12 completed, 10 unknown, 5 active not recruiting, 4 recruiting. 35 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 35 | Completed 12, Unknown 10, Active not recruiting 5, Recruiting 4, Terminated 3, Not yet recruiting 1 |
Follow Immunosuppression: new trials by email Literature Review of Immunosuppression trials Research Report on Immunosuppression
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Evaluation of PCV21 Vaccination Among PPSV23-experienced, Immunocompromised Elderly Veterans 21-valent pneumococcal conjugate vaccine - Pneumococcal Vaccines, Immunosuppression | Phase 4 | Not yet recruiting | VA Sierra Nevada Health Care System | 45 | 2026-01-01 | 2025-08-14 |
| Effectiveness and Cost-effectiveness of a Pre-emptive Genotyping Strategy in Patients Receiving Tacrolimus Tacrolimus - Kidney Disease, Chronic, Transplant Recipient (Kidney) | Phase 4 | Recruiting | Instituto de Investigación Hospital Universitario La Paz | 114 | 2025-06-02 | 2025-09-11 |
| Evaluation of the Benefits of Administering Immunosuppressive Drugs as Single Daily Doses Over the First Year After Liver Transplantation (EASY) XR-tacrolimus QD + MMF BID then MMF QD, XR-tacrolimus QD + MMF BID, LCP-tacrolimus QD + MMF QD then MMF QD - Liver Transplantation, Immunosuppression | Phase 4 | Recruiting | University Hospital, Limoges | 162 | 2025-04-15 | 2026-03-19 |
| Tacrolimus C:D Ratio Measured in Renal Transplant Recipients Treated With Once-daily Prolonged-release Drugs Tacrolimus Pill, Tacrolimus capsule - Immunosuppression | Phase 4 | Active not recruiting | Edward Geissler | 322 | 2024-03-09 | 2026-11-05 |
| PREPARE-iVAC Trial COVID-19 vaccination - COVID-19 Vaccines, Varicella Zoster Vaccine | Phase 4 | Completed | University Medical Center Groningen | 110 | 2023-08-22 | 2024-03-04 |
| Tacrolimus Associated Tremors in Liver Transplantation: Immediate-Release Versus Extended-Release Formulations Tacrolimus, Immediate Release, Oral, Tacrolimus Extended Release Oral Tablet - Liver Transplantation, Immunosuppression | Phase 4 | Recruiting | University of British Columbia | 124 | 2023-01-09 | 2024-01-02 |
| Study to Evaluate the Efficacy of Immunosuppression in Myocarditis or Inflammatory Cardiomyopathy. Prednisone, Azathioprine, Placebo Prednisone - Myocarditis, Heart Failure | Phase 4 | Active not recruiting | Medical University of Warsaw | 100 | 2022-12-01 | 2026-09-22 |
| Combined Immunosuppression for Pediatric Crohn's Disease Infliximab and immunosuppressives, Infliximab - Crohn Disease, Infliximab | Phase 4 | Recruiting | Children's Hospital of Fudan University | 128 | 2022-10-10 | 2026-03-19 |
| Efficacy and Safety of Pitavastatin and PCSK9 Inhibitors in Liver Transplant Patients Pitavastatin, PCSK9 inhibitor - Dyslipidemias, Hyperlipidemias | Phase 4 | Active not recruiting | National Medical Research Center for Therapy and Preventive Medicine | 59 | 2021-10-01 | 2025-01-22 |
| Booster Dose of COVID-19 Vaccine for Kidney Transplant Recipients Without Adequate Humoral Response The Pfizer mRNA-based BNT162b2 vaccine - COVID-19 Acute Respiratory Distress Syndrome, Immunosuppression | Phase 4 | Unknown | dafna yahav | 504 | 2021-10-01 | 2021-10-08 |
| Impact of Immunosuppression Adjustment on COVID-19 Vaccination Response in Kidney Transplant Recipients Reduction in antimetabolite immunosuppression - COVID-19, Immunosuppression | Phase 4 | Active not recruiting | University of California, Davis | 14 | 2021-09-24 | 2026-04-03 |
| Immunoinflammatory Regulation of Esketamine in Septic Patients Esketamine hydrochloride - Esketamine, Sepsis | Phase 4 | Terminated | Union Hospital, Tongji Medical College, Huazhong University of Science and Technology | 10 | 2021-07-28 | 2026-09-30 |
| Mycophenolate Mofetil Versus Cyclosporin A in the Treatment of Primary Biliary Cholangitis-autoimmune Hepatitis Overlap Syndrome Due to Nonresponse to Standard Therapy Cyclosporin A, Mycophenolate Mofetil - Hepatitis, Autoimmune, Primary Biliary Cholangitis | Phase 4 | Unknown | West China Hospital | 89 | 2021-06-16 | 2021-06-22 |
| Immune Monitoring to Facilitate Belatacept Monotherapy Allosure, Immunosuppression reduction, Trugraf - Kidney Transplant Rejection, Immunosuppression | Phase 4 | Completed | Massachusetts General Hospital | 17 | 2020-02-11 | 2023-12-04 |
| RCT Comparing Immunosuppressive Regimens in Elderly Renal Transplant Recipients low dose tacrolimus in combination with everolimus, standard dose tacrolimus with mycophenolate mofetil - Renal Transplant Recipients, Elderly Patients | Phase 4 | Active not recruiting | University Medical Center Groningen | 374 | 2019-07-29 | 2023-05-10 |
| Veloxis de Novo Kidney Transplant ECSWD Tacrolimus Extended Release Oral Tablet [Envarsus], Mycophenolate Mofetil, Mycophenolic Acid Oral Product - Kidney Transplantation, Immunosuppression | Phase 4 | Unknown | Simon Tremblay, PharmD, PhD | 60 | 2019-06-21 | 2020-05-13 |
| Use of Sublingual Tacrolimus in Adult Blood and Marrow Transplant Patients Tacrolimus - Immunosuppression, Stem Cell Transplant | Phase 4 | Completed | Mayo Clinic | 10 | 2019-06-17 | 2020-08-07 |
| Extended Release Versus Immediate Release Tacrolimus Following Renal Allograft Failure to Reduce Allosensitisation Envarsus Oral Product - Kidney Transplant Failure, Allosensitization | Phase 4 | Terminated | Imperial College Healthcare NHS Trust | 35 | 2018-11-01 | 2025-04-13 |
| Dosing Requirements of Astagraf XL® in African American Kidney Transplant Recipients Tacrolimus Extended Release Capsule, Mycophenolate mofetil, Prednisone - Immunosuppression | Phase 4 | Completed | Medical University of South Carolina | 25 | 2017-05-05 | 2019-12-26 |
| Intracoronary Analysis of Cardiac Allograft Vasculopathy by Means of Optical Coherence Tomography Protocol with Everolimus (Certican®), Protocol with Mycophenolate mofetil (CellCept®) - Intimal Proliferation, Immunosuppression | Phase 4 | Unknown | University of Zurich | 278 | 2013-12-01 | 2014-10-02 |
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COVID-19 (2) · Acquired Immunodeficiency Syndrome (1) · Cardiomyopathies (1) · Cardiovascular Diseases (1) · Coronary Disease (1) · Crohn Disease (1) · Cytomegalovirus Infections (1) · Dyslipidemias (1) · Heart Failure (1) · Hepatitis, Autoimmune (1) · Hyperlipidemias (1) · Influenza, Human (1) · Kidney Failure, Chronic (1) · Liver Cirrhosis, Biliary (1) · Liver Diseases (1)
Infections (5) · Pathological Conditions, Signs and Symptoms (5) · Pathologic Processes (4) · Respiratory Tract Diseases (4) · Urogenital Diseases (4) · Virus Diseases (4) · Digestive System Diseases (3) · Female Urogenital Diseases (3) · Female Urogenital Diseases and Pregnancy Complications (3) · Kidney Diseases (3) · Lung Diseases (3) · Male Urogenital Diseases (3) · RNA Virus Infections (3) · Respiratory Tract Infections (3) · Urologic Diseases (3)
Tacrolimus (15) · Mycophenolic Acid (8) · Cyclosporine (5) · Everolimus (5) · Prednisone (4) · Sirolimus (4) · Methylprednisolone (2) · thymoglobulin (2) · Abatacept (1) · Adrenal Cortex Hormones (1) · Antilymphocyte Serum (1) · Azathioprine (1) · Calcineurin Inhibitors (1) · Clinical Protocols (1) · Combined Modality Therapy (1)
National Taiwan University Hospital (2) · University Medical Center Groningen (2) · Andre Barreto Pereira (1) · Children's Hospital of Fudan University (1) · Deise de Boni Monteiro de Carvalho (1) · Edward Geissler (1) · Fakultas Kedokteran Universitas Indonesia (1) · Goethe University (1) · Imperial College Healthcare NHS Trust (1) · Insel Gruppe AG, University Hospital Bern (1) · Instituto de Investigación Hospital Universitario La Paz (1) · King's College London (1) · Klemens Budde (1) · Massachusetts General Hospital (1) · Mayo Clinic (1)
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Ahmed Shoker, MD (1) · Aiko De Vries, MD, PhD (1) · Alexandra Ershova, PhD (1) · Andre B Pereira, PhD (1) · Anthony Dorling, PhD FRCP (1) · Arjan Van Zuilen, MD, PhD (1) · Azam Nurmohamed, Md, PhD (1) · Bernhard Banas, MD (1) · Christian Templin, MD, PhD (1) · Christoph Stephan, MD (1) · David A Baran, MD (1) · Dennis Hesselink, MD, PhD (1) · Dirk Kuypers, MD, PhD (1) · Francisco G Miloski, MD (1)
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