8 completed, 3 recruiting, 2 active not recruiting, 1 not yet recruiting. 7 Phase 2, 3 Not applicable, 3 Phase 3, 1 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 7 | Completed 4, Recruiting 2, Not yet recruiting 1 |
| Not applicable | 3 | Completed 2, Recruiting 1 |
| Phase 3 | 3 | Active not recruiting 1, Completed 1, Recruiting 1 |
| Phase 1 | 1 | Completed 1 |
Follow Lymphangioma: new trials by email Literature Review of Lymphangioma trials Research Report on Lymphangioma
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Study to Evaluate the Efficacy and Safety of Everolimus in Patients With Teratment-refractory Vascular Anomalies Everolimus - Vascular Malformations, Arteriovenous Malformations | Phase 2 | Not yet recruiting | Yonsei University | 67 | 2026-04-01 | 2026-03-17 |
| Radiological Diagnosis of Pediatric Neck Swellings Lipoma, Branchial Cleft Anomalies | Active not recruiting | Sohag University | 50 | 2026-02-20 | 2026-07-30 | |
| A Trial of Targeted Therapies for Patients With Slow-Flow or Fast-Flow Vascular Malformations Alpelisib, Mirdametinib - Slow-Flow Vascular Malformation, Fast-Flow Vascular Malformation | Phase 2 | Recruiting | Murdoch Childrens Research Institute | 50 | 2024-09-13 | 2026-05-05 |
| Bleomycin Intralesional Injections of Cystic Hygromas Intralesional Injections - Lymphatic Malformations | Not applicable | Completed | Delta University for Science and Technology | 30 | 2024-09-01 | 2026-04-28 |
| Ultraspound-guided Intralesional Injection of Cystic Hygroma - A Case Report Intralesional Injection of Bleomycin - Intralesional Injection of Cystic Hygroma, Cystic Hygroma (Macro-cystic Lymphatic Malformation) | Not applicable | Completed | Delta University for Science and Technology | 1 | 2024-09-01 | 2026-04-30 |
| SELVA: A Phase 3 Study Evaluating QTORIN 3.9% Rapamycin Anhydrous Gel in the Treatment of Microcystic Lymphatic Malformations QTORIN 3.9% Rapamycin Anhydrous Gel - Microcystic Lymphatic Malformation | Phase 3 | Active not recruiting | Palvella Therapeutics, Inc. | 51 | 2024-07-31 | 2026-03-27 |
| Institution of an Italian Registry and Biobank for Biological Sample Collection Genetic profiling of all eligible patients - Lymphatic Malformation, Lymphatic Abnormality | Not applicable | Recruiting | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | 70 | 2024-06-27 | 2025-03-25 |
| Alpelisib in Pediatric and Adult Patients With Lymphatic Malformations Associated With a PIK3CA Mutation. Alpelisib, Placebo - Lymphatic Malformations | Phase 2 / Phase 3 | Recruiting | Novartis Pharmaceuticals | 232 | 2023-11-24 | 2026-10-09 |
| Role of Sirolimus in Treatment of Microcystic , Mixed Lymphatic and Vascular Malformations Sirolimus 1Mg Oral Tablet - Microcystic Lymphatic Malformation, Combined Vascular Malformation | Unknown | Sohag University | 10 | 2023-11-20 | 2023-12-15 | |
| Study Evaluating the Safety and Efficacy of PTX-022 (QTORIN Sirolimus) in the Treatment of Microcystic Lymphatic Malformations PTX-022 - Microcystic Lymphatic Malformation | Phase 2 | Completed | Palvella Therapeutics, Inc. | 12 | 2022-01-13 | 2025-01-17 |
| Bleomycin as an Effective and Curative Adjunct Therapy for Lymphangioma Sclerotherapy with intralesional bleomycin injection - Lymphangioma, Lymphatic Malformations | Completed | National Children's Hospital, Vietnam | 809 | 2018-01-01 | 2025-04-24 | |
| A Study to Evaluate Sildenafil for the Treatment of Lymphatic Malformations Sildenafil - Lymphangioma | Phase 1 / Phase 2 | Completed | Stanford University | 7 | 2010-12-01 | 2015-06-19 |
| Safety and Efficacy Study of Sirolimus in Complicated Vascular Anomalies sirolimus - Kaposiform Hemangioendotheliomas, Tufted Angioma | Phase 2 | Completed | Denise Martin Adams | 61 | 2009-10-01 | 2026-01-06 |
| Clinical Characteristics of Lymphatic Malformations Compare the epidemiological characteristics, clinical presentations, surgical treatments and risk factors for preoperative complications of ALMs between paediatric and adult participants. - Lymphatic Malformation, Lymphangioma | Completed | West China Hospital | 320 | 2009-01-01 | 2024-02-14 | |
| Study of Picibanil (OK432) Sclerotherapy in Children With Macrocystic Lymphatic Malformations picibanil - Lymphatic Malformations | Phase 2 / Phase 3 | Completed | University of Iowa | 150 | 2000-04-01 | 2015-03-25 |
| Compassionate Use of BYL 719 Alpelisib Alpelisib - Lymphangioma | No longer available | New Mexico Cancer Research Alliance | 2024-01-11 |
Lymphatic Abnormalities (9) · Lymphangioma, Cystic (6) · Vascular Malformations (5) · Arteriovenous Malformations (2) · Hemangioma (2) · Abdomen, Acute (1) · Branchial Cleft Anomalies (1) · Branchioma (1) · Chondrosarcoma, Extraskeletal Myxoid (1) · Congenital Abnormalities (1) · Hemangioendothelioma (1) · Lipoma (1) · Lymphadenitis (1) · Nevus (1)
Neoplasm, Lymphatic Tissue (16) · Neoplasms (16) · Neoplasms by Histologic Type (16) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (11) · Hemic and Lymphatic Diseases (11) · Congenital Abnormalities (10) · Lymphatic Diseases (10) · Cardiovascular Abnormalities (5) · Cardiovascular Diseases (5) · Neoplasms, Vascular Tissue (2) · Vascular Diseases (2) · Abdominal Pain (1) · Blood Platelet Disorders (1) · Cysts (1)
Alpelisib (3) · Sirolimus (2) · Everolimus (1) · Injections, Intralesional (1) · Picibanil (1) · Risk Factors (1) · Sclerotherapy (1) · Sildenafil Citrate (1) · Surgical Procedures, Operative (1) · Tablets (1) · mirdametinib (1)
Delta University for Science and Technology (2) · Palvella Therapeutics, Inc. (2) · Sohag University (2) · Denise Martin Adams (1) · Fondazione Policlinico Universitario Agostino Gemelli IRCCS (1) · Murdoch Childrens Research Institute (1) · National Children's Hospital, Vietnam (1) · New Mexico Cancer Research Alliance (1) · Novartis Pharmaceuticals (1) · Stanford University (1) · University of Iowa (1) · West China Hospital (1) · Yonsei University (1)
United States (7) · Egypt (4) · Australia (2) · Italy (2) · Argentina (1) · Belgium (1) · China (1) · Czechia (1) · France (1) · Germany (1) · Netherlands (1) · Spain (1) · Switzerland (1) · United Kingdom (1) · Vietnam (1)
Alfred T Lane, MD (1) · Chiara Leoni (1) · Denise M Adams, MD (1) · Gamal El-Tagy, MD (1) · Ian Rabinowitz, MD (1) · Joyce Teng (1) · Lydia Pathmanathan, MBBS, FRACP. (1) · Mohamad Zaki Ali, MD (1) · Quang T Nguyen, M.D. (1) · Richard J Smith (1) · Stephen Luen, MBChB, FRACP. (1) · Tony Penington, MBBS, FRACS. (1) · Yi Ji, Ph.D. (1)
PMID 11527161, PMID 16418953, PMID 19117316, PMID 19407619, PMID 20843632, PMID 24656411, PMID 25682445, PMID 29456959, PMID 29928081, PMID 30672136, PMID 32139985, PMID 33059994, PMID 33625132, PMID 35787784, PMID 35852876, PMID 39044220
2023 (1), UL1TR000093 (1)