6 completed, 5 recruiting, 2 active not recruiting, 1 not yet recruiting. 4 Not applicable, 3 Phase 3, 1 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 4 | Completed 2, Not yet recruiting 1, Recruiting 1 |
| Phase 3 | 3 | Completed 1, Recruiting 1, Suspended 1 |
| Phase 4 | 1 | Completed 1 |
Follow Ehlers-Danlos Syndrome, Type IV: new trials by email Literature Review of Ehlers-Danlos Syndrome, Type IV trials Research Report on Ehlers-Danlos Syndrome, Type IV
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| An Exercise and Lifestyle Programme for Adults With Vascular Ehlers-Danlos Syndrome: A Feasibility Study Co-designed exercise-based lifestyle intervention - Vascular Ehlers Danlos Syndrome | Not applicable | Not yet recruiting | Sheffield Hallam University | 40 | 2027-03-01 | 2026-07-13 |
| PregnAncy-Related Aortic DISsEction in China Intervention strategies including medication or surgery - Pregnancy Complication, Aortic Dissection | Recruiting | DeltaHealth Hospital · Shanghai | 500 | 2026-03-17 | 2026-07-17 | |
| Metabolic Phenotyping in vEDS No intervention, observational - Vascular Ehlers-Danlos Syndrome, Vascular Ehlers Danlos Syndrome | Recruiting | Cambridge University Hospitals NHS Foundation Trust | 15 | 2026-03-05 | 2026-10-28 | |
| National Network for Cardiovascular Genomics: Advancing Cardiovascular Healthcare for Hereditary Diseases in Brazil's Unified Health System Through a Multicenter Registry whole genome sequencing - Cardiomyopathy, Hypertrophic, Cardiomyopathy, Dilated | Recruiting | Hospital do Coracao | 1211 | 2025-04-30 | 2026-05-08 | |
| Investigate Efficacy, Safety, and Pharmacokinetics of Enzastaurin for the Prevention of Arterial Events in Patients With Vascular Ehlers-Danlos Syndrome. Enzastaurin, Placebo - Vascular Ehlers-Danlos Syndrome | Phase 3 | Suspended | Aytu BioPharma, Inc. | 260 | 2025-01-01 | 2024-03-08 |
| Heart Coherence Training on Vascular Ehlers-Danlos Syndrome Patients Heartmath Intervention, Control Group - Vascular Ehlers-Danlos Syndrome | Not applicable | Recruiting | Baylor College of Medicine | 40 | 2024-04-01 | 2024-07-01 |
| Single-Session "Empowered Relief" Class for Marfan Syndrome and Related Conditions Empowered Relief - Chronic Pain, Marfan Syndrome | Not applicable | Completed | Stanford University | 92 | 2024-03-21 | 2024-10-26 |
| Clinical Trial to Compare the Efficacy of Celiprolol to Placebo in Patients With Vascular Ehlers-Danlos Syndrome ACER-002 (celiprolol) 200 mg BID, Placebo BID - Vascular Ehlers-Danlos Syndrome | Phase 3 | Recruiting | Acer Therapeutics Inc. | 150 | 2022-11-07 | 2025-08-24 |
| Characterization of Bleeding Disorders in EDS 20 ml venous blood collection - Ehlers-Danlos Syndrome, EDS | Unknown | University Health Network, Toronto | 45 | 2022-11-01 | 2023-05-09 | |
| SEDVasc (RaDiCo Cohort) (RaDiCo-SEDVasc) Ehlers-Danlos Syndrome, Vascular Type | Active not recruiting | Institut National de la Santé Et de la Recherche Médicale, France | 340 | 2016-12-05 | 2026-02-12 | |
| Angiotensin II Receptor Blockade in Vascular Ehlers Danlos Syndrome (ARCADE) Irbesartan, Placebo - Ehlers-Danlos Syndrome, Vascular Type | Phase 3 | Completed | Assistance Publique - Hôpitaux de Paris | 61 | 2016-01-01 | 2024-02-29 |
| Pathogenetic Basis of Aortopathy and Aortic Valve Disease Aortopathies, Thoracic Aortic Aneurysm | Active not recruiting | Yale University | 3000 | 2015-12-10 | 2026-02-13 | |
| Micro RNAs as a Marker of Aortic Aneurysm in Hereditary Aortopathy Syndromes Marfan Syndrome, Loeys-Dietz Syndrome | Completed | University of Colorado, Denver | 20 | 2014-07-01 | 2017-03-15 | |
| Biomarkers in Vascular Ehlers-Danlos Syndrome Vascular Ehlers-Danlos Syndrome | Completed | Assistance Publique - Hôpitaux de Paris | 211 | 2013-06-01 | 2016-03-17 | |
| Non-Invasive Quantitative Imaging of Human Local Arterial Wall Elasticity Using Supersonic Shear Imaging SSI and SphygmoCor® evaluations - Healthy Volunteers, Vascular Ehlers Danlos Syndrome | Not applicable | Completed | French Cardiology Society | 145 | 2010-03-01 | 2015-03-09 |
| Celiprolol in Patients With Ehlers-Danlos Syndrome, Vascular Type celiprolol, Control - EHLERS-DANLOS SYNDROME, TYPE IV, AUTOSOMAL DOMINANT, CHROMOSOME 2q31.2 DELETION SYNDROME | Phase 4 | Completed | Assistance Publique - Hôpitaux de Paris | 54 | 2003-10-01 | 2013-01-16 |
Loeys-Dietz Syndrome (5) · Marfan Syndrome (5) · Aortic Aneurysm, Thoracic (2) · Aortic Dissection (2) · Connective Tissue Diseases (2) · Ehlers-Danlos Syndrome (2) · Turner Syndrome (2) · Aneurysm, Ascending Aorta (1) · Aortic Aneurysm (1) · Aortic Aneurysm, Familial Thoracic 1 (1) · Aortic Aneurysm, Giant Congenital (1) · Aortic Valve Disease (1) · Arrhythmogenic Right Ventricular Dysplasia (1) · Arterial Tortuosity Syndrome (1)
Aneurysm (16) · Collagen Diseases (16) · Congenital Abnormalities (16) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (16) · Dissection, Blood Vessel (16) · Genetic Diseases, Inborn (16) · Hematologic Diseases (16) · Hemic and Lymphatic Diseases (16) · Hemorrhagic Disorders (16) · Hemostatic Disorders (16) · Skin Abnormalities (16) · Skin Diseases (16) · Skin Diseases, Genetic (16) · Skin and Connective Tissue Diseases (16) · Vascular Diseases (16)
Celiprolol (2) · BID protein, human (1) · Control Groups (1) · Irbesartan (1) · Surgical Procedures, Operative (1) · enzastaurin (1)
Assistance Publique - Hôpitaux de Paris (3) · Acer Therapeutics Inc. (1) · Aytu BioPharma, Inc. (1) · Baylor College of Medicine (1) · Cambridge University Hospitals NHS Foundation Trust (1) · DeltaHealth Hospital · Shanghai (1) · French Cardiology Society (1) · Hospital do Coracao (1) · Institut National de la Santé Et de la Recherche Médicale, France (1) · Sheffield Hallam University (1) · Stanford University (1) · University Health Network, Toronto (1) · University of Colorado, Denver (1) · Yale University (1)
United States (6) · France (4) · United Kingdom (2) · Brazil (1) · Canada (1) · China (1)
Anne Blanchard, MD (1) · Benjamin Landis, MD (1) · Beth Darnall, PhD (1) · Emmanuel Messas, MD (1) · Joseph Emmerich, MD, PhD (1) · Kathryn C Chatfield, MD, PhD (1) · Markos Klonizakis (1) · Michael Franck, MD (1) · Michael Frank, MD (1) · Michel Azizi, MD, PhD (1) · Nimish Mittal, MBBS, MD (1) · Olivier Steinchen, MD (1) · Shaine A Morris, MD, MPH (1) · Shaine Morris, M.D.,M.P.H. (1)
PMID 20825986, PMID 23630948, PMID 39906986, PMID 41495090
2015 (1), UL1TR001082 (1)