1075 completed, 511 unknown, 498 recruiting, 313 terminated. 2929 Phase 2, 548 Phase 1, 108 Phase 3.
Follow Head and Neck Neoplasms: new trials by email Literature Review of Head and Neck Neoplasms trials Research Report on Head and Neck Neoplasms
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| 9-ING-41 Plus Carboplatin in Patients With Advanced, Metastatic Salivary Gland Carcinoma 9-ING-41, Carboplatin - Salivary Gland Carcinoma, Adenoid Cystic Carcinoma | Phase 2 | Withdrawn | Actuate Therapeutics Inc. | 2030-12-18 | 2022-02-22 | |
| The FORCE Trial Pilot: Fish Oil-enriched Nutrition for Radiotherapy in Cancer of the hEad and Neck Nutrition counseling, Fresubin Supportan - Head &Amp;Amp; Neck Squamous Cell Carcinoma | Phase 1 / Phase 2 | Not yet recruiting | Anna Arthur, PhD | 15 | 2027-06-01 | 2026-08-07 |
| Chemo-embolization for Head and Neck Cancer Cisplatin - SCCHN, Squamous Cell Carcinoma | Phase 2 | Withdrawn | University of Alabama at Birmingham | 2027-05-01 | 2025-04-27 | |
| A Ph2, Colchicine For Inflammatory Carotid Injury And Disease Evolution After Radiotherapy Colchicine, Placebo - Head and Neck Cancer | Phase 2 | Not yet recruiting | M.D. Anderson Cancer Center | 250 | 2027-03-01 | 2026-10-05 |
| Stereotactic Body Radiation Therapy (SBRT) and Immunotherapy for Oligometastatic Esophageal Cancer Stereotactic body radiation treatment (SBRT) - Esophageal Cancer | Phase 2 | Not yet recruiting | AHS Cancer Control Alberta | 22 | 2027-03-01 | 2026-10-28 |
| RESTAGE (REpurposing STAtins to Improve Outcomes in GastroEsophageal Cancer) Trial FLOT (Fluorouracil+Leucovorin+Oxaliplatin+Docetaxel), Simvastatin, Durvalumab - Gastroesophageal Adenocarcinoma | Phase 2 | Not yet recruiting | McGill University Health Centre/Research Institute of the McGill University Health Centre | 184 | 2027-01-01 | 2026-07-10 |
| Becotatug Vedotin Plus Pucotenlimab in Locally Advanced Head and Neck Squamous Cell Carcinoma With Suboptimal Response to Induction Immunochemotherapy Becotatug Vedotin (MRG003), Pucotenlimab - Squamous Cell Carcinoma of Head and Neck (SCCHN) | Phase 2 | Not yet recruiting | Sun Yat-sen University | 22 | 2027-01-01 | 2026-11-04 |
| PhII Study of Toripalimab Followed by Definitive CRT & Adjuvant Toripalimab in Locally Advanced ESCC Toripalimab, Carboplatin + Paclitaxel - Esophageal Squamous Cell Carcinoma | Phase 2 | Not yet recruiting | Vanderbilt-Ingram Cancer Center | 20 | 2026-12-31 | 2026-09-23 |
| Pulsed Stereotactic Ablative Radiotherapy (PULSAR) With Systematic Therapy for Thyroid Cancer Dabrafenib, Trametinib, Pembrolizumab - Anaplastic Thyroid Carcinoma, Thyroid Cancer | Phase 2 | Not yet recruiting | Washington University School of Medicine | 12 | 2026-12-31 | 2026-10-21 |
| Aspirin and PAClitaxel in Head & Neck Squamous Cell Carcinoma Aspirin, Paclitaxel - Head and Neck (HNSCC), Head and Neck Squamous Cell Carcinoma (HNSCC) - Recurrent/Metastatic (R/M) | Phase 2 | Not yet recruiting | Washington University School of Medicine | 40 | 2026-12-31 | 2026-10-28 |
| A Study of LG00313112 in Participants With Advanced Solid Malignancies Harboring a TP53 Y220C Mutation LG00313112 - Ovarian Cancer, Small Cell Lung Cancer | Phase 1 / Phase 2 | Not yet recruiting | LG Chem | 250 | 2026-12-01 | 2026-08-07 |
| Risk-adapted Therapy in HPV-positive Oropharyngeal Cancer Using Circulating Tumor (ct) HPV DNA Profiling (ReACT 2.0) Pembroluzimab, Observation - HPV-positive Oropharyngeal Squamous Cell Carcinoma, Oropharyngeal Squamous Cell Carcinoma | Phase 2 | Withdrawn | Dana-Farber Cancer Institute | 2026-12-01 | 2026-10-08 | |
| Head and Neck Cancer Patients With Oral Mucositis Treated With Ketamine Oral Rinse Placebo, Ketamine Topical - Head and Neck Cancer | Phase 2 | Not yet recruiting | University of Oklahoma | 62 | 2026-12-01 | 2026-10-16 |
| Low Dose, Reduced Frequency Nivolumab for the Treatment of Unresectable or Metastatic Cancer, AFFORD IO Trial Biospecimen Collection, Computed Tomography, Magnetic Resonance Imaging - Clinical Stage III Cutaneous Melanoma AJCC v8, Clinical Stage III Cutaneous Merkel Cell Carcinoma AJCC v8 | Phase 2 | Not yet recruiting | Fred Hutchinson Cancer Center | 50 | 2026-12-01 | 2026-09-17 |
| Intralesional Chemotherapy (IC): Cisplatin + Epinephrine Cisplatin, Epinephrine injection, Laryngeal Biopsy - Laryngeal Squamous Cell Carcinoma | Phase 2 | Recruiting | University of Miami | 20 | 2026-12-01 | 2026-08-26 |
| Dynamic Plasma EBV DNA-Guided Risk-Adapted Treatment With Becotatug Vedotin (MRG003) Plus PD-1 Blockade in Locoregionally Advanced Nasopharyngeal Carcinoma Becotatug Vedotin, Pucotenlimab, Intensity-Modulated Radiotherapy - Nasopharyngeal Cancinoma (NPC), Nasopharyngeal Cancer | Phase 2 | Not yet recruiting | Sun Yat-sen University | 298 | 2026-12-01 | 2026-10-27 |
| Ficerafusp Alfa, Pembrolizumab, and Stereotactic Body Radiotherapy (SBRT) for Head and Neck Squamous Cell Carcinoma (HNSCC) Hypofractionated Stereotactic Body Radiotherapy (SBRT), Pembrolizumab, Ficerafusp alfa - Head and Neck Squamous Cell Carcinoma, HPV-Negative Squamous Cell Carcinoma | Phase 1 / Phase 2 | Not yet recruiting | Washington University School of Medicine | 45 | 2026-11-30 | 2026-11-03 |
| Docetaxel and SX-682 in Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma, Salivary Gland Carcinoma, and Advanced Prostate Cancer SX-682, DTX - Head and Neck Cancer, Head and Neck Squamous Cell Carcinoma | Phase 1 / Phase 2 | Recruiting | National Cancer Institute (NCI) | 120 | 2026-11-11 | 2026-11-06 |
| 177Lu-DOTA-EB-TATE in Adult Patients With Metastatic, Radioactive Iodine Non-Responsive Oncocytic (Hurthle-Cell) Thyroid Cancer 68Ga-DOTA-TATE PET Scan, Amino acid infusions, 177Lu-DOTA-EB-TATE - Thyroid Cancer | Phase 1 / Phase 2 | Not yet recruiting | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) | 18 | 2026-11-11 | 2026-11-06 |
| Proton Spatially Fractionated Radiotherapy or Photon Stereotactic Body Radiotherapy in Combination With Pembrolizumab Before Surgery for the Treatment of Locally Advanced and Radiation-Naive Locoregionally Recurrent Oral Cavity Cancer, OSPRI Trial Biopsy Procedure, Biospecimen Collection, Computed Tomography - Locally Advanced Oral Cavity Squamous Cell Carcinoma, Locally Recurrent Oral Cavity Squamous Cell Carcinoma | Phase 2 | Recruiting | Mayo Clinic | 30 | 2026-11-04 | 2026-11-06 |
Showing 20 of 2929. Sign in to see all of them.
Squamous Cell Carcinoma of Head and Neck (900) · Esophageal Neoplasms (614) · Esophageal Squamous Cell Carcinoma (353) · Nasopharyngeal Carcinoma (284) · Stomach Neoplasms (220) · Carcinoma, Non-Small-Cell Lung (202) · Thyroid Neoplasms (192) · Carcinoma, Squamous Cell (140) · Neoplasm Metastasis (138) · Oropharyngeal Neoplasms (136) · Neoplasms (133) · Adenocarcinoma Of Esophagus (130) · Colorectal Neoplasms (114) · Melanoma (114)
Neoplasms by Site (2912) · Neoplasms (2796) · Neoplasms by Histologic Type (1810) · Neoplasms, Glandular and Epithelial (1780) · Carcinoma (1694) · Carcinoma, Squamous Cell (1155) · Digestive System Diseases (1043) · Gastrointestinal Diseases (1023) · Digestive System Neoplasms (1007) · Gastrointestinal Neoplasms (968) · Esophageal Diseases (875) · Stomatognathic Diseases (727) · Otorhinolaryngologic Diseases (565) · Otorhinolaryngologic Neoplasms (532)
Cisplatin (542) · Radiotherapy (283) · pembrolizumab (248) · Paclitaxel (239) · Carboplatin (219) · Fluorouracil (216) · Docetaxel (198) · Cetuximab (194) · Radiotherapy, Intensity-Modulated (130) · Nivolumab (109) · Drug Therapy (94) · Capecitabine (92) · Oxaliplatin (90) · Radiation (84) · toripalimab (78)
Sun Yat-sen University (128) · National Cancer Institute (NCI) (122) · M.D. Anderson Cancer Center (66) · Memorial Sloan Kettering Cancer Center (63) · Fudan University (60) · Dana-Farber Cancer Institute (47) · University of Chicago (29) · Washington University School of Medicine (29) · Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University (28) · Zhejiang Cancer Hospital (28) · University of Michigan Rogel Cancer Center (27) · Cancer Institute and Hospital, Chinese Academy of Medical Sciences (25) · Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University (25) · Tianjin Medical University Cancer Institute and Hospital (25) · West China Hospital (21)
United States (1272) · China (860) · France (198) · Canada (160) · Spain (146) · United Kingdom (138) · South Korea (134) · Germany (108) · Taiwan (108) · Italy (105) · Belgium (93) · Australia (90) · Netherlands (68) · Japan (62) · Singapore (58)
Aminah Jatoi, MD (8) · Douglas Adkins, M.D. (8) · Yue He, M.D. (8) · David H. Ilson, MD, PhD (7) · Douglas R Adkins, M.D. (7) · Nancy Lee, MD (7) · A. Dimitrios Colevas, MD (6)
PMID 25057165, PMID 22646630, PMID 37934000, PMID 26313683, PMID 26884585, PMID 30207593, PMID 31150573, PMID 33720067, PMID 34503735, PMID 35623069, PMID 36990609, PMID 39532605, PMID 39584361, PMID 40341199, PMID 41044356, PMID 19097774, PMID 19564532, PMID 21183517, PMID 25081901, PMID 25979390, PMID 26808342, PMID 27240885, PMID 28434660, PMID 28742685, PMID 28797458, PMID 31838007, PMID 32017652, PMID 32665297, PMID 32852531, PMID 33720068, PMID 33963014, PMID 34341578, PMID 34937871, PMID 35046059, PMID 35355438, PMID 37195667, PMID 37496366, PMID 37580352, PMID 37816266, PMID 40086048, PMID 40855191, PMID 41309527, PMID 41531940, PMID 42568612, PMID 10235156, PMID 10444409, PMID 10811668, PMID 11208820, PMID 11224527, PMID 11240232
2023 (28), 2016 (19), U10CA032102 (19), 2019 (16), 2017 (15), 2015 (13), U10CA021115 (12), N01CM62201 (10), P30CA006516 (10), U10CA180868 (10), 2025 (9), P30CA016672 (9), 2014 (8), 2018 (8), P30CA014599 (8)