5 recruiting, 3 active not recruiting, 2 completed, 1 terminated. 10 Not applicable, 1 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 10 | Active not recruiting 3, Recruiting 3, Completed 2, Terminated 1, Withdrawn 1 |
| Phase 2 | 1 | Recruiting 1 |
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Combination Therapy Using Durvalumab and Histotripsy for Treatment of Intrahepatic Cholangiocarcinoma Histotripsy, Durvalumab, Biopsy - Intrahepatic Cholangiocarcinoma | Phase 2 | Recruiting | University of Wisconsin, Madison | 12 | 2026-10-01 | 2026-10-13 |
| The Edison System for Treatment of Benign Prostatic Hyperplasia (BPH) Using Histotripsy HistoSonics Edison System - Benign Prostatic Hyperplasia | Not applicable | Recruiting | HistoSonics, Inc. | 80 | 2026-03-20 | 2026-04-09 |
| Histotripsy Plus Chemotherapy vs Chemotherapy Alone for Advanced Colorectal Liver Metastasis HistoSonics Edison® System, Chemotherapy - Colorectal Cancer, Liver Metastases | Not applicable | Recruiting | Case Comprehensive Cancer Center | 100 | 2025-11-19 | 2026-09-15 |
| The HistoSonics Edison™ System for Treatment of Pancreatic Adenocarcinoma Using Histotripsy HistoSonics Edison™ System for the treatment of pancreatic adenocarcinoma using histotripsy - Pancreas Cancer, Adenocarcinoma of the Pancreas | Not applicable | Recruiting | HistoSonics, Inc. | 50 | 2024-12-10 | 2026-07-09 |
| Real-world Evaluation of the HistoSonics Edison System for Treatment of Liver Tumors Across Multidisciplinary Users (BOOMBOX: Master Study) HistoSonics Edison System - Liver Neoplasms, Primary Liver Cancer | Recruiting | HistoSonics, Inc. | 5000 | 2024-10-14 | 2026-09-11 | |
| The HistoSonics Edison™ System for Treatment of Primary Solid Renal Tumors Using Histotripsy (#HOPE4KIDNEY) HistoSonics Edison System - Renal Cancer, Tumor, Solid | Not applicable | Active not recruiting | HistoSonics, Inc. | 67 | 2024-01-04 | 2026-06-23 |
| The HistoSonics Investigational System for Treatment of Primary Solid Renal Tumors Using Histotripsy HistoSonics Investigational System - Renal Cancer, Tumor, Solid | Not applicable | Completed | HistoSonics, Inc. | 20 | 2023-03-23 | 2026-09-11 |
| The HistoSonics System for Treatment of Primary and Metastatic Liver Tumors Using Histotripsy (#HOPE4LIVER EU/UK) HistoSonics System - Liver Neoplasms, Hepatocellular Carcinoma | Not applicable | Active not recruiting | HistoSonics, Inc. | 24 | 2021-06-04 | 2026-01-12 |
| The HistoSonics System for Treatment of Primary and Metastatic Liver Tumors Using Histotripsy HistoSonics System - Liver Neoplasms, Hepatocellular Carcinoma | Not applicable | Active not recruiting | HistoSonics, Inc. | 47 | 2021-01-27 | 2025-11-19 |
| Study to Evaluate VORTX Rx (Theresa) VORTX Rx treatment - Carcinoma, Hepatocellular, Liver Metastases | Not applicable | Completed | HistoSonics, Inc. | 8 | 2018-03-21 | 2021-04-20 |
| Safety and Initial Efficacy Study of the Vortx Rx for Treatment of Benign Prostatic Hyperplasia (US) Vortx Rx - Histotripsy BPH Device - Benign Prostatic Hyperplasia (BPH) | Not applicable | Terminated | HistoSonics, Inc. | 28 | 2013-07-01 | 2023-11-07 |
| Safety and Initial Efficacy Study of the Vortx Rx for Treatment of Benign Prostatic Hyperplasia (Canada) Vortx Rx - Histotripsy BPH Device - Benign Prostatic Hyperplasia (BPH) | Not applicable | Withdrawn | HistoSonics, Inc. | 2013-06-01 | 2015-08-19 |
Carcinoma, Hepatocellular (4) · Liver Neoplasms (4) · Prostatic Hyperplasia (3) · Kidney Neoplasms (2) · Neoplasms (2) · Cholangiocarcinoma (1) · Colorectal Neoplasms (1) · Pancreatic Neoplasms (1)
Biopsy (1) · Drug Therapy (1) · durvalumab (1)
United States (6) · Spain (3) · United Kingdom (2) · Germany (1) · Hong Kong (1) · Italy (1)
Clifford S Cho, MD (1) · Federico Aucejo, MD (1) · Joan Vidal Jove, MD (1) · John Swietlik, MD (1) · John Wei, MD (1) · Luigi A Solbiati, MD (1) · Timonthy Schuster, MD (1) · Timothy J Ziemlewicz, MD (1)