95 completed, 56 unknown, 52 recruiting, 22 terminated. 82 Phase 2, 68 Not applicable, 40 Phase 1, 36 Phase 3, 2 Early Phase 1.
Follow Liver Metastases: new trials by email Literature Review of Liver Metastases trials Research Report on Liver Metastases
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Therapeutic Efficacy and Safety of Ultrasound-Guided Microwave Ablation for Hepatic Metastatic Nodules Ultrasound-Guided Microwave Ablation - Liver Metastases, Hepatic Metastases | Not applicable | Not yet recruiting | Assiut University | 30 | 2026-11-01 | 2026-10-13 |
| End Hole vs. Pressure-Modulated Delivery of Y-90 Resin Microspheres to Liver Metastases. The TriNav Infusion Systems, Standard End Hole Microcatheter - Liver Metastases, Tumor | Not applicable | Not yet recruiting | Stanford University | 65 | 2026-11-01 | 2026-08-28 |
| Intestinal Low-Dose Radiotherapy Combined With Immune Checkpoint Inhibitors in Solid Tumors With Liver Metastases Intestinal Low-Dose Radiotherapy (ILDR), PD-1/PD-L1 inhibitors, Combined Chemotherapy - Liver Metastases, Non-Small Cell Lung Cancer | Phase 2 | Not yet recruiting | Bing Xia | 120 | 2026-10-01 | 2026-10-15 |
| SAMe in Prevention of Oxaliplatin-associated Liver Injury Standard of care oxaliplatin-based chemotherapy, S-adenosylmethionine (SAMe) supplement, Surgery - Colorectal Cancer, Liver Metastases | Phase 2 | Not yet recruiting | Cedars-Sinai Medical Center | 30 | 2026-10-01 | 2026-09-30 |
| Hepzato Kit and Opdualag for Metastatic Melanoma and Liver Metastasis Nivolumab and Relatlimab, Melphalan - Metastatic Melanoma, Liver Metastases | Phase 1 / Phase 2 | Recruiting | University of Wisconsin, Madison | 15 | 2026-10-01 | 2026-09-29 |
| Local Ablation Plus Systemic Therapy for Metachronous Liver and/or Lung Oligometastases From Nasopharyngeal Carcinoma CT-guided percutaneous local ablation, Gemcitabine, Cisplatin - Nasopharyngeal Carcinoma, Neoplasm Metastasis | Phase 2 | Not yet recruiting | Sun Yat-sen University | 138 | 2026-10-01 | 2026-09-17 |
| Non-Contrast Versus Contrast-Enhanced MRI in Colorectal Liver Metastases Liver Metastases, Liver Neoplasms | Not yet recruiting | Assiut University | 40 | 2026-09-27 | 2026-10-05 | |
| Neoadjuvant Dupilumab and Toripalimab in MSS CRC Subjects With Resectable Liver Metastases Dupilumab, Toripalimab - Metastatic Colorectal Cancer, Liver Metastases | Phase 1 / Phase 2 | Recruiting | Dan Feng | 24 | 2026-09-01 | 2026-08-12 |
| Radiogenomic Profiling of Dendritic Cells and Macrophages to Predict Recurrence in Colorectal Liver Metastasis Radiogenomic and Immune Profiling, Prospective Radiogenomic and ctDNA Profiling - Colo-rectal Cancer, Liver Metastases | Not yet recruiting | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | 210 | 2026-09-01 | 2026-08-06 | |
| CT Volumetry and Hepatic Vascular Deformation Mapping to Predict Post-Hepatectomy Liver Failure Preoperative CT volumetry with hepatic vascular deformation mapping (VDM) - Post-Hepatectomy Liver Failure, Liver Failure | Recruiting | Minia University | 1070 | 2026-08-15 | 2026-08-18 | |
| China Metastatic Liver Cancer Clinical Registry Cohort Database Standard of Care for Metastatic Liver Cancer - Liver Metastases, Metastases to Liver | Recruiting | Anhui Provincial Hospital | 2000 | 2026-06-01 | 2026-05-22 | |
| Outcomes After Liver and Biliary Resection at a High-Volume Center Liver Neoplasms, Hepatobiliary Diseases | Not yet recruiting | Azienda USL Toscana Centro | 1000 | 2026-04-01 | 2026-04-29 | |
| EUS-guided CTCs + Multi-omics: Predicting Pancreatic Cancer Recurrence and Metastases CTC - CTCs, Pancreatic Cancer | Not yet recruiting | Huazhong University of Science and Technology | 20 | 2026-03-01 | 2026-03-04 | |
| An Open-Label, Single-Arm, Dose-Escalation Phase I Study Evaluating the Safety, Tolerability, and Preliminary Efficacy of EDB-102 in Patients With EGFR L858R-Mutant, Third-Generation TKI-Resistant Advanced Non-Small Cell Lung Cancer With Liver Metastases EDB-102 - Non-Small Cell Lung Cancer, Metastatic Non-small Cell Lung Cancer | Phase 1 | Not yet recruiting | Cancer Institute and Hospital, Chinese Academy of Medical Sciences | 15 | 2026-02-10 | 2026-03-10 |
| REGULUS: MRI-guided Adaptive SABR for Liver Cancers MRI-guided adaptive stereotactic ablative body radiotherapy (SABR) - Liver Cancer, Intrahepatic Cholangiocarcinoma | Phase 2 | Recruiting | Stanford University | 62 | 2026-01-23 | 2026-02-09 |
| Promoting Immunotherapy Efficacy With Low-Dose Liver RT LD-LRT - Low-Dose Liver Radiation (LD-LRT), Non Small Cell Lung Cancer | Not applicable | Recruiting | Jordan Kharofa | 21 | 2025-12-15 | 2026-02-27 |
| Histotripsy Plus Chemotherapy vs Chemotherapy Alone for Advanced Colorectal Liver Metastasis HistoSonics Edison® System, Chemotherapy - Colorectal Cancer, Liver Metastases | Not applicable | Recruiting | Case Comprehensive Cancer Center | 100 | 2025-11-19 | 2026-09-15 |
| Functional Liver After SBRT Functional liver imaging using hepatobiliary scintigraphy (HEBIS) - Liver Metastases | Recruiting | The Netherlands Cancer Institute | 15 | 2025-07-21 | 2025-08-20 | |
| HepQuant: Study to Assess the Role of Blood-based Biomarkers and Quantitative MR Imaging for Patients Receiving Radiation Therapy for Liver Cancer HepQuant DuO, Multiparametric MRI Scans - Liver Cancer, Hepatocellular Carcinoma | Not applicable | Recruiting | Montefiore Medical Center | 40 | 2025-07-16 | 2026-08-11 |
| Transarterial Chemoembolization (TACE) Plus Bevacizumab for Liver Metastases Bevacizumab - Cancer, Metastatic Cancer | Phase 1 / Phase 2 | Active not recruiting | Pardis Noor Medical Imaging and Cancer Center | 40 | 2025-06-01 | 2026-09-16 |
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Colorectal Neoplasms (103) · Liver Neoplasms (41) · Carcinoma, Hepatocellular (34) · Colonic Neoplasms (23) · Breast Neoplasms (19) · Pancreatic Neoplasms (19) · Neoplasm Metastasis (18) · Rectal Neoplasms (18) · Neoplasms (12) · Cholangiocarcinoma (11) · Melanoma (8) · Neuroendocrine Tumors (8) · Liver Diseases (6) · Stomach Neoplasms (6) · Uveal Melanoma (6)
Neoplasms (217) · Neoplasms by Site (214) · Digestive System Neoplasms (189) · Digestive System Diseases (187) · Gastrointestinal Diseases (128) · Gastrointestinal Neoplasms (126) · Intestinal Diseases (122) · Intestinal Neoplasms (122) · Colonic Diseases (119) · Rectal Diseases (118) · Neoplasms by Histologic Type (67) · Liver Diseases (57) · Neoplasms, Glandular and Epithelial (47) · Carcinoma (46) · Adenocarcinoma (40)
Oxaliplatin (21) · Bevacizumab (15) · Drug Therapy (15) · Fluorouracil (13) · Hepatectomy (12) · Radiosurgery (12) · Cetuximab (11) · Irinotecan (11) · Leucovorin (11) · Floxuridine (10) · Folfox protocol (9) · Liver Transplantation (8) · Capecitabine (7) · Ipilimumab (7) · Nivolumab (6)
Fudan University (15) · Sun Yat-sen University (7) · National Cancer Institute (NCI) (6) · Oslo University Hospital (6) · University Health Network, Toronto (6) · Amsterdam UMC, location VUmc (4) · City of Hope Medical Center (4) · European Organisation for Research and Treatment of Cancer - EORTC (4) · University of Aarhus (4) · HistoSonics, Inc. (3) · Hospital Miguel Servet (3) · Institute of Oncology Ljubljana (3) · Memorial Sloan Kettering Cancer Center (3) · Roger Williams Medical Center (3) · Stanford University (3)
United States (75) · China (42) · Netherlands (19) · Canada (17) · Germany (17) · Italy (16) · Spain (16) · Sweden (15) · Denmark (14) · France (14) · Belgium (12) · United Kingdom (9) · Austria (8) · Norway (7) · Poland (6)
Jianmin Xu, MD (3) · Bernard Nordlinger, Pr. (2) · Dorte Nielsen, Professor (2) · Guido Torzilli, MD, PhD (2) · Jeffrey Wong (2) · Jianmin Xu, MD, Ph.D. (2) · Martijn R. Meijerink, Prof. (2) · Matteo Donadon, MD, PhD (2) · Steven C Katz, MD (2) · Adrian Sacher, MD (1) · Alexander Haug, MD (1) · Alexander Kirichenko, MD, PhD (1) · Alexandra Gangi, MD (1) · Ali Zarrinpar, MD, PhD (1)
PMID 39225612, PMID 40201962, PMID 10829040, PMID 11981766, PMID 15177433, PMID 15273542, PMID 15454134, PMID 16183489, PMID 16269386, PMID 16343071, PMID 16420849, PMID 16600979, PMID 16671066, PMID 16754172, PMID 16953487, PMID 16982547, PMID 17283834, PMID 17543307, PMID 18019945, PMID 18172187, PMID 18362622, PMID 18981929, PMID 19080906, PMID 19457245, PMID 19541011, PMID 19698857, PMID 19826645, PMID 19858707, PMID 19942479, PMID 20007735, PMID 20048179, PMID 20231127, PMID 2032882, PMID 20590903, PMID 20799289, PMID 20937118, PMID 21187495, PMID 21236455, PMID 21353044, PMID 21627788, PMID 21762295, PMID 21895032, PMID 21929676, PMID 21975322, PMID 22628393, PMID 22778934, PMID 22962059, PMID 23123988, PMID 23219567, PMID 23220893
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