19 completed, 4 terminated, 2 unknown. 25 Phase 3, 2 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 25 | Completed 19, Terminated 4, Unknown 2 |
| Phase 2 | 2 | Completed 2 |
Follow Growth Hormone Deficiency: new trials by email Literature Review of Growth Hormone Deficiency trials Research Report on Growth Hormone Deficiency
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Research Study of How Well Macimorelin Works to Find Out if Children Have a Lack of Growth Hormone and How Safe it is Macimorelin, Arginine, Clonidine - Growth Hormone Deficiency | Phase 3 | Completed | AEterna Zentaris | 101 | 2021-11-16 | 2024-08-12 |
| A Trial to Compare the Efficacy and Safety of Once-weekly Lonapegsomatropin With Placebo and a Daily Somatropin Product in Adults With Growth Hormone Deficiency Lonapegsomatropin, Placebo, Somatropin - Growth Hormone Deficiency, Endocrine System Diseases | Phase 3 | Completed | Ascendis Pharma Endocrinology Division A/S | 264 | 2020-12-03 | 2026-07-07 |
| Safety, Tolerability and Efficacy of TransCon hGH Weekly Versus Daily hGH in Chinese Pediatric Growth Hormone Deficiency TransCon hGH, daily hGH - Growth Hormone Deficiency, Endocrine System Diseases | Phase 3 | Unknown | Visen Pharmaceuticals (Shanghai) Co., Ltd. | 150 | 2019-12-30 | 2020-03-30 |
| Treatment of GHD Associated With CHF Human growth hormone, Placebo - Heart Failure, Growth Hormone Deficiency | Phase 3 | Unknown | Federico II University | 64 | 2019-03-01 | 2019-02-15 |
| Patient Perception of Treatment Burden in Weekly Versus Daily Growth Hormone Injections in Children With GHD Genotropin, somatrogon - Growth Hormone Deficiency | Phase 3 | Completed | Pfizer | 87 | 2019-02-07 | 2021-10-14 |
| Safety and Efficacy of Y-shape Pegylated Somatropin in Growth Hormone Deficiency Children Y-shape pegylated somatropin, Norditropin®, Norditropin - Growth Hormone Deficiency | Phase 2 / Phase 3 | Completed | Xiamen Amoytop Biotech Co., Ltd. | 434 | 2018-12-26 | 2024-01-24 |
| Safety and Efficacy Study of MOD-4023 to Treat Children With Growth Hormone Deficiency MOD-4023, Genotropin - Growth Hormone Deficiency | Phase 3 | Completed | OPKO Health, Inc. | 44 | 2017-12-07 | 2021-08-12 |
| A Long-Term Safety Study of Somavaratan in Japanese Children With Growth Hormone Deficiency Somavaratan - Growth Hormone Deficiency | Phase 3 | Terminated | Versartis Inc. | 21 | 2017-03-31 | 2018-03-09 |
| Study of TV-1106 in Growth Hormone-Deficient Adults TV-1106, Placebo - Growth Hormone Deficiency | Phase 3 | Terminated | Teva Branded Pharmaceutical Products R&D, Inc. | 14 | 2015-04-30 | 2022-01-24 |
| Study to Assess Safety and Tolerability in Adults With Growth Hormone-Deficiency (GHD) TV-1106, dGH - Growth Hormone Deficiency | Phase 3 | Terminated | Teva Branded Pharmaceutical Products R&D, Inc. | 34 | 2015-04-30 | 2021-12-10 |
| Cross Over Convenience And Preference Study Of New Mark VII Compared To Genotropin Pen In Pediatric And Adult Subjects Genotropin Pen, MARK VII pen - Growth Hormone Deficiency | Phase 3 | Completed | Pfizer | 120 | 2010-08-01 | 2012-05-22 |
| A Study of Zomacton in Children With Growth Hormone Deficiency Genotropin, Zomacton - Growth Hormone Deficiency | Phase 3 | Completed | Ferring Pharmaceuticals | 165 | 2010-01-01 | 2012-07-17 |
| Genotropin Study Assessing Use of Injection Pen New Genotropin Pen - Growth Hormone Deficiency, Idiopathic Short Stature | Phase 3 | Completed | Pfizer | 136 | 2009-10-01 | 2011-01-28 |
| Efficacy of Somatropin in Adult Patients With Isolated Growth Hormone Deficiency Placebo, Somatropin - Growth Hormone Deficiency | Phase 3 | Terminated | Pfizer | 9 | 2008-05-01 | 2013-03-04 |
| Phase III Clinical Study of Pegylated Somatropin (PEG Somatropin) to Treat Growth Hormone Deficiency Children PEG-somatropin - Growth Hormone Deficiency | Phase 3 | Completed | Changchun GeneScience Pharmaceutical Co., Ltd. | 343 | 2007-03-01 | 2017-07-31 |
| Evolution Of Growth Rate In Children With Growth Retardation Due to Glucocorticosteroid Therapy And Treated By Genotonorm Somatropin - Growth Hormone Deficiency | Phase 3 | Completed | Pfizer | 98 | 2005-01-01 | 2024-02-21 |
| Efficacy and Safety of a High Dosage Compared to the Label Dosage of Somatropin in Early Pubertal Stage Children With Growth Hormone Deficiency Somatropin - Growth Hormone Deficiency | Phase 3 | Completed | Eli Lilly and Company | 27 | 2004-03-01 | 2009-06-10 |
| Comparative Validation of the Growth Hormone Releasing Hormone and Arginine Test for the Diagnosis of Adult Growth Hormone Deficiency GHRH+Arg, GHRH+Arg, ITT, ITT, ITT, GHRH+Arg. - Growth Hormone Deficiency | Phase 3 | Completed | Merck KGaA, Darmstadt, Germany | 69 | 2004-01-01 | 2014-08-05 |
| Evaluation of Efficacy and Safety of Recombinant Somatroipn in Patients With Growth Hormone Deficiency somatropin, Eutropin - Growth Hormone Deficiency | Phase 3 | Completed | Daewoong Pharmaceutical Co. LTD. | 52 | 2003-10-01 | 2016-02-29 |
| Sustained Release Formulation of Somatropin (rDNA Origin)for Injection BPLG-003 - Growth Hormone Deficiency | Phase 2 / Phase 3 | Completed | BioPartners GmbH | 51 | 2003-06-01 | 2008-01-25 |
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Dwarfism, Pituitary (25) · Endocrine System Diseases (2) · Failure to Thrive (1) · Heart Failure (1) · Pituitary Diseases (1)
Bone Diseases (25) · Bone Diseases, Developmental (25) · Bone Diseases, Endocrine (25) · Brain Diseases (25) · Central Nervous System Diseases (25) · Dwarfism (25) · Hypopituitarism (25) · Hypothalamic Diseases (25) · Musculoskeletal Diseases (25) · Nervous System Diseases (25) · Pituitary Diseases (24) · Endocrine System Diseases (23) · Cardiovascular Diseases (1) · Heart Diseases (1) · Pathological Conditions, Signs and Symptoms (1)
Human Growth Hormone (14) · Growth Hormone (3) · albusomatropin (2) · lonapegsomatropin (2) · somatrogon (2) · Arginine (1) · Blood Specimen Collection (1) · Citrullination (1) · MOD-4023 (1) · Neuropsychological Tests (1) · WW Domain-Containing Oxidoreductase (1) · X-Rays (1) · macimorelin (1)
Pfizer (7) · Eli Lilly and Company (2) · Teva Branded Pharmaceutical Products R&D, Inc. (2) · AEterna Zentaris (1) · Ascendis Pharma Endocrinology Division A/S (1) · BioPartners GmbH (1) · Changchun GeneScience Pharmaceutical Co., Ltd. (1) · Daewoong Pharmaceutical Co. LTD. (1) · Federico II University (1) · Ferring Pharmaceuticals (1) · Merck KGaA, Darmstadt, Germany (1) · OPKO Health, Inc. (1) · Sanofi (1) · The University of Texas Health Science Center at San Antonio (1) · Versartis Inc. (1)
United States (9) · France (5) · Italy (5) · Slovakia (5) · Czechia (4) · Germany (4) · China (3) · Greece (3) · Hungary (3) · Poland (3) · Romania (3) · Turkey (Türkiye) (3) · United Kingdom (3) · Armenia (2) · Austria (2)
Daniel E. Hale, M.D. (1) · Ference Peter, MD (1) · Nicola K Ammer, MD (1) · Philippe Chanson, MD, Professor (1) · Reiko Horikawa, M.D, Ph. D. (1) · Will Charlton, MD (1) · Xiaoping Luo, MD (1) · Xiaoping Luo, MD, Ph.D (1)
PMID 20484474, PMID 21118739, PMID 24748824, PMID 28566441, PMID 29029101, PMID 30910221, PMID 36034448, PMID 40047762, PMID 41183961
2018 (2), 2004 (1), 2008 (1), 2014 (1), 2016 (1)