11 completed. 11 Phase 1, 3 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 11 | Completed 11 |
| Phase 2 | 3 | Completed 3 |
Follow Down Syndrome: new trials by email Literature Review of Down Syndrome trials Research Report on Down Syndrome
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Leucettinib-21 First-in-Human Phase 1 in Healthy Volunteers and Subjects With Down Syndrome and Alzheimer's Disease Leucettinib-21 - Healthy Volunteers, Down Syndrome | Phase 1 | Completed | Perha Pharmaceuticals | 152 | 2024-01-18 | 2026-06-30 |
| Phase 1/2 Trial of AEF0217 in Participants With Down Syndrome Placebo, AEF0217 - Down Syndrome | Phase 1 / Phase 2 | Completed | Aelis Farma | 40 | 2022-12-15 | 2024-10-10 |
| Safety, Tolerability and Immunogenicity of ACI-24 Vaccine in Adults With Down Syndrome ACI-24 low dose, ACI-24 high dose, Placebo - Down Syndrome | Phase 1 | Completed | AC Immune SA | 20 | 2016-03-01 | 2021-10-15 |
| Investigation of the Safety of Intranasal Glulisine in Down Syndrome Insulin glulisine, Saline - Down Syndrome | Phase 1 | Completed | HealthPartners Institute | 12 | 2015-04-01 | 2019-12-06 |
| Parents Resources for Decreasing the Incidence of Change Triggered Temper Outbursts Visual Scheduling, signalling change - Child Behavior | Phase 1 | Completed | Queen's University, Belfast | 80 | 2015-01-01 | 2020-02-17 |
| Nicotine Treatment of Cognitive Decline in Down Syndrome Low Dose Nicotine (7mg), Moderate Dose Nicotine (14mg) - Down Syndrome, Mild Cognitive Impairment | Phase 1 / Phase 2 | Completed | Vanderbilt University Medical Center | 7 | 2013-04-01 | 2022-05-10 |
| A Molecular and Functional Brain Imaging Study in Individuals With Down Syndrome and Healthy Controls Following Single Dose RG1662 RG1662, placebo - Healthy Volunteer, Down Syndrome | Phase 1 | Completed | Hoffmann-La Roche | 13 | 2012-08-01 | 2015-09-02 |
| A Study of RG1662 in Individuals With Down Syndrome Placebo, RG1662 - Down Syndrome | Phase 1 | Completed | Hoffmann-La Roche | 35 | 2011-11-01 | 2015-03-03 |
| An Interactive Informed Consent and Education Program for Pregnant Women Information about Prenatal Screening and Diagnosis - Pregnancy, Down Syndrome | Phase 1 | Completed | Northwestern University | 150 | 2010-08-01 | 2014-11-07 |
| Rivastigmine Study in Adolescents With Down Syndrome Rivastigmine, Liquid Placebo - Down Syndrome | Phase 1 / Phase 2 | Completed | Duke University | 42 | 2009-11-01 | 2015-04-06 |
| Rehabilitation of Children With Multiple Disabilities CTN model of care for children and their families - Cerebral Palsy, Autism | Phase 1 | Completed | Children's Treatment Network | 445 | 2007-04-01 | 2011-06-23 |
Alzheimer Disease (2) · Autistic Disorder (2) · Cognitive Dysfunction (2) · Brain Injuries (1) · Cerebral Palsy (1) · Child Behavior (1) · Dementia (1) · Fragile X Syndrome (1) · Intellectual Disability (1) · Prader-Willi Syndrome (1) · Psychological Well-Being (1)
Abnormalities, Multiple (11) · Chromosome Disorders (11) · Congenital Abnormalities (11) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (11) · Genetic Diseases, Inborn (11) · Nervous System Diseases (11) · Neurobehavioral Manifestations (11) · Neurologic Manifestations (11) · Intellectual Disability (10) · Mental Disorders (5) · Brain Diseases (3) · Central Nervous System Diseases (3) · Neurocognitive Disorders (3) · Autism Spectrum Disorder (2) · Behavior (2)
Diagnosis (1) · Insulin (1) · Nicotine (1) · Rivastigmine (1) · Sodium Chloride (1) · Tobacco Use Cessation Devices (1) · insulin glulisine (1)
Hoffmann-La Roche (2) · AC Immune SA (1) · Aelis Farma (1) · Children's Treatment Network (1) · Duke University (1) · HealthPartners Institute (1) · Northwestern University (1) · Perha Pharmaceuticals (1) · Queen's University, Belfast (1) · Vanderbilt University Medical Center (1)
United States (6) · United Kingdom (3) · Canada (1) · France (1) · Spain (1)
Alexander C Conley, PhD (1) · Bill Grobman, M.D., M.B.A (1) · George Capone, MD (1) · Kate Woodcock, PhD (1) · Michael H Rosenbloom, MD (1) · Michael S. Rafii, MD, PhD (1) · Michael Wolf, Ph.D, M.P.H (1) · Paul A Newhouse, MD (1) · Priya Kishnani, MD (1) · Robert Levine, M.D. (1) · Sandy Thurston (1)
2023 (1), R01AG047922 (1)