8 completed, 1 unknown, 1 withdrawn. 10 Phase 3, 3 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 10 | Completed 8, Unknown 1, Withdrawn 1 |
| Phase 2 | 3 | Completed 3 |
Follow Eye Hemorrhage: new trials by email Literature Review of Eye Hemorrhage trials Research Report on Eye Hemorrhage
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Anti-VEGF vs. Prompt Vitrectomy for VH From PDR 2-mg Intravitreous Aflibercept Injection, Prompt Vitrectomy Plus Panretinal Photocoagulation - Proliferative Diabetic Retinopathy, Vitreous Hemorrhage | Phase 2 / Phase 3 | Completed | Jaeb Center for Health Research | 205 | 2016-11-01 | 2021-04-20 |
| Intravitreal tPA and C3F8 for the Treatment of Submacular Haemorrhage as a Complication of Neovascular AMD Ranibizumab, C3F8 Gas, tPA - Exudative Macular Degeneration, Retinal Hemorrhage | Phase 2 / Phase 3 | Completed | King's College Hospital NHS Trust | 55 | 2014-09-01 | 2020-07-14 |
| A Study of the Safety, Tolerability, and Efficacy of IVT Pre-op 0.3mg Pegaptanib Sodium Versus Sham, for Management of Tractional Retinal Detachment and Vitreous Hemorrhage With Proliferative Diabetic Retinopathy Macugen, Sham - Proliferative Diabetic Retinopathy | Phase 3 | Withdrawn | Greater Houston Retina Research | 2012-04-01 | 2014-03-05 | |
| Intravitreal Ranibizumab for Vitreous Hemorrhage Due to Proliferative Diabetic Retinopathy (N) Ranibizumab, Saline - Vitreous Hemorrhage, Proliferative Diabetic Retinopathy | Phase 2 / Phase 3 | Completed | Jaeb Center for Health Research | 261 | 2010-06-01 | 2016-08-26 |
| Bevacizumab and Long Acting Gas in Diabetic Vitrectomy Bevacizumab - Proliferative Diabetic Retinopathy | Phase 3 | Completed | National Taiwan University Hospital | 16 | 2006-12-01 | 2008-04-11 |
| Intravitreal Bevacizumab for Management of Active Progressive Proliferative Diabetic Retinopathy (PDR) bevacizumab - Diabetic Retinopathy | Phase 3 | Unknown | Shahid Beheshti University of Medical Sciences | 2006-03-01 | 2008-06-26 | |
| Safety and Efficacy Study of Vitrase for Clearance of Severe Vitreous Hemorrhage Placebo, Vitrase - Vitreous Hemorrhage, Diabetic Retinopathy | Phase 3 | Completed | Bausch & Lomb Incorporated | 510 | 1999-06-01 | 2013-03-15 |
| Safety and Efficacy Study of Vitrase for Clearance of Severe Vitreous Hemorrhage Vitrase - Vitreous Hemorrhage, Diabetic Retinopathy | Phase 3 | Completed | Bausch & Lomb Incorporated | 750 | 1998-11-01 | 2013-03-15 |
| Branch Vein Occlusion Study Macular Argon Laser Photocoagulation, Peripheral Scatter Argon Laser Photocoagulation, Scatter Argon Laser Photocoagulation - Macular Degeneration, Neovascularization, Pathologic | Phase 3 | Completed | National Eye Institute (NEI) | 1977-07-01 | 2005-06-24 | |
| Diabetic Retinopathy Vitrectomy Study (DRVS) Vitrectomy - Diabetic Retinopathy, Retinal Detachment | Phase 3 | Completed | National Eye Institute (NEI) | 1976-10-01 | 2005-06-24 |
Vitreous Hemorrhage (9) · Diabetic Retinopathy (4) · Macular Degeneration (2) · Hemorrhage (1) · Neovascularization, Pathologic (1) · Retinal Detachment (1) · Retinal Diseases (1) · Retinal Hemorrhage (1) · Wet Macular Degeneration (1)
Eye Diseases (10) · Pathologic Processes (10) · Pathological Conditions, Signs and Symptoms (10) · Hemorrhage (9) · Retinal Diseases (6) · Cardiovascular Diseases (4) · Diabetes Complications (4) · Diabetes Mellitus (4) · Diabetic Angiopathies (4) · Endocrine System Diseases (4) · Vascular Diseases (4) · Retinal Degeneration (2) · Metaplasia (1)
Bevacizumab (2) · Chondroitinases and Chondroitin Lyases (2) · Ranibizumab (2) · Hyaluronoglucosaminidase (1) · Saline Solution (1) · Sodium Chloride (1) · Tissue Plasminogen Activator (1) · Vitrectomy (1) · aflibercept (1) · pegaptanib (1) · perflutren (1) · salicylhydroxamic acid (1)
Bausch & Lomb Incorporated (2) · Jaeb Center for Health Research (2) · National Eye Institute (NEI) (2) · Greater Houston Retina Research (1) · King's College Hospital NHS Trust (1) · National Taiwan University Hospital (1) · Shahid Beheshti University of Medical Sciences (1)
United States (4) · Canada (2) · United Kingdom (2) · Australia (1) · Brazil (1) · Hungary (1) · Iran (1) · Italy (1) · Mexico (1) · Netherlands (1) · Poland (1) · South Africa (1) · Spain (1) · Taiwan (1)
Lisa R Grillone, PhD (2) · Abdhish Bhavsar, MD (1) · Adam R. Glassman, MS (1) · Andrew Antoszyk, MD (1) · Chung-May Yang, MD (1) · Hamid Ahmadieh, MD (1) · James C Major, MD (1) · Timothy L Jackson, PhD,FRCOpht (1)
PMID 18441312, PMID 23370902, PMID 33320223, PMID 33956075, PMID 37260074, PMID 37972038, PMID 39418015
U10EY014231 (1), U10EY018817 (1)