19 completed, 14 recruiting, 6 not yet recruiting, 4 terminated. 13 Phase 1, 11 Not applicable, 9 Phase 2, 1 Early Phase 1, 1 Phase 3.
Follow Lupus: new trials by email Literature Review of Lupus trials Research Report on Lupus
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| CRISPR-Edited Allogeneic Anti-CD19 CAR-T Cell Therapy, in Patients With Refractory Systemic Lupus Erythematosus (GALLOP) CB-010 - Systemic Lupus Erythematosus, Lupus | Phase 1 | Withdrawn | Caribou Biosciences, Inc. | 2027-12-01 | 2025-09-19 | |
| Teams Engaged in Accessible Mental Health Interventions for Lupus Erythematosus and Dermatomyositis Stress TEAM-LEADS - Lupus, Dermatomyositis, Juvenile | Not applicable | Not yet recruiting | Duke University | 25 | 2027-02-01 | 2026-05-27 |
| Exploring Biological Mechanisms Underlying the TEACH Intervention for Adolescents With Lupus TEACH - Lupus | Not applicable | Not yet recruiting | The Hospital for Sick Children | 20 | 2026-12-01 | 2026-10-13 |
| Safety of Cultured Allogeneic Adult Umbilical Cord or Placental Derived Mesenchymal Stem Cell Intravenous Infusion for Lupus cultured allogeneic adult umbilical cord or placental derived mesenchymal stem cells - Lupus | Phase 1 | Recruiting | The Foundation for Orthopaedics and Regenerative Medicine | 15 | 2026-12-01 | 2026-10-20 |
| Evaluating the Safety and Tolerability of Baricitinib in Patients With Job Syndrome With Lupus-Like Disease and/or Atopic Dermatitis baricitinib - Hyper IgE Syndrome From STAT3 Mutation, Job s Syndrome | Phase 1 | Recruiting | National Institute of Allergy and Infectious Diseases (NIAID) | 20 | 2026-11-17 | 2026-11-12 |
| Cardiac Imaging in Systemic Disorders: the ORACLES Registry data collection - Lupus | Not yet recruiting | Assistance Publique - Hôpitaux de Paris | 1500 | 2026-11-01 | 2026-02-13 | |
| Biopsychosocial Risk Influences on the Development and Generation of Early-Onset Chronic Pain Not applicable- observational study - Juvenile Idiopathic Arthritis (JIA), Fibromyalgia | Recruiting | Children's Hospital Medical Center, Cincinnati | 600 | 2026-10-01 | 2026-10-16 | |
| Safety and Efficacy of ONT01 in Lupus ONT01 is a small molecule CD11b modulator. - Lupus Nephritis (LN), Lupus Nephritis - WHO Class III | Early Phase 1 | Recruiting | Hospital for Special Surgery, New York | 61 | 2026-09-04 | 2025-11-20 |
| Inflammatory Disease Biobank for Immunophenotyping and Cardiovascular Research Pericarditis, Tako-TSUBO Cardiomyopathy | Not yet recruiting | Assistance Publique - Hôpitaux de Paris | 300 | 2026-09-01 | 2026-08-10 | |
| Pain-Sleep in Rheumatic Disease Better Nights, Better Days for Youth - Rheumatic Diseases, Arthritis | Not applicable | Not yet recruiting | The Hospital for Sick Children | 43 | 2026-09-01 | 2026-08-20 |
| A Study to Evaluate Mosunetuzumab in Participants With Systemic Lupus Erythematosus With or Without Active Lupus Nephritis Mosunetuzumab - Lupus, Systemic Lupus Erythematosus | Phase 2 | Recruiting | Hoffmann-La Roche | 30 | 2026-05-25 | 2026-10-19 |
| Complete Cognitive Intervention for cSLE Lupus Teen Online Problem Solving program - Lupus | Not applicable | Recruiting | Andrea Knight | 60 | 2026-01-15 | 2026-05-01 |
| Helping Lupus Patients Manage Fibromyalgia Symptoms Through Emotional Awareness and Expression Therapy (EAET) Emotional Awareness and Expression Therapy (EAET) - Lupus, Fibromyalgia (FM) | Not applicable | Recruiting | University of Utah | 30 | 2025-12-01 | 2025-12-29 |
| The Burden of Lupus in Canada From a Patient Perspective: A Canadian Real-World PROxy Study No Intervention: Observational Cohort - Lupus, Lupus Arthritis | Completed | PeriPharm | 88 | 2025-11-03 | 2026-01-29 | |
| CD19-Directed Chimeric Antigen Receptor Autologous T Cells (CART19) for Lupus CART19 - SLE, Systemic Lupus Erythematosus (SLE) | Phase 1 / Phase 2 | Recruiting | Children's Hospital of Philadelphia | 24 | 2025-05-06 | 2026-09-24 |
| Direct to Patient Minimal Risk Biospecimen and Data Collection Research Observation - Healthy, Lupus | Recruiting | Joined Bio | 100000 | 2025-04-01 | 2026-05-05 | |
| UC-MSC Cell Therapy Study for Systemic Lupus Erythematosus (SLE) Patients Physical examination, Electrocardiogram, SF-36 questionnaire - SLE, Lupus | Phase 1 | Recruiting | LiveKidney.Bio | 10 | 2025-01-07 | 2025-09-11 |
| Ultrasonic COmparison of Salivary Glands in Autoimmune Diseases (COUGAR) Sjogren Syndrome, Dry Syndrome | Not yet recruiting | University Hospital, Brest | 501 | 2024-12-01 | 2024-11-08 | |
| S100A8 in Serum and Urine as a New Biomarker in Lupus Nephritis S100A8, Serum | Completed | Theodor Bilharz Research Institute | 70 | 2024-11-01 | 2025-05-21 | |
| Phase I/II Study of AD-PluReceptor Plus Tafasitamab-cxix and Lymphodepleting Chemotherapy in Patients With Autoimmune Disorders Tafasitamab, Fludarabine phosphate, Cyclophosphamide - Autoimmune Disorders, Systemic Sclerosis | Phase 1 / Phase 2 | Recruiting | M.D. Anderson Cancer Center | 47 | 2024-07-31 | 2026-11-03 |
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Lupus Erythematosus, Systemic (19) · Lupus Nephritis (6) · Arthritis, Juvenile (5) · Autoimmune Diseases (5) · Arthritis, Psoriatic (4) · Arthritis, Rheumatoid (4) · Scleroderma, Systemic (4) · Anxiety Disorders (3) · Celiac Disease (3) · Chronic Pain (3) · Depression (3) · Fatigue (3) · Fatigue Syndrome, Chronic (3) · Fibromyalgia (3) · Multiple Sclerosis (3)
Immune System Diseases (31) · Skin and Connective Tissue Diseases (29) · Connective Tissue Diseases (27) · Autoimmune Diseases (23) · Musculoskeletal Diseases (14) · Skin Diseases (13) · Pathological Conditions, Signs and Symptoms (10) · Female Urogenital Diseases (9) · Female Urogenital Diseases and Pregnancy Complications (9) · Joint Diseases (9) · Nervous System Diseases (9) · Urogenital Diseases (9) · Male Urogenital Diseases (8) · Muscular Diseases (8) · Neuromuscular Diseases (8)
sifalimumab (3) · deucravacitinib (2) · AMG 557 (1) · Aspirin (1) · Azathioprine (1) · CTL019 chimeric antigen receptor (1) · Cholecalciferol (1) · Cognitive Behavioral Therapy (1) · Coping Skills (1) · Cyclophosphamide (1) · Data Collection (1) · Dehydroepiandrosterone (1) · Electrocardiography (1) · Famotidine (1) · Folic Acid (1)
Bristol-Myers Squibb (4) · MedImmune LLC (3) · National Institute of Allergy and Infectious Diseases (NIAID) (3) · Amgen (2) · Assistance Publique - Hôpitaux de Paris (2) · Brigham and Women's Hospital (2) · Centre Hospitalier Universitaire Dijon (2) · The Hospital for Sick Children (2) · Andrea Knight (1) · Brain Inflammation Collaborative (1) · Cairo University (1) · Caribou Biosciences, Inc. (1) · Children's Hospital Medical Center, Cincinnati (1) · Children's Hospital of Philadelphia (1) · Duke University (1)
United States (33) · Canada (5) · France (5) · Argentina (4) · Brazil (3) · Mexico (3) · Netherlands (3) · Chile (2) · Colombia (2) · Egypt (2) · Germany (2) · Italy (2) · Poland (2) · Romania (2) · South Africa (2)
Warren Greth, M.D. (2) · Alexandra F Freeman, M.D. (1) · Andrea Knight, MD, MSCE (1) · Bao Chun De (1) · Barbara White, M.D. (1) · Brian M Everist, MD (1) · Busi Zapparoli, PhD (1) · Caitlin Elgarten, MD (1) · Candace H Feldman, MD, MPH, ScD (1) · Chadwick Prodromos, MD (1) · Chitra Hosing, MD (1) · Chris Ianelli, MD (1)
PMID 21798883, PMID 33687069, PMID 16208639, PMID 18634158, PMID 19479852, PMID 23400715, PMID 23754736, PMID 25777546, PMID 28118537, PMID 35483736, PMID 35788493, PMID 35816681, PMID 41712512, PMID 42309556, PMID 42641149
2014 (1), 2017 (1), K23AR084475 (1), P60AR047782 (1), P60AR049459 (1), UC2AR086503 (1), UM1AI110494 (1)