29 completed, 22 unknown, 15 recruiting, 3 not yet recruiting. 11 Not applicable, 3 Phase 1, 3 Phase 2, 1 Early Phase 1, 1 Phase 3.
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Parallel Sequencing of Fetal Genome and RNA in the Presence of Ultrasound Warning Signs: a Complementary Approach for the Prenatal Diagnosis of Rare Diseases. Genome Sequencing (GS) + RNA-Sequencing (RNA-Seq) - Couples Eligible for Prenatal Exome Sequencing | Not yet recruiting | Assistance Publique - Hôpitaux de Paris | 100 | 2026-09-01 | 2026-08-27 | |
| Integrated Clinical-molecular Risk Stratification to Early Recurrence in Colorectal Liver Metastases gene sequencing, observational study - Colorectal Liver Metastases | Not yet recruiting | Fudan University | 200 | 2026-01-31 | 2026-02-05 | |
| Etiologic Diagnosis Algorithm in Infective Endocarditis Molecular tests (PCR, sequencing), Standard Clinical Practice - Infective Endocarditis, Microbiology | Not applicable | Recruiting | I.M. Sechenov First Moscow State Medical University | 128 | 2026-01-20 | 2026-07-02 |
| Transcriptomic Approach for the Identification and Prioritization of Genome Variants in Neurodevelopmental Disorders With Malformation RNA sequencing and whole genome sequencing in a trio way - Neurodevelopmental Disorders and Developmental Abnormalities | Not applicable | Recruiting | University Hospital, Angers | 58 | 2025-11-04 | 2026-06-29 |
| Implementation of Digital Workflow for Complete Dentures - A Crossover Study Sequence in receiving the fabricated dentures made using the conventional and partial digital method - Complete Edentulism | Not applicable | Not yet recruiting | National Dental Centre, Singapore | 20 | 2025-10-30 | 2025-06-03 |
| Combined Genome and RNA Sequencing for Genetic Diagnosis of Parkinsonism Combiner whole genome and RNA sequencing - Parkinson's Disease | Not applicable | Recruiting | University Hospital, Strasbourg, France | 14 | 2025-01-14 | 2026-08-21 |
| Utilizing Long-read Sequencing to Investigate the EGFR Landscape of EGFR Positive Lung Cancer Patients blood draw, Gene sequencing - Lung Cancer - Non Small Cell, EGFR Exon 19 Deletion Mutation | Recruiting | Our Lady of the Lake Hospital | 20 | 2025-01-01 | 2025-03-20 | |
| Investigation of Predictive Biomarkers in Patients With Advanced BTC Treated With Lenvatinib Plus Pembrolizumab lenvatinib plus pembrolizumab - Biliary Tract Cancer, Cholangiocarcinoma | Recruiting | CHA University | 100 | 2024-09-23 | 2026-03-18 | |
| Carbon Ion Radiotherapy for Locally Advanced Lung Cancer in Elderly Patients carbon ion radiotherapy, targeted therapy, single regimen chemotherapy in sequence with radiotherapy - Non-small Cell Lung Cancer, Older People | Phase 2 | Recruiting | Jian Chen | 29 | 2024-08-08 | 2025-06-13 |
| Cervical Cancer Susceptible Population Classification PCR and sequence - Cervical Cancer Susceptible Population Classification | Recruiting | Anhui Provincial Hospital | 10000 | 2024-05-01 | 2024-05-09 | |
| Human Papillomavirus Association and Genomic Exploration in Head-Neck Squamous Cell Carcinomas Histopathology, Immunohistochemistry, Real-Time PCR, Sequencing - Head Neck Cancer, Oropharyngeal Neoplasms | Recruiting | Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh | 550 | 2024-04-30 | 2024-12-31 | |
| GENETIC VARIABILITY TO GLP1 TREATMENT DNA Sequencing and Analysis, differential expression analysis with RNA-sequencing (RNA seq) experiments - Type 2 Diabetes, Obesity | Not applicable | Unknown | GENGE | 400 | 2023-10-01 | 2024-03-07 |
| Functional Characterization of Thrombopoietin/cMPL Receptor Mutations in Myeloproliferative Neoplasia Gene sequencing - Myeloproliferative Disorder | Unknown | Centre Hospitalier Universitaire de Nīmes | 30 | 2023-10-01 | 2024-02-07 | |
| Changes in Gene Expression and Prognosis of Blood Immune Cells After Cardiopulmonary Bypass Surgery Gene sequencing - Acute Kidney Injury | Unknown | Second Affiliated Hospital, Zhejiang University, School of Medicine | 12 | 2023-05-17 | 2023-05-23 | |
| Predictive Biomarkers of Response to Checkpoint Inhibitors in Triple Negative Breast Cancer: a Multiomics Platform Whole Genome Sequencing, RNA-Sequencing, Microbiome analysis - Triple Negative Breast Cancer | Recruiting | Vall d'Hebron Institute of Oncology | 100 | 2023-01-13 | 2023-06-23 | |
| Deciphering the Role of Circular RNAs in ALKpositive Anaplastic Large-cell Lymphoma RNAseq - ALK-Positive Anaplastic Large Cell Lymphoma | Unknown | University Hospital, Toulouse | 80 | 2023-01-01 | 2023-07-06 | |
| Precision Medicine for Every Child With Cancer Whole Genome Sequencing, RNA seq, DNA Methylation - Childhood Cancer, Childhood Solid Tumor | Recruiting | Australian & New Zealand Children's Haematology/Oncology Group | 3500 | 2022-12-16 | 2024-07-17 | |
| Biomarkers of Response to Systemic Treatments in FH-deficient RCC Sequencing - Metabolomics, Renal Cell Carcinoma | Unknown | RenJi Hospital | 100 | 2022-05-25 | 2022-08-16 | |
| Diagnosis and Phenotype Characterisation Using Genomics in Patients With Inherited Bone Marrow Failure (IBMDx Study) whole genome and transcriptome sequencing - Inherited BMF Syndrome, Inherited Platelet Disorder | Recruiting | Peter MacCallum Cancer Centre, Australia | 350 | 2022-03-18 | 2024-11-07 | |
| Analysis of Biological Characteristics of Advanced ALK-rearranged NSCLC RNAseq - Non-small Cell Lung Cancer, ALK Gene Rearrangement Positive | Not applicable | Recruiting | Groupe Francais De Pneumo-Cancerologie | 100 | 2021-09-22 | 2026-04-29 |
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Leukemia (8) · Sarcoma (5) · Neoplasms (4) · Breast Neoplasms (3) · Carcinoma, Non-Small-Cell Lung (3) · Colorectal Neoplasms (3) · Biliary Tract Neoplasms (2) · Cholangiocarcinoma (2) · Congenital Abnormalities (2) · Endometrial Neoplasms (2) · Genetic Diseases, Inborn (2) · Head and Neck Neoplasms (2) · Leukemia, Erythroblastic, Acute (2) · Leukemia, Lymphocytic, Chronic, B-Cell (2) · Leukemia, Megakaryoblastic, Acute (2)
Children's Oncology Group (11) · Institut National de la Santé Et de la Recherche Médicale, France (3) · University of Nebraska (3) · CHA University (2) · Case Comprehensive Cancer Center (2) · German Cancer Research Center (2) · Lei Li (2) · Second Affiliated Hospital, Zhejiang University, School of Medicine (2) · Alliance for Clinical Trials in Oncology (1) · Anhui Provincial Hospital (1) · Assistance Publique - Hôpitaux de Paris (1) · Australian & New Zealand Children's Haematology/Oncology Group (1) · Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh (1) · Centre Hospitalier Universitaire de Nīmes (1) · Charles University, Czech Republic (1)
France (14) · United States (14) · China (12) · Australia (2) · Germany (2) · Israel (2) · South Korea (2) · Bangladesh (1) · Czechia (1) · Egypt (1) · French Guiana (1) · Hong Kong (1) · Moldova (1) · Netherlands (1) · New Zealand (1)
Andreas Schneeweiss, MD (2) · Peter Lichter, PhD (2) · Verena Thewes, PhD (2) · Agustin Garcia, MD (1) · Alberto S. Pappo, MD (1) · Amita Dave, PhD (1) · Antoine Italiano (1) · Bin Liu, MD (1) · Ching-Mao Chang, M.D., Ph.D. (1) · Crystal Denlinger (1) · David Ziegler (1) · Elizabeth C. Reed, MD (1) · Elizabeth DeChene, MS, GCG (1)
PMID 32713836, PMID 20375404, PMID 20434914, PMID 25623140, PMID 25860647, PMID 26242208, PMID 27125753, PMID 28233803, PMID 31307542, PMID 32832493, PMID 32898291, PMID 33798493, PMID 34740331, PMID 34818479, PMID 35967452, PMID 36347967, PMID 37075781, PMID 38319896, PMID 38367687, PMID 38564220, PMID 38631269, PMID 38650446, PMID 38806657, PMID 39153572, PMID 39939648
P30CA036727 (2), 2017 (1)