7 completed, 5 recruiting, 4 unknown, 3 terminated. 9 Phase 2, 7 Not applicable, 5 Phase 1, 2 Phase 3.
Follow Head Neck Cancer: new trials by email Literature Review of Head Neck Cancer trials Research Report on Head Neck Cancer
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Stereotactic MRI-guided Focused Ultrasound Mesencephalotomy ExAblate Neuro - Head Neck Cancer, Squamous Cell Cancer of Head and Neck (SCCHN) | Not applicable | Recruiting | University of Virginia | 20 | 2026-02-15 | 2026-02-12 |
| CApecitabine Prior to TUmor Resection in Ent Oncology (CAPTURE) Capecitabine, Standard of Care (SOC) - Head Neck Cancer, Mouth Cancer | Phase 2 | Not yet recruiting | Sir Mortimer B. Davis - Jewish General Hospital | 75 | 2026-01-01 | 2025-11-28 |
| Intratumoral Delivery of Viral Replicon (saRNA) Particles Expressing IL-12 in Head and Neck Cancer VRP-encapsulated saRNA encoding IL-12 (1 x 10^9 viral particles per injection), Pembrolizumab (KEYTRUDA®), VRP-encapsulated saRNA encoding IL-12 (3 x 10^8 viral particles per injection) - Head and Neck Cancers- Squamous Cell, Head and Neck Cancer | Phase 1 | Recruiting | VLP Therapeutics | 41 | 2025-05-13 | 2026-09-21 |
| Pretreatment Botulinum Toxin in Head and Neck Cancer Surgery OnabotulinumtoxinA, Placebo - Head Neck Cancer, Xerostomia Following Radiotherapy | Phase 2 | Not yet recruiting | Sir Mortimer B. Davis - Jewish General Hospital | 50 | 2024-10-01 | 2024-07-31 |
| Human Papillomavirus Association and Genomic Exploration in Head-Neck Squamous Cell Carcinomas Histopathology, Immunohistochemistry, Real-Time PCR, Sequencing - Head Neck Cancer, Oropharyngeal Neoplasms | Recruiting | Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh | 550 | 2024-04-30 | 2024-12-31 | |
| Evaluating Illustrated Vs. Traditional Pamphlets for Enhancing Self-Care in Radiation Therapy Patients Optimized illustrated pamphlets - Radiation Therapy, Head Neck Cancer | Not applicable | Completed | Chung Shan Medical University | 200 | 2023-11-02 | 2024-11-07 |
| Evaluation of Skin Health and QoL in Pts Receiving Anti-PD1/PDL1/CTLA4 or CDK Inhibitors. EQ-5D-5L questionnaire, FACT-G (Functional Assessment of Cancer Therapy - General), FACT-EGFRI-18 (Functional Assessment of Cancer Therapy - Epidermal Growth Factor Inhibitors 18 Item) - Lung Cancer, Breast Cancer | Unknown | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | 420 | 2023-05-22 | 2024-10-04 | |
| Study of RiMO-301 and Radiotherapy With PD-1 Inhibitor for the Treatment of Head-Neck Cancer RiMO-301 - Head Neck Cancer, Intratumoral Injection | Phase 1 / Phase 2 | Recruiting | Coordination Pharmaceuticals, Inc. | 16 | 2023-04-03 | 2025-09-17 |
| A Safety, Tolerability and Efficacy Study of NC410 Plus Pembrolizumab in Participants With Advanced Unresectable or Metastatic Solid Tumors NC410, pembrolizumab - Advanced or Metastatic Solid Tumors, Microsatellite Instability Low | Phase 1 / Phase 2 | Terminated | NextCure, Inc. | 97 | 2022-10-06 | 2026-08-13 |
| First Line Weekly Chemo/Immunotherapy for Metastatic Head/Neck Squamous Cell Carcinoma Patients Pembrolizumab, Carboplatin, Paclitaxel - Head Neck Cancer, Metastatic Squamous Cell Carcinoma | Phase 2 | Active not recruiting | Wake Forest University Health Sciences | 31 | 2021-05-27 | 2026-07-13 |
| Swallowing Function in Patients With Head and Neck Cancers Surface Electromyography and Video fluoroscopy - Head Neck Cancer, Oral Cancer | Not applicable | Completed | Banaras Hindu University | 50 | 2021-05-01 | 2023-04-27 |
| Blue Laser Imaging (BLI) for Detection of Secondary Head and Neck Cancer blue laser imaging - Head Neck Cancer, Esophageal Cancer | Not applicable | Unknown | Georg Dultz | 140 | 2020-09-22 | 2023-07-13 |
| Investigation of Two Swallowing Therapy Models During Radiation Therapy for Head and Neck Cancer Virtual Coach - Head Neck Cancer | Not applicable | Completed | Stanford University | 98 | 2019-04-22 | 2024-04-10 |
| Study of Efficacy and Safety of Gabapentin to Reduce the Need for Strong Opioid Use in Head and Neck Cancer Patients. Gabapentin, Placebo - Head Neck Cancer, Radiation Neuropathy | Phase 3 | Withdrawn | University Hospital, Ghent | 2019-03-01 | 2024-09-19 | |
| Aprepitant for Nause and Vomiting Induced by Chemoradiotherapy in HNSCC Aprepitant - Vomiting, Nausea Post Chemotherapy | Phase 2 | Completed | Chinese Academy of Medical Sciences | 44 | 2018-03-01 | 2020-07-15 |
| Newer Therapeutic Targets in Head and Neck Cancers Next generation Sequencing - Head Neck Cancer, Oral Cancer | Recruiting | Banaras Hindu University | 200 | 2017-04-01 | 2024-08-13 | |
| Calcium Electroporation for Head and Neck Cancer Calcium chloride, Electroporation - Head Neck Cancer | Phase 1 | Unknown | Copenhagen University Hospital, Rigshospitalet | 6 | 2016-05-01 | 2017-02-13 |
| A Trial of Intratumoral Injections of SD-101 in Combination With Pembrolizumab in Patients With Metastatic Melanoma or Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma SD-101(1), Pembrolizumab, SD-101(2) - Metastatic Melanoma, Head Neck Cancer | Phase 1 / Phase 2 | Terminated | Dynavax Technologies Corporation | 241 | 2015-09-01 | 2021-08-03 |
| Brief Intraoperative Electrical Stimulation for Prevention of Shoulder Dysfunction After Oncologic Neck Dissection Grass SD9 Stimulator - Shoulder Pain, Head Neck Cancer | Not applicable | Completed | University of Alberta | 68 | 2014-10-06 | 2020-05-07 |
| Electrochemotherapy on Head and Neck Cancer Electrochemotherapy, Cliniporator, Bleomycin - Head Neck Cancer | Phase 2 | Unknown | Copenhagen University Hospital, Rigshospitalet | 25 | 2014-02-01 | 2017-01-18 |
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Head and Neck Neoplasms (23) · Mouth Neoplasms (4) · Carcinoma, Squamous Cell (3) · Squamous Cell Carcinoma of Head and Neck (3) · Deglutition Disorders (2) · Esophageal Neoplasms (2) · Lung Neoplasms (2) · Melanoma (2) · Skin Neoplasms (2) · Stomach Neoplasms (2) · Breast Neoplasms (1) · Cancer Pain (1) · Carcinoma (1) · Colonic Neoplasms (1) · Communication Disorders (1)
Neoplasms by Site (23) · Neoplasms (22) · Pathological Conditions, Signs and Symptoms (6) · Digestive System Diseases (5) · Gastrointestinal Diseases (5) · Neoplasms by Histologic Type (5) · Otorhinolaryngologic Diseases (5) · Signs and Symptoms (5) · Stomatognathic Diseases (5) · Esophageal Diseases (4) · Mouth Diseases (4) · Neoplasms, Glandular and Epithelial (4) · Neurologic Manifestations (4) · Respiratory Tract Diseases (4) · Carcinoma (3)
pembrolizumab (4) · Bleomycin (2) · Electroporation (2) · Aprepitant (1) · Base Sequence (1) · Botulinum Toxins, Type A (1) · Calcium (1) · Calcium Chloride (1) · Capecitabine (1) · Carboplatin (1) · Dexamethasone (1) · Drug Therapy (1) · Electric Stimulation (1) · Electrochemotherapy (1) · Electromyography (1)
Banaras Hindu University (2) · Copenhagen University Hospital, Rigshospitalet (2) · Sir Mortimer B. Davis - Jewish General Hospital (2) · Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh (1) · Barretos Cancer Hospital (1) · Chinese Academy of Medical Sciences (1) · Chung Shan Medical University (1) · Coordination Pharmaceuticals, Inc. (1) · Dynavax Technologies Corporation (1) · Fondazione Policlinico Universitario Agostino Gemelli IRCCS (1) · Georg Dultz (1) · Inovio Pharmaceuticals (1) · NextCure, Inc. (1) · Stanford University (1) · University Hospital, Ghent (1)
United States (9) · Canada (2) · Denmark (2) · Germany (2) · India (2) · Australia (1) · Bangladesh (1) · Belgium (1) · Brazil (1) · China (1) · Italy (1) · New Zealand (1) · Taiwan (1)
Alexandre Jacinto, MD (1) · Antoni Ribas, MD (1) · Barbara Murphy, MD (1) · Brittany Barber, MD (1) · Daniel O'Connell, MD MSc FRCSC (1) · Ezra Cohen, MD (1) · Fred M Baik, MD (1) · Hadi Seikaly, MD MAL FRCSC (1) · Heather Starmer (1) · Irene Wessel (1) · Jaret Olson, MD FRCSC (1) · Jeffrey Harris, MD MHA FRCSC (1) · Juliana Portas, MSC (1) · Julie Gehl, MD (1)
PMID 26021563, PMID 30154193, PMID 31775759, PMID 35960394, PMID 41723472
P30CA012197 (1), R21CA173202 (1)