4 completed, 2 active not recruiting, 1 not yet recruiting, 1 recruiting. 3 Not applicable, 2 Phase 2, 1 Phase 1, 1 Phase 3, 1 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 3 | Active not recruiting 1, Completed 1, Not yet recruiting 1 |
| Phase 2 | 2 | Completed 1, Recruiting 1 |
| Phase 1 | 1 | Completed 1 |
| Phase 3 | 1 | Recruiting 1 |
| Phase 4 | 1 | Completed 1 |
Follow Early Onset Alzheimer Disease: new trials by email Literature Review of Early Onset Alzheimer Disease trials Research Report on Early Onset Alzheimer Disease
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Study of Donanemab, RG6289, or the Combination of Donanemab and RG6289 in Presenilin 1 (PSEN1) E280A Mutation Carriers for the Treatment of Autosomal-Dominant Alzheimer's Disease Donanemab, RG6289, Donanemab placebo - Autosomal Dominant Alzheimers Disease, Early Onset Alzheimer Disease | Phase 2 / Phase 3 | Recruiting | Banner Health | 240 | 2026-07-08 | 2026-09-02 |
| A Study Testing Whether Low-Dose Radiation Could Help the Immune System and Possibly Improve Early-Onset Alzheimer's Disease. Low-Dose Whole-Brain Radiotherapy, Control Condition (No Radiotherapy) - Alzheimer Disease (AD), Early Onset Alzheimer Disease | Not applicable | Not yet recruiting | Heinrich-Heine University, Duesseldorf | 50 | 2026-05-15 | 2026-05-04 |
| 48-hour Ambulatory EEG Monitoring in Early Onset Alzheimer's Disease Computer assisted ambulatory electroencephalogram - Early Onset Alzheimer Disease | Not applicable | Active not recruiting | Mayo Clinic | 20 | 2020-02-19 | 2026-03-05 |
| Gene Therapy for APOE4 Homozygote of Alzheimer's Disease LX1001 - Alzheimer Disease, Early Onset Alzheimer Disease | Phase 1 / Phase 2 | Completed | Lexeo Therapeutics | 15 | 2019-11-06 | 2025-10-20 |
| Exploratory Clinical Study and Validation of Blood Biomarkers for Alzheimer's Disease Alzheimer Disease, Dementia | Completed | Amoneta Diagnostics SAS | 200 | 2019-10-28 | 2025-12-19 | |
| Longitudinal Early-onset Alzheimer's Disease Study Protocol Flortaucipir, Florbetaben, Fluorodeoxyglucose - Early Onset Alzheimer Disease, Alzheimer Disease | Active not recruiting | Indiana University | 850 | 2018-04-30 | 2026-07-29 | |
| RHAPSODY-plus: Online Counseling for Family Caregivers of Patients With Young Onset Dementia RHAPSODY online program and MEET online sessions - Early Onset Alzheimer Disease, Frontotemporal Dementia | Not applicable | Completed | Technical University of Munich | 20 | 2018-01-01 | 2019-09-17 |
| Reference Database & Longitudinal Registry of the Normal and Pathological Aging Brain Early Onset Alzheimer Disease, Mild Cognitive Impairment | Unknown | ElMindA Ltd | 2000 | 2016-08-01 | 2019-11-27 | |
| Sleep Apnea in Early to Mid-Stage Alzheimer's Disease CPAP Treatment, No treatment - Early Onset Alzheimer Disease, Alzheimer Disease | Terminated | Centre Hospitalier Universitaire de Saint Etienne | 22 | 2010-12-01 | 2016-08-11 | |
| Neptune Krill Oil (NKO™) in Early Stage Alzheimer's Disease (MNEMOSYNE) Neptune Krill Oil, Fish Oil, Placebo (soy oil) - Early Onset Alzheimer Disease | Phase 4 | Completed | NeuroBioPharm Inc. | 175 | 2009-05-01 | 2011-10-03 |
Alzheimer Disease (10) · Cognitive Dysfunction (3) · Dementia (3) · Plaque, Amyloid (2) · Cognition Disorders (1) · Depression (1) · Disease (1) · Frontotemporal Dementia (1) · Memory Disorders (1) · Microcephaly, Primary Autosomal Recessive, 6 (1) · Nerve Degeneration (1) · Neurodegenerative Diseases (1) · Pick Disease of the Brain (1) · Sleep Apnea Syndromes (1)
Brain Diseases (10) · Central Nervous System Diseases (10) · Mental Disorders (10) · Nervous System Diseases (10) · Neurocognitive Disorders (10) · Tauopathies (10) · Neurodegenerative Diseases (9) · Dementia (7) · Cognition Disorders (2) · Frontotemporal Lobar Degeneration (2) · Pathological Conditions, Anatomical (2) · Pathological Conditions, Signs and Symptoms (2) · Apnea (1) · Behavior (1) · Behavioral Symptoms (1)
4-(N-methylamino)-4'-(2-(2-(2-fluoroethoxy)ethoxy)ethoxy)stilbene (1) · 7-(6-fluoropyridin-3-yl)-5H-pyrido(4,3-b)indole (1) · Continuous Positive Airway Pressure (1) · Fish Oils (1) · Fluorodeoxyglucose F18 (1) · Soybean Oil (1) · donanemab (1)
Amoneta Diagnostics SAS (1) · Banner Health (1) · Centre Hospitalier Universitaire de Saint Etienne (1) · ElMindA Ltd (1) · Heinrich-Heine University, Duesseldorf (1) · Indiana University (1) · Lexeo Therapeutics (1) · Mayo Clinic (1) · NeuroBioPharm Inc. (1) · Technical University of Munich (1)
United States (4) · France (2) · Germany (2) · Argentina (1) · Canada (1) · Colombia (1) · Netherlands (1) · Spain (1) · Sweden (1) · United Kingdom (1)
Carla VandeWeerd, PhD (1) · Eric Reiman, M.D. (1) · Janine Diehl-Schmid, Prof. (1) · Jeffrey Lowenkron, MD (1) · Jessica Langbaum, Ph.D. (1) · Liana Apostolova, MD (1) · Neill Graff-Radford, MD (1) · Robert Alexander, M.D. (1) · Yakeel T. Quiroz-Gaviria, Ph.D. (1)
R01AG086363 (1), R56AG057195 (1)