11 completed, 2 terminated. 5 Phase 2, 4 Phase 3, 2 Phase 1, 1 Early Phase 1, 1 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 5 | Completed 3, Terminated 2 |
| Phase 3 | 4 | Completed 4 |
| Phase 1 | 2 | Completed 2 |
| Early Phase 1 | 1 | Completed 1 |
| Phase 4 | 1 | Completed 1 |
Follow Chondroitinases and Chondroitin Lyases: new trials by email Literature Review of Chondroitinases and Chondroitin Lyases trials Research Report on Chondroitinases and Chondroitin Lyases
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Hyaluronidase Via LADD Scleroderma-induced Microstomia Hyaluronidase, CO2 laser - Microstomia, Scleroderma | Early Phase 1 | Completed | University of Nebraska | 3 | 2024-03-01 | 2026-04-15 |
| Evaluation of the Allergenicity of AMPHADASE INJECTION (Hyaluronidase Injection USP) Hyaluronidase, Histamine, Saline - Allergic Skin Reaction | Phase 2 | Completed | Amphastar Pharmaceuticals, Inc. | 253 | 2012-09-01 | 2017-01-20 |
| Efficacy and Safety Study of BMN 110 for Morquio A Syndrome Patients Who Have Limited Ambulation BMN 110 - Mucopolysaccharidosis IVA, Morquio A Syndrome | Phase 2 | Terminated | BioMarin Pharmaceutical | 16 | 2012-08-01 | 2016-01-12 |
| Safety and Exercise Study of Two Doses of BMN 110 for Morquio A Syndrome BMN 110 - Mucopolysaccharidosis IVA, Morquio A Syndrome | Phase 2 | Terminated | BioMarin Pharmaceutical | 25 | 2012-04-01 | 2016-02-01 |
| Study of BMN 110 in Pediatric Patients < 5 Years of Age With Mucopolysaccharidosis IVA (Morquio A Syndrome) BMN 110 - Mucopolysaccharidosis IVA, Morquio A Syndrome | Phase 2 | Completed | BioMarin Pharmaceutical | 15 | 2011-10-01 | 2017-08-10 |
| Long-Term Efficacy and Safety Extension Study of BMN 110 in Patients With Mucopolysaccharidosis IVA (Morquio A Syndrome) BMN 110 - Weekly, BMN 110 - Every Other Week - Mucopolysaccharidosis IV A, Morquio A Syndrome | Phase 3 | Completed | BioMarin Pharmaceutical | 173 | 2011-07-01 | 2021-07-21 |
| Assessment of Intravitreous Injections of Vitrase for Inducing Posterior Vitreous Detachment Vitrase - Vitreous Detachment, Diabetic Retinopathy | Phase 2 | Completed | Bausch & Lomb Incorporated | 10 | 2005-07-01 | 2013-03-15 |
| Evaluation of Vitrase as a Spreading Agent Vitrase - Pain | Phase 3 | Completed | Bausch & Lomb Incorporated | 108 | 2004-10-01 | 2013-03-14 |
| Evaluation of Vitrase as an Adjuvant to Increase Absorption and Dispersion of Other Injected Anesthetics Vitrase (ovine hyaluronidase) Lyophilized - Pain | Phase 4 | Completed | Bausch & Lomb Incorporated | 40 | 2004-09-01 | 2013-03-19 |
| Hypersensitivity Reaction to Vitrase (Ovine Hyaluronidase) Vitrase - Drug Hypersensitivity | Phase 1 | Completed | Bausch & Lomb Incorporated | 65 | 2004-07-01 | 2013-03-18 |
| Hypersensitivity Reaction to Vitrase (Ovine Hyaluronidase) Vitrase - Drug Hypersensitivity | Phase 1 | Completed | Bausch & Lomb Incorporated | 65 | 2004-03-01 | 2013-03-14 |
| Safety and Efficacy Study of Vitrase for Clearance of Severe Vitreous Hemorrhage Placebo, Vitrase - Vitreous Hemorrhage, Diabetic Retinopathy | Phase 3 | Completed | Bausch & Lomb Incorporated | 510 | 1999-06-01 | 2013-03-15 |
| Safety and Efficacy Study of Vitrase for Clearance of Severe Vitreous Hemorrhage Vitrase - Vitreous Hemorrhage, Diabetic Retinopathy | Phase 3 | Completed | Bausch & Lomb Incorporated | 750 | 1998-11-01 | 2013-03-15 |
Lysosomal Storage Diseases (4) · Mucopolysaccharidosis IV (4) · Diabetic Retinopathy (3) · Drug Hypersensitivity (2) · Pain (2) · Vitreous Hemorrhage (2) · Hypersensitivity (1) · Microstomia (1) · Scleroderma, Diffuse (1) · Vitreous Detachment (1)
Bausch & Lomb Incorporated (7) · BioMarin Pharmaceutical (4) · Amphastar Pharmaceuticals, Inc. (1) · University of Nebraska (1)
United States (12) · United Kingdom (5) · Canada (3) · Germany (3) · Italy (3) · Brazil (2) · Netherlands (2) · Spain (2) · Taiwan (2) · Argentina (1) · Australia (1) · Colombia (1) · Denmark (1) · France (1) · Hungary (1)
Lisa R Grillone, PhD (6) · Debra Lounsbury (2) · Adam Shaywitz, MD PhD (1) · Celeste Decker, M.D. (1) · Jon Williams, PhD (1) · Sarah L Lonowski, MD (1) · Selina Su, MPH (1)
PMID 18441312, PMID 26331768, PMID 27955919, PMID 28535791, PMID 29159458, PMID 29248359