebo - Age-related Macular Degeneration | Phase 1 / Phase 2 | Unknown | Peking University | 120 | 2009-09-01 | 2012-03-16 |
| Long Term Effects of Lutein/Zeaxanthin and Omega-3- Supplementation for Two More Years (LUTEGA 2) Lutein/ Zeaxanthin + Omega- 3- Fatty Acids - Age Related Maculopathy | Not applicable | Completed | University of Jena | 80 | 2009-05-01 | 2013-01-10 |
| Macular Pigment and Glare Disability 12 mg Lutein + Zeaxanthin, Visually identical placebo - Vision, Entoptic | Not applicable | Completed | University of Georgia | 109 | 2009-05-01 | 2020-07-13 |
| Long Term Effects of Lutein/Zeaxanthin and Omega-3- Supplementation on Optical Density of AMD Patients (LUTEGA) Lutein/ Zeaxanthin + Omega-3-FA, Placebo - Age Related Maculopathy | Not applicable | Completed | University of Jena | 172 | 2008-05-01 | 2012-07-20 |
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Macular Degeneration (10) · Cataract (2) · Glaucoma (2) · Albinism, Ocular (1) · Albinism, Oculocutaneous (1) · Alzheimer Disease (1) · Behavior (1) · Bone Diseases, Metabolic (1) · Cognition Disorders (1) · Diabetes Mellitus, Type 2 (1) · Diabetic Retinopathy (1) · Epiretinal Membrane (1) · Glaucoma, Open-Angle (1) · Idiopathic Juxtafoveal Retinal Telangiectasia (1) · Mitochondrial Diseases (1)
Federal University of São Paulo (2) · Paul S. Bernstein (2) · Peking University (2) · University of Georgia (2) · University of Jena (2) · Affordance (1) · Azienda Ospedaliero-Universitaria Careggi (1) · Centre for Eye Research Ireland (1) · Chrysantis, Inc. (1) · Felipe Medeiros, MD (1) · Insight Eyecare Specialties, Inc. dba Vision Source Eyecare, (1) · Johns Hopkins University (1) · Maastricht University Medical Center (1) · Mansoura University (1) · National Eye Institute (NEI) (1)
United States (12) · Brazil (2) · China (2) · Egypt (1) · France (1) · Germany (1) · Ireland (1) · Italy (1) · Mexico (1) · Netherlands (1)
Billy R Hammond, Ph.D. (2) · Jens Dawczynski, MD (2) · Adolfo D. Rodriguez-Carrizalez, M.Sc. (1) · Emily Y Chew, MD (1) · Felipe A Medeiros, MD, PhD (1) · James Loughman, PhD (1) · John Paul SanGiovanni, Sc.D. (1) · Karen M Beathard, PhD (1) · Martine Mauget-faysse (1) · Mary E. Frey (1) · Neil Bressler, MD (1) · Paul S Bernstein, MD, PhD (1)
PMID 37702300, PMID 24310343, PMID 18421079, PMID 19365036, PMID 22247465, PMID 22595020, PMID 22835510, PMID 22879423, PMID 23211814, PMID 23519529, PMID 23620429, PMID 23644932, PMID 23645227, PMID 23695657, PMID 23830564, PMID 23887802, PMID 24441951, PMID 24638908, PMID 24675775, PMID 25468896, PMID 26305649, PMID 26990164, PMID 28032115, PMID 29927057, PMID 30400586, PMID 32285590, PMID 33888136, PMID 34793832, PMID 36247822, PMID 37247819