40 completed, 12 unknown, 8 recruiting, 4 terminated. 28 Not applicable, 14 Phase 2, 6 Phase 1, 3 Phase 3, 3 Phase 4.
Follow Hepatic Steatosis: new trials by email Literature Review of Hepatic Steatosis trials Research Report on Hepatic Steatosis
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Pre-hepatectomy Rehabilitation in Obese MASLD-Complicated Living Liver Donors With Mazdutide (PRIME) Mazdutide, Placebo (Normal Saline), Lifestyle Optimization - Metabolic Dysfunction-Associated Steatohepatitis, Hepatic Steatosis | Phase 4 | Recruiting | West China Hospital | 60 | 2026-09-01 | 2026-09-23 |
| Siemens Biomarker Multi-modality Photon-counting CT (PCCT), Ultrasound, Magnetic Resonance Imaging (MRI) - Fatty Liver, Hepatic Steatosis | Not applicable | Recruiting | Duke University | 45 | 2026-03-27 | 2026-04-03 |
| Tesamorelin for Reduction of Liver Fat in Adults With Fatty Liver Disease (Mock Study) Tesamorelin, Placebo, Standardized lifestyle counseling - Metabolic Associated Steatotic Liver Disease, Nonalcoholic Steatohepatitis | Phase 2 | Recruiting | Hudson Biotech | 120 | 2026-02-02 | 2026-03-19 |
| A Clinical Trial of Longqi Jiangzhi Decoction Against Non-alcoholic Fatty Liver Disease Longqi Jiangzhi decoction, Control placebo - Hepatic Steatosis | Phase 2 | Not yet recruiting | Shanghai Municipal Hospital of Traditional Chinese Medicine | 80 | 2025-12-29 | 2026-01-06 |
| Benefit of a Hospital Intervention in Patients With Hepatic Steatosis Specialized Unit, Usual Follow-Up - Hepatic Steatosis | Not applicable | Not yet recruiting | Consorci Sanitari de l'Alt Penedès i Garraf | 86 | 2025-12-01 | 2025-02-12 |
| Incidence of Liver Disease-Related Outcomes in People With HIV Abdominal ultrasound , Fibroscan and body composition analysis examination - MAFLD, Liver Fibrosis | Completed | Shanghai Public Health Clinical Center | 315 | 2025-07-01 | 2026-06-02 | |
| Quantitative Ultrasound (RS85 and R20) for Liver Fat Quantification in MASLD Using MRI-PDFF as Reference Quantitative ultrasound (DeepUSFF) - Metabolic Dysfunction-Associated Steatotic Liver Disease, Hepatic Steatosis | Not applicable | Active not recruiting | Seoul National University Hospital | 182 | 2025-06-24 | 2026-10-13 |
| Acute Exercise and Endogenous Glucose Production in Type 2 Diabetes: Implications for Glycemic Control and Treatment of Hepatic Steatosis Magnetic Resonance Liver Assessment, Bike Exercise VO2max, DEXA - Type 2 Diabetes, Hepatic Steatosis | Not applicable | Recruiting | AdventHealth Translational Research Institute | 12 | 2025-04-25 | 2026-08-12 |
| Effect of an Early Time Restricted Eating Mediterranean Diet Compared to Naltrexone/Bupropion on Liver Fibrosis in People With Cardiometabolic Risk Factors in a Hospital Outpatient Clinic (MEDFAST-study) early time restricted Mediterranean diet, Mysimba - Diabetes Mellitus, Type 2, Liver Fibrosis | Phase 4 | Enrolling by invitation | Carmen Dietvorst | 70 | 2025-04-14 | 2026-04-21 |
| Multiple Dose Study for a New Medication to Potentially Treat Liver Diseases NNC0581-0001, Placebo (NNC0581-0001) - Healthy Volunteers, Hepatic Steatosis | Phase 1 | Recruiting | Novo Nordisk A/S | 48 | 2025-03-12 | 2026-04-07 |
| Efficacy of Sodium Glucose Cotransporter 2 Inhibitors on Non-Alcoholic Fatty Liver Disease Non Alcholic Fatty Liver Disease, Hepatic Steatosis | Not yet recruiting | Assiut University | 100 | 2024-12-20 | 2024-12-18 | |
| Osaka Cardiometabolic Epidemiological Study: Ohtori Study Part 2 Type 2 Diabetes Mellitus (T2DM), Type 2 Diabetes | Recruiting | Osaka Metropolitan University | 2000 | 2024-11-01 | 2024-12-04 | |
| MHT and Liver Function in Postmenopausal Women Menopausal hormone therapy - Menopause, Non Alcholic Fatty Liver Disease | Not applicable | Completed | Ipek B. Ozcivit Erkan, MD | 44 | 2024-10-30 | 2026-01-27 |
| Hyperbaric Oxygen Therapy for Metabolic Dysfunction-associated Steatotic Liver Diseases Hyperbaric oxygen therapy - Metabolic Dysfunction-associated Steatotic Liver Disease, Hepatic Steatosis | Not applicable | Unknown | Jinling Hospital, China | 150 | 2024-07-29 | 2024-10-01 |
| A Clinical Trial of Chazhu Xiaozhi Decoction Against Non-alcoholic Fatty Liver Disease Chazhu Xiaozhi decoction, Control placebo - Hepatic Steatosis, Symptoms and Signs | Phase 2 | Completed | Shanghai Municipal Hospital of Traditional Chinese Medicine | 70 | 2024-07-17 | 2025-04-03 |
| Effect of Amino Acids on Hepatic Fat Content in Adolescents (AMINOS Study) Essential Amino Acid Supplement by Amino Co, Placebo - Hepatic Steatosis, NAFLD | Phase 3 | Completed | University of Colorado, Denver | 31 | 2024-06-18 | 2026-08-31 |
| Implementation of the Fatty Liver Index in Primary Care FLI - Hepatic Steatosis, Overweight and Obesity | Not applicable | Completed | Consorci Sanitari de l'Alt Penedès i Garraf | 434 | 2024-05-02 | 2025-06-29 |
| Metabolic Changes Induced by NMN in Healthy Subjects With Acute Binge Drink β-nicotinamide Mononucleotide, Maltodextrin - Binge Drinking, Liver Injury | Phase 1 / Phase 2 | Completed | Zhejiang Chinese Medical University | 22 | 2024-05-01 | 2025-04-10 |
| Probiotic Lysate (Postbiotic and Metabiotic) Supplementation for Adults MASLD Patients (DELI_MASLD Study) Probiotic lysate (postbiotic and metabiotc), Placebo - Metabolic Dysfunction Associated Steatotic Liver Disease, Steatotic Liver Disease | Not applicable | Completed | Bogomolets National Medical University | 52 | 2024-05-01 | 2026-09-23 |
| Metabolic Changes in Healthy Subjects with Acute Binge Drink Vodka, water - Binge Drinking, Liver Injury | Phase 1 | Completed | Zhejiang Chinese Medical University | 40 | 2024-04-27 | 2025-01-22 |
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Fatty Liver (70) · Non-alcoholic Fatty Liver Disease (14) · Obesity (10) · Liver Cirrhosis (9) · Metabolic Syndrome (8) · Insulin Resistance (6) · Diabetes Mellitus (5) · Hepatitis B, Chronic (5) · Pediatric Obesity (5) · Diabetes Mellitus, Type 2 (4) · Liver Diseases (4) · Dyslipidemias (3) · Overweight (3) · Polycystic Ovary Syndrome (3) · Binge Drinking (2)
Digestive System Diseases (70) · Liver Diseases (66) · Nutritional and Metabolic Diseases (30) · Pathological Conditions, Signs and Symptoms (29) · Metabolic Diseases (20) · Glucose Metabolism Disorders (17) · Nutrition Disorders (16) · Body Weight (15) · Overnutrition (15) · Pathologic Processes (15) · Signs and Symptoms (15) · Hyperinsulinism (12) · Overweight (12) · Endocrine System Diseases (10) · Fibrosis (9)
Diet (2) · Diet, Fat-Restricted (2) · Ultrasonography (2) · Vitamin E (2) · maltodextrin (2) · Amino Acids, Essential (1) · Blood Specimen Collection (1) · Bupropion (1) · Cholecystectomy, Laparoscopic (1) · Cholic Acid (1) · Continuous Glucose Monitoring (1) · Control Groups (1) · Diagnostic Tests, Routine (1) · Diet Therapy (1) · Diet, Mediterranean (1)
University of Colorado, Denver (5) · Bogomolets National Medical University (2) · Consorci Sanitari de l'Alt Penedès i Garraf (2) · National Institute of Allergy and Infectious Diseases (NIAID) (2) · Novo Nordisk A/S (2) · Seoul National University Hospital (2) · Shanghai Municipal Hospital of Traditional Chinese Medicine (2) · University of Texas Southwestern Medical Center (2) · Zhejiang Chinese Medical University (2) · AdventHealth Translational Research Institute (1) · Assistance Publique - Hôpitaux de Paris (1) · Assiut University (1) · Azienda Ospedaliera Specializzata in Gastroenterologia Saverio de Bellis (1) · Boston Children's Hospital (1) · Cairo University (1)
United States (22) · China (13) · Canada (4) · France (4) · Spain (4) · United Kingdom (4) · Italy (3) · South Korea (3) · Netherlands (2) · Turkey (Türkiye) (2) · Ukraine (2) · Denmark (1) · Egypt (1) · Hungary (1) · Japan (1)
Melanie Cree-Green, MD, PhD (3) · Abdallah A Gamal, Resident (1) · Abhimanyu Garg, M.D. (1) · Abhimanyu Garg, MD (1) · Ahmed M Abdul Ghani, MD (1) · Colleen M Hadigan, M.D. (1) · David S Ludwig, MD, PhD (1) · Dazhi Zhang, Doctor (1) · Dongho Choi (1) · Gyongyi Szabo, MD, PhD (1) · Jeffery Carr, DR (1) · Jeffrey Schwimmer, MD (1)
PMID 42014131, PMID 31301251, PMID 16012941, PMID 16020491, PMID 19211827, PMID 20014114, PMID 22170723, PMID 23447519, PMID 23545713, PMID 23705885, PMID 24257718, PMID 26707365, PMID 26796885, PMID 27462372, PMID 28314735, PMID 28427875, PMID 29119002, PMID 29509992, PMID 30178600, PMID 30888398, PMID 31134334, PMID 31266617, PMID 31279902, PMID 31782258, PMID 32027858, PMID 32553151, PMID 32747349, PMID 32984925, PMID 33372630, PMID 33815743, PMID 33848277, PMID 34220701, PMID 34545037, PMID 35090390, PMID 35901073, PMID 36594835, PMID 37312098, PMID 38267239, PMID 38296273, PMID 38851997, PMID 39544247, PMID 39602327, PMID 42350004
2017 (1), K23DK107871 (1), R01DK114504 (1), R44DK135312 (1), U01AA021893 (1), UL1TR001082 (1)