1394 completed, 305 unknown, 210 recruiting, 133 not yet recruiting. 1480 Not applicable, 197 Phase 2, 113 Phase 3, 62 Phase 4, 55 Phase 1.
Follow Fatigue: new trials by email Literature Review of Fatigue trials Research Report on Fatigue
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Collaborative Care Intervention for Cancer Patients and Their Family Caregivers -LITE Stepped collaborative care intervention, Enhanced Usual Care - Cancer, Depression | Not applicable | Not yet recruiting | University of Pittsburgh | 40 | 2028-01-14 | 2026-04-09 |
| Work Design Interventions for Heat Resilience Standard work pace, Reduced-pace work, Increased-pace work - Hyperthermia, Fatigue; Heat | Not applicable | Not yet recruiting | State University of New York at Buffalo | 32 | 2027-09-01 | 2026-06-30 |
| Sildenafil to Prevent and Reduce Cancer Related Cognitive Impairment Sildenafil - Cancer | Phase 2 / Phase 3 | Not yet recruiting | The University of Texas Medical Branch, Galveston | 30 | 2027-06-15 | 2026-05-11 |
| Adapted Physical Activity for Persistent Fatigue in Patients With Inflammatory Bowel Disease in Remission Adapted Physical Activity, Usual Care - Inflammatory Bowel Diseases (IBD), Fatigue | Not applicable | Not yet recruiting | University Hospital, Grenoble | 120 | 2027-06-01 | 2026-09-11 |
| The Effects of Chiropractic on Cancer-related Fatigue Immediate Chiropractic Care, Delayed Chiropractic Care - Cancer, Fatigue | Not applicable | Suspended | Life University | 40 | 2027-02-01 | 2026-03-30 |
| Virtual Reality-Guided Imagery in Hemodialysis Patients ( VRGI-HD ) virtual reality-guided imagery (VRGI) - End-Stage Kidney Disease (ESKD) | Not applicable | Not yet recruiting | Islamic University of Najaf | 80 | 2027-01-01 | 2026-10-09 |
| CD19-B Cell Depletion in PAIS-ME/CFS Patients Inebilizumab, Placebo - Post-acute Infectious Syndrome (PAIS), Post-COVID 19 Condition (PCC or Long COVID) | Phase 2 | Not yet recruiting | Charite University, Berlin, Germany | 38 | 2026-12-01 | 2026-07-24 |
| Predicting Declines in Attention and Memory During a Prolonged Mental Task Individually Calibrated Time Load Dual-back Task With Seated Rest - Mental Fatigue, Cognitive Performance | Not applicable | Not yet recruiting | DSW Ideis University | 250 | 2026-12-01 | 2026-10-16 |
| Home-Based High-Intensity Interval Training in Systemic Lupus Erythematosus Personalized Home-Based High-Intensity Interval Training - Systemic Lupus Erthematosus, Fatigue | Not applicable | Not yet recruiting | University of Alabama at Birmingham | 20 | 2026-12-01 | 2026-10-13 |
| Efficacy and Safety of Modafinil to Treat Fatigue in People With Mitochondrial Disease. Modafinil (Placebo) - Mitochondrial Disease | Phase 3 | Not yet recruiting | Kenneth Myers, MD | 15 | 2026-12-01 | 2026-10-21 |
| Guanfacine and Cromolyn Sodium for POTS: The DBPOTS Trial Guanfacine (GFC), Cromolyn Sodium, Placebo - Postural Orthostatic Tachycardia Syndrome (POTS), Dysautonomia | Early Phase 1 | Not yet recruiting | Johns Hopkins University | 25 | 2026-11-15 | 2026-10-09 |
| Telemedicine-mHealth Symptom Cluster Intervention for Advanced Cancer Patients: Finding Our Center Under Stress (FOCUS) mHealth Intervention - Lung Cancer, Breast Cancer | Not applicable | Suspended | Ohio State University Comprehensive Cancer Center | 120 | 2026-11-15 | 2026-08-17 |
| Evaluation of an Online, On Demand Multimodal Wellness Program to Reduce Fatigue and Improve Quality of Life in Progressive Multiple Sclerosis. Online wellness course and online exercise platform, Usual Care Group - Primary Progressive Multiple Sclerosis (PPMS), Secondary Progressive Multiple Sclerosis (SPMS) | Not applicable | Not yet recruiting | University of Iowa | 118 | 2026-11-15 | 2026-09-28 |
| Fatigue in Long COVID Lightning Process, Activity Pacing - Long COVID | Not applicable | Not yet recruiting | McMaster University | 100 | 2026-11-01 | 2026-07-13 |
| The Precision Mito- Mito Map COMPASS Study Mito Map Energy Score and Home Functional Assessments - Mitochondrial Diseases, Myalgic Encephalomyelitis Chronic Fatigue Syndrome | Not yet recruiting | AI Agent Vault, Inc. d/b/a Precision Mito | 400 | 2026-11-01 | 2026-10-02 | |
| Whole-Food Magnesium for Mental and Cardiometabolic Health Low-Dose Whole-Food-Based Magnesium Supplement, Moderate-Dose Whole-Food-Based Magnesium Supplement, Placebo - Elevated Blood Glucose | Not applicable | Not yet recruiting | George Mason University | 45 | 2026-11-01 | 2026-10-08 |
| Effectiveness of Resonance Frequency Breathing Exercises in Patients With Systemic Lupus Erythematosus and Central Sensitization Resonance Frequency Breathing, Standard Exercise Program - Systemic Lupus Erythematosus (SLE), Central Sensitization | Not applicable | Not yet recruiting | Istanbul University - Cerrahpasa | 38 | 2026-11-01 | 2026-10-13 |
| A Study to Learn About the Study Medicine Called Ponsegromab in Adults With Lung Cancer-Associated Significant Body Weight Loss ponsegromab, placebo - Non-small Cell Lung Cancer (NSCLC), Cachexia | Phase 1 | Not yet recruiting | Pfizer | 80 | 2026-10-23 | 2026-09-25 |
| Determination of Optimal Exercise Duration Using Intradialytic Exercises on Dialysis Adequacy, Fatigue, Depression, VO2 Max, Muscle Strength, Physical Functioning, and Quality of Life in Patients Undergoing Hemodialysis Combined Aerobic and Resistance Exercise - Hemodialysis | Not applicable | Not yet recruiting | Ibadat International University, Islamabad | 120 | 2026-10-15 | 2026-10-08 |
| Effects of a Mobile Game in Menopausal Women Menopause Mobile Game - Menopause, Brain Fog | Not applicable | Not yet recruiting | Medipol University | 82 | 2026-10-15 | 2026-09-17 |
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Depression (234) · Motor Activity (231) · Pain (220) · Multiple Sclerosis (195) · Anxiety Disorders (180) · Mental Fatigue (174) · Breast Neoplasms (171) · Neoplasms (171) · Sleep Initiation and Maintenance Disorders (160) · Post-Acute COVID-19 Syndrome (77) · Cognitive Dysfunction (71) · Parasomnias (66) · COVID-19 (64) · Fatigue Syndrome, Chronic (63)
Pathological Conditions, Signs and Symptoms (2302) · Signs and Symptoms (2295) · Nervous System Diseases (792) · Behavior (755) · Behavioral Symptoms (504) · Mental Disorders (504) · Neurologic Manifestations (427) · Immune System Diseases (368) · Pathologic Processes (348) · Neoplasms (322) · Neoplasms by Site (315) · Autoimmune Diseases (284) · Skin and Connective Tissue Diseases (262) · Respiratory Tract Diseases (249) · Sleep Wake Disorders (237)
Exercise (79) · Modafinil (42) · Therapeutics (41) · Surveys and Questionnaires (27) · Transcranial Direct Current Stimulation (24) · Control Groups (23) · Cognitive Behavioral Therapy (22) · Yoga (21) · Acupuncture Therapy (19) · Methylphenidate (19) · Sugars (18) · Massage (15) · Psychiatric Rehabilitation (15) · Resistance Training (15) · Educational Status (13)
M.D. Anderson Cancer Center (33) · Cairo University (20) · Riphah International University (20) · Wake Forest University Health Sciences (20) · Gazi University (18) · Hacettepe University (18) · Vrije Universiteit Brussel (18) · Centre Hospitalier Universitaire de Saint Etienne (16) · Charite University, Berlin, Germany (15) · Radicle Science (14) · Ataturk University (13) · Johns Hopkins University (13) · Mayo Clinic (13) · University of Michigan (12) · University of Pittsburgh (12)
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Susan Hewlings (9) · Leorey N Saligan, C.R.N.P. (7) · Melinda Sheffield-Moore, PhD (5) · Cagla Ozkul (4) · Fernando Dimeo, MD (4) · Suzanna M Zick, ND, MPH (4) · Andrew H Miller, MD (3) · Catherine E Mosher, Ph.D. (3) · Diana Horta (3) · Eduardo Bruera, MD (3) · Edward G. Shaw, MD (3) · Emily K. Pauli, PharmD (3) · Jung-Piao Tsao (3) · Karen Mustian, Ph.D. (3)
PMID 32627860, PMID 40243391, PMID 40421669, PMID 41170811, PMID 36602886, PMID 38588457, PMID 10673515, PMID 12814166, PMID 12914662, PMID 20602109, PMID 22987089, PMID 23695501, PMID 23791482, PMID 25386668, PMID 26112278, PMID 26212172, PMID 2748771, PMID 2803071, PMID 29866196, PMID 33561279, PMID 33847150, PMID 34550079, PMID 35018639, PMID 35149627, PMID 35639525, PMID 36247954, PMID 37651553, PMID 38780066, PMID 39198005, PMID 39387227, PMID 6880820, PMID 1002644, PMID 10091805, PMID 1015603, PMID 10512918, PMID 10687321, PMID 10773854, PMID 10784636, PMID 10793162, PMID 10839209, PMID 10853723, PMID 10923010, PMID 10930491, PMID 10960931, PMID 11033374, PMID 11040270, PMID 11049150, PMID 11074395, PMID 11150837, PMID 11205620
2025 (9), 2023 (7), U10CA081851 (6), P30CA033572 (4), P30CA068485 (4), U10CA037420 (4), 2017 (3), 2019 (3), U10CA081920 (3), 2009 (2), 2014 (2), 2015 (2), 4UL1TR000427-10 (2), P30CA012197 (2), P30CA014520 (2)