37 completed, 5 terminated. 19 Phase 2, 16 Phase 1, 10 Phase 3, 2 Not applicable.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 19 | Completed 16, Terminated 3 |
| Phase 1 | 16 | Completed 14, Terminated 2 |
| Phase 3 | 10 | Completed 8, Terminated 2 |
| Not applicable | 2 | Completed 2 |
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Research Study of How Well Macimorelin Works to Find Out if Children Have a Lack of Growth Hormone and How Safe it is Macimorelin, Arginine, Clonidine - Growth Hormone Deficiency | Phase 3 | Completed | AEterna Zentaris | 101 | 2021-11-16 | 2024-08-12 |
| Validation of Macimorelin as a Test for Adult Growth Hormone Deficiency Macimorelin, Insulin - Growth Hormone Deficiency With Pituitary Anomalies | Phase 3 | Completed | AEterna Zentaris | 157 | 2015-12-03 | 2018-04-10 |
| Perifosine and Torisel (Temsirolimus) for Recurrent/Progressive Malignant Gliomas Cytoreductive surgery, Perifosine, Temsirolimus - Brain Tumor, Recurrent, Glioblastoma | Phase 1 | Completed | Andrew B Lassman, MD | 10 | 2014-12-08 | 2023-05-25 |
| Zoptarelin Doxorubicin (AEZS 108) as Second Line Therapy for Endometrial Cancer AEZS-108 / zoptarelin doxorubicin, doxorubicin - Endometrial Cancer | Phase 3 | Completed | AEterna Zentaris | 511 | 2013-04-01 | 2018-07-31 |
| Phase 2 Trial of AEZS-108 in Chemotherapy Refractory in Triple Negative Breast Cancer AEZS-108, SCCC, Dexamethasone - Breast Cancer | Phase 2 | Terminated | AEterna Zentaris | 7 | 2012-12-01 | 2018-02-22 |
| Pilot Clinical Trial of Repeated Doses of Macimorelin to Assess Safety and Efficacy in Patients With Cancer Cachexia Macimorelin, Placebo - Cancer Cachexia | Phase 2 | Completed | Garcia, Jose M., MD, PhD | 15 | 2012-05-01 | 2024-03-20 |
| A Food Effect and QTc Study of Perifosine in Patients With Advanced Malignancies perifosine - Cancer | Phase 1 | Completed | AEterna Zentaris | 24 | 2012-01-24 | 2018-03-14 |
| Doxorubicin-GnRH Agonist Conjugate AEZS-108 in Treating Patients With Metastatic Hormone-Resistant Prostate Cancer laboratory biomarker analysis, questionnaire administration, doxorubicin-GnRH agonist conjugate AEZS-108 - Prostate Cancer, Hormone-resistant Prostate Cancer | Phase 1 / Phase 2 | Completed | University of Southern California | 43 | 2010-11-02 | 2017-07-11 |
| A Phase I/II Trial of AEZS-108 in Urothelial Cancer Patients Who Failed Platinum-chemotherapy AEZS-108, AEZS-108 at MTD - Urothelial Carcinoma | Phase 1 / Phase 2 | Terminated | AEterna Zentaris | 12 | 2010-11-01 | 2018-03-15 |
| Perifosine Plus Capecitabine Versus Placebo Plus Capecitabine in Patients With Refractory Advanced Colorectal Cancer Capecitabine, Perifosine, Placebo - Colorectal Cancer | Phase 3 | Completed | AEterna Zentaris | 468 | 2010-04-01 | 2013-07-02 |
| Perifosine With Temsirolimus for Recurrent Pediatric Solid Tumors perifosine + temsirolimus - Pediatric Solid Tumors | Phase 1 | Completed | Memorial Sloan Kettering Cancer Center | 23 | 2010-01-01 | 2017-03-10 |
| Assessment of Efficacy and Safety of Perifosine, Bortezomib and Dexamethasone in Multiple Myeloma Patients Perifosine, Perifosine Placebo, Bortezomib - Multiple Myeloma | Phase 3 | Terminated | AEterna Zentaris | 135 | 2009-12-01 | 2018-02-09 |
| Study of Perifosine + Capecitabine for Colon Cancer Patients Perifosine, Capecitabine - Colon Cancer | Phase 1 | Completed | AEterna Zentaris | 10 | 2009-10-01 | 2018-06-28 |
| Study of Single Agent Perifosine for Recurrent Pediatric Solid Tumors perifosine - Solid Tumors | Phase 1 | Completed | Memorial Sloan Kettering Cancer Center | 38 | 2008-10-01 | 2017-08-01 |
| Open Label Trial of Perifosine in Patients Currently Being Treated on Perifosine Trials in Solid Tumors or Multiple Myeloma Perifosine, Trastuzumab, Tamoxifen - Non Small Cell Lung Cancer, Solid Tumors | Not applicable | Completed | AEterna Zentaris | 10 | 2008-05-01 | 2018-03-15 |
| Cetrorelix Pamoate in Patients With Symptomatic Benign Prostatic Hypertrophy (BPH) Cetrorelix 78+78, Cetrorelix 78 + Placebo, Placebo - Benign Prostatic Hypertrophy | Phase 3 | Completed | AEterna Zentaris | 420 | 2008-03-01 | 2011-01-17 |
| Cetrorelix Pamoate IM Regimens in Patients With Symptomatic Benign Prostatic Hyperplasia (BPH) Cetrorelix Pamoate - Benign Prostatic Hypertrophy | Phase 3 | Completed | AEterna Zentaris | 528 | 2008-03-01 | 2011-04-05 |
| Antitumoral Activity and Safety of AEZS-108 in Women With LHRH Receptor Positive Gynecological Tumors AEZS-108 - Ovarian Cancer, Endometrial Cancer | Phase 2 | Completed | AEterna Zentaris | 85 | 2007-12-01 | 2011-12-13 |
| Ph II Study of Perifosine for Patients With Carcinoma of the Kidney Perifosine - Kidney Cancer | Phase 2 | Completed | AEterna Zentaris | 50 | 2007-07-01 | 2018-02-05 |
| Trial of Miltefosine in Cutaneous Leishmaniasis (Brazil) Miltefosine., Meglumine antimoniate. - Treatment of Cutaneous Leishmaniasis in Brazil. | Phase 2 | Completed | Hospital Universitário Professor Edgard Santos | 180 | 2007-07-01 | 2010-04-15 |
Showing 20 of 42. Sign in to see all of them.
Neoplasms (6) · Multiple Myeloma (5) · Kidney Neoplasms (4) · Prostatic Hyperplasia (3) · Breast Neoplasms (2) · Carcinoma, Non-Small-Cell Lung (2) · Carcinoma, Renal Cell (2) · Colonic Neoplasms (2) · Dwarfism, Pituitary (2) · Endometrial Neoplasms (2) · Recurrence (2) · Astrocytoma (1) · Brain Neoplasms (1) · Carcinoma, Transitional Cell (1) · Chondrosarcoma (1)
perifosine (25) · Dexamethasone (5) · LHRH, lysine(6)-doxorubicin (5) · macimorelin (4) · Capecitabine (3) · cetrorelix (3) · Bortezomib (2) · shark cartilage extract (2) · temsirolimus (2) · Absorptiometry, Photon (1) · Allopurinol (1) · Antiemetics (1) · Calcium Dobesilate (1) · Citrullination (1) · Cytoreduction Surgical Procedures (1)
United States (26) · Germany (7) · Canada (6) · Bulgaria (4) · Italy (4) · Czechia (3) · Poland (3) · Romania (3) · Spain (3) · United Kingdom (3) · Austria (2) · Belarus (2) · Brazil (2) · France (2) · Ireland (2)
Ira Dunkel, MD (2) · Paul Richardson, MD (2) · Alberto J. Montero, MD (1) · Andrew B. Lassman, MD (1) · Andrzej J Jakubowiak, MD, PhD (1) · Beverly MK Biller, MD (1) · Craig Henderson, MD (1) · Daniel Cho, MD (1) · David S Miller, MD (1) · David Spigel, MD (1) · Dejka Araujo, MD (1) · Dr. Hebert Lepor, MD (1) · Ed Cullen, PhD (1) · Eric Grossman, MD (1) · Frank Giles, MD (1)
PMID 22419878, PMID 17868728, PMID 20103671, PMID 21200420, PMID 21969495, PMID 21990396, PMID 22640031, PMID 23559086, PMID 27649927, PMID 29575771, PMID 29860473, PMID 36124638, PMID 36860137
2015 (1), 2018 (1)