22 completed, 3 recruiting, 1 not yet recruiting, 1 terminated. 7 Phase 3, 6 Not applicable, 6 Phase 2, 3 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 7 | Completed 5, Recruiting 1, Unknown 1 |
| Not applicable | 6 | Completed 3, Not yet recruiting 1, Recruiting 1, Terminated 1 |
| Phase 2 | 6 | Completed 6 |
| Phase 4 | 3 | Completed 2, Withdrawn 1 |
Follow Lymphatic Filariasis: new trials by email Literature Review of Lymphatic Filariasis trials Research Report on Lymphatic Filariasis
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Better Options for Lymphatic Filariasis Treatment MoxDA - Moxidectin + Diethylcarbamzine (DEC) + Albendazole, IDA - Ivermectin + DEC + albendazole - Lymphatic Filariasis, Scabies | Phase 3 | Recruiting | Medicines Development for Global Health | 5100 | 2026-09-28 | 2026-10-07 |
| Expanding Access to Preventive Chemotherapy Among Mobile and Migrant Populations Modified Mass Administration of Medicines Strategy, Albendazole 400 mg, Praziquantel 40 mg/kg - Onchocerciasis (River Blindness), Schistosomiasis | Not applicable | Recruiting | Uwemedimo Friday Ekpo | 5760 | 2026-07-01 | 2026-07-16 |
| Early Detection and AI-Based Management of Skin-Related Neglected Tropical Diseases in Sub-Saharan Africa by Frontline Health Workers A mobile app with AI functionality for diagnosing skin-related NTDs - Skin and Connective Tissue Diseases, Neglected Tropical Diseases | Not applicable | Not yet recruiting | Kenya Medical Research Institute | 2420 | 2026-05-01 | 2026-04-02 |
| Risk Assessment of Community Spread of Multiple Endemic Infectious Diseases in a One Health Perspective Dengue, Chikungunya | Recruiting | Institut Pasteur du Cambodge | 10000 | 2025-12-18 | 2026-01-22 | |
| Adjunctive Ivermectin Mass Drug Administration for Malaria Control Ivermectin, Placebo, Dihydroartemisinin-piperaquine - Malaria,Falciparum, Neglected Tropical Diseases | Phase 3 | Unknown | London School of Hygiene and Tropical Medicine | 24000 | 2021-05-03 | 2022-02-24 |
| Moxidectin for LF, Cote d'Ivoire (DOLF) Ivermectin, Diethylcarbamazine, Albendazole - Lymphatic Filariasis | Phase 3 | Completed | Washington University School of Medicine | 164 | 2020-08-20 | 2026-01-29 |
| Spontaneous Antigenemia in Loiasis No intervention - Loiasis, Lymphatic Filariasis | Completed | Washington University School of Medicine | 86 | 2020-01-23 | 2026-08-21 | |
| A 24 Month Study to Compare Efficacy of Doxycycline vs Placebo for Improving Filarial Lymphedema in India Doxycycline, Placebo - Lymphedema, Lymphatic Filariasis | Phase 3 | Completed | The Task Force for Global Health | 235 | 2019-01-15 | 2021-06-24 |
| PK PD Study of IDA and Azithromycin for NTDs ( ComboNTDs ) Azithromycin, Albendazole, Ivermectin - Lymphatic Filariasis, Yaws | Phase 2 | Completed | Lihir Medical Centre | 42 | 2018-09-01 | 2019-02-28 |
| A 24 Month Study, to Compare the Efficacy of Doxycycline vs. Placebo for Improving Filarial Lymphedema in Mali Doxycycline, Placebo - Lymphedema, Lymphatic Filariasis | Phase 3 | Completed | The Task Force for Global Health | 220 | 2018-06-19 | 2021-06-24 |
| A 24 Month Study to Compare Efficacy of Doxycycline vs Placebo for Improving Filarial Lymphedema in Sri Lanka Doxycycline, Placebo - Lymphedema, Lymphatic Filariasis | Phase 3 | Completed | The Task Force for Global Health | 219 | 2018-02-16 | 2021-03-17 |
| Twice Yearly Treatment for the Control of LF 400 μg/kg Ivermectin + 400 mg Albendazole - Lymphatic Filariasis, Helminth Infection | Phase 4 | Completed | Noguchi Memorial Institute for Medical Research | 1462 | 2017-05-19 | 2020-02-26 |
| Death to Onchocerciasis and Lymphatic Filariasis (DOLF) Triple Drug Therapy for Lymphatic Filariasis 3 drug dose - IDA, 2 drug dose - DA - Lymphatic Filariasis | Not applicable | Completed | Washington University School of Medicine | 23789 | 2016-07-01 | 2020-12-31 |
| Repeat Ivermectin Mass Drug Administrations for Control of Malaria: a Pilot Safety and Efficacy Study Ivermectin, Albendazole - Malaria, Lymphatic Filariasis | Phase 2 / Phase 3 | Completed | Colorado State University | 2712 | 2015-06-01 | 2019-01-04 |
| Lymphatic Filariasis (LF) in Ivory Coast Albendazole, Ivermectin, Diethylcarbamazine - Lymphatic Filariasis | Not applicable | Completed | University Hospitals Cleveland Medical Center | 189 | 2015-01-01 | 2022-04-21 |
| Eval 3-Drug Therapy Diethylcarbamize, Albendazole and Ivermectin That Could Accelerate LF Elimination Outside of Africa Diethylcarbamazine, Albendazole, Ivermectin - Lymphatic Filariasis | Phase 2 | Completed | University Hospitals Cleveland Medical Center | 182 | 2014-05-01 | 2018-10-09 |
| Safety Study of Combined Azithromycin, Ivermectin and Albendazole for Trachoma and Lymphatic Filariasis azithromycin, ivermectin, albendazole - Trachoma, Lymphatic Filariasis | Phase 4 | Withdrawn | Emory University | 2014-02-01 | 2014-05-22 | |
| Optimization of Mass Drug Administration With Existing Drug Regimens for Lymphatic Filariasis and Onchocerciasis for Ivory Coast (DOLF-Ivory Coast) Annual versus Semiannual Albendazole plus Ivermectin MDA - Lymphatic Filariasis, Onchocerciasis | Completed | Washington University School of Medicine | 14457 | 2014-02-01 | 2018-05-04 | |
| Optimization of MDA With Existing Drug Regimens for LF: Monitoring Efficacy of Ongoing Treatment Programs in PNG Lymphatic Filariasis | Completed | University Hospitals Cleveland Medical Center | 3200 | 2012-06-01 | 2019-04-26 | |
| Disability and Quality of Life in Patients With Lymphatic Filariasis in Rural Southern India Lymphatic Filariasis | Completed | Northwestern University | 72 | 2012-05-01 | 2014-03-20 |
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Elephantiasis, Filarial (29) · Filariasis (7) · Neglected Diseases (5) · Onchocerciasis (4) · Infections (3) · Lymphedema (3) · Malaria (3) · Scabies (3) · Schistosomiasis (2) · Strongyloidiasis (2) · Yaws (2) · Adenoviridae Infections (1) · Ancylostomiasis (1) · Arenaviridae Infections (1) · Brucellosis (1)
Helminthiasis (29) · Hemic and Lymphatic Diseases (29) · Lymphatic Diseases (29) · Mosquito-Borne Diseases (29) · Nematode Infections (29) · Parasitic Diseases (29) · Secernentea Infections (29) · Spirurida Infections (29) · Vector Borne Diseases (28) · Infections (26) · Lymphedema (26) · Filariasis (22) · Skin Diseases (8) · Skin Diseases, Infectious (8) · Skin Diseases, Parasitic (7)
Albendazole (16) · Ivermectin (14) · Diethylcarbamazine (7) · Doxycycline (3) · Albumins (2) · Azithromycin (2) · Intravital Microscopy (1) · Mass Drug Administration (1) · Mebendazole (1) · Praziquantel (1) · moxidectin (1)
Washington University School of Medicine (7) · National Institute of Allergy and Infectious Diseases (NIAID) (3) · The Task Force for Global Health (3) · University Hospitals Cleveland Medical Center (3) · London School of Hygiene and Tropical Medicine (2) · Centre d'Appui à la lutte contre la Maladie (1) · Colorado State University (1) · DBL -Institute for Health Research and Development (1) · Emory University (1) · Institut Pasteur du Cambodge (1) · Kenya Medical Research Institute (1) · Lihir Medical Centre (1) · Medicines Development for Global Health (1) · Noguchi Memorial Institute for Medical Research (1) · Northwestern University (1)
India (5) · Papua New Guinea (4) · Côte d’Ivoire (3) · Indonesia (2) · Mali (2) · Nigeria (2) · United States (2) · Burkina Faso (1) · Cambodia (1) · Cameroon (1) · Democratic Republic of the Congo (1) · Egypt (1) · Ethiopia (1) · Fiji (1) · Ghana (1)
Eric Ottesen, MD (3) · Gary J Weil, MD (3) · Peter U Fischer, PhD (2) · Philip Budge, MD, PhD (2) · Aboulaye Miete, MD (1) · Anna R Last, MBChB PhD (1) · Benjamin Koudou, PhD (1) · Brian D. Foy, PhD (1) · Catherine Bjerum, MD, MPH (1) · Christopher King, MD PHD (1) · Christopher L King, MD PhD (1) · Christopher L King, MD, PhD (1) · Claude Flamand, Ph.D. (1) · Dziedzom K de Souza, PhD (1)
PMID 11873261, PMID 22610930, PMID 32228663, PMID 10656038, PMID 42848323, PMID 23981378, PMID 25877874, PMID 26486704, PMID 28969715, PMID 30403937, PMID 30878222, PMID 31233507, PMID 31641754, PMID 32818264, PMID 32976514, PMID 33674871, PMID 33780481, PMID 35139070, PMID 35533701, PMID 37262040, PMID 37419638, PMID 37616301, PMID 37721964, PMID 39551062, PMID 40345209