3 active not recruiting, 3 recruiting, 1 completed, 1 enrolling by invitation. 4 Phase 1, 4 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 4 | Active not recruiting 3, Completed 1 |
| Phase 2 | 4 | Active not recruiting 2, Completed 1, Recruiting 1 |
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Study of LX2006 Gene Therapy in Friedreich Ataxia Cardiomyopathy LX2006, Usual Care - Friedreich Ataxia, Cardiomyopathy, Secondary | Phase 2 | Recruiting | Lexeo Therapeutics | 26 | 2026-06-25 | 2026-09-02 |
| Clinical Course Of Disease In Participants With FA-CM Friedreich Ataxia, Cardiomyopathy | Recruiting | Lexeo Therapeutics | 65 | 2025-09-30 | 2026-10-19 | |
| Long-term Follow-up Study of Gene Therapy for Arrhythmogenic Cardiomyopathy Due to a Plakophilin-2 Pathogenic Variant Arrhythmogenic Cardiomyopathy, PKP2-ACM | Enrolling by invitation | Lexeo Therapeutics | 10 | 2025-08-29 | 2025-11-12 | |
| Gene Therapy for ACM Due to a PKP2 Pathogenic Variant LX2020 - Arrhythmogenic Cardiomyopathy, PKP2-ACM | Phase 1 / Phase 2 | Active not recruiting | Lexeo Therapeutics | 10 | 2024-02-29 | 2025-11-12 |
| A Study to Assess Real-world Patient Characteristics and Clinical Course for Symptomatic Patients With PKP2-ACM Arrhythmogenic Cardiomyopathy, PKP2-ACM | Recruiting | Lexeo Therapeutics | 40 | 2024-01-23 | 2025-05-16 | |
| Long-Term Follow-up of Gene Therapy for APOE4 Homozygote Alzheimer's Disease LX1001 - Alzheimer Disease | Phase 1 | Active not recruiting | Lexeo Therapeutics | 10 | 2023-05-08 | 2025-07-01 |
| Gene Therapy for Cardiomyopathy Associated With Friedreich's Ataxia Low dose LX2006, Mid Dose LX2006, High Dose LX2006 - Friedreich Ataxia, Cardiomyopathy, Secondary | Phase 1 / Phase 2 | Active not recruiting | Lexeo Therapeutics | 8 | 2022-08-24 | 2025-12-23 |
| Gene Therapy for APOE4 Homozygote of Alzheimer's Disease LX1001 - Alzheimer Disease, Early Onset Alzheimer Disease | Phase 1 / Phase 2 | Completed | Lexeo Therapeutics | 15 | 2019-11-06 | 2025-10-20 |
Cardiomyopathies (6) · Arrhythmogenic Right Ventricular Dysplasia (3) · Death, Sudden, Cardiac (3) · Friedreich Ataxia (3) · Heart Arrest (3) · Alzheimer Disease (2) · Heart Diseases (2) · Cardiomyopathy, Hypertrophic (1) · Hypertrophy, Left Ventricular (1)
United States (8) · Brazil (1) · Canada (1) · Czechia (1) · France (1) · Germany (1) · Italy (1) · Spain (1)
PMID 37171121, PMID 40739200, PMID 42307907
2025 (1)