21 completed, 6 recruiting, 6 terminated, 3 unknown. 40 Phase 2, 4 Phase 1, 4 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 40 | Completed 21, Recruiting 6, Terminated 6, Unknown 3, Not yet recruiting 2, Withdrawn 2 |
| Phase 1 | 4 | Completed 3, Unknown 1 |
| Phase 3 | 4 | Completed 2, Recruiting 1, Withdrawn 1 |
Follow Liver Diseases, Alcoholic: new trials by email Literature Review of Liver Diseases, Alcoholic trials Research Report on Liver Diseases, Alcoholic
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Study to Investigate the Safety and Efficacy of Efimosfermin Alfa Compared With Placebo in Adult Participants With Alcohol-related Liver Disease (ALD) Efimosfermin alfa, Placebo - Liver Diseases, Alcoholic | Phase 2 | Recruiting | GlaxoSmithKline | 274 | 2026-08-31 | 2026-09-30 |
| A-TANGO Phase 2 Study Placebo, TAK-242, G-CSF (Filgrastim) - Acute-On-Chronic Liver Failure, Alcoholic Hepatitis | Phase 2 | Recruiting | Yaqrit Ltd | 78 | 2026-06-29 | 2026-09-21 |
| The Efficacy of Tocotrienol Rich Fraction for Liver Protection in Adult Patients With Alcoholic Fatty Liver Disease (AFLD) Palm Tocotrienol Rich Fraction (TRF), Refined, bleached, and deodorised (RBD) palm olein - Alcoholic Fatty Liver Disease | Phase 2 | Not yet recruiting | Universiti Kebangsaan Malaysia Medical Centre | 26 | 2026-05-02 | 2026-04-29 |
| A Clinical Trial Investigating the Safety and Efficacy of Subjects With Alcohol Associated Hepatitis (Part 1) ADX-629 - Alcohol Hepatitis | Phase 2 | Completed | Aldeyra Therapeutics, Inc. | 4 | 2024-11-04 | 2026-06-03 |
| A Study to Investigate the Safety and Efficacy of GSK4532990 Compared With Placebo in Adult Participants Aged 18 to 70 Years With Alcohol-related Liver Disease GSK4532990, Placebo - Liver Diseases, Alcoholic | Phase 2 | Recruiting | GlaxoSmithKline | 393 | 2024-09-27 | 2026-08-03 |
| MRG-001 in Patients With Alcoholic Hepatitis MRG-001 - Alcoholic Hepatitis, Acute Alcoholic Hepatitis | Phase 2 | Not yet recruiting | MedRegen LLC | 32 | 2024-09-01 | 2024-03-13 |
| Liver Cirrhosis Network Rosuvastatin Efficacy and Safety for Cirrhosis in the United States Rosuvastatin - Cirrhosis, Cirrhosis, Liver | Phase 2 | Recruiting | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) | 260 | 2023-12-07 | 2026-09-28 |
| Safety Evaluation of Fecal Microbiota Transplantation in Severe Alcoholic Hepatitis Fecal Microbiota Transplantation, Placebo - Alcoholic Hepatitis | Phase 1 / Phase 2 | Unknown | Prasun Kumar Jalal | 50 | 2023-01-21 | 2025-01-23 |
| FXR Effect on Severe Alcohol-Associated Hepatitis (FRESH) Study INT-787, Placebo - Alcohol Associated Hepatitis | Phase 2 | Terminated | Intercept Pharmaceuticals | 67 | 2022-12-15 | 2026-05-05 |
| Digoxin In Treatment of Alcohol Associated Hepatitis Intravenous digoxin - Acute Alcoholic Hepatitis, Chemical and Drug Induced Liver Injury | Phase 2 | Terminated | Yale University | 23 | 2021-10-08 | 2026-09-29 |
| Faecal Microbiota Transplantation for Liver Cirrhosis Faecal microbiota transplantation, Placebo - Liver Cirrhosis | Phase 2 / Phase 3 | Recruiting | University of Aarhus | 220 | 2021-07-01 | 2025-01-24 |
| DUR-928 in Patients With Alcoholic Hepatitis DUR-928 (Moderate AH), DUR-928 (Severe AH) - Alcoholic Hepatitis | Phase 2 | Completed | Craig James McClain | 43 | 2021-06-01 | 2023-10-18 |
| A Phase 2b Study in Subjects With Alcoholic Hepatitis to Evaluate Safety and Efficacy of DUR-928 Treatment DUR-928 30 mg, DUR-928 90 mg, Placebo+ Standard of Care (SOC) - Alcoholic Hepatitis | Phase 2 | Completed | Durect | 307 | 2021-01-22 | 2024-09-05 |
| SAMe Trial for Patients With Alcoholic Cirrhosis Placebo, SAMe 400 mg tablet - Alcoholic Cirrhosis | Phase 2 | Recruiting | Indiana University | 196 | 2020-10-22 | 2026-03-31 |
| Trial of Anakinra (Plus Zinc) or Prednisone in Patients With Severe Alcoholic Hepatitis Anakinra and Zinc, Prednisone, Placebos - Alcoholic Hepatitis | Phase 2 | Completed | Indiana University | 147 | 2020-07-10 | 2025-02-10 |
| Vitamin C Infusion for TReatment in Sepsis and Alcoholic Hepatitis Vitamin C, Dextrose 5% in water - Alcoholic Hepatitis, Sepsis | Phase 2 | Completed | Virginia Commonwealth University | 20 | 2019-04-16 | 2023-08-28 |
| IL-1 Signal Inhibition in Alcoholic Hepatitis Canakinumab 150mg/ml solution for injection, Placebo - Alcoholic Hepatitis | Phase 2 | Completed | Imperial College London | 55 | 2019-02-12 | 2025-03-11 |
| A Research Study to Assess the Safety, Pharmacokinetics and Pharmacodynamics of DUR-928 in Patients With Alcoholic Hepatitis DUR-928 30 mg, DUR-928 90 mg, DUR-928 150 mg - Alcoholic Hepatitis | Phase 2 | Completed | Durect | 19 | 2018-04-18 | 2024-09-24 |
| Pegfilgrastim in Patients With Alcoholic Hepatitis Standard of care + pegfiltrastim, Standard of care - Alcoholic Hepatitis | Phase 2 | Completed | Timothy Morgan, MD | 34 | 2017-01-21 | 2021-09-29 |
| Selonsertib in Combination With Prednisolone Versus Prednisolone Alone in Participants With Severe Alcoholic Hepatitis (AH) Selonsertib, Prednisolone, Placebo - Alcoholic Hepatitis (AH) | Phase 2 | Completed | Gilead Sciences | 104 | 2016-09-01 | 2019-02-06 |
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Hepatitis, Alcoholic (26) · Liver Cirrhosis, Alcoholic (8) · Liver Cirrhosis (5) · Liver Diseases (5) · Alcoholism (4) · Fibrosis (4) · Hepatitis (4) · Fatty Liver, Alcoholic (3) · Non-alcoholic Fatty Liver Disease (3) · Acute-On-Chronic Liver Failure (2) · Chanarin-Dorfman Syndrome (2) · Cholesterol Ester Storage Disease (2) · Cirrhosis, Cryptogenic (2) · Liver Failure (2)
Alcohol-Related Disorders (40) · Chemically-Induced Disorders (40) · Digestive System Diseases (40) · Substance-Related Disorders (40) · Alcohol-Induced Disorders (39) · Liver Diseases (35) · Hepatitis (23) · Pathologic Processes (13) · Pathological Conditions, Signs and Symptoms (13) · Fibrosis (8) · Fatty Liver (6) · Liver Cirrhosis (6) · Hepatic Insufficiency (5) · Mental Disorders (4)
Prednisolone (3) · 3-(2-(2-tert-butylphenylaminooxalyl)aminopropionylamino)-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acid (2) · Fecal Microbiota Transplantation (2) · Interleukin 1 Receptor Antagonist Protein (2) · Prednisone (2) · Sebelipase alfa (2) · metadoxine (2) · 25-hydroxycholesterol 3-sulfate (1) · ADX-629 (1) · Arginine (1) · Ascorbic Acid (1) · Baclofen (1) · Digoxin (1) · Drugs, Generic (1) · Filgrastim (1)
Alexion Pharmaceuticals, Inc. (2) · Conatus Pharmaceuticals Inc. (2) · Durect (2) · GlaxoSmithKline (2) · Indiana University (2) · Virginia Commonwealth University (2) · Yonsei University (2) · Aldeyra Therapeutics, Inc. (1) · Brown University (1) · Catholic University of the Sacred Heart (1) · Craig James McClain (1) · Gilead Sciences (1) · Hospital Universitari Vall d'Hebron Research Institute (1) · Imperial College London (1) · Intercept Pharmaceuticals (1)
United States (27) · United Kingdom (9) · France (5) · South Korea (5) · Argentina (2) · Australia (2) · Austria (2) · Belgium (2) · Canada (2) · Denmark (2) · Italy (2) · Spain (2) · Egypt (1) · Finland (1) · Germany (1)
Abigail Smith, PhD (1) · Ali R Ahmadi, MD PhD (1) · Arthur J McCullough, MD (1) · Arun J Sanyal, MBBS MD (1) · Arun J Sanyal, MD (1) · Bubu Banini, MD, PhD (1) · Craig J McClain, M.D. (1) · Craig J McClain, MD (1) · David Hagerty, MD (1) · Dr Sandeep Nijhwan Nijhwan, MD., DM (1) · Dr Sanjay Kolte Kolte, DNB., FCPS (1) · Dr Uma Devi, MD (1) · Dr. Aejaz Habeeb, MD., DM (1) · Dr. BV Tantry, MD., DM (1) · Dr. Dinesh Kini, MD., DM (1)
PMID 37011138, PMID 11605686, PMID 15763232, PMID 18068515, PMID 21085006, PMID 23782511, PMID 23855300, PMID 25901427, PMID 31811953, PMID 34763711, PMID 35084335, PMID 35340032, PMID 36267499, PMID 37633275, PMID 38215876, PMID 38342441, PMID 39181422, PMID 39873544, PMID 39938959, PMID 40304564, PMID 40916722, PMID 41691535
U01AA021788 (2), U01AA021886 (2), U01AA021891 (2), 2016 (1), R21AA014269 (1), R21AA021128 (1), U01AA021840 (1), U01AA021883 (1), U01AA021893 (1), U01AA026817 (1), U01AA026934 (1), U01AA026966 (1), U24DK130164 (1)