37 completed, 23 unknown, 10 recruiting, 8 not yet recruiting. 36 Not applicable, 4 Phase 2, 2 Early Phase 1, 2 Phase 1, 2 Phase 3.
Follow Solitary Pulmonary Nodule: new trials by email Literature Review of Solitary Pulmonary Nodule trials Research Report on Solitary Pulmonary Nodule
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Multiparametric Lung MRI With Diffusion-Weighted Imaging in Lung-RADS 4 Lesion Characterization Multiparametric chest MRI with diffusion-weighted imaging - Solitary Pulmonary Nodule, Multiple Pulmonary Nodules | Not yet recruiting | University of Florida | 30 | 2027-01-01 | 2026-08-19 | |
| Radiomics for Distinguishing Benign and Malignant Lung Nodules Solitary Pulmonary Nodule, Lung Neoplasms | Not yet recruiting | Assiut University | 255 | 2026-10-01 | 2026-10-01 | |
| Iriscope for the Diagnosis of Peripheral Pulmonary Lesions: a Multicentre Randomised Controlled Trial Use of Iriscope via guide sheath to guide biopsies, Bronchoscopy - Lung Nodule, Solitary, Lung Nodule | Not applicable | Not yet recruiting | Erasme University Hospital | 140 | 2026-09-01 | 2026-09-01 |
| ICG Fluorescence Versus CO₂ Inflation-Deflation for Intersegmental Plane Identification During Thoracoscopic Segmentectomy Indocyanine Green Fluorescence Imaging, Carbon Dioxide Inflation-Deflation - Pulmonary Nodule, Solitary | Not applicable | Not yet recruiting | Tongji Hospital | 50 | 2026-07-15 | 2026-08-04 |
| Intraoperative Longitude-Latitude-Depth Localization Versus Preoperative CT-Guided Percutaneous Lung Puncture Localization for 0.8-2 cm Peripheral Pulmonary Nodules Longitude-Latitude-Depth Localization, CT-Guided Percutaneous Lung Puncture Localization - Pulmonary Nodule, Solitary, Peripheral Pulmonary Nodules | Not applicable | Recruiting | Qilu Hospital of Shandong University | 274 | 2026-07-01 | 2026-10-01 |
| Smoking Cessation Before Bronchoscopy or CT-guided Puncture Pulmonary Nodule, Solitary, Smoking Behaviors | Recruiting | RWTH Aachen University | 25 | 2026-01-01 | 2026-01-28 | |
| An Exploratory Clinical Study on the Safety and Efficacy of Autologous NK Cells in the Treatment of Pulmonary Nodules KN5001 - Pulmonary Nodules, Solitary, Pulmonary Nodules, Multiple | Early Phase 1 | Recruiting | The First Affiliated Hospital with Nanjing Medical University | 24 | 2025-09-20 | 2025-12-01 |
| iNod™ Ultrasound-Guided Needle Biopsy System Study iNod™ System - Solitary Pulmonary Nodule, Multiple Pulmonary Nodules | Not applicable | Withdrawn | Boston Scientific Corporation | 2025-01-01 | 2024-03-08 | |
| A Prospective, Non-interventional Cohort Study of Subsolid Pulmonary Nodules Solitary Lung Nodule, Multiple Pulmonary Nodules | Not yet recruiting | Guangdong Provincial People's Hospital | 1184 | 2024-12-01 | 2024-12-02 | |
| Robotic Versus Electromagnetic Bronchoscopy for Pulmonary LesIon AssessmeNT Using Integrated Intraprocedural Imaging Robotic assisted bronchoscopy (RAB), Electromagnetic navigation bronchoscopy (ENB) - Peripheral Pulmonary Lesion, Lung Nodule, Solitary | Not applicable | Active not recruiting | Vanderbilt University Medical Center | 440 | 2024-11-11 | 2025-10-20 |
| Differentiation of Benign and Malignant Pulmonary Nodules by Volatile Organic Compounds in Human Exhaled Breath Gas chromatography-mass spectrometry(GC-MS) and micro Gas Chromatography-photoionisation detector (μGC-PID) system - Pulmonary Nodules, Multiple, Pulmonary Nodules, Solitary | Recruiting | ChromX Health | 3000 | 2024-06-30 | 2025-12-24 | |
| Non-Invasive Malignancy Classifiers Using Blood-Biomarkers for Lung Nodule Evaluation Blood tests - Lung Cancer (Diagnosis), Nodule, Solitary Pulmonary | Recruiting | Herlev and Gentofte Hospital | 1800 | 2024-05-22 | 2026-06-03 | |
| A Trial to Compare Robotic Assisted Bronchoscopy Ion's Clinical Utility for Peripheral Lung Nodule Access and Diagnosis to ENB Ion Endoluminal System, superDimension Navigation System and Accessories - Pulmonary Nodule, Solitary, Lung Cancer | Not applicable | Active not recruiting | Intuitive Surgical | 354 | 2024-03-20 | 2026-06-08 |
| Assessment of a Radiomics-based Computer-Aided Diagnosis Tool for Pulmonary nodulES Optellum Virtual Nodule Clinic - Lung Cancer, Pulmonary Nodule, Solitary | Not applicable | Recruiting | Abramson Cancer Center at Penn Medicine | 300 | 2024-01-09 | 2026-06-02 |
| LungVision AI-Augmented Fluoroscopic Navigation for Intraoperative Pulmonary Nodule Localization LungVision System, Preoperative Dual Localization - Lung Neoplasms, Pulmonary Nodule, Solitary | Not applicable | Completed | Tri-Service General Hospital (TSGH) | 14 | 2024-01-01 | 2026-07-02 |
| AI Assisted Detection of Chest X-Rays Cases reading, Ground truthing - Pulmonary Nodules, Solitary, Pulmonary Nodules, Multiple | Completed | Oxford University Hospitals NHS Trust | 33 | 2023-10-31 | 2025-11-24 | |
| Benign/Malignant Pulmonary Nodule Classification Based on High-throughput Whole-genome Methylation Sequencing(GM-seq) Whole-genome Methylation Sequencing(GM-seq) - Pulmonary Nodule, Solitary, Whole-genome Methylation Sequencing | Completed | Geneplus-Beijing Co. Ltd. | 158 | 2023-07-01 | 2025-09-04 | |
| Comprehensive Prospective Comparison Of Two Robotic Platforms In Anatomical Lung Resections: Clinical Outcomes And Cost-utility Analysis da Vinci Xi Surgical System, Versius Surgical System - Pulmonary Nodule, Solitary, Lung Cancer (NSCLC) | Active not recruiting | Fundacion para la Investigacion Biomedica del Hospital Universitario Ramon y Cajal | 150 | 2023-04-01 | 2026-04-17 | |
| DOLCE: Determining the Impact of Optellum's Lung Cancer Prediction Solution AI (Artificial Intelligence), Pulmonary Nodule, Solitary | Recruiting | Nottingham University Hospitals NHS Trust | 2000 | 2023-03-23 | 2025-04-08 | |
| Multi-Reader Retrospective Study Examining Carebot AI CXR 2.0.21-v2.01 Implementation in Everyday Radiology Clinical Practice Carebot AI CXR - Pneumothorax, Pulmonary Nodule, Solitary | Completed | Carebot s.r.o. | 956 | 2022-10-18 | 2026-06-03 |
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Lung Neoplasms (40) · Multiple Pulmonary Nodules (36) · Carcinoma, Non-Small-Cell Lung (6) · Disease (4) · Neoplasms (3) · Pulmonary Atelectasis (3) · Breast Neoplasms (2) · Cardiomegaly (2) · Cigarette Smoking (2) · Kidney Neoplasms (2) · Pleural Effusion (2) · Pneumothorax (2) · Smoking (2) · Adenocarcinoma of Lung (1)
Lung Diseases (92) · Respiratory Tract Diseases (92) · Neoplasms by Site (63) · Respiratory Tract Neoplasms (62) · Thoracic Neoplasms (62) · Neoplasms (61) · Lung Neoplasms (22) · Bronchial Neoplasms (6) · Pathologic Processes (6) · Pathological Conditions, Signs and Symptoms (6) · Carcinoma, Bronchogenic (5) · Behavior (4) · Cardiovascular Diseases (3) · Digestive System Diseases (3) · Neoplasms by Histologic Type (3)
Indocyanine Green (3) · Anterior Temporal Lobectomy (2) · Oxygen (2) · 4-(3-fluoropropyl)glutamic acid (1) · 4-fluoroglutamine (1) · Anti-Bacterial Agents (1) · Blood Specimen Collection (1) · Bronchoscopy (1) · Carbon Dioxide (1) · Chest Tubes (1) · Defecation (1) · Diagnostic Imaging (1) · Diffusion Magnetic Resonance Imaging (1) · Drug Delivery Systems (1) · Fluorodeoxyglucose F18 (1)
Beijing Aerospace General Hospital (2) · Biodesix, Inc. (2) · Boston Scientific Corporation (2) · Chinese Alliance Against Lung Cancer (2) · Erasme University Hospital (2) · Fresh Medical Laboratories (2) · Guangdong Provincial People's Hospital (2) · Intuitive Surgical (2) · Peking University People's Hospital (2) · Seoul National University Hospital (2) · The First Affiliated Hospital with Nanjing Medical University (2) · Tongji Hospital (2) · Veran Medical Technologies (2) · Wen-zhao ZHONG (2) · Abramson Cancer Center at Penn Medicine (1)
United States (27) · China (26) · United Kingdom (4) · Canada (3) · Netherlands (3) · Taiwan (3) · Belgium (2) · France (2) · Germany (2) · Australia (1) · Colombia (1) · Czechia (1) · Denmark (1) · Italy (1) · Puerto Rico (1)
Jianxing He, MD (2) · Alexander Chen, MD (1) · Anand Rose (1) · Blandine Jelli (1) · Changli Wang, Prof (1) · Chirayu Shah, MD (1) · Chiu-kuei Nien (1) · Christopher G. Slatore, MD MS (1) · Chunxue Bai, M.D, Ph.D (1) · Chunxue Bai, MD (1) · David M DiBardino, MD (1) · Dirk-Jan Slebos, MD PhD (1) · Douglas W Johnson, MD (1) · Elien Derveaux, dr. (1) · Ertan Pamuklar, MD (1)
PMID 14615902, PMID 15511470, PMID 16554568, PMID 17923508, PMID 18773240, PMID 19018537, PMID 20417792, PMID 20851940, PMID 23673455, PMID 23900983, PMID 26135833, PMID 26466180, PMID 27207315, PMID 28240562, PMID 28331824, PMID 28392613, PMID 28392615, PMID 2868172, PMID 28825886, PMID 29622070, PMID 29627067, PMID 30567584, PMID 35399240, PMID 35509435, PMID 36087843, PMID 37356710, PMID 37432960, PMID 37868257, PMID 38176863, PMID 39146624, PMID 39341207, PMID 39812961, PMID 40518364, PMID 40688277, PMID 40885487, PMID 41336287, PMID 41338713, PMID 41588450, PMID 41831027, PMID 42714956
P30CA068485 (1), R21CA216780 (1), U01AI123832 (1)