1575 completed. 1575 Phase 1, 519 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 1575 | Completed 1575 |
| Phase 2 | 519 | Completed 519 |
Follow Digestive System Neoplasms: new trials by email Literature Review of Digestive System Neoplasms trials Research Report on Digestive System Neoplasms
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A First-in-Human Study to Learn About How BAY3630942 is Distributed and Processed Inside the Body When Given After BAY3547922 and How Safe it is in People With Liver Cancer or Other Select Solid Cancers BAY3630942, BAY3547922 - Hepatocellular Carcinoma (HCC), Solid Tumors | Phase 1 | Completed | Bayer | 14 | 2024-08-26 | 2025-04-13 |
| A Study of SGN-B6A in Chinese Participants With Advanced Solid Tumors sigvotatug vedotin - Carcinoma, Non-Small Cell Lung, Squamous Cell Carcinoma of Head and Neck | Phase 1 | Completed | Seagen, a wholly owned subsidiary of Pfizer | 6 | 2024-08-21 | 2025-12-15 |
| Clinical Study of Cord Blood-Derived CAR-NK Cells in Gastric Cancer and Pancreatic Cancer CB CAR-NK18.2, Cyclophosphamide, Fludarabine - Gastric Cancer, Pancreas Adenocarcinoma | Phase 1 | Completed | Zhejiang Provincial People's Hospital | 9 | 2024-07-03 | 2026-07-09 |
| A Study to Investigate APL-5125 in Adults With Advanced Solid Tumors APL-5125 - Colorectal Cancer, Cholangiocarcinoma | Phase 1 | Completed | Apollo Therapeutics Ltd | 27 | 2024-06-18 | 2026-10-05 |
| Assessment of Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of GKL-006 Injection in Combination With TACE in Unresectable Hepatocellular Carcinoma GKL-006 Injection, transarterial chemoembolization - Hepatocellular Carcinoma (HCC), Unresectable Hepatocellular Carcinoma | Phase 1 | Completed | Beijing Gene Key Life Technology Co., Ltd | 13 | 2024-04-16 | 2026-09-28 |
| Irreversible Electroporation & Pembro Immunotherapy in Locally Advanced Pancreatic Cancer Pembrolizumab, Irreversible Electroporation - Pancreatic Cancer, Locally Advanced Pancreatic Cancer | Phase 1 | Completed | H. Lee Moffitt Cancer Center and Research Institute | 2 | 2024-04-10 | 2026-02-09 |
| A Study of AMG 355 Alone and in Combination With Pembrolizumab in Participants With Advanced Solid Tumors AMG 355, Pembrolizumab - Advanced Solid Tumors | Phase 1 | Completed | Amgen | 77 | 2024-03-07 | 2026-08-11 |
| Study to Evaluate the Safety, Pharmacokinetics, and Activity of GDC-1971 in Combination With Either Osimertinib in Participants With Unresectable, Locally Advanced, or Metastatic Non-Small Cell Lung Cancer, or With Cetuximab in Participants With Metastatic Colorectal Cancer GDC-1971, Osimertinib, Cetuximab - Colorectal Cancer, Non-Small Cell Lung Cancer | Phase 1 | Completed | Genentech, Inc. | 10 | 2024-01-08 | 2025-11-13 |
| Trastuzumab Deruxtecan Plus Nivolumab Plus Capecitabine Plus Oxaliplatin for HER2 Low Gastric and Gastroesophageal Junction Adenocarcinoma T-DXd, Nivolumab, Capecitabine - Gastric Adenocarcinoma, Gastroesophageal Junction Adenocarcinoma | Phase 1 / Phase 2 | Completed | National Cancer Center Hospital East | 30 | 2023-12-20 | 2026-04-14 |
| Phase 1 Trial of AZD6422 in CLDN18.2+ GI Tumors AZD6422 CLDN18.2 CAR-T product - Gastrointestinal Tumors | Phase 1 | Completed | Peking University | 8 | 2023-12-14 | 2025-07-31 |
| First-in-human Interleukin-15-transpresenting Wilms' Tumor Protein 1-targeting Autologous Dendritic Cell Vaccination in Cancer Patients IL15-transpresenting WT1-targeted Dendritic Cell Vaccine - Esophageal Cancer, Pancreas Cancer | Phase 1 / Phase 2 | Completed | University Hospital, Antwerp | 10 | 2023-12-06 | 2026-06-08 |
| Safety, Tolerability, Pharmacokinetics, Radiation Dosimetry, and PET Imaging Properties of 89Zr-labeled hNd2 (NMK89) in Patients With Pancreatic Cancer NMK89 - Pancreatic Cancer | Phase 1 | Completed | Nihon Medi-Physics Co., Ltd. | 10 | 2023-10-31 | 2025-11-26 |
| A Study to Evaluate Safety, Pharmacokinetics, & Activity of RO7496353 in Combination With a Checkpoint Inhibitor With or Without Standard-of-care Chemotherapy in Participants With Locally Advanced or Metastatic Solid Tumors; Urothelial Carcinoma Substudy in Association With RO7496353 Study GO44010 RO7496353, Atezolizumab, Capecitabine - Non-small Cell Lung Cancer, Gastric Cancer | Phase 1 | Completed | Genentech, Inc. | 102 | 2023-10-02 | 2026-06-18 |
| Safety, PK and Efficacy of AI-061 in Advanced Solid Tumors AI-061 - Melanoma, Non Small Cell Lung Cancer | Phase 1 | Completed | OncoC4, Inc. | 18 | 2023-07-11 | 2026-09-14 |
| A Study of SNS-101 (Anti VISTA) Monotherapy and in Combination With Cemiplimab in Patients With Advanced Solid Tumors SNS-101 (anti-VISTA), Cemiplimab - Solid Tumor, Adult, Advanced Solid Tumor | Phase 1 / Phase 2 | Completed | Sensei Biotherapeutics, Inc. | 98 | 2023-05-31 | 2026-09-02 |
| A Study of CDX-585 in Patients With Advanced Malignancies CDX-585 - Non-small Cell Lung Cancer, Gastric Cancer | Phase 1 | Completed | Celldex Therapeutics | 20 | 2023-05-11 | 2025-06-15 |
| Nivolumab With Ipilimumab Combined With TGFβ-15 Peptide Vaccine and Radiotherapy for Pancreatic Cancer Nivolumab, Ipilimumab, SBRT - Pancreatic Cancer | Phase 1 | Completed | Inna Chen, MD | 20 | 2023-05-03 | 2026-09-02 |
| Live Biotherapeutic Product GB104 Phase 1 Study in Colorectal Cancer GB104(Level 1), GB104(Level 2), GB104(Level 3) - Solid Tumor, Colorectal Cancer | Phase 1 | Completed | GILongevity | 9 | 2023-04-28 | 2025-02-14 |
| A Study to Evaluate the Safety and Dosimetry of 68Ga-labelled OncoFAP Derivatives in Solid Tumors [68Ga]Ga-OncoFAP administration - Breast Cancer, Colorectal Cancer | Phase 1 | Completed | Philogen S.p.A. | 18 | 2023-04-27 | 2024-11-15 |
| A Phase Ib/II Clinical Study of Camrelizumab and Apatinib Plus GP in the Treatment of Advanced Biliary Tract Cancer Camrelizumab and Apatinib Plus GP - Locally Advanced Biliary Tract Cancer, Metastatic Biliary Tract Cancer | Phase 1 / Phase 2 | Completed | Sun Yat-sen University | 49 | 2023-04-27 | 2026-06-22 |
Showing 20 of 1575. Sign in to see all of them.
Colorectal Neoplasms (515) · Pancreatic Neoplasms (468) · Stomach Neoplasms (246) · Colonic Neoplasms (241) · Carcinoma, Hepatocellular (231) · Breast Neoplasms (205) · Carcinoma, Non-Small-Cell Lung (198) · Neoplasms (188) · Rectal Neoplasms (183) · Ovarian Neoplasms (174) · Esophageal Neoplasms (165) · Liver Neoplasms (141) · Neoplasm Metastasis (131) · Lung Neoplasms (117) · Melanoma (113)
Digestive System Diseases (1565) · Neoplasms by Site (1546) · Neoplasms (1387) · Gastrointestinal Diseases (975) · Gastrointestinal Neoplasms (924) · Intestinal Diseases (687) · Intestinal Neoplasms (680) · Colonic Diseases (628) · Rectal Diseases (621) · Endocrine System Diseases (603) · Endocrine Gland Neoplasms (599) · Neoplasms by Histologic Type (590) · Neoplasms, Glandular and Epithelial (496) · Pancreatic Diseases (486)
Gemcitabine (171) · Oxaliplatin (125) · Fluorouracil (117) · Capecitabine (113) · Irinotecan (98) · Leucovorin (84) · Cisplatin (74) · Bevacizumab (65) · pembrolizumab (62) · Nivolumab (61) · Radiotherapy (61) · Sorafenib (61) · Cetuximab (59) · 130-nm albumin-bound paclitaxel (56) · Albumin-Bound Paclitaxel (51)
National Cancer Institute (NCI) (101) · M.D. Anderson Cancer Center (36) · Memorial Sloan Kettering Cancer Center (34) · Novartis Pharmaceuticals (28) · Eli Lilly and Company (24) · Fuda Cancer Hospital, Guangzhou (19) · AstraZeneca (18) · Pfizer (18) · H. Lee Moffitt Cancer Center and Research Institute (17) · City of Hope Medical Center (15) · Bristol-Myers Squibb (14) · Roswell Park Cancer Institute (14) · Dana-Farber Cancer Institute (13) · Hoffmann-La Roche (13) · Mayo Clinic (13)
United States (1018) · Spain (127) · China (126) · South Korea (111) · France (105) · United Kingdom (102) · Canada (97) · Japan (94) · Germany (89) · Italy (69) · Netherlands (68) · Belgium (63) · Taiwan (62) · Australia (58) · Singapore (30)
Richard Kim, M.D. (8) · Tim F Greten, M.D. (6)
PMID 22473314, PMID 39863139, PMID 19192962, PMID 19949018, PMID 22002018, PMID 32939319, PMID 35771259, PMID 36897458, PMID 37082579, PMID 37496366, PMID 39462179, PMID 41044356, PMID 10235156, PMID 10496568, PMID 10628373, PMID 10811496, PMID 11573045, PMID 11705489, PMID 11743810, PMID 11870157, PMID 11919232, PMID 11919233, PMID 12196376, PMID 12393999, PMID 12454110, PMID 12528778, PMID 12576903, PMID 12607634, PMID 12663720, PMID 12680184, PMID 12717353, PMID 12750250, PMID 12771884, PMID 12885811, PMID 12957454, PMID 14666038, PMID 14666667, PMID 14981738, PMID 15010069, PMID 15013589, PMID 15160338, PMID 15169795, PMID 15199546, PMID 15289858, PMID 1544146, PMID 15508084, PMID 15592836, PMID 16009951, PMID 16062074, PMID 16091763
2016 (24), 2015 (14), 2017 (14), 2018 (11), P30CA016672 (11), 2014 (9), 2019 (9), 2008 (7), P30CA012197 (6), P30CA015083 (6), U01CA069856 (6), U01CA132123 (6), 2009 (5), P30CA016056 (5), P30CA033572 (5)