196 completed, 136 unknown, 29 recruiting, 18 not yet recruiting. 144 Phase 4, 98 Not applicable, 43 Phase 3, 24 Phase 2, 19 Phase 1.
Follow Helicobacter Pylori Infection: new trials by email Literature Review of Helicobacter Pylori Infection trials Research Report on Helicobacter Pylori Infection
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Vonoprazan-Amoxicillin Dual Therapy for Helicobacter Pylori Infection in United States Adolescents Vonoprazan, Amoxicillin - Helicobacter Pylori Infection | Phase 2 | Not yet recruiting | Boston Children's Hospital | 55 | 2026-11-01 | 2026-10-06 |
| Vonoprazan High-Dose Dual VS Levofloxacin Concomitant Vonoprazan, Levofloxacin 500mg - Helicobacter Pylori Infection, Peptic Ulcer Disease | Phase 4 | Not yet recruiting | Damascus Hospital | 150 | 2026-11-01 | 2026-06-03 |
| European Implementation Study on Simultaneous Screening for Gastric and Colorectal Cancers Fecal sample acquisition for Helicobacter pylori stool antigen test, Upper endoscopy with biopsies, Colonoscopy with biopsies after bowel cleansing - Helicobacter Pylori Infection, Colorectal Cancer | Not yet recruiting | University of Latvia | 8000 | 2026-10-01 | 2026-10-14 | |
| Bacillus Probiotics With Bismuth Quadruple Therapy for Helicobacter Pylori Infection RO water, LiveSpo CLAUSY, LiveSpo DIA30 - Helicobacter Pylori Infection, Gastrointestinal Dysbiosis | Not applicable | Not yet recruiting | Anabio R&D | 336 | 2026-10-01 | 2026-09-22 |
| Factors Affecting Helicobacter Pylori Infection: Diet and Lifestyle Patterns Helicobacter Pylori Infection | Not yet recruiting | Asian Institute of Gastroenterology, India | 1000 | 2026-09-20 | 2026-09-23 | |
| NLR and PLR in H. Pylori-Associated Gastritis Helicobacter Pylori Infection, Gastritis | Not yet recruiting | Assiut University | 90 | 2026-09-01 | 2026-09-09 | |
| Pylori Duo for Adjunctive Treatment and Prevention of Recurrence of Helicobacter Pylori Infection Omeprazole, Pylera (Bismuth subcitrate potassium, metronidazole, tetracycline) given in combination with omeprazole, Pylori Duo - Helicobacter Pylori Infection, Dyspepsia | Not applicable | Not yet recruiting | Gala Servicios Clinicos S.L. | 140 | 2026-08-31 | 2026-07-27 |
| Metronidazole- Versus Tinidazole-Based Bismuth Quadruple Therapy for Helicobacter Pylori Eradication Metronidazole, Tinidazole 500mg, tetracyline - Helicobacter Pylori Infection | Not applicable | Not yet recruiting | University of Medicine and Pharmacy at Ho Chi Minh City | 600 | 2026-07-27 | 2026-08-05 |
| Study on the Effect of Fecal Microbiota Transplantation on Eradication of Refractory Helicobacter Pylori Infection transanal fecal bacteria transplant - Helicobacter Pylori Infection | Phase 4 | Recruiting | Sichuan Provincial People's Hospital | 10 | 2026-07-20 | 2026-07-15 |
| Simplified Dual Regimen Guided by Fecal Clarithromycin Resistance Gene Detection for First-line H. Pylori Eradication Vonoprazan 20 mg twice daily + clarithromycin 500 mg twice daily for 14 days - Helicobacter Pylori Infection | Not applicable | Recruiting | Peking University First Hospital | 70 | 2026-04-25 | 2026-04-30 |
| Vonoprazan-based Versus Esomeprazole-based Triple Therapy for Helicobacter Pylori Eradication vonoprazan-based triple therapy (VAL regimen), Esomeprazole-based triple therapy (EAL regimen) - Helicobacter Pylori Infection, Dyspepsia | Phase 4 | Recruiting | Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh | 80 | 2026-04-15 | 2026-04-22 |
| Predicting Peptic Complications Using H. Pylori Serology and Gastric Ultrasound Peptic Ulcer Disease, HELICOBACTER PYLORI INFECTIONS | Not yet recruiting | Assiut University | 230 | 2026-04-01 | 2026-03-09 | |
| Fecal Molecular Susceptibility-guided Hp Rescue Therapy 7-day fecal molecular susceptibility-guided therapy, 14-day fecal molecular susceptibility-guided therapy - Helicobacter Pylori Infection | Phase 4 | Not yet recruiting | Shanghai Zhongshan Hospital | 290 | 2026-02-28 | 2026-02-12 |
| Effect of H. Pylori Eradication on The Improvement of Gastrointestinal Symptoms Helicobacter Pylori Infection, Dyspepsia | Not yet recruiting | Amany Usama Ahmed Arafa | 100 | 2025-12-20 | 2025-12-16 | |
| P-CABs-based Bismuth Quadruple Therapy for Helicobacter Pylori Eradication Doctors prescribe Helicobacter pylori treatment regimens for patients based on current guidelines and consensus statements, tailored to individual circumstances，not involve any intervention procedures - Helicobacter Pylori Infection | Recruiting | Yueyue Li | 1730 | 2025-12-16 | 2025-12-23 | |
| Comparison of Two Treatment Regimens of Helicobacter Pylori Infection Clarithromycin, Levofloxacin - Helicobacter Pylori Infection | Phase 4 | Not yet recruiting | Rehman Medical Institute - RMI | 156 | 2025-12-01 | 2025-06-15 |
| Saccharomyces Boulardii Combined With Bismuth Quadruple Therapy for Helicobacter Pylori Rescue Treatment Bismuth, Esomeprazole, Tetracycline - Gastritis, Dyspepsia | Phase 4 | Recruiting | Yongquan Shi | 1248 | 2025-10-28 | 2025-12-02 |
| Efficacies of Bismuth-amoxicillin-vonoprazan Triple Therapy and Bismuth Quadruple Therapy vonoprazan, tripotassium dicitrate bismuthate, amoxicilline, rabeprazole, tripotassium dicitrate bismuthate, tetracycline, metronidazole - Helicobacter Pylori Infection | Not applicable | Recruiting | Kaohsiung Medical University | 552 | 2025-10-21 | 2026-01-22 |
| Potassium-Competitive Acid Blocker Versus Proton Pump Inhibitor as A Part of Bismuth Based Quadruple Therapy for Treatment of Helicobacter Pylori Infection Potassium-Competitive Acid Blocker, Proton Pump Inhibitor - Potassium-Competitive Acid Blocker, Proton Pump Inhibitor | Not applicable | Recruiting | Tanta University | 320 | 2025-09-11 | 2025-09-12 |
| Tailored Vs. Empirical Helicobacter Pylori Infection Treatment Clarithromycin (mutations in the 23S rRNA gene, A2134G, A2142G and A2142C mutations) and levofloxacin resistance (mutations in the gyrA gene) PCR test, Empirically H. pylori eradication treatment with bismuth quadruple therapy (Pylera®), PPI, amoxicillin 1 g and clarithromycin 500 mg, twice daily, for 10 days - Helicobacter Pylori Infection | Phase 4 | Not yet recruiting | Manuel Coelho da Rocha | 160 | 2025-09-01 | 2024-12-20 |
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Stomach Neoplasms (26) · Dyspepsia (18) · Peptic Ulcer (15) · Gastritis (14) · Gastritis, Atrophic (6) · Stomach Ulcer (6) · Anemia, Iron-Deficiency (5) · cyclopia sequence (5) · Infections (4) · Abdominal Pain (3) · Duodenal Ulcer (3) · Anorexia (2) · Bile Reflux (2) · Colorectal Neoplasms (2) · Heartburn (2)
Digestive System Diseases (53) · Gastrointestinal Diseases (52) · Stomach Diseases (46) · Pathological Conditions, Signs and Symptoms (32) · Digestive System Neoplasms (27) · Gastrointestinal Neoplasms (27) · Neoplasms (27) · Neoplasms by Site (27) · Signs and Symptoms (26) · Intestinal Diseases (25) · Signs and Symptoms, Digestive (23) · Duodenal Diseases (21) · Gastroenteritis (21) · Nutritional and Metabolic Diseases (8) · Hemic and Lymphatic Diseases (7)
Amoxicillin (148) · Clarithromycin (91) · Metronidazole (78) · Esomeprazole (67) · Tetracycline (46) · Levofloxacin (38) · 1-(5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl)-N-methylmethanamine (36) · Rabeprazole (30) · Omeprazole (21) · Bismuth (19) · Furazolidone (19) · bismuth tripotassium dicitrate (16) · Lansoprazole (15) · Pantoprazole (14) · tegoprazan (12)
Shandong University (31) · Shanghai Jiao Tong University School of Medicine (20) · National Taiwan University Hospital (18) · Kaohsiung Veterans General Hospital. (12) · Nanjing First Hospital, Nanjing Medical University (12) · Xijing Hospital of Digestive Diseases (11) · Second Affiliated Hospital, Zhejiang University, School of Medicine (8) · Assiut University (7) · Mackay Memorial Hospital (7) · Seoul National University Bundang Hospital (7) · Shanghai Zhongshan Hospital (7) · TenNor Therapeutics (Suzhou) Limited (6) · Alexandria University (5) · Chang Gung Memorial Hospital (5) · Sohag University (5)
China (132) · Taiwan (54) · South Korea (41) · United States (20) · Egypt (17) · Italy (13) · Pakistan (8) · Spain (7) · Germany (5) · Israel (5) · Thailand (5) · Chile (4) · France (4) · Slovenia (4) · Syria (4)
Xiuli Zuo, MD,PhD (13) · Ping-I Hsu, Bachelor (8) · Jyh-Chin Yang, M.D.Ph.D. (6) · Tai-cherng Liou, MD (5) · Taotao Liu, MD (5) · Zhenyu Zhang (4) · Il Ju Choi, M.D., Ph.D. (3) · Marouf M Alhalabi, MD (3) · Xiuli Zuo, PhD,MD (3) · Bin Cheng, Doctor (2) · Byung-Wook Kim, MD, PhD (2) · David Y Graham, MD (2) · Deng-Chyang Wu, MD, PHD (2)
PMID 27707777, PMID 28456631, PMID 38359854, PMID 32348007, PMID 34836916, PMID 15371921, PMID 15691312, PMID 17608775, PMID 25741163, PMID 27769562, PMID 29914954, PMID 31111585, PMID 32545856, PMID 33004546, PMID 34862940, PMID 10086658, PMID 10406244, PMID 10452677, PMID 10811322, PMID 11281437, PMID 11677476, PMID 12039901, PMID 12526935, PMID 12641522, PMID 15128344, PMID 16437639, PMID 16494583, PMID 16611267, PMID 16961802, PMID 17170018, PMID 17382282, PMID 17438314, PMID 17466292, PMID 1771934, PMID 17854602, PMID 18159172, PMID 18205663, PMID 18205666, PMID 18300349, PMID 18446147, PMID 18753649, PMID 19298337, PMID 19457415, PMID 19788600, PMID 20427808, PMID 20525969, PMID 20571304, PMID 20616418, PMID 21188333, PMID 21777974
2019 (1), R21DE017378 (1)