2 active not recruiting, 2 recruiting, 1 completed. 5 Phase 1, 3 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 5 | Active not recruiting 2, Recruiting 2, Completed 1 |
| Phase 2 | 3 | Recruiting 2, Active not recruiting 1 |
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Phase 1/2 Clinical Trial to Assess the Safety, Tolerability, Pharmacokinetics and Preliminary Efficacy of HMBD-501 in Patients With HER3-Expressing Solid Tumors ENV-501 - Melanoma (Skin), Non Small Cell Lung Cancer | Phase 1 / Phase 2 | Recruiting | Hummingbird Bioscience | 180 | 2025-12-17 | 2026-03-02 |
| A Phase Ib/II Study of an Anti-HER3 Antibody, HMBD-001, With Cetuximab +/- Docetaxel in Advanced Squamous Cell Cancers HMBD-001, Docetaxel, Cetuximab - Advanced or Metastatic Squamous Non-Small Cell Lung Cancer, Advanced Head and Neck Squamous Cell Carcinoma | Phase 1 / Phase 2 | Recruiting | Hummingbird Bioscience | 398 | 2024-02-05 | 2026-05-27 |
| Study of an Anti-HER3 Antibody, HMBD-001, With or Without Chemotherapy in Patients With Solid Tumors Harboring an NRG1 Fusion or HER3 Mutation HMBD-001, Docetaxel, Nab-paclitaxel - Non-Small Cell Lung Cancer, Pancreatic Cancer | Phase 1 | Active not recruiting | Hummingbird Bioscience | 68 | 2023-09-06 | 2025-04-18 |
| A Study of HMBD-002, a Monoclonal Antibody Targeting VISTA, as Monotherapy and Combined With Pembrolizumab, in Patients With Advanced Solid Tumors HMBD-002, Pembrolizumab - Cancer, Tumor, Solid | Phase 1 | Completed | Hummingbird Bioscience | 48 | 2022-02-28 | 2025-10-16 |
| A Phase I/IIa Trial of HMBD-001 in Advanced HER3 Positive Solid Tumours HMBD-001, HMBD-001 and enzalutamide - Bladder Cancer, Triple Negative Breast Cancer | Phase 1 / Phase 2 | Active not recruiting | Cancer Research UK | 81 | 2021-11-10 | 2025-08-11 |
Carcinoma, Non-Small-Cell Lung (5) · Fibromatosis, Gingival, 2 (2) · Melanoma (2) · Neoplasm Metastasis (2) · Pancreatic Neoplasms (2) · Triple Negative Breast Neoplasms (2) · Breast Neoplasms (1) · Carcinoma, Hepatocellular (1) · Carcinoma, Squamous Cell (1) · Endometrial Neoplasms (1) · Esophageal Neoplasms (1) · Lethal Congenital Contracture Syndrome 2 (1) · Neoplasms (1) · Ovarian Neoplasms (1) · Prostatic Neoplasms, Castration-Resistant (1)
Docetaxel (2) · 130-nm albumin-bound paclitaxel (1) · Cetuximab (1) · Gemcitabine (1) · enzalutamide (1) · pembrolizumab (1)
Australia (3) · United States (2) · Moldova (1) · Singapore (1) · South Korea (1) · Taiwan (1) · United Kingdom (1)
Johann de Bono, Prof (1) · Kevin Heller (1)