656 completed, 250 recruiting, 245 terminated, 145 unknown. 1534 Phase 1, 547 Phase 2.
Follow Head and Neck Neoplasms: new trials by email Literature Review of Head and Neck Neoplasms trials Research Report on Head and Neck Neoplasms
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| The FORCE Trial Pilot: Fish Oil-enriched Nutrition for Radiotherapy in Cancer of the hEad and Neck Nutrition counseling, Fresubin Supportan - Head &Amp;Amp; Neck Squamous Cell Carcinoma | Phase 1 / Phase 2 | Not yet recruiting | Anna Arthur, PhD | 15 | 2027-06-01 | 2026-08-07 |
| Trial of a Personalized and Adaptive Neoantigen Dose-Adjusted Vaccine Concurrently With Pembrolizumab PANDA-VAC, Pembrolizumab - Squamous Cell Lung Cancer, Squamous Non-small Cell Lung Cancer | Phase 1 | Suspended | UNC Lineberger Comprehensive Cancer Center | 6 | 2027-05-20 | 2026-04-23 |
| Proactively Intervening On Early Cranial Nerve Injury As A Delayed Sequela Of Oropharyngeal Cancer: A Randomized Feasibility Clinical Trial For Pro-Habilitation (proNERVE RCT) Prednisone, Ajovy, Manual Therapy - Cranial Nerve Injury, Oropharyngeal Cancer | Phase 1 | Not yet recruiting | M.D. Anderson Cancer Center | 48 | 2027-03-01 | 2026-09-21 |
| Testing the Addition of an Anti-Cancer Drug, Camonsertib, to Radiation Therapy for Recurrent Head and Neck Squamous Cell Carcinoma Biospecimen Collection, Camonsertib, Computed Tomography - Clinical Stage III HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8, Recurrent Head and Neck Squamous Cell Carcinoma | Phase 1 | Recruiting | National Cancer Institute (NCI) | 39 | 2027-02-13 | 2026-09-03 |
| Outside the Cage (OTC) Robotic Esophagectomy OTC MIE Esophagectomy - Esophageal Cancer | Phase 1 | Not yet recruiting | Centre hospitalier de l'Université de Montréal (CHUM) | 31 | 2027-01-01 | 2026-03-18 |
| Antitumor-B KAC PK Study Antitumor B KAC - Squamous Cell Carcinoma of the Oral Cavity | Phase 1 | Withdrawn | Medical College of Wisconsin | 2026-12-01 | 2025-03-18 | |
| A Study of LG00313112 in Participants With Advanced Solid Malignancies Harboring a TP53 Y220C Mutation LG00313112 - Ovarian Cancer, Small Cell Lung Cancer | Phase 1 / Phase 2 | Not yet recruiting | LG Chem | 250 | 2026-12-01 | 2026-08-07 |
| 177Lu-DOTA-EB-TATE in Adult Patients With Metastatic, Radioactive Iodine Non-Responsive Oncocytic (Hurthle-Cell) Thyroid Cancer 68Ga-DOTA-TATE PET Scan, Amino acid infusions, 177Lu-DOTA-EB-TATE - Thyroid Cancer | Phase 1 / Phase 2 | Not yet recruiting | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) | 18 | 2026-11-02 | 2026-10-28 |
| Docetaxel and SX-682 in Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma, Salivary Gland Carcinoma, and Advanced Prostate Cancer SX-682, DTX - Head and Neck Cancer, Head and Neck Squamous Cell Carcinoma | Phase 1 / Phase 2 | Recruiting | National Cancer Institute (NCI) | 120 | 2026-11-02 | 2026-10-28 |
| A Study of [225Ac]Ac-AKY-2519 in Patients With B7-H3 Expressing Solid Tumors [225Ac]Ac-AKY-2519 (therapeutic), [64Cu]Cu-AKY-2519 (imaging) - NSCLC, NSCLC (Advanced Non-small Cell Lung Cancer) | Phase 1 | Recruiting | Aktis Oncology, Inc. | 152 | 2026-11-01 | 2026-10-22 |
| A Study of MDSY-1240, a STAT3 Degrader, for the Treatment of Hematologic Malignancies and Advanced Solid Tumors MDSY-1240 - Triple-Negative Breast Cancer (TNBC), Gastric Cancer (GC) | Phase 1 / Phase 2 | Not yet recruiting | Medsyn Biopharma, LLC | 75 | 2026-11-01 | 2026-10-27 |
| A Phase 1, Multicenter Imaging Study of LNTH-2403 in Participants With Locally Advanced or Metastatic Solid Tumors. LNTH-2403 - Imaging, Colorectal Cancer | Phase 1 | Not yet recruiting | Radiopharm Theranostics, Ltd | 16 | 2026-10-30 | 2026-08-12 |
| Pharmacokinetics Study of Larotinib in Subjects With Impaired Hepatic Function Larotinib - Esophageal Cancer, Advanced Solid Tumor | Phase 1 | Withdrawn | Sunshine Lake Pharma Co., Ltd. | 2026-10-30 | 2026-09-28 | |
| MTX-531-001 Phase 1 Study in Advanced Solid Tumors MTX-531 - Solid Tumors (Phase 1), HNSCC | Phase 1 | Not yet recruiting | MEKanistic Therapeutics, Inc. | 71 | 2026-10-20 | 2026-10-15 |
| Phase 1 Study of STRO-006 in Adults With Refractory Solid Tumors That Are Recurrent or Metastatic STRO-006, Pembrolizumab - Head & Neck Squamous Cell Carcinoma, Non-Small Cell Lung Cancer | Phase 1 | Recruiting | Sutro Biopharma, Inc. | 285 | 2026-10-19 | 2026-10-23 |
| Safety and Tolerability of Metformin and Naproxen for Cancer Prevention in Fanconi Anemia Metformin, Naproxen Sodium - Fanconi Anemia, Head and Neck Cancer | Phase 1 | Recruiting | Rockefeller University | 80 | 2026-10-14 | 2026-10-28 |
| SumMET: Study of [225Ac]Ac-FL-261 in Participants With Solid Tumors Overexpressing c-MET [225Ac]Ac-FL-261 - Solid Tumor, NSCLC | Phase 1 / Phase 2 | Recruiting | Full-Life Technologies UK Limited | 208 | 2026-10-01 | 2026-10-16 |
| Randomized Clinical Trial of the Application of TrachPhone HME and the Impact on Patient Satisfaction for Tracheostomized Head and Neck Cancer Patients TrachPhone Heat Moisture Exchange, Trach Collar - Patient Satisfaction, Pulmonary Rehabilitation | Phase 1 / Phase 2 | Not yet recruiting | University of South Florida | 80 | 2026-10-01 | 2026-09-01 |
| Study Evaluating the Safety and Feasibility of Panitumumab-IRDye800 and [18F]NOTA-ABY-030 for Targeted Dual-Modality Imaging (TDMI) in Head and Neck Squamous Cell Carcinoma Panitumumab-IRDye800, [18F]NOTA-ABY-030 - HNSCC,Larynx, Pharynx and Oral Cavity, Squamous Cell Carcinoma | Phase 1 | Recruiting | Vanderbilt-Ingram Cancer Center | 30 | 2026-10-01 | 2026-10-19 |
| Drug Repurposing in Thyroid Carcinoma: a Feasibility Trial Personalised treatment - Thyroid Cancer Stage IV, Anaplastic Thyroid Cancer | Phase 1 | Recruiting | Radboud University Medical Center | 10 | 2026-10-01 | 2026-10-28 |
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Squamous Cell Carcinoma of Head and Neck (625) · Carcinoma, Non-Small-Cell Lung (390) · Esophageal Neoplasms (380) · Colorectal Neoplasms (265) · Stomach Neoplasms (262) · Melanoma (237) · Breast Neoplasms (223) · Ovarian Neoplasms (209) · Neoplasms (182) · Pancreatic Neoplasms (179) · Lung Neoplasms (172) · Neoplasm Metastasis (164) · Uterine Cervical Neoplasms (159) · Carcinoma, Renal Cell (149)
Neoplasms by Site (1520) · Neoplasms (1352) · Neoplasms by Histologic Type (1046) · Neoplasms, Glandular and Epithelial (992) · Carcinoma (915) · Digestive System Diseases (738) · Digestive System Neoplasms (724) · Gastrointestinal Diseases (705) · Gastrointestinal Neoplasms (674) · Carcinoma, Squamous Cell (649) · Respiratory Tract Diseases (556) · Respiratory Tract Neoplasms (547) · Thoracic Neoplasms (513) · Lung Diseases (508)
pembrolizumab (178) · Cisplatin (143) · Radiotherapy (101) · Cetuximab (93) · Paclitaxel (76) · Carboplatin (69) · Fluorouracil (64) · Nivolumab (64) · Docetaxel (63) · Cyclophosphamide (42) · Radiotherapy, Intensity-Modulated (39) · Gemcitabine (33) · Oxaliplatin (31) · Capecitabine (30) · Radiation (30)
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David S Schrump, M.D. (6) · Eben Rosenthal, MD (6) · A. Dimitrios Colevas, MD (4) · David Hong, MD (4)
PMID 33720067, PMID 36897458, PMID 37171634, PMID 37496366, PMID 37934000, PMID 39462179, PMID 41044356, PMID 41423415, PMID 42201333, PMID 42580817, PMID 10235156, PMID 11127145, PMID 11240232, PMID 11573045, PMID 11870157, PMID 12049861, PMID 12196376, PMID 12393999, PMID 12607634, PMID 12717353, PMID 12771884, PMID 12885811, PMID 14666038, PMID 14710949, PMID 15013589, PMID 15033677, PMID 15108222, PMID 15159012, PMID 15240677, PMID 15287078, PMID 15331400, PMID 15542583, PMID 15975518, PMID 16004814, PMID 16116597, PMID 16149148, PMID 16415901, PMID 16597660, PMID 16672085, PMID 16818691, PMID 16884839, PMID 16950583, PMID 17140960, PMID 17538162, PMID 17538163, PMID 17602769, PMID 17985341, PMID 18077538, PMID 18276844, PMID 18407446
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