30 completed, 29 recruiting, 15 unknown, 13 not yet recruiting. 39 Not applicable, 7 Phase 2, 6 Phase 1, 5 Phase 3, 4 Early Phase 1.
Follow Lynch Syndrome: new trials by email Literature Review of Lynch Syndrome trials Research Report on Lynch Syndrome
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Study Aiming to Test Whether Non-invasive Liquid Biopsies Can Safely Reduce Invasive Surveillance Methods in Lynch Syndrome INVITRO DIAGNOSTIC TESTS AND COLONOSCOPY - Lynch Syndrome | Not applicable | Not yet recruiting | UNICANCER | 2000 | 2026-12-01 | 2026-08-03 |
| Protocol for Non-invasive Gynaecological Surveillance in Lynch Syndrome Lynch Syndrome | Not yet recruiting | University of Edinburgh | 1450 | 2026-10-16 | 2026-10-22 | |
| Preventive Dendritic Cell Vaccination for Lynch Syndrome Carriers Arm A: DC vaccination, Arm B: Placebo vaccination - Lynch Syndrome | Phase 3 | Not yet recruiting | Radboud University Medical Center | 372 | 2026-10-01 | 2026-05-27 |
| Preventive Dendritic Cell Vaccination for Lynch Syndrome DC vaccination - Lynch Syndrome | Phase 1 / Phase 2 | Not yet recruiting | Radboud University Medical Center | 16 | 2026-10-01 | 2026-08-19 |
| Overcoming Barriers to Uptake of Cascade Screening Let's Talk Genetics Providers, Let's Talk Patients - Lynch Syndrome | Not applicable | Not yet recruiting | UNC Lineberger Comprehensive Cancer Center | 20 | 2026-09-01 | 2026-08-26 |
| A Web-Based Program (Kindred) to Improve the Understanding of Genetic Cancer Risk and Cancer Genetic Testing in African American Families Discussion, Internet-Based Intervention, Survey Administration - BRCA1-Related Hereditary Breast and Ovarian Cancer Syndrome, BRCA2-Related Hereditary Breast and Ovarian Cancer Syndrome | Not applicable | Not yet recruiting | University of Michigan Rogel Cancer Center | 150 | 2026-06-15 | 2026-05-19 |
| Periodontal Disease in Patients With Lynch Syndrome periodontal charting for the diagnosis of periodontitis - Lynch Syndrome, Periodontal Disease | Not yet recruiting | Rotundo Roberto | 25 | 2026-06-01 | 2026-05-22 | |
| Impact of Consumption of Ultra-processed Foods in Individuals at High Risk of Cancer educational workshop on nutrition + additional intervention on UPF tool and how to use it - Breast Cancer, Pancreas Cancer | Not applicable | Recruiting | Gustave Roussy, Cancer Campus, Grand Paris | 170 | 2026-05-04 | 2026-05-08 |
| Evaluation of Capsule Colonoscopy in Patients With Lynch Syndrome colon capsule endoscopy - Lynch Syndrome | Not yet recruiting | Region Skane | 78 | 2026-05-01 | 2026-04-30 | |
| Determining the Prevalence of Muir-Torre Syndrome in Patients With Lynch Syndrome Sampling of suspected skin lesions (in accordance with good care practices)., Constitution of a biobank - Basal Cell Carcinoma of Skin, Site Unspecified, Epidermoid Carcinoma | Not applicable | Recruiting | Centre Hospitalier Universitaire de Nīmes | 150 | 2026-03-13 | 2026-06-22 |
| Menstrual Cup for Early Endometrial Cancer Detection in Lynch Syndrome Menstrual cup use - Endometrial Cancer, Lynch Syndrome | Not applicable | Recruiting | Jessica D. St. Laurent, MD | 25 | 2025-11-20 | 2026-06-10 |
| Clinical Validation of Sophia Genetics Assay Sophia Herditary Cancer Solution - Ovarian Cancer, Breast Cancer | Not yet recruiting | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | 248 | 2025-09-15 | 2025-09-08 | |
| Initial Testing of a Behavioral Intervention About Genetic Services for Families at Risk of Lynch Syndrome Information Letter and Booklet, Information Letter - Cascade Testing, Lynch Syndrome | Not applicable | Recruiting | University of Alabama at Birmingham | 185 | 2025-09-15 | 2026-07-21 |
| First in Human Pilot Study to Assess the Safety and Efficacy of Dendritic Cells Loaded With Frameshift Derived Neopeptides for the Prevention of Cancer in of Lynch Syndrome Carriers Autologous Tolerogenic Dendritic cells - Lynch Syndrome | Phase 1 | Recruiting | Fundacion Clinic per a la Recerca Biomédica | 20 | 2025-09-04 | 2026-04-13 |
| Assessing Uterine Cancer Risk in Lynch Syndrome Carriers Using Vaginal Self-sampling and a Health Questionnaire Vaginal DNA swab, microbiome swab and pH test - Endometrial Cancer, Lynch Syndrome | Not applicable | Recruiting | University of British Columbia | 30 | 2025-08-29 | 2026-09-03 |
| Patient Centered Clinical Decision Support for Hereditary Cancer Syndromes Patient Centered Clinical Decision Support (PC-CDS) - Hereditary Breast/Ovarian Cancer (brca1, brca2), Lynch Syndrome | Not applicable | Enrolling by invitation | HealthPartners Institute | 2488 | 2025-07-09 | 2026-07-10 |
| Lynch Syndrome in Colorectal Cancer Surgery diagnostic test - Colo-rectal Cancer, Hereditary Diseases | Not yet recruiting | Izmir Ataturk Training and Research Hospital | 180 | 2025-07-01 | 2025-05-25 | |
| Small Bowel Capsule Endoscopy in Lynch Syndrome MMR Mutation, Small Bowel Adenoma | Recruiting | Assistance Publique - Hôpitaux de Paris | 400 | 2025-06-16 | 2026-03-16 | |
| Predictive Value of PREMM5, MMRpredict, and Universal Tumor Screening for Lynch Syndrome in Vietnam Lynch Syndrome, Colorectal Cancer (CRC) | Not yet recruiting | University of Medicine and Pharmacy at Ho Chi Minh City | 572 | 2025-03-17 | 2025-03-07 | |
| DYNAMICS-LYNCH：DNA Methylation Analysis in Stool for Screening of Lynch Syndrome-Associated Colorectal Cancer fecal DNA methylation testing - Colorectal Cancer Screening, Lynch Syndrome | Not yet recruiting | Sun Yat-sen University | 400 | 2025-01-10 | 2025-01-15 |
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Colorectal Neoplasms, Hereditary Nonpolyposis (106) · Colorectal Neoplasms (26) · Endometrial Neoplasms (16) · Colonic Neoplasms (11) · Hereditary Breast and Ovarian Cancer Syndrome (10) · Ovarian Neoplasms (10) · Turcot syndrome (10) · Breast Neoplasms (9) · Peutz-Jeghers Syndrome (7) · Neoplastic Syndromes, Hereditary (6) · Pancreatic Neoplasms (6) · Adenomatous Polyposis Coli (5) · Hamartoma Syndrome, Multiple (5) · Dysplastic Nevus Syndrome (4) · Li-Fraumeni Syndrome (4)
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PMID 20733131, PMID 22062356, PMID 23254892, PMID 23825568, PMID 24916333, PMID 25047061, PMID 25209657, PMID 25833335, PMID 28107763, PMID 30538291, PMID 31028782, PMID 31197699, PMID 31498154, PMID 31520613, PMID 31676359, PMID 32414353, PMID 32641470, PMID 32887653, PMID 32958357, PMID 33161160, PMID 34086597, PMID 34149034, PMID 35705312, PMID 36670100, PMID 36946440, PMID 37027812, PMID 37099777, PMID 37516165, PMID 37787643, PMID 37972346, PMID 38105176, PMID 38453598, PMID 38920120, PMID 39033774, PMID 40632977, PMID 40953502, PMID 41193187, PMID 41213710, PMID 41282898, PMID 41545594, PMID 41880612, PMID 42078573, PMID 42214493, PMID 42238576, PMID 42658496, PMID 42682457
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