7 completed, 2 recruiting, 2 terminated, 1 active not recruiting. 7 Phase 2, 6 Phase 3, 1 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 7 | Completed 4, Terminated 2, Active not recruiting 1 |
| Phase 3 | 6 | Completed 3, Recruiting 2, Active not recruiting 1 |
| Phase 1 | 1 | Completed 1 |
Follow pridopidine: new trials by email Literature Review of pridopidine trials Research Report on pridopidine
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Pridopidine Phase 3 Study in Huntington's Disease Pridopidine, Placebo - Huntington Disease | Phase 3 | Recruiting | Prilenia | 400 | 2026-07-01 | 2026-10-28 |
| Pridopidine Phase 3 Study to Evaluate Efficacy and Safety in ALS Pridopidine, Placebo - Amyotrophic Lateral Sclerosis | Phase 3 | Recruiting | Prilenia | 500 | 2026-02-01 | 2026-10-27 |
| HEALEY ALS Platform Trial - Regimen D Pridopidine Pridopidine, Matching Placebo - Amyotrophic Lateral Sclerosis | Phase 2 / Phase 3 | Completed | Merit E. Cudkowicz, MD | 163 | 2020-12-18 | 2023-08-23 |
| PRidopidine's Outcome On Function in Huntington Disease, PROOF- HD Pridopidine, Placebo - Huntington Disease | Phase 3 | Completed | Prilenia | 499 | 2020-10-16 | 2025-03-12 |
| HEALEY ALS Platform Trial - Master Protocol Zilucoplan, Verdiperstat, CNM-Au8 - Amyotrophic Lateral Sclerosis | Phase 2 / Phase 3 | Active not recruiting | Merit E. Cudkowicz, MD | 1500 | 2020-06-14 | 2026-07-21 |
| A Study to Assess the Safety and Effectiveness of Pridopidine Compared to Placebo in the Treatment of Levodopa-Induced Dyskinesia in Patients With Parkinson's Disease Pridopidine, Placebo - Parkinson Disease | Phase 2 | Terminated | Prilenia | 23 | 2019-05-22 | 2022-07-01 |
| A Study to Evaluate Sigma-1 and Dopamine-2 Receptor Occupancy by Pridopidine in the Human Brain of Healthy Volunteers and in Patients With Huntington's Disease pridopidine (90 mg) - Health Volunteers, Huntington Disease | Phase 1 | Completed | Prilenia | 23 | 2017-04-19 | 2021-11-19 |
| A Study Evaluating if Pridopidine is Safe, Efficacious, and Tolerable in Patients With Huntington's Disease Pridopidine - Huntington's Disease | Phase 2 | Terminated | Prilenia | 248 | 2015-09-24 | 2021-09-17 |
| A Phase 2, to Evaluating the Safety and Efficacy of Pridopidine Vs Placebo for Symptomatic Treatment in Patients With Huntington's Disease Pridopidine, Placebo - Huntington's Disease | Phase 2 | Completed | Prilenia | 408 | 2014-02-28 | 2021-07-19 |
| Open-label Extension Study of Pridopidine (ACR16) in the Symptomatic Treatment of Huntington Disease pridopidine - Huntington Disease | Phase 2 | Completed | Prilenia | 134 | 2011-03-24 | 2022-02-09 |
| A Study of Pridopidine (ACR16) for the Treatment of Participants With Huntington's Disease ACR16, Placebo - Huntington Disease | Phase 2 | Completed | Teva Branded Pharmaceutical Products R&D, Inc. | 227 | 2008-10-24 | 2023-08-31 |
| A Study of Treatment With Pridopidine (ACR16) in Participants With Huntington's Disease ACR16, Placebo - Huntington's Disease | Phase 3 | Completed | Teva Branded Pharmaceutical Products R&D, Inc. | 437 | 2008-04-24 | 2023-08-29 |
| A Second Intermediate-Size Expanded Access Protocol (EAP) for Pridopidine in People With Amyotrophic Lateral Sclerosis (Pridopidine EAP 2) Pridopidine - Amyotrophic Lateral Sclerosis | No longer available | Prilenia | 2025-05-18 |
Huntington Disease (8) · Amyotrophic Lateral Sclerosis (4) · Dyskinesias (2) · Basal Ganglia Diseases (1) · Brain Diseases (1) · Central Nervous System Diseases (1) · Cognition Disorders (1) · Dementia (1) · Heredodegenerative Disorders, Nervous System (1) · Mental Disorders (1) · Movement Disorders (1) · Nervous System Diseases (1) · Neurocognitive Disorders (1) · Neurodegenerative Diseases (1) · Parkinson Disease (1)
Prilenia (9) · Merit E. Cudkowicz, MD (2) · Teva Branded Pharmaceutical Products R&D, Inc. (2)
United States (10) · Germany (7) · Canada (6) · France (6) · Italy (6) · United Kingdom (6) · Netherlands (5) · Poland (5) · Austria (4) · Spain (4) · Belgium (3) · Australia (2) · Czechia (2) · Portugal (2) · Russia (2)
Merit Cudkowicz, MD (2) · Yael Cohen (2)
PMID 36811812, PMID 40067755, PMID 22071279, PMID 28826192, PMID 30563778, PMID 30572891, PMID 30776019, PMID 31356217, PMID 39960672, PMID 40067754, PMID 40067821, PMID 40913168, PMID 41406304
2015 (1), 2016 (1)