18 completed, 5 unknown, 2 active not recruiting, 1 withdrawn. 26 Phase 2, 2 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 26 | Completed 18, Unknown 5, Active not recruiting 2, Withdrawn 1 |
| Phase 3 | 2 | Completed 2 |
Follow Impaired Glucose Tolerance: new trials by email Literature Review of Impaired Glucose Tolerance trials Research Report on Impaired Glucose Tolerance
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Evaluation of the Safety and Efficacy of SGLT2 Inhibitors in Pre-diabetic Patients Dapagliflozin 10mg Tab, lifestyle interventions - Prediabetic State, Impaired Fasting Glucose | Phase 2 | Unknown | Yangjin | 120 | 2023-12-20 | 2023-07-25 |
| Semaglutide Effects in Obese Youth With Prediabetes/New Onset Type 2 Diabetes and Metabolic Dysfunction-Associated Steatotic Liver Disease Semaglutide Pen Injector, Placebo - Type 2 Diabetes Mellitus, Impaired Glucose Tolerance | Phase 2 | Active not recruiting | Yale University | 60 | 2023-07-17 | 2026-04-15 |
| HSK7653 in Chinese Patients with Impaired Glucose Tolerance HSK7653 10mg Q2W, HSK7653 25mg Q2W, Placebo - Impaired Glucose Tolerance | Phase 2 | Completed | Haisco Pharmaceutical Group Co., Ltd. | 99 | 2021-03-29 | 2024-11-25 |
| Effects of Glucose Lowering Agents in South Asian Women With Impaired Glucose Tolerance or Impaired Fasting Glucose Metformin capsule 500 mg, Empagliflozin encapsulated tablet 10 mg, Pioglitazone encapsulated tablet 30 mg, Linagliptin encapsulated tablet 5 mg - Impaired Glucose Tolerance, Insulin Sensitivity | Phase 2 | Unknown | Oslo University Hospital | 64 | 2021-02-10 | 2021-04-08 |
| Type 2 Diabetes Mellitus Prevention Ukraine Physical activity, Macronutrient modification - Impaired Fasting Glucose, Impaired Glucose Tolerance | Phase 2 | Completed | Komisarenko Institute of Endocrinology and Metobolism | 30 | 2020-02-20 | 2022-08-26 |
| Effect of Probiotics Versus Metformin on Glycemic Control, Insulin Sensitivity and Insulin Secretion in Prediabetes. Probiotics, Metformin - PreDiabetes, Impaired Glucose Tolerance | Phase 2 | Active not recruiting | University of Guadalajara | 30 | 2019-10-24 | 2026-10-07 |
| Effect of Gymnema Sylvestre on Patients With Impaired Glucose Tolerance. Gymnema Sylvestre, Placebo - Impaired Glucose Tolerance | Phase 2 | Completed | University of Guadalajara | 30 | 2016-03-01 | 2021-02-02 |
| Effect of Chlorogenic Acid on Patients With Impaired Glucose Tolerance Placebo, Chlorogenic acid - Impaired Glucose Tolerance | Phase 2 | Completed | University of Guadalajara | 30 | 2015-09-01 | 2019-08-02 |
| Psoriatic Arthritis Treated With Liraglutide Therapy: a QUality of Life and Efficacy Study liraglutide, Placebo - Psoriatic Arthritis, Psoriasis | Phase 2 | Withdrawn | University Health Network, Toronto | 2015-05-01 | 2017-07-17 | |
| ARA290 in T2D (Effects of ARA 290, an Erythropoietin Analogue) in Prediabetes and Type 2 Diabetes) ARA 290 - Diabetes Type 2, Impaired Glucose Tolerance | Phase 2 | Unknown | Claes-Göran Östenson | 24 | 2013-10-01 | 2015-09-03 |
| ACute and Chronic Effects of Saxagliptin saxagliptin, placebo pill - Impaired Glucose Tolerance | Phase 2 | Completed | Assistance Publique - Hôpitaux de Paris | 24 | 2012-09-01 | 2015-02-03 |
| Mood and Insulin Resistance in Adolescents At-Risk for Diabetes The Blues Program, Hey Durham - Depression, Impaired Glucose Tolerance | Phase 2 | Completed | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) | 174 | 2011-08-23 | 2019-12-16 |
| Safety, Tolerability, PK, and PD of LIM-0705 in Subjects With Impaired Glucose Tolerance or Abnormal HOMA-IR LIM-0705, Placebo capsules - Impaired Glucose Tolerance, Insulin Resistance | Phase 2 | Unknown | Limerick BioPharma | 50 | 2011-05-01 | 2011-06-02 |
| Teplizumab for Prevention of Type 1 Diabetes In Relatives "At-Risk" Teplizumab, Placebo infusion - Autoantibody Positive, Non-diabetic Relatives at Risk for Type 1 Diabetes | Phase 2 | Completed | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) | 76 | 2010-08-01 | 2020-08-05 |
| To Compare the Effect of a Subcutaneous Canakinumab Administration to Placebo in Patients With Impaired Glucose Tolerance or Patients With Type 2 Diabetes With Differing Baseline Diabetes Therapies Canakinumab 150 mg, Placebo to Canakinumab - Type 2 Diabetes Mellitus, Impaired Glucose Tolerance | Phase 2 | Completed | Novartis | 246 | 2010-02-01 | 2011-09-05 |
| Effect of Sitagliptin in Impaired Glucose Tolerance Sitagliptin, Placebo - Impaired Glucose Tolerance | Phase 2 | Unknown | National Taiwan University Hospital | 60 | 2009-12-01 | 2010-03-22 |
| Glucose Control in Pre-Diabetic Renal Transplant Patients Vildagliptin, Pioglitazone, Life-Style Modification - Impaired Glucose Tolerance, Kidney Transplantation | Phase 2 | Completed | Marcus Saemann | 51 | 2009-12-01 | 2011-12-05 |
| Pilot Study With GFT505 (80mg) in Patients Presenting With Impaired Glucose Tolerance and Abdominal Obesity. GFT505 80mg, Placebo - Impaired Glucose Tolerance, Abdominal Obesity | Phase 2 | Completed | Genfit | 47 | 2009-06-01 | 2011-01-12 |
| Evaluation of Soluble Epoxide Hydrolase (s-EH) Inhibitor in Patients With Mild to Moderate Hypertension and Impaired Glucose Tolerance AR9281, Placebo - Hypertension, Impaired Glucose Tolerance | Phase 2 | Completed | Arete Therapeutics | 150 | 2009-01-01 | 2009-11-20 |
| Enhancing Fitness in Older Pre-diabetic Veterans Physical Activity Counseling - Impaired Glucose Tolerance, Obesity | Phase 2 / Phase 3 | Completed | US Department of Veterans Affairs | 302 | 2008-10-01 | 2015-04-27 |
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Glucose Intolerance (26) · Insulin Resistance (9) · Diabetes Mellitus, Type 2 (6) · Obesity (4) · Prediabetic State (4) · Diabetes Mellitus (3) · Metabolic Syndrome (3) · Motor Activity (2) · Arthritis, Psoriatic (1) · Atherosclerosis (1) · Depression (1) · Diabetes Mellitus, Type 1 (1) · Glucose Metabolism Disorders (1) · Hyperglycemia (1) · Hypertension (1)
Metabolic Diseases (26) · Nutritional and Metabolic Diseases (26) · Glucose Metabolism Disorders (25) · Hyperglycemia (25) · Endocrine System Diseases (12) · Hyperinsulinism (11) · Diabetes Mellitus (9) · Pathological Conditions, Signs and Symptoms (7) · Body Weight (6) · Nutrition Disorders (6) · Overnutrition (6) · Signs and Symptoms (6) · Overweight (5) · Behavior (3) · Cardiovascular Diseases (2)
Metformin (3) · Exercise (2) · 1-(1-acetyl-piperidine-4-yl)-3-adamantan-1-yl-urea (1) · 2-(2,6-dimethyl-4-(3-(4-(methylthio)phenyl)-3-oxo-1-propenyl)phenoxyl)-2-methylpropanoic acid (1) · Acetohexamide (1) · Biguanides (1) · Chlorogenic Acid (1) · Chlorpropamide (1) · Cholecalciferol (1) · Chromium (1) · Continuous Positive Airway Pressure (1) · Diet (1) · Fruit (1) · Glipizide (1) · Glyburide (1)
University of Guadalajara (3) · Arete Therapeutics (1) · Assistance Publique - Hôpitaux de Paris (1) · Brigham and Women's Hospital (1) · Charite University, Berlin, Germany (1) · Claes-Göran Östenson (1) · Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) (1) · Genfit (1) · Griffin Hospital (1) · Haisco Pharmaceutical Group Co., Ltd. (1) · Komisarenko Institute of Endocrinology and Metobolism (1) · Limerick BioPharma (1) · Marcus Saemann (1) · Marjukka Kolehmainen (1) · National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) (1)
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Carla J Greenbaum, MD (1) · Carol Rosen, M.D. (1) · David L Katz, MD, MPH (1) · Denise Babineau, PhD (1) · Faramarz Beigi (1) · H Lester Kirchner, PhD (1) · Jack A Yanovski, M.D. (1) · Jin Yang, doctorate (1) · John Haaga, M.D. (1) · Kingman Strohl, M.D. (1)
PMID 20634174, PMID 20847403, PMID 21741058, PMID 21816979, PMID 21870174, PMID 21901116, PMID 22059803, PMID 22547887, PMID 22866170, PMID 22985140, PMID 23514765, PMID 23682163, PMID 23703580, PMID 24055327, PMID 24587337, PMID 24933726, PMID 25527657, PMID 25874636, PMID 26210388, PMID 26511012, PMID 26829443, PMID 27333897, PMID 30256894, PMID 31180194, PMID 32803882, PMID 33618922, PMID 34420816, PMID 35367918, PMID 35713929, PMID 37158990, PMID 38494571, PMID 39137044, PMID 39735417, PMID 40614321, PMID 41891171
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