16 recruiting, 11 completed, 11 not yet recruiting, 4 enrolling by invitation. 30 Not applicable, 1 Early Phase 1, 1 Phase 2, 1 Phase 3.
Follow Lung Cancer Screening: new trials by email Literature Review of Lung Cancer Screening trials Research Report on Lung Cancer Screening
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Increasing Lung Cancer Screening Among Emergency Department Patients - LCS R01 Basic Referral, Facilitated Referral, Text Messaging - Smoking History, Current Smoker | Not applicable | Not yet recruiting | University of Rochester | 1036 | 2027-03-01 | 2026-05-05 |
| Multiparametric Lung MRI With Diffusion-Weighted Imaging in Lung-RADS 4 Lesion Characterization Multiparametric chest MRI with diffusion-weighted imaging - Solitary Pulmonary Nodule, Multiple Pulmonary Nodules | Not yet recruiting | University of Florida | 30 | 2027-01-01 | 2026-08-19 | |
| C-Raven LDCT: Lung Cancer Screening Intervention Video/Brochure, Video/Brochure/Follow-up Call - Lung Cancer Screening | Not applicable | Not yet recruiting | Johns Hopkins University | 300 | 2026-10-15 | 2026-09-14 |
| ICARE-LCS QUERI Partnered Evaluation Initiative: Integrating Comprehensive Tobacco Treatment to Enhance Lung Cancer Screening External Facilitation - Tobacco Dependence Treatment, Lung Cancer Screening | Not yet recruiting | VA Office of Research and Development | 7 | 2026-10-01 | 2026-05-26 | |
| Empowering Patients' Lung Cancer Screening Uptake (Empower LCS/Call+) Empower LCS, Call+ Telephone Navigation, Usual Care - Lung Cancer Screening, Lung Neoplasms | Not applicable | Recruiting | University of California, Irvine | 80 | 2026-09-16 | 2026-09-21 |
| Assessing the Effectiveness of Low-Dose Computed Tomography in Lung Cancer Screening for High-Risk Smokers: A Randomized Controlled Trial in Hong Kong Low-dose computed tomography (LDCT) - Lung Cancer, Lung Cancer Screening | Not applicable | Not yet recruiting | The University of Hong Kong | 15000 | 2026-07-01 | 2026-03-17 |
| Pilot Testing a Web-based Prototype of a Lung Cancer Screening Digital Health Tool Digital health tool prototype, Control Arm - standard of care - Lung Cancer Screening | Not applicable | Enrolling by invitation | Rutgers, The State University of New Jersey | 500 | 2026-06-01 | 2026-07-21 |
| Prediction Augmented Screening Initiative PCP-Facing Tools, LCS team population management tools - Lung Cancer, Lung Cancer Screening | Not applicable | Recruiting | VA Office of Research and Development | 23520 | 2026-06-01 | 2026-06-26 |
| ctDNA Mutations and Methylation Status for Early Detection of Lung Cancer in Patients With Suspicious Lung Nodules ctDNA mutations and methylation with SPOTMAS Lung assays, Non-contrast LDCT Thorax scans - Lung Nodules, Lung Cancer Screening | Not yet recruiting | The University of Hong Kong | 200 | 2026-06-01 | 2026-06-08 | |
| Community-Based Engagement to Improve Lung Cancer Screening and Outcomes: The "Our Lungs Our Health" Study Low-Dose Computed Tomography Scan - Lung Cancer Screening | Not applicable | Not yet recruiting | Brigham and Women's Hospital | 125 | 2026-05-01 | 2025-12-08 |
| Lung Cancer Screening for Early Detection of Suspicious Lung Nodules in Latin America(LUCAS-LATAM) Chest X-Ray, Low Dose CT scan - Lung Cancer Screening | Not yet recruiting | Latin American Consortium for the Lung Cancer Research | 2000 | 2026-05-01 | 2026-04-13 | |
| Facilitation of Information eXchange for Shared Decision Making for Lung Cancer Screening FIX-SDM, Usual Care - Lung Cancer Screening | Not applicable | Enrolling by invitation | University of Massachusetts, Worcester | 120 | 2026-04-07 | 2026-08-07 |
| LUNG-07: Advancing Precision-Based Lung Cancer Screening: Implementation, AI-Guided Risk Stratification, and Biomarker Integration (CREST AI) Sybil Artificial Intelligence (AI) screening - Lung Cancer Screening | Not applicable | Recruiting | University of Illinois at Chicago | 2500 | 2026-03-12 | 2026-08-06 |
| Statewide Optimization of Lung Cancer Screening Utilizing the QUILS™ System in Nevada and Mississippi: State-Based Initiative Component QUILS SBI Intervention - Lung Cancer Screening | Not applicable | Recruiting | Timothy Mullett | 200 | 2026-03-01 | 2026-07-06 |
| Advancing Lung Cancer Screening One Text at a Time Text messaging program, Educational material - Lung Cancer Screening | Not applicable | Recruiting | University of Rochester | 40 | 2026-02-17 | 2026-02-19 |
| Centralized Lung Cancer Screening Engagement in At-Risk Populations Centralized patient outreach for lung cancer screening - Lung Cancer Screening | Not applicable | Enrolling by invitation | Weill Medical College of Cornell University | 2000 | 2025-10-15 | 2025-12-10 |
| Methylated Biomarkers of Smoking as a Selection Tool in Participants for Lung Cancer Screening DNA-methylation in saliva - Epigenetics, DNA Methylation | Not applicable | Recruiting | University Hospital, Antwerp | 1000 | 2025-10-04 | 2026-06-08 |
| Akershus Cardiac Examination (ACE) 5 Study Lung Cancer Screening Plus Program, Standard of Care - Heavy Smokers, Lung Cancer Screening | Not applicable | Recruiting | University Hospital, Akershus | 1000 | 2025-10-01 | 2025-12-24 |
| Validation of the SPOT-MAS Lung Test Using Circulating Tumor DNA for the Detection of Lung Cancer Lung Diseases, Lung Cancer Screening | Not yet recruiting | Gene Solutions | 1184 | 2025-08-18 | 2025-08-17 | |
| Evaluating the Impact of CONNECT in a Multilingual Population CONNECT Intervention for multilingual populations, Saliva Sample, Interview - Smoking Cessation, Smoking Cessation Counseling Ability and Practice | Not applicable | Recruiting | University of California, San Francisco | 439 | 2025-08-07 | 2026-08-13 |
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Lung Neoplasms (16) · Smoking Cessation (7) · Smoking (5) · Tobacco Smoking (2) · Tobacco Use (2) · Atherosclerosis (1) · Cigarette Smoking (1) · Emergencies (1) · Lung Diseases (1) · Multiple Pulmonary Nodules (1) · Patient Participation (1) · Pulmonary Disease, Chronic Obstructive (1) · Solitary Pulmonary Nodule (1) · Tobacco Use Disorder (1)
Respiratory Tract Diseases (17) · Lung Diseases (16) · Neoplasms (16) · Neoplasms by Site (16) · Respiratory Tract Neoplasms (16) · Thoracic Neoplasms (16) · Behavior (12) · Health Behavior (8) · Disease Attributes (2) · Pathologic Processes (2) · Pathological Conditions, Signs and Symptoms (2) · Tobacco Use (2) · Arterial Occlusive Diseases (1) · Arteriosclerosis (1) · Cardiovascular Diseases (1)
Standard of Care (2) · Surveys and Questionnaires (2) · Tomography, X-Ray Computed (2) · Blood Specimen Collection (1) · DNA Methylation (1) · Decision Support Techniques (1) · Diagnostic Imaging (1) · Diffusion Magnetic Resonance Imaging (1) · Drug Delivery Systems (1) · Educational Status (1) · Focus Groups (1) · Interviews as Topic (1) · Mass Screening (1) · Methylation (1) · Patient Education as Topic (1)
VA Office of Research and Development (4) · Timothy Mullett (3) · M.D. Anderson Cancer Center (2) · Memorial Sloan Kettering Cancer Center (2) · Scientific Institute San Raffaele (2) · The University of Hong Kong (2) · University of Illinois at Chicago (2) · University of Rochester (2) · Assistance Publique - Hôpitaux de Paris (1) · Assiut University (1) · Biobizkaia Health Research Institute (1) · Boston University (1) · Brigham and Women's Hospital (1) · Centre Hospitalier d'Abbeville (1) · Dana-Farber Cancer Institute (1)
United States (28) · Italy (3) · Belgium (2) · France (2) · Hong Kong (2) · Canada (1) · Colombia (1) · Costa Rica (1) · Egypt (1) · Finland (1) · Israel (1) · Latvia (1) · Norway (1) · Spain (1) · Vietnam (1)
Robert Volk, PHD (2) · Aimee S James, Ph.D., MPH (1) · Alana Rojewski, PhD (1) · Alejandra Ellison-Barnes, MD, MPH (1) · Alexis Chidi, MD, PhD (1) · Aliae Mohamed-Hussein, MD (1) · Alvils Krams, MD (1) · Anne C. Melzer, MD MS (1) · Annemiek Snoeckx, MD, PhD (1) · Arnon Makori, MD (1) · Benjamin Toll, PhD (1) · Bradley B Pua, MD (1) · David Vicente-Baz, MD (1) · Dennis KM Ip, MD (1) · Gelareh Sadigh (1)
PMID 32184197, PMID 33554740, PMID 33868901, PMID 33964415, PMID 34077535, PMID 34540821, PMID 35143041, PMID 35448154, PMID 35818122, PMID 35818125, PMID 35997854, PMID 36270476, PMID 36427394, PMID 36600392, PMID 36788585, PMID 37550304, PMID 37602818, PMID 37647070, PMID 38467273, PMID 39070744, PMID 40153794, PMID 40939933, PMID 41333381, PMID 42082236, PMID 42482048, PMID 42574003, PMID 42846115
I01CX002686 (1), K08CA283304 (1), R01CA207228 (1), R01CA207229 (1), R01MD019690 (1)